Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances

Autores
Simian, Marina; Raffo, Diego Alejandro; Pontiggia, Osvaldo Alejandro
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Matrix metalloproteinases (MMPs) have been implicated in both normal and pathologic processes. In cancer in particular, in vitro and animal studies showed an involvement of MMPs in many stages of cancer progression. This led to the development of MMP inhibitors that in most cases failed in clinical trials. In this review we go over the role of MMPs in the different stages of cancer progression and try to understand why the early generation of MMP inhibitors failed. The analysis of the lessons from this first experience, plus the review of the current knowledge that shows that MMPs may be pro-or anti-tumorigenic may set the stage for a future success for this therapeutic strategy in cancer.
Fil: Simian, Marina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Raffo, Diego Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Pontiggia, Osvaldo Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
Cancer
Clinical Trials
Mmp
Mmp Inhibitors
Therapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13328
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Role of MMPs in Metastatic Dissemination: Implications for Therapeutic AdvancesSimian, MarinaRaffo, Diego AlejandroPontiggia, Osvaldo AlejandroCancerClinical TrialsMmpMmp InhibitorsTherapyhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Matrix metalloproteinases (MMPs) have been implicated in both normal and pathologic processes. In cancer in particular, in vitro and animal studies showed an involvement of MMPs in many stages of cancer progression. This led to the development of MMP inhibitors that in most cases failed in clinical trials. In this review we go over the role of MMPs in the different stages of cancer progression and try to understand why the early generation of MMP inhibitors failed. The analysis of the lessons from this first experience, plus the review of the current knowledge that shows that MMPs may be pro-or anti-tumorigenic may set the stage for a future success for this therapeutic strategy in cancer.Fil: Simian, Marina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Raffo, Diego Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Pontiggia, Osvaldo Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaBentham Science Publishers2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13328Simian, Marina; Raffo, Diego Alejandro; Pontiggia, Osvaldo Alejandro; Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 12; 11; 4-2011; 1937-19471389-2010enginfo:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/ben/cpb/2011/00000012/00000011/art00021info:eu-repo/semantics/altIdentifier/doi/10.2174/138920111798377085info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:59:51Zoai:ri.conicet.gov.ar:11336/13328instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:59:51.976CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
title Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
spellingShingle Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
Simian, Marina
Cancer
Clinical Trials
Mmp
Mmp Inhibitors
Therapy
title_short Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
title_full Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
title_fullStr Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
title_full_unstemmed Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
title_sort Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
dc.creator.none.fl_str_mv Simian, Marina
Raffo, Diego Alejandro
Pontiggia, Osvaldo Alejandro
author Simian, Marina
author_facet Simian, Marina
Raffo, Diego Alejandro
Pontiggia, Osvaldo Alejandro
author_role author
author2 Raffo, Diego Alejandro
Pontiggia, Osvaldo Alejandro
author2_role author
author
dc.subject.none.fl_str_mv Cancer
Clinical Trials
Mmp
Mmp Inhibitors
Therapy
topic Cancer
Clinical Trials
Mmp
Mmp Inhibitors
Therapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Matrix metalloproteinases (MMPs) have been implicated in both normal and pathologic processes. In cancer in particular, in vitro and animal studies showed an involvement of MMPs in many stages of cancer progression. This led to the development of MMP inhibitors that in most cases failed in clinical trials. In this review we go over the role of MMPs in the different stages of cancer progression and try to understand why the early generation of MMP inhibitors failed. The analysis of the lessons from this first experience, plus the review of the current knowledge that shows that MMPs may be pro-or anti-tumorigenic may set the stage for a future success for this therapeutic strategy in cancer.
Fil: Simian, Marina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Raffo, Diego Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Pontiggia, Osvaldo Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description Matrix metalloproteinases (MMPs) have been implicated in both normal and pathologic processes. In cancer in particular, in vitro and animal studies showed an involvement of MMPs in many stages of cancer progression. This led to the development of MMP inhibitors that in most cases failed in clinical trials. In this review we go over the role of MMPs in the different stages of cancer progression and try to understand why the early generation of MMP inhibitors failed. The analysis of the lessons from this first experience, plus the review of the current knowledge that shows that MMPs may be pro-or anti-tumorigenic may set the stage for a future success for this therapeutic strategy in cancer.
publishDate 2011
dc.date.none.fl_str_mv 2011-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13328
Simian, Marina; Raffo, Diego Alejandro; Pontiggia, Osvaldo Alejandro; Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 12; 11; 4-2011; 1937-1947
1389-2010
url http://hdl.handle.net/11336/13328
identifier_str_mv Simian, Marina; Raffo, Diego Alejandro; Pontiggia, Osvaldo Alejandro; Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 12; 11; 4-2011; 1937-1947
1389-2010
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/ben/cpb/2011/00000012/00000011/art00021
info:eu-repo/semantics/altIdentifier/doi/10.2174/138920111798377085
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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