Radial percolation reveals that cancer stem cells are trapped in the core of colonies
- Autores
- Barberis, Lucas Miguel
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Using geometrical arguments, it is shown that Cancer Stem Cells (CSCs) must be con-fined inside solid tumors under natural conditions. Aided by an agent-based model and percolation theory, the probability of a CSC being positioned at the border of a colony is estimated. This probability is estimated as a function of the CSC self-renewal probability ps; i.e., the chance that a CSC remains undifferentiated after mitosis. In the most common situations ps is low, and most CSCs produce differentiated cells at a very low rate. The results presented here show that CSCs form a small core in the center of a cancer cell colony; they become quiescent due to the lack of space to proliferate, which stabilizes their population size. This result provides a simple explanation for the CSC niche size, dispensing with the need for quorum sensing or other proposed signaling mechanisms. It also supports the hypothesis that metastases are likely to start at the very beginning of tumor development.
Fil: Barberis, Lucas Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina - Materia
-
CANCER STEM CELLS
TUMORSPHERES
METASTASIS
PERCOLATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/189271
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Radial percolation reveals that cancer stem cells are trapped in the core of coloniesBarberis, Lucas MiguelCANCER STEM CELLSTUMORSPHERESMETASTASISPERCOLATIONhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Using geometrical arguments, it is shown that Cancer Stem Cells (CSCs) must be con-fined inside solid tumors under natural conditions. Aided by an agent-based model and percolation theory, the probability of a CSC being positioned at the border of a colony is estimated. This probability is estimated as a function of the CSC self-renewal probability ps; i.e., the chance that a CSC remains undifferentiated after mitosis. In the most common situations ps is low, and most CSCs produce differentiated cells at a very low rate. The results presented here show that CSCs form a small core in the center of a cancer cell colony; they become quiescent due to the lack of space to proliferate, which stabilizes their population size. This result provides a simple explanation for the CSC niche size, dispensing with the need for quorum sensing or other proposed signaling mechanisms. It also supports the hypothesis that metastases are likely to start at the very beginning of tumor development.Fil: Barberis, Lucas Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaInstituto de Física de Líquidos y Sistemas Biológicos2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/189271Barberis, Lucas Miguel; Radial percolation reveals that cancer stem cells are trapped in the core of colonies; Instituto de Física de Líquidos y Sistemas Biológicos; Papers In Physics; 13; 4-2021; 1-111852-4249CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.papersinphysics.org/papersinphysics/article/view/641info:eu-repo/semantics/altIdentifier/doi/10.4279/PIP.130002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:18:47Zoai:ri.conicet.gov.ar:11336/189271instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:18:47.478CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Radial percolation reveals that cancer stem cells are trapped in the core of colonies |
title |
Radial percolation reveals that cancer stem cells are trapped in the core of colonies |
spellingShingle |
Radial percolation reveals that cancer stem cells are trapped in the core of colonies Barberis, Lucas Miguel CANCER STEM CELLS TUMORSPHERES METASTASIS PERCOLATION |
title_short |
Radial percolation reveals that cancer stem cells are trapped in the core of colonies |
title_full |
Radial percolation reveals that cancer stem cells are trapped in the core of colonies |
title_fullStr |
Radial percolation reveals that cancer stem cells are trapped in the core of colonies |
title_full_unstemmed |
Radial percolation reveals that cancer stem cells are trapped in the core of colonies |
title_sort |
Radial percolation reveals that cancer stem cells are trapped in the core of colonies |
dc.creator.none.fl_str_mv |
Barberis, Lucas Miguel |
author |
Barberis, Lucas Miguel |
author_facet |
Barberis, Lucas Miguel |
author_role |
author |
dc.subject.none.fl_str_mv |
CANCER STEM CELLS TUMORSPHERES METASTASIS PERCOLATION |
topic |
CANCER STEM CELLS TUMORSPHERES METASTASIS PERCOLATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.3 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Using geometrical arguments, it is shown that Cancer Stem Cells (CSCs) must be con-fined inside solid tumors under natural conditions. Aided by an agent-based model and percolation theory, the probability of a CSC being positioned at the border of a colony is estimated. This probability is estimated as a function of the CSC self-renewal probability ps; i.e., the chance that a CSC remains undifferentiated after mitosis. In the most common situations ps is low, and most CSCs produce differentiated cells at a very low rate. The results presented here show that CSCs form a small core in the center of a cancer cell colony; they become quiescent due to the lack of space to proliferate, which stabilizes their population size. This result provides a simple explanation for the CSC niche size, dispensing with the need for quorum sensing or other proposed signaling mechanisms. It also supports the hypothesis that metastases are likely to start at the very beginning of tumor development. Fil: Barberis, Lucas Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina |
description |
Using geometrical arguments, it is shown that Cancer Stem Cells (CSCs) must be con-fined inside solid tumors under natural conditions. Aided by an agent-based model and percolation theory, the probability of a CSC being positioned at the border of a colony is estimated. This probability is estimated as a function of the CSC self-renewal probability ps; i.e., the chance that a CSC remains undifferentiated after mitosis. In the most common situations ps is low, and most CSCs produce differentiated cells at a very low rate. The results presented here show that CSCs form a small core in the center of a cancer cell colony; they become quiescent due to the lack of space to proliferate, which stabilizes their population size. This result provides a simple explanation for the CSC niche size, dispensing with the need for quorum sensing or other proposed signaling mechanisms. It also supports the hypothesis that metastases are likely to start at the very beginning of tumor development. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/189271 Barberis, Lucas Miguel; Radial percolation reveals that cancer stem cells are trapped in the core of colonies; Instituto de Física de Líquidos y Sistemas Biológicos; Papers In Physics; 13; 4-2021; 1-11 1852-4249 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/189271 |
identifier_str_mv |
Barberis, Lucas Miguel; Radial percolation reveals that cancer stem cells are trapped in the core of colonies; Instituto de Física de Líquidos y Sistemas Biológicos; Papers In Physics; 13; 4-2021; 1-11 1852-4249 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.papersinphysics.org/papersinphysics/article/view/641 info:eu-repo/semantics/altIdentifier/doi/10.4279/PIP.130002 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Instituto de Física de Líquidos y Sistemas Biológicos |
publisher.none.fl_str_mv |
Instituto de Física de Líquidos y Sistemas Biológicos |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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