One Health: potential synergy between infectious and toxic agents. The case of COVID-19

Autores
Herkovits, Jorge
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although the relationship between environmental toxicity and infectious diseases is poorly studied, it is probably more common than is recognized, since the chemical substances could be associated with pre-existing pathologies. For example, some conditions that influence the progression of COVID-19 could have toxicological causes such as cancer, endocrine, neurological and inflammatory disorders, kidney failure, etc. This contribution highlights that SARS-CoV-2 and some high-volume organic and inorganic chemicals could also exert dysfunctions in the same homeostatic regulators such as HIF-1 and ACE2, with a potential synergistic effect that could affect the severity of COVID-19. This potential synergy is illustrated with adverse effects obtained through bioassays performed with free-living vertebrate embryos indicating that their use as sentinel organisms for environmental contamination could be beneficial both for the ecosystem and human health.
Fil: Herkovits, Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Pro Salud y Medio Ambiente; Argentina
Materia
COVID-19
ACE-2
HIF-1
CHEMICALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/247511
Acceder
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network_name_str CONICET Digital (CONICET)
spelling One Health: potential synergy between infectious and toxic agents. The case of COVID-19Herkovits, JorgeCOVID-19ACE-2HIF-1CHEMICALShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Although the relationship between environmental toxicity and infectious diseases is poorly studied, it is probably more common than is recognized, since the chemical substances could be associated with pre-existing pathologies. For example, some conditions that influence the progression of COVID-19 could have toxicological causes such as cancer, endocrine, neurological and inflammatory disorders, kidney failure, etc. This contribution highlights that SARS-CoV-2 and some high-volume organic and inorganic chemicals could also exert dysfunctions in the same homeostatic regulators such as HIF-1 and ACE2, with a potential synergistic effect that could affect the severity of COVID-19. This potential synergy is illustrated with adverse effects obtained through bioassays performed with free-living vertebrate embryos indicating that their use as sentinel organisms for environmental contamination could be beneficial both for the ecosystem and human health.Fil: Herkovits, Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Pro Salud y Medio Ambiente; ArgentinaAcademia2023-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/247511Herkovits, Jorge; One Health: potential synergy between infectious and toxic agents. The case of COVID-19; Academia; Academia Medicine; 1; 1; 10-2023; 1-62994-435XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.20935/AcadMed6106info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:26Zoai:ri.conicet.gov.ar:11336/247511instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:27.136CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv One Health: potential synergy between infectious and toxic agents. The case of COVID-19
title One Health: potential synergy between infectious and toxic agents. The case of COVID-19
spellingShingle One Health: potential synergy between infectious and toxic agents. The case of COVID-19
Herkovits, Jorge
COVID-19
ACE-2
HIF-1
CHEMICALS
title_short One Health: potential synergy between infectious and toxic agents. The case of COVID-19
title_full One Health: potential synergy between infectious and toxic agents. The case of COVID-19
title_fullStr One Health: potential synergy between infectious and toxic agents. The case of COVID-19
title_full_unstemmed One Health: potential synergy between infectious and toxic agents. The case of COVID-19
title_sort One Health: potential synergy between infectious and toxic agents. The case of COVID-19
dc.creator.none.fl_str_mv Herkovits, Jorge
author Herkovits, Jorge
author_facet Herkovits, Jorge
author_role author
dc.subject.none.fl_str_mv COVID-19
ACE-2
HIF-1
CHEMICALS
topic COVID-19
ACE-2
HIF-1
CHEMICALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Although the relationship between environmental toxicity and infectious diseases is poorly studied, it is probably more common than is recognized, since the chemical substances could be associated with pre-existing pathologies. For example, some conditions that influence the progression of COVID-19 could have toxicological causes such as cancer, endocrine, neurological and inflammatory disorders, kidney failure, etc. This contribution highlights that SARS-CoV-2 and some high-volume organic and inorganic chemicals could also exert dysfunctions in the same homeostatic regulators such as HIF-1 and ACE2, with a potential synergistic effect that could affect the severity of COVID-19. This potential synergy is illustrated with adverse effects obtained through bioassays performed with free-living vertebrate embryos indicating that their use as sentinel organisms for environmental contamination could be beneficial both for the ecosystem and human health.
Fil: Herkovits, Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Pro Salud y Medio Ambiente; Argentina
description Although the relationship between environmental toxicity and infectious diseases is poorly studied, it is probably more common than is recognized, since the chemical substances could be associated with pre-existing pathologies. For example, some conditions that influence the progression of COVID-19 could have toxicological causes such as cancer, endocrine, neurological and inflammatory disorders, kidney failure, etc. This contribution highlights that SARS-CoV-2 and some high-volume organic and inorganic chemicals could also exert dysfunctions in the same homeostatic regulators such as HIF-1 and ACE2, with a potential synergistic effect that could affect the severity of COVID-19. This potential synergy is illustrated with adverse effects obtained through bioassays performed with free-living vertebrate embryos indicating that their use as sentinel organisms for environmental contamination could be beneficial both for the ecosystem and human health.
publishDate 2023
dc.date.none.fl_str_mv 2023-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/247511
Herkovits, Jorge; One Health: potential synergy between infectious and toxic agents. The case of COVID-19; Academia; Academia Medicine; 1; 1; 10-2023; 1-6
2994-435X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/247511
identifier_str_mv Herkovits, Jorge; One Health: potential synergy between infectious and toxic agents. The case of COVID-19; Academia; Academia Medicine; 1; 1; 10-2023; 1-6
2994-435X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.20935/AcadMed6106
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academia
publisher.none.fl_str_mv Academia
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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