Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue

Autores
Reiter, Russel; Sharma, Ramaswamy; Romero, Alejandro; Manucha, Walter Ariel Fernando; Tan, Dun Xian; Aparecida Pires de Campos Zuccari, Debora; de Almeida Chuffa, Luiz Gustavo
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues, with the middle-aged shutdown leading to infertility. Reduced fertility and consequent inability to conceive by women in present-day societies who choose to have children later in life leads to increased frustration. Melatonin is known to have anti-aging properties related to its antioxidant and anti-inflammatory actions. Its higher follicular fluid levels, relative to blood concentrations, and its likely synthesis in the oocyte, granulosa, and luteal cells, suggest that it is optimally positioned to interfere with age-associated deterioration of the ovary. Additionally, the end of the female reproductive span coincides with a significant reduction in endogenous melatonin levels. Thus, the aims are to review literature indicating melatonin production in mitochondria of oocytes, granulosa cells, and luteal cells, identify the multiple processes underlying changes in the ovary especially late in the cessation of the reproductive life span, summarize the physiological and molecular actions of melatonin in the maintenance of normal ovaries and in the aging ovaries, and, integrate the acquired information into an explanation for considering melatonin in the treatment of age-related infertility. Use of supplemental melatonin may help preserve fertility later in life and alleviate frustration in women delaying childbearing age, reduce the necessity of in vitro fertilization-embryo transfer (IVF-ET) procedures, and, help solve the progressively-increasing problem of non-aging related infertility in women throughout their reproductive life span.
Fil: Reiter, Russel. University of Texas; Estados Unidos
Fil: Sharma, Ramaswamy. University of Texas; Estados Unidos
Fil: Romero, Alejandro. Universidad Complutense de Madrid. Facultad de Veterinaria; España
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
Fil: Tan, Dun Xian. University of Texas; Estados Unidos
Fil: Aparecida Pires de Campos Zuccari, Debora. University of Texas; Estados Unidos
Fil: de Almeida Chuffa, Luiz Gustavo. Institute Of Bioscience Of Botucatu; Brasil
Materia
MELATONIN
AGING
INFERTILITY
OVARIAN FAILURE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/230644
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Aging-Related Ovarian Failure and Infertility: Melatonin to the RescueReiter, RusselSharma, RamaswamyRomero, AlejandroManucha, Walter Ariel FernandoTan, Dun XianAparecida Pires de Campos Zuccari, Deborade Almeida Chuffa, Luiz GustavoMELATONINAGINGINFERTILITYOVARIAN FAILUREhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Aging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues, with the middle-aged shutdown leading to infertility. Reduced fertility and consequent inability to conceive by women in present-day societies who choose to have children later in life leads to increased frustration. Melatonin is known to have anti-aging properties related to its antioxidant and anti-inflammatory actions. Its higher follicular fluid levels, relative to blood concentrations, and its likely synthesis in the oocyte, granulosa, and luteal cells, suggest that it is optimally positioned to interfere with age-associated deterioration of the ovary. Additionally, the end of the female reproductive span coincides with a significant reduction in endogenous melatonin levels. Thus, the aims are to review literature indicating melatonin production in mitochondria of oocytes, granulosa cells, and luteal cells, identify the multiple processes underlying changes in the ovary especially late in the cessation of the reproductive life span, summarize the physiological and molecular actions of melatonin in the maintenance of normal ovaries and in the aging ovaries, and, integrate the acquired information into an explanation for considering melatonin in the treatment of age-related infertility. Use of supplemental melatonin may help preserve fertility later in life and alleviate frustration in women delaying childbearing age, reduce the necessity of in vitro fertilization-embryo transfer (IVF-ET) procedures, and, help solve the progressively-increasing problem of non-aging related infertility in women throughout their reproductive life span.Fil: Reiter, Russel. University of Texas; Estados UnidosFil: Sharma, Ramaswamy. University of Texas; Estados UnidosFil: Romero, Alejandro. Universidad Complutense de Madrid. Facultad de Veterinaria; EspañaFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; ArgentinaFil: Tan, Dun Xian. University of Texas; Estados UnidosFil: Aparecida Pires de Campos Zuccari, Debora. University of Texas; Estados UnidosFil: de Almeida Chuffa, Luiz Gustavo. Institute Of Bioscience Of Botucatu; BrasilMDPI2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/230644Reiter, Russel; Sharma, Ramaswamy; Romero, Alejandro; Manucha, Walter Ariel Fernando; Tan, Dun Xian; et al.; Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue; MDPI; Antioxidants; 12; 3; 3-2023; 695-7102076-3921CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/antiox12030695info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:05:25Zoai:ri.conicet.gov.ar:11336/230644instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:05:25.559CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue
title Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue
spellingShingle Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue
Reiter, Russel
MELATONIN
AGING
INFERTILITY
OVARIAN FAILURE
title_short Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue
title_full Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue
title_fullStr Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue
title_full_unstemmed Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue
title_sort Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue
dc.creator.none.fl_str_mv Reiter, Russel
Sharma, Ramaswamy
Romero, Alejandro
Manucha, Walter Ariel Fernando
Tan, Dun Xian
Aparecida Pires de Campos Zuccari, Debora
de Almeida Chuffa, Luiz Gustavo
author Reiter, Russel
author_facet Reiter, Russel
Sharma, Ramaswamy
Romero, Alejandro
Manucha, Walter Ariel Fernando
Tan, Dun Xian
Aparecida Pires de Campos Zuccari, Debora
de Almeida Chuffa, Luiz Gustavo
author_role author
author2 Sharma, Ramaswamy
Romero, Alejandro
Manucha, Walter Ariel Fernando
Tan, Dun Xian
Aparecida Pires de Campos Zuccari, Debora
de Almeida Chuffa, Luiz Gustavo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv MELATONIN
AGING
INFERTILITY
OVARIAN FAILURE
topic MELATONIN
AGING
INFERTILITY
OVARIAN FAILURE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues, with the middle-aged shutdown leading to infertility. Reduced fertility and consequent inability to conceive by women in present-day societies who choose to have children later in life leads to increased frustration. Melatonin is known to have anti-aging properties related to its antioxidant and anti-inflammatory actions. Its higher follicular fluid levels, relative to blood concentrations, and its likely synthesis in the oocyte, granulosa, and luteal cells, suggest that it is optimally positioned to interfere with age-associated deterioration of the ovary. Additionally, the end of the female reproductive span coincides with a significant reduction in endogenous melatonin levels. Thus, the aims are to review literature indicating melatonin production in mitochondria of oocytes, granulosa cells, and luteal cells, identify the multiple processes underlying changes in the ovary especially late in the cessation of the reproductive life span, summarize the physiological and molecular actions of melatonin in the maintenance of normal ovaries and in the aging ovaries, and, integrate the acquired information into an explanation for considering melatonin in the treatment of age-related infertility. Use of supplemental melatonin may help preserve fertility later in life and alleviate frustration in women delaying childbearing age, reduce the necessity of in vitro fertilization-embryo transfer (IVF-ET) procedures, and, help solve the progressively-increasing problem of non-aging related infertility in women throughout their reproductive life span.
Fil: Reiter, Russel. University of Texas; Estados Unidos
Fil: Sharma, Ramaswamy. University of Texas; Estados Unidos
Fil: Romero, Alejandro. Universidad Complutense de Madrid. Facultad de Veterinaria; España
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
Fil: Tan, Dun Xian. University of Texas; Estados Unidos
Fil: Aparecida Pires de Campos Zuccari, Debora. University of Texas; Estados Unidos
Fil: de Almeida Chuffa, Luiz Gustavo. Institute Of Bioscience Of Botucatu; Brasil
description Aging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues, with the middle-aged shutdown leading to infertility. Reduced fertility and consequent inability to conceive by women in present-day societies who choose to have children later in life leads to increased frustration. Melatonin is known to have anti-aging properties related to its antioxidant and anti-inflammatory actions. Its higher follicular fluid levels, relative to blood concentrations, and its likely synthesis in the oocyte, granulosa, and luteal cells, suggest that it is optimally positioned to interfere with age-associated deterioration of the ovary. Additionally, the end of the female reproductive span coincides with a significant reduction in endogenous melatonin levels. Thus, the aims are to review literature indicating melatonin production in mitochondria of oocytes, granulosa cells, and luteal cells, identify the multiple processes underlying changes in the ovary especially late in the cessation of the reproductive life span, summarize the physiological and molecular actions of melatonin in the maintenance of normal ovaries and in the aging ovaries, and, integrate the acquired information into an explanation for considering melatonin in the treatment of age-related infertility. Use of supplemental melatonin may help preserve fertility later in life and alleviate frustration in women delaying childbearing age, reduce the necessity of in vitro fertilization-embryo transfer (IVF-ET) procedures, and, help solve the progressively-increasing problem of non-aging related infertility in women throughout their reproductive life span.
publishDate 2023
dc.date.none.fl_str_mv 2023-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/230644
Reiter, Russel; Sharma, Ramaswamy; Romero, Alejandro; Manucha, Walter Ariel Fernando; Tan, Dun Xian; et al.; Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue; MDPI; Antioxidants; 12; 3; 3-2023; 695-710
2076-3921
CONICET Digital
CONICET
url http://hdl.handle.net/11336/230644
identifier_str_mv Reiter, Russel; Sharma, Ramaswamy; Romero, Alejandro; Manucha, Walter Ariel Fernando; Tan, Dun Xian; et al.; Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue; MDPI; Antioxidants; 12; 3; 3-2023; 695-710
2076-3921
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/antiox12030695
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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