Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats

Autores
Galeano, Pablo; Romero, Juan Ignacio; Luque Rojas, María Jesus; Suárez, Juan; Holubiec, Mariana Ines; Bisagno, Veronica; Santín, Luis Javier; Rodriguez de Fonseca, Fernando; Capani, Francisco; Blanco, Eduardo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Perinatal asphyxia (PA) increases the likelihood of suffering from dopamine related disorders, such as ADHD and schizophrenia. Since dopaminergic transmission plays a major role in cocaine sensitization, the purpose of this study was to determine whether PA could be associated with altered behavioral sensitization to cocaine. To this end, adult rats born vaginally (CTL), by caesarean section (C+), or by C+ with 15 min (PA15, moderate PA) or 19 min (PA19, severe PA) of global anoxia were repeatedly administered with cocaine (i.p., 15 mg/kg) and then challenged with cocaine (i.p., 15 mg/kg) after a five day withdrawal period. In addition, c-Fos, FosB/deltaFosB, DAT and TH expression were assessed in dorsal (CPu) and ventral (NAcc) striatum. Results indicated that PA15 rats exhibited an increased locomotor sensitization to cocaine, while PA19 rats displayed an abnormal acquisition of locomotor sensitization and did not express a sensitized response to cocaine. c-Fos expression in NAcc, but not in CPu, was associated with these alterations in cocaine sensitization. FosB/deltaFosB expression was increased in all groups and regions after repeated cocaine administration, although it reached lower expression levels in PA19 rats. In CTL, C+ and PA15, but not in PA19 rats, the expression of TH in NAcc was reduced in groups repeatedly treated with cocaine, independently of the challenge test. Furthermore, this reduction was more pronounced in PA15 rats. DAT expression remained unaltered in all groups and regions studied. These results suggest that moderate PA may increase the vulnerability to drug abuse and in particular to cocaine addiction.
Fil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Luque Rojas, María Jesus. Hospital Carlos Haya; España
Fil: Suárez, Juan. Hospital Carlos Haya; España
Fil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Santín, Luis Javier. Universidad de Malaga; España
Fil: Rodriguez de Fonseca, Fernando. Hospital Carlos Haya; España
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universidad Arg."john F.kennedy"; Argentina
Fil: Blanco, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Hospital Carlos Haya; España. Universidad de Malaga; España
Materia
Perinatal Asphyxia
Cocaine Sensitization
C-Fos
Delta-Fosb
Tyrosine Hydroxylase
Dopamine Transporter
Caudate-Putamen
Nucleus Accumbens
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7898
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/7898
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult ratsGaleano, PabloRomero, Juan IgnacioLuque Rojas, María JesusSuárez, JuanHolubiec, Mariana InesBisagno, VeronicaSantín, Luis JavierRodriguez de Fonseca, FernandoCapani, FranciscoBlanco, EduardoPerinatal AsphyxiaCocaine SensitizationC-FosDelta-FosbTyrosine HydroxylaseDopamine TransporterCaudate-PutamenNucleus Accumbenshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Perinatal asphyxia (PA) increases the likelihood of suffering from dopamine related disorders, such as ADHD and schizophrenia. Since dopaminergic transmission plays a major role in cocaine sensitization, the purpose of this study was to determine whether PA could be associated with altered behavioral sensitization to cocaine. To this end, adult rats born vaginally (CTL), by caesarean section (C+), or by C+ with 15 min (PA15, moderate PA) or 19 min (PA19, severe PA) of global anoxia were repeatedly administered with cocaine (i.p., 15 mg/kg) and then challenged with cocaine (i.p., 15 mg/kg) after a five day withdrawal period. In addition, c-Fos, FosB/deltaFosB, DAT and TH expression were assessed in dorsal (CPu) and ventral (NAcc) striatum. Results indicated that PA15 rats exhibited an increased locomotor sensitization to cocaine, while PA19 rats displayed an abnormal acquisition of locomotor sensitization and did not express a sensitized response to cocaine. c-Fos expression in NAcc, but not in CPu, was associated with these alterations in cocaine sensitization. FosB/deltaFosB expression was increased in all groups and regions after repeated cocaine administration, although it reached lower expression levels in PA19 rats. In CTL, C+ and PA15, but not in PA19 rats, the expression of TH in NAcc was reduced in groups repeatedly treated with cocaine, independently of the challenge test. Furthermore, this reduction was more pronounced in PA15 rats. DAT expression remained unaltered in all groups and regions studied. These results suggest that moderate PA may increase the vulnerability to drug abuse and in particular to cocaine addiction.Fil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Luque Rojas, María Jesus. Hospital Carlos Haya; EspañaFil: Suárez, Juan. Hospital Carlos Haya; EspañaFil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); ArgentinaFil: Santín, Luis Javier. Universidad de Malaga; EspañaFil: Rodriguez de Fonseca, Fernando. Hospital Carlos Haya; EspañaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universidad Arg."john F.kennedy"; ArgentinaFil: Blanco, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Hospital Carlos Haya; España. Universidad de Malaga; EspañaWiley2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7898Galeano, Pablo; Romero, Juan Ignacio; Luque Rojas, María Jesus; Suárez, Juan; Holubiec, Mariana Ines; et al.; Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats; Wiley; Synapse; 67; 9; 7-2013; 553-5670887-4476enginfo:eu-repo/semantics/altIdentifier/doi/10.1002/syn.21660info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/syn.21660/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:15Zoai:ri.conicet.gov.ar:11336/7898instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:15.601CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats
title Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats
spellingShingle Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats
Galeano, Pablo
Perinatal Asphyxia
Cocaine Sensitization
C-Fos
Delta-Fosb
Tyrosine Hydroxylase
Dopamine Transporter
Caudate-Putamen
Nucleus Accumbens
title_short Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats
title_full Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats
title_fullStr Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats
title_full_unstemmed Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats
title_sort Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats
dc.creator.none.fl_str_mv Galeano, Pablo
Romero, Juan Ignacio
Luque Rojas, María Jesus
Suárez, Juan
Holubiec, Mariana Ines
Bisagno, Veronica
Santín, Luis Javier
Rodriguez de Fonseca, Fernando
Capani, Francisco
Blanco, Eduardo
author Galeano, Pablo
author_facet Galeano, Pablo
Romero, Juan Ignacio
Luque Rojas, María Jesus
Suárez, Juan
Holubiec, Mariana Ines
Bisagno, Veronica
Santín, Luis Javier
Rodriguez de Fonseca, Fernando
Capani, Francisco
Blanco, Eduardo
author_role author
author2 Romero, Juan Ignacio
Luque Rojas, María Jesus
Suárez, Juan
Holubiec, Mariana Ines
Bisagno, Veronica
Santín, Luis Javier
Rodriguez de Fonseca, Fernando
Capani, Francisco
Blanco, Eduardo
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Perinatal Asphyxia
Cocaine Sensitization
C-Fos
Delta-Fosb
Tyrosine Hydroxylase
Dopamine Transporter
Caudate-Putamen
Nucleus Accumbens
topic Perinatal Asphyxia
Cocaine Sensitization
C-Fos
Delta-Fosb
Tyrosine Hydroxylase
Dopamine Transporter
Caudate-Putamen
Nucleus Accumbens
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Perinatal asphyxia (PA) increases the likelihood of suffering from dopamine related disorders, such as ADHD and schizophrenia. Since dopaminergic transmission plays a major role in cocaine sensitization, the purpose of this study was to determine whether PA could be associated with altered behavioral sensitization to cocaine. To this end, adult rats born vaginally (CTL), by caesarean section (C+), or by C+ with 15 min (PA15, moderate PA) or 19 min (PA19, severe PA) of global anoxia were repeatedly administered with cocaine (i.p., 15 mg/kg) and then challenged with cocaine (i.p., 15 mg/kg) after a five day withdrawal period. In addition, c-Fos, FosB/deltaFosB, DAT and TH expression were assessed in dorsal (CPu) and ventral (NAcc) striatum. Results indicated that PA15 rats exhibited an increased locomotor sensitization to cocaine, while PA19 rats displayed an abnormal acquisition of locomotor sensitization and did not express a sensitized response to cocaine. c-Fos expression in NAcc, but not in CPu, was associated with these alterations in cocaine sensitization. FosB/deltaFosB expression was increased in all groups and regions after repeated cocaine administration, although it reached lower expression levels in PA19 rats. In CTL, C+ and PA15, but not in PA19 rats, the expression of TH in NAcc was reduced in groups repeatedly treated with cocaine, independently of the challenge test. Furthermore, this reduction was more pronounced in PA15 rats. DAT expression remained unaltered in all groups and regions studied. These results suggest that moderate PA may increase the vulnerability to drug abuse and in particular to cocaine addiction.
Fil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Luque Rojas, María Jesus. Hospital Carlos Haya; España
Fil: Suárez, Juan. Hospital Carlos Haya; España
Fil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Santín, Luis Javier. Universidad de Malaga; España
Fil: Rodriguez de Fonseca, Fernando. Hospital Carlos Haya; España
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universidad Arg."john F.kennedy"; Argentina
Fil: Blanco, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Hospital Carlos Haya; España. Universidad de Malaga; España
description Perinatal asphyxia (PA) increases the likelihood of suffering from dopamine related disorders, such as ADHD and schizophrenia. Since dopaminergic transmission plays a major role in cocaine sensitization, the purpose of this study was to determine whether PA could be associated with altered behavioral sensitization to cocaine. To this end, adult rats born vaginally (CTL), by caesarean section (C+), or by C+ with 15 min (PA15, moderate PA) or 19 min (PA19, severe PA) of global anoxia were repeatedly administered with cocaine (i.p., 15 mg/kg) and then challenged with cocaine (i.p., 15 mg/kg) after a five day withdrawal period. In addition, c-Fos, FosB/deltaFosB, DAT and TH expression were assessed in dorsal (CPu) and ventral (NAcc) striatum. Results indicated that PA15 rats exhibited an increased locomotor sensitization to cocaine, while PA19 rats displayed an abnormal acquisition of locomotor sensitization and did not express a sensitized response to cocaine. c-Fos expression in NAcc, but not in CPu, was associated with these alterations in cocaine sensitization. FosB/deltaFosB expression was increased in all groups and regions after repeated cocaine administration, although it reached lower expression levels in PA19 rats. In CTL, C+ and PA15, but not in PA19 rats, the expression of TH in NAcc was reduced in groups repeatedly treated with cocaine, independently of the challenge test. Furthermore, this reduction was more pronounced in PA15 rats. DAT expression remained unaltered in all groups and regions studied. These results suggest that moderate PA may increase the vulnerability to drug abuse and in particular to cocaine addiction.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7898
Galeano, Pablo; Romero, Juan Ignacio; Luque Rojas, María Jesus; Suárez, Juan; Holubiec, Mariana Ines; et al.; Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats; Wiley; Synapse; 67; 9; 7-2013; 553-567
0887-4476
url http://hdl.handle.net/11336/7898
identifier_str_mv Galeano, Pablo; Romero, Juan Ignacio; Luque Rojas, María Jesus; Suárez, Juan; Holubiec, Mariana Ines; et al.; Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats; Wiley; Synapse; 67; 9; 7-2013; 553-567
0887-4476
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/syn.21660
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/syn.21660/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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