What evolution tells us about protein physics, and protein physics tells us about evolution

Autores
Bastolla, Ugo; Dehouck, Yves; Echave, Julián
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The integration of molecular evolution and protein biophysics is an emerging theme that steadily gained importance during the last 15 years, significantly advancing both fields. The central integrative concept is the stability of the native state, although non-native conformations are increasingly recognized to play a major role, concerning, for example, aggregation, folding kinetics, or functional dynamics. Besides molecular requirements on fitness, the stability of native and alternative conformations is modulated by a variety of factors, including population size, selective pressure on the replicative system, which determines mutation rates and biases, and epistatic effects. We discuss some of the recent advances, open questions, and integrating views in protein evolution, in light of the many underlying trade-offs, correlations, and dichotomies.
Fil: Bastolla, Ugo. Centro de Biologia Molecular “Severo Ochoa”; España
Fil: Dehouck, Yves. Université Libre de Bruxelles. Machine Learning Group; Bélgica
Fil: Echave, Julián. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Protein
Evolution
Biophysics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53308
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/53308
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling What evolution tells us about protein physics, and protein physics tells us about evolutionBastolla, UgoDehouck, YvesEchave, JuliánProteinEvolutionBiophysicshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The integration of molecular evolution and protein biophysics is an emerging theme that steadily gained importance during the last 15 years, significantly advancing both fields. The central integrative concept is the stability of the native state, although non-native conformations are increasingly recognized to play a major role, concerning, for example, aggregation, folding kinetics, or functional dynamics. Besides molecular requirements on fitness, the stability of native and alternative conformations is modulated by a variety of factors, including population size, selective pressure on the replicative system, which determines mutation rates and biases, and epistatic effects. We discuss some of the recent advances, open questions, and integrating views in protein evolution, in light of the many underlying trade-offs, correlations, and dichotomies.Fil: Bastolla, Ugo. Centro de Biologia Molecular “Severo Ochoa”; EspañaFil: Dehouck, Yves. Université Libre de Bruxelles. Machine Learning Group; BélgicaFil: Echave, Julián. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2017-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53308Bastolla, Ugo; Dehouck, Yves; Echave, Julián; What evolution tells us about protein physics, and protein physics tells us about evolution; Elsevier; Current Opinion In Structural Biology; 42; 2-2017; 59-660959-440XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.sbi.2016.10.020info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0959440X16301816info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:19:34Zoai:ri.conicet.gov.ar:11336/53308instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:19:34.382CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv What evolution tells us about protein physics, and protein physics tells us about evolution
title What evolution tells us about protein physics, and protein physics tells us about evolution
spellingShingle What evolution tells us about protein physics, and protein physics tells us about evolution
Bastolla, Ugo
Protein
Evolution
Biophysics
title_short What evolution tells us about protein physics, and protein physics tells us about evolution
title_full What evolution tells us about protein physics, and protein physics tells us about evolution
title_fullStr What evolution tells us about protein physics, and protein physics tells us about evolution
title_full_unstemmed What evolution tells us about protein physics, and protein physics tells us about evolution
title_sort What evolution tells us about protein physics, and protein physics tells us about evolution
dc.creator.none.fl_str_mv Bastolla, Ugo
Dehouck, Yves
Echave, Julián
author Bastolla, Ugo
author_facet Bastolla, Ugo
Dehouck, Yves
Echave, Julián
author_role author
author2 Dehouck, Yves
Echave, Julián
author2_role author
author
dc.subject.none.fl_str_mv Protein
Evolution
Biophysics
topic Protein
Evolution
Biophysics
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The integration of molecular evolution and protein biophysics is an emerging theme that steadily gained importance during the last 15 years, significantly advancing both fields. The central integrative concept is the stability of the native state, although non-native conformations are increasingly recognized to play a major role, concerning, for example, aggregation, folding kinetics, or functional dynamics. Besides molecular requirements on fitness, the stability of native and alternative conformations is modulated by a variety of factors, including population size, selective pressure on the replicative system, which determines mutation rates and biases, and epistatic effects. We discuss some of the recent advances, open questions, and integrating views in protein evolution, in light of the many underlying trade-offs, correlations, and dichotomies.
Fil: Bastolla, Ugo. Centro de Biologia Molecular “Severo Ochoa”; España
Fil: Dehouck, Yves. Université Libre de Bruxelles. Machine Learning Group; Bélgica
Fil: Echave, Julián. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The integration of molecular evolution and protein biophysics is an emerging theme that steadily gained importance during the last 15 years, significantly advancing both fields. The central integrative concept is the stability of the native state, although non-native conformations are increasingly recognized to play a major role, concerning, for example, aggregation, folding kinetics, or functional dynamics. Besides molecular requirements on fitness, the stability of native and alternative conformations is modulated by a variety of factors, including population size, selective pressure on the replicative system, which determines mutation rates and biases, and epistatic effects. We discuss some of the recent advances, open questions, and integrating views in protein evolution, in light of the many underlying trade-offs, correlations, and dichotomies.
publishDate 2017
dc.date.none.fl_str_mv 2017-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53308
Bastolla, Ugo; Dehouck, Yves; Echave, Julián; What evolution tells us about protein physics, and protein physics tells us about evolution; Elsevier; Current Opinion In Structural Biology; 42; 2-2017; 59-66
0959-440X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53308
identifier_str_mv Bastolla, Ugo; Dehouck, Yves; Echave, Julián; What evolution tells us about protein physics, and protein physics tells us about evolution; Elsevier; Current Opinion In Structural Biology; 42; 2-2017; 59-66
0959-440X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.sbi.2016.10.020
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0959440X16301816
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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