Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples

Autores
Kuitunen, Marja Leena; Altamirano, Jorgelina Cecilia; Siegenthaler, Peter; Taure, Terhi Hannele; Häkkinen, Vesa Antero; Vanninen, Paula Sinikka
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A simple derivatization technique was developed for the analysis of seven Schedule 3 chemicals and one Schedule 2 chemical listed in the Chemical Weapons Convention (CWC). Phosgene, phosphorus oxychloride, phosphorus trichloride, phosphorus pentachloride, thionyl chloride, sulfur monochloride, sulfur dichloride (Schedule 3) as well as arsenic trichloride (Schedule 2) were derivatized using 1-propanol in 40% pyridine solution for analysis with gas chromatography-mass spectrometry (GC?MS). Derivatization temperature and concentration of the derivatization solution were optimized for maximum derivatization recovery. The stabilities of the target analytes and their derivatives in different solvents were studied. The derivatization yield showed a linear response within the analyte concentration range of 0.1?2 mM (10?200 µg/ml) with correlation coefficients > 0.99 (r2), except for AsCl3 which did not show a linear response after derivatization. Good reproducibility with relative standard deviations (RSDs) from 3 to 13% was achieved. The derivatization recovery was 66% for phosgene and 67?80% for the P-containing chemicals phosphorus oxychloride, phosphorus trichloride and phosphorus pentachloride. Recommendations to use the method for screening the presence of these chemicals in organic liquid samples are given. The method is used when CWC-related samples are screened at VERIFIN.
Fil: Kuitunen, Marja Leena. University of Helsinki; Finlandia
Fil: Altamirano, Jorgelina Cecilia. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentina
Fil: Siegenthaler, Peter. Federal Office for Civil Protection; Suiza
Fil: Taure, Terhi Hannele. University of Helsinki; Finlandia
Fil: Häkkinen, Vesa Antero. University of Helsinki; Finlandia
Fil: Vanninen, Paula Sinikka. University of Helsinki; Finlandia
Materia
CHEMICAL WEAPONS CONVENTION
GC-MS
DERIVATIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/111549
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/111549
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samplesKuitunen, Marja LeenaAltamirano, Jorgelina CeciliaSiegenthaler, PeterTaure, Terhi HanneleHäkkinen, Vesa AnteroVanninen, Paula SinikkaCHEMICAL WEAPONS CONVENTIONGC-MSDERIVATIZATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A simple derivatization technique was developed for the analysis of seven Schedule 3 chemicals and one Schedule 2 chemical listed in the Chemical Weapons Convention (CWC). Phosgene, phosphorus oxychloride, phosphorus trichloride, phosphorus pentachloride, thionyl chloride, sulfur monochloride, sulfur dichloride (Schedule 3) as well as arsenic trichloride (Schedule 2) were derivatized using 1-propanol in 40% pyridine solution for analysis with gas chromatography-mass spectrometry (GC?MS). Derivatization temperature and concentration of the derivatization solution were optimized for maximum derivatization recovery. The stabilities of the target analytes and their derivatives in different solvents were studied. The derivatization yield showed a linear response within the analyte concentration range of 0.1?2 mM (10?200 µg/ml) with correlation coefficients > 0.99 (r2), except for AsCl3 which did not show a linear response after derivatization. Good reproducibility with relative standard deviations (RSDs) from 3 to 13% was achieved. The derivatization recovery was 66% for phosgene and 67?80% for the P-containing chemicals phosphorus oxychloride, phosphorus trichloride and phosphorus pentachloride. Recommendations to use the method for screening the presence of these chemicals in organic liquid samples are given. The method is used when CWC-related samples are screened at VERIFIN.Fil: Kuitunen, Marja Leena. University of Helsinki; FinlandiaFil: Altamirano, Jorgelina Cecilia. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Siegenthaler, Peter. Federal Office for Civil Protection; SuizaFil: Taure, Terhi Hannele. University of Helsinki; FinlandiaFil: Häkkinen, Vesa Antero. University of Helsinki; FinlandiaFil: Vanninen, Paula Sinikka. University of Helsinki; FinlandiaRoyal Society of Chemistry2020-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/111549Kuitunen, Marja Leena; Altamirano, Jorgelina Cecilia; Siegenthaler, Peter; Taure, Terhi Hannele; Häkkinen, Vesa Antero; et al.; Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples; Royal Society of Chemistry; Analytical Methods; 12; 4-2020; 2527–25351759-96601759-9679CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=D0AY00263Ainfo:eu-repo/semantics/altIdentifier/doi/10.1039/D0AY00263Ainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:46:16Zoai:ri.conicet.gov.ar:11336/111549instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:46:16.711CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples
title Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples
spellingShingle Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples
Kuitunen, Marja Leena
CHEMICAL WEAPONS CONVENTION
GC-MS
DERIVATIZATION
title_short Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples
title_full Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples
title_fullStr Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples
title_full_unstemmed Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples
title_sort Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples
dc.creator.none.fl_str_mv Kuitunen, Marja Leena
Altamirano, Jorgelina Cecilia
Siegenthaler, Peter
Taure, Terhi Hannele
Häkkinen, Vesa Antero
Vanninen, Paula Sinikka
author Kuitunen, Marja Leena
author_facet Kuitunen, Marja Leena
Altamirano, Jorgelina Cecilia
Siegenthaler, Peter
Taure, Terhi Hannele
Häkkinen, Vesa Antero
Vanninen, Paula Sinikka
author_role author
author2 Altamirano, Jorgelina Cecilia
Siegenthaler, Peter
Taure, Terhi Hannele
Häkkinen, Vesa Antero
Vanninen, Paula Sinikka
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CHEMICAL WEAPONS CONVENTION
GC-MS
DERIVATIZATION
topic CHEMICAL WEAPONS CONVENTION
GC-MS
DERIVATIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A simple derivatization technique was developed for the analysis of seven Schedule 3 chemicals and one Schedule 2 chemical listed in the Chemical Weapons Convention (CWC). Phosgene, phosphorus oxychloride, phosphorus trichloride, phosphorus pentachloride, thionyl chloride, sulfur monochloride, sulfur dichloride (Schedule 3) as well as arsenic trichloride (Schedule 2) were derivatized using 1-propanol in 40% pyridine solution for analysis with gas chromatography-mass spectrometry (GC?MS). Derivatization temperature and concentration of the derivatization solution were optimized for maximum derivatization recovery. The stabilities of the target analytes and their derivatives in different solvents were studied. The derivatization yield showed a linear response within the analyte concentration range of 0.1?2 mM (10?200 µg/ml) with correlation coefficients > 0.99 (r2), except for AsCl3 which did not show a linear response after derivatization. Good reproducibility with relative standard deviations (RSDs) from 3 to 13% was achieved. The derivatization recovery was 66% for phosgene and 67?80% for the P-containing chemicals phosphorus oxychloride, phosphorus trichloride and phosphorus pentachloride. Recommendations to use the method for screening the presence of these chemicals in organic liquid samples are given. The method is used when CWC-related samples are screened at VERIFIN.
Fil: Kuitunen, Marja Leena. University of Helsinki; Finlandia
Fil: Altamirano, Jorgelina Cecilia. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentina
Fil: Siegenthaler, Peter. Federal Office for Civil Protection; Suiza
Fil: Taure, Terhi Hannele. University of Helsinki; Finlandia
Fil: Häkkinen, Vesa Antero. University of Helsinki; Finlandia
Fil: Vanninen, Paula Sinikka. University of Helsinki; Finlandia
description A simple derivatization technique was developed for the analysis of seven Schedule 3 chemicals and one Schedule 2 chemical listed in the Chemical Weapons Convention (CWC). Phosgene, phosphorus oxychloride, phosphorus trichloride, phosphorus pentachloride, thionyl chloride, sulfur monochloride, sulfur dichloride (Schedule 3) as well as arsenic trichloride (Schedule 2) were derivatized using 1-propanol in 40% pyridine solution for analysis with gas chromatography-mass spectrometry (GC?MS). Derivatization temperature and concentration of the derivatization solution were optimized for maximum derivatization recovery. The stabilities of the target analytes and their derivatives in different solvents were studied. The derivatization yield showed a linear response within the analyte concentration range of 0.1?2 mM (10?200 µg/ml) with correlation coefficients > 0.99 (r2), except for AsCl3 which did not show a linear response after derivatization. Good reproducibility with relative standard deviations (RSDs) from 3 to 13% was achieved. The derivatization recovery was 66% for phosgene and 67?80% for the P-containing chemicals phosphorus oxychloride, phosphorus trichloride and phosphorus pentachloride. Recommendations to use the method for screening the presence of these chemicals in organic liquid samples are given. The method is used when CWC-related samples are screened at VERIFIN.
publishDate 2020
dc.date.none.fl_str_mv 2020-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/111549
Kuitunen, Marja Leena; Altamirano, Jorgelina Cecilia; Siegenthaler, Peter; Taure, Terhi Hannele; Häkkinen, Vesa Antero; et al.; Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples; Royal Society of Chemistry; Analytical Methods; 12; 4-2020; 2527–2535
1759-9660
1759-9679
CONICET Digital
CONICET
url http://hdl.handle.net/11336/111549
identifier_str_mv Kuitunen, Marja Leena; Altamirano, Jorgelina Cecilia; Siegenthaler, Peter; Taure, Terhi Hannele; Häkkinen, Vesa Antero; et al.; Derivatization and rapid GC-MS screening of chlorides relevant to the chemical weapons convention in organic liquid samples; Royal Society of Chemistry; Analytical Methods; 12; 4-2020; 2527–2535
1759-9660
1759-9679
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=D0AY00263A
info:eu-repo/semantics/altIdentifier/doi/10.1039/D0AY00263A
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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