Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)

Autores
Fernandez, Ariel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The dielectric response of bulk water follows laws of continuum electrostatics,a scheme often extrapolated without justification to treat confined interfacialwater, where the Debye polarization ansatz breaks down and discrete effectsmatter. Reconciling the discrete behavior with the continuum equationsrequires a conceptual leap, all the more so when assessing the electrostaticimpact of exclusion of individual water molecules. This work takes up thechallenge and identifies the nanoscale stickiness of a preformedwater-embedded hydrogen bond as phenomena not encompassed bycontinuum laws but quantitatively predictable when adopting a nanoscaletheory of dielectric response holding down to molecular dimensions.Nanoscale stickiness is known to drive basic cellular events and has beenmeasured using a molecular force probe but its physical underpinnings andcomputation have been lacking so far. The findings reported may impactmolecular design in bio-nanotechnology and shed light on standingchallenges in biophysics, especially on the protein folding problem, whereorganized compaction of the protein chain following nucleatingintramolecular hydrogen bonding demands explanation.
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
HYDROGEN BONDS
MOLECULAR FORCE PROBES
NANOSCALE DIELECTRICS
NON-DEBYE POLARIZATION
WATER STRUCTURE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/91371
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)Fernandez, ArielHYDROGEN BONDSMOLECULAR FORCE PROBESNANOSCALE DIELECTRICSNON-DEBYE POLARIZATIONWATER STRUCTUREhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1The dielectric response of bulk water follows laws of continuum electrostatics,a scheme often extrapolated without justification to treat confined interfacialwater, where the Debye polarization ansatz breaks down and discrete effectsmatter. Reconciling the discrete behavior with the continuum equationsrequires a conceptual leap, all the more so when assessing the electrostaticimpact of exclusion of individual water molecules. This work takes up thechallenge and identifies the nanoscale stickiness of a preformedwater-embedded hydrogen bond as phenomena not encompassed bycontinuum laws but quantitatively predictable when adopting a nanoscaletheory of dielectric response holding down to molecular dimensions.Nanoscale stickiness is known to drive basic cellular events and has beenmeasured using a molecular force probe but its physical underpinnings andcomputation have been lacking so far. The findings reported may impactmolecular design in bio-nanotechnology and shed light on standingchallenges in biophysics, especially on the protein folding problem, whereorganized compaction of the protein chain following nucleatingintramolecular hydrogen bonding demands explanation.Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaWiley VCH Verlag2018-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91371Fernandez, Ariel; Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018); Wiley VCH Verlag; Annalen Der Physik; 530; 9; 9-2018; 1800162(1-4)0003-3804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/andp.201870038info:eu-repo/semantics/altIdentifier/doi/10.1002/andp.201870038info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-05-06T17:03:09Zoai:ri.conicet.gov.ar:11336/91371instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-05-06 17:03:10.111CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)
title Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)
spellingShingle Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)
Fernandez, Ariel
HYDROGEN BONDS
MOLECULAR FORCE PROBES
NANOSCALE DIELECTRICS
NON-DEBYE POLARIZATION
WATER STRUCTURE
title_short Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)
title_full Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)
title_fullStr Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)
title_full_unstemmed Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)
title_sort Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018)
dc.creator.none.fl_str_mv Fernandez, Ariel
author Fernandez, Ariel
author_facet Fernandez, Ariel
author_role author
dc.subject.none.fl_str_mv HYDROGEN BONDS
MOLECULAR FORCE PROBES
NANOSCALE DIELECTRICS
NON-DEBYE POLARIZATION
WATER STRUCTURE
topic HYDROGEN BONDS
MOLECULAR FORCE PROBES
NANOSCALE DIELECTRICS
NON-DEBYE POLARIZATION
WATER STRUCTURE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The dielectric response of bulk water follows laws of continuum electrostatics,a scheme often extrapolated without justification to treat confined interfacialwater, where the Debye polarization ansatz breaks down and discrete effectsmatter. Reconciling the discrete behavior with the continuum equationsrequires a conceptual leap, all the more so when assessing the electrostaticimpact of exclusion of individual water molecules. This work takes up thechallenge and identifies the nanoscale stickiness of a preformedwater-embedded hydrogen bond as phenomena not encompassed bycontinuum laws but quantitatively predictable when adopting a nanoscaletheory of dielectric response holding down to molecular dimensions.Nanoscale stickiness is known to drive basic cellular events and has beenmeasured using a molecular force probe but its physical underpinnings andcomputation have been lacking so far. The findings reported may impactmolecular design in bio-nanotechnology and shed light on standingchallenges in biophysics, especially on the protein folding problem, whereorganized compaction of the protein chain following nucleatingintramolecular hydrogen bonding demands explanation.
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description The dielectric response of bulk water follows laws of continuum electrostatics,a scheme often extrapolated without justification to treat confined interfacialwater, where the Debye polarization ansatz breaks down and discrete effectsmatter. Reconciling the discrete behavior with the continuum equationsrequires a conceptual leap, all the more so when assessing the electrostaticimpact of exclusion of individual water molecules. This work takes up thechallenge and identifies the nanoscale stickiness of a preformedwater-embedded hydrogen bond as phenomena not encompassed bycontinuum laws but quantitatively predictable when adopting a nanoscaletheory of dielectric response holding down to molecular dimensions.Nanoscale stickiness is known to drive basic cellular events and has beenmeasured using a molecular force probe but its physical underpinnings andcomputation have been lacking so far. The findings reported may impactmolecular design in bio-nanotechnology and shed light on standingchallenges in biophysics, especially on the protein folding problem, whereorganized compaction of the protein chain following nucleatingintramolecular hydrogen bonding demands explanation.
publishDate 2018
dc.date.none.fl_str_mv 2018-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/91371
Fernandez, Ariel; Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018); Wiley VCH Verlag; Annalen Der Physik; 530; 9; 9-2018; 1800162(1-4)
0003-3804
CONICET Digital
CONICET
url http://hdl.handle.net/11336/91371
identifier_str_mv Fernandez, Ariel; Hydrogen Bonds: Stickiness of the Hydrogen Bond (Ann. Phys. 9/2018); Wiley VCH Verlag; Annalen Der Physik; 530; 9; 9-2018; 1800162(1-4)
0003-3804
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/andp.201870038
info:eu-repo/semantics/altIdentifier/doi/10.1002/andp.201870038
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.637756

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