Radial percolation reveals that cancer stem cells are trapped in the core of colonies

Autores
Barberis, Lucas Miguel
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Using geometrical arguments, it is shown that Cancer Stem Cells (CSCs) must be con-fined inside solid tumors under natural conditions. Aided by an agent-based model and percolation theory, the probability of a CSC being positioned at the border of a colony is estimated. This probability is estimated as a function of the CSC self-renewal probability ps; i.e., the chance that a CSC remains undifferentiated after mitosis. In the most common situations ps is low, and most CSCs produce differentiated cells at a very low rate. The results presented here show that CSCs form a small core in the center of a cancer cell colony; they become quiescent due to the lack of space to proliferate, which stabilizes their population size. This result provides a simple explanation for the CSC niche size, dispensing with the need for quorum sensing or other proposed signaling mechanisms. It also supports the hypothesis that metastases are likely to start at the very beginning of tumor development.
Fil: Barberis, Lucas Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Materia
CANCER STEM CELLS
TUMORSPHERES
METASTASIS
PERCOLATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/189271

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spelling Radial percolation reveals that cancer stem cells are trapped in the core of coloniesBarberis, Lucas MiguelCANCER STEM CELLSTUMORSPHERESMETASTASISPERCOLATIONhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Using geometrical arguments, it is shown that Cancer Stem Cells (CSCs) must be con-fined inside solid tumors under natural conditions. Aided by an agent-based model and percolation theory, the probability of a CSC being positioned at the border of a colony is estimated. This probability is estimated as a function of the CSC self-renewal probability ps; i.e., the chance that a CSC remains undifferentiated after mitosis. In the most common situations ps is low, and most CSCs produce differentiated cells at a very low rate. The results presented here show that CSCs form a small core in the center of a cancer cell colony; they become quiescent due to the lack of space to proliferate, which stabilizes their population size. This result provides a simple explanation for the CSC niche size, dispensing with the need for quorum sensing or other proposed signaling mechanisms. It also supports the hypothesis that metastases are likely to start at the very beginning of tumor development.Fil: Barberis, Lucas Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaInstituto de Física de Líquidos y Sistemas Biológicos2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/189271Barberis, Lucas Miguel; Radial percolation reveals that cancer stem cells are trapped in the core of colonies; Instituto de Física de Líquidos y Sistemas Biológicos; Papers In Physics; 13; 4-2021; 1-111852-4249CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.papersinphysics.org/papersinphysics/article/view/641info:eu-repo/semantics/altIdentifier/doi/10.4279/PIP.130002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:18:47Zoai:ri.conicet.gov.ar:11336/189271instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:18:47.478CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Radial percolation reveals that cancer stem cells are trapped in the core of colonies
title Radial percolation reveals that cancer stem cells are trapped in the core of colonies
spellingShingle Radial percolation reveals that cancer stem cells are trapped in the core of colonies
Barberis, Lucas Miguel
CANCER STEM CELLS
TUMORSPHERES
METASTASIS
PERCOLATION
title_short Radial percolation reveals that cancer stem cells are trapped in the core of colonies
title_full Radial percolation reveals that cancer stem cells are trapped in the core of colonies
title_fullStr Radial percolation reveals that cancer stem cells are trapped in the core of colonies
title_full_unstemmed Radial percolation reveals that cancer stem cells are trapped in the core of colonies
title_sort Radial percolation reveals that cancer stem cells are trapped in the core of colonies
dc.creator.none.fl_str_mv Barberis, Lucas Miguel
author Barberis, Lucas Miguel
author_facet Barberis, Lucas Miguel
author_role author
dc.subject.none.fl_str_mv CANCER STEM CELLS
TUMORSPHERES
METASTASIS
PERCOLATION
topic CANCER STEM CELLS
TUMORSPHERES
METASTASIS
PERCOLATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Using geometrical arguments, it is shown that Cancer Stem Cells (CSCs) must be con-fined inside solid tumors under natural conditions. Aided by an agent-based model and percolation theory, the probability of a CSC being positioned at the border of a colony is estimated. This probability is estimated as a function of the CSC self-renewal probability ps; i.e., the chance that a CSC remains undifferentiated after mitosis. In the most common situations ps is low, and most CSCs produce differentiated cells at a very low rate. The results presented here show that CSCs form a small core in the center of a cancer cell colony; they become quiescent due to the lack of space to proliferate, which stabilizes their population size. This result provides a simple explanation for the CSC niche size, dispensing with the need for quorum sensing or other proposed signaling mechanisms. It also supports the hypothesis that metastases are likely to start at the very beginning of tumor development.
Fil: Barberis, Lucas Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
description Using geometrical arguments, it is shown that Cancer Stem Cells (CSCs) must be con-fined inside solid tumors under natural conditions. Aided by an agent-based model and percolation theory, the probability of a CSC being positioned at the border of a colony is estimated. This probability is estimated as a function of the CSC self-renewal probability ps; i.e., the chance that a CSC remains undifferentiated after mitosis. In the most common situations ps is low, and most CSCs produce differentiated cells at a very low rate. The results presented here show that CSCs form a small core in the center of a cancer cell colony; they become quiescent due to the lack of space to proliferate, which stabilizes their population size. This result provides a simple explanation for the CSC niche size, dispensing with the need for quorum sensing or other proposed signaling mechanisms. It also supports the hypothesis that metastases are likely to start at the very beginning of tumor development.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/189271
Barberis, Lucas Miguel; Radial percolation reveals that cancer stem cells are trapped in the core of colonies; Instituto de Física de Líquidos y Sistemas Biológicos; Papers In Physics; 13; 4-2021; 1-11
1852-4249
CONICET Digital
CONICET
url http://hdl.handle.net/11336/189271
identifier_str_mv Barberis, Lucas Miguel; Radial percolation reveals that cancer stem cells are trapped in the core of colonies; Instituto de Física de Líquidos y Sistemas Biológicos; Papers In Physics; 13; 4-2021; 1-11
1852-4249
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.papersinphysics.org/papersinphysics/article/view/641
info:eu-repo/semantics/altIdentifier/doi/10.4279/PIP.130002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Instituto de Física de Líquidos y Sistemas Biológicos
publisher.none.fl_str_mv Instituto de Física de Líquidos y Sistemas Biológicos
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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