Effects of saliva on early post-tooth extraction tissue repair in rats

Autores
Mohn, Claudia Ester; Steimetz, Tammy; Surkin, Pablo Nicolas; Fernández Solari, José Javier; Elverdín, Juan Carlos; Guglielmotti, Maria Beatriz
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present study was to perform a biochemical, histological, and histomorphometrical evaluation of the mechanisms involved in tissue repair in rats subjected to submandibulectomy-induced hyposialia, 24, 48, and 72 hours of post-tooth extraction. We studied the correlation between the lack of submandibular saliva and the modulation of inflammatory mediators involved in tissue repair, such as prostaglandin E2, nitric oxide (NO), and tumor necrosis factor alpha (TNF-α). Rats with hyposialia showed a delay in socket healing, slow replacement of the clot with granulation tissue, and fewer cells and collagen fibers, concomitant with a longer inflammatory process, as compared to controls. The lack of saliva induced by submandibulectomy modified the levels of prostaglandin E2, NO, and TNF-α, and tissue response in the early stages of wound healing compared to controls, and could thus determine alterations in later osteogenic response. Our results allow concluding that hyposialia modulates the parameters of inflammation studied here, and that it is essential for optimal healing. Therefore, these findings provide evidence for the importance of submandibular saliva to final bone socket healing.
Fil: Mohn, Claudia Ester. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Steimetz, Tammy. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Surkin, Pablo Nicolas. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernández Solari, José Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Elverdín, Juan Carlos. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Guglielmotti, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Hyposalivation
Salivary Glands
Surgery
Wound Healing
Inflammation Mediators
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38122
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/38122
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of saliva on early post-tooth extraction tissue repair in ratsMohn, Claudia EsterSteimetz, TammySurkin, Pablo NicolasFernández Solari, José JavierElverdín, Juan CarlosGuglielmotti, Maria BeatrizHyposalivationSalivary GlandsSurgeryWound HealingInflammation Mediatorshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of the present study was to perform a biochemical, histological, and histomorphometrical evaluation of the mechanisms involved in tissue repair in rats subjected to submandibulectomy-induced hyposialia, 24, 48, and 72 hours of post-tooth extraction. We studied the correlation between the lack of submandibular saliva and the modulation of inflammatory mediators involved in tissue repair, such as prostaglandin E2, nitric oxide (NO), and tumor necrosis factor alpha (TNF-α). Rats with hyposialia showed a delay in socket healing, slow replacement of the clot with granulation tissue, and fewer cells and collagen fibers, concomitant with a longer inflammatory process, as compared to controls. The lack of saliva induced by submandibulectomy modified the levels of prostaglandin E2, NO, and TNF-α, and tissue response in the early stages of wound healing compared to controls, and could thus determine alterations in later osteogenic response. Our results allow concluding that hyposialia modulates the parameters of inflammation studied here, and that it is essential for optimal healing. Therefore, these findings provide evidence for the importance of submandibular saliva to final bone socket healing.Fil: Mohn, Claudia Ester. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Steimetz, Tammy. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Surkin, Pablo Nicolas. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fernández Solari, José Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: Elverdín, Juan Carlos. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: Guglielmotti, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley Blackwell Publishing, Inc2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38122Mohn, Claudia Ester; Steimetz, Tammy; Surkin, Pablo Nicolas; Fernández Solari, José Javier; Elverdín, Juan Carlos; et al.; Effects of saliva on early post-tooth extraction tissue repair in rats; Wiley Blackwell Publishing, Inc; Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and The European Tissue Repair Society.; 23; 2; 3-2015; 241-2501067-1927CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/wrr.12271info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/wrr.12271/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T09:06:02Zoai:ri.conicet.gov.ar:11336/38122instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 09:06:02.434CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of saliva on early post-tooth extraction tissue repair in rats
title Effects of saliva on early post-tooth extraction tissue repair in rats
spellingShingle Effects of saliva on early post-tooth extraction tissue repair in rats
Mohn, Claudia Ester
Hyposalivation
Salivary Glands
Surgery
Wound Healing
Inflammation Mediators
title_short Effects of saliva on early post-tooth extraction tissue repair in rats
title_full Effects of saliva on early post-tooth extraction tissue repair in rats
title_fullStr Effects of saliva on early post-tooth extraction tissue repair in rats
title_full_unstemmed Effects of saliva on early post-tooth extraction tissue repair in rats
title_sort Effects of saliva on early post-tooth extraction tissue repair in rats
dc.creator.none.fl_str_mv Mohn, Claudia Ester
Steimetz, Tammy
Surkin, Pablo Nicolas
Fernández Solari, José Javier
Elverdín, Juan Carlos
Guglielmotti, Maria Beatriz
author Mohn, Claudia Ester
author_facet Mohn, Claudia Ester
Steimetz, Tammy
Surkin, Pablo Nicolas
Fernández Solari, José Javier
Elverdín, Juan Carlos
Guglielmotti, Maria Beatriz
author_role author
author2 Steimetz, Tammy
Surkin, Pablo Nicolas
Fernández Solari, José Javier
Elverdín, Juan Carlos
Guglielmotti, Maria Beatriz
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hyposalivation
Salivary Glands
Surgery
Wound Healing
Inflammation Mediators
topic Hyposalivation
Salivary Glands
Surgery
Wound Healing
Inflammation Mediators
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of the present study was to perform a biochemical, histological, and histomorphometrical evaluation of the mechanisms involved in tissue repair in rats subjected to submandibulectomy-induced hyposialia, 24, 48, and 72 hours of post-tooth extraction. We studied the correlation between the lack of submandibular saliva and the modulation of inflammatory mediators involved in tissue repair, such as prostaglandin E2, nitric oxide (NO), and tumor necrosis factor alpha (TNF-α). Rats with hyposialia showed a delay in socket healing, slow replacement of the clot with granulation tissue, and fewer cells and collagen fibers, concomitant with a longer inflammatory process, as compared to controls. The lack of saliva induced by submandibulectomy modified the levels of prostaglandin E2, NO, and TNF-α, and tissue response in the early stages of wound healing compared to controls, and could thus determine alterations in later osteogenic response. Our results allow concluding that hyposialia modulates the parameters of inflammation studied here, and that it is essential for optimal healing. Therefore, these findings provide evidence for the importance of submandibular saliva to final bone socket healing.
Fil: Mohn, Claudia Ester. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Steimetz, Tammy. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Surkin, Pablo Nicolas. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernández Solari, José Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Elverdín, Juan Carlos. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Guglielmotti, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The aim of the present study was to perform a biochemical, histological, and histomorphometrical evaluation of the mechanisms involved in tissue repair in rats subjected to submandibulectomy-induced hyposialia, 24, 48, and 72 hours of post-tooth extraction. We studied the correlation between the lack of submandibular saliva and the modulation of inflammatory mediators involved in tissue repair, such as prostaglandin E2, nitric oxide (NO), and tumor necrosis factor alpha (TNF-α). Rats with hyposialia showed a delay in socket healing, slow replacement of the clot with granulation tissue, and fewer cells and collagen fibers, concomitant with a longer inflammatory process, as compared to controls. The lack of saliva induced by submandibulectomy modified the levels of prostaglandin E2, NO, and TNF-α, and tissue response in the early stages of wound healing compared to controls, and could thus determine alterations in later osteogenic response. Our results allow concluding that hyposialia modulates the parameters of inflammation studied here, and that it is essential for optimal healing. Therefore, these findings provide evidence for the importance of submandibular saliva to final bone socket healing.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38122
Mohn, Claudia Ester; Steimetz, Tammy; Surkin, Pablo Nicolas; Fernández Solari, José Javier; Elverdín, Juan Carlos; et al.; Effects of saliva on early post-tooth extraction tissue repair in rats; Wiley Blackwell Publishing, Inc; Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and The European Tissue Repair Society.; 23; 2; 3-2015; 241-250
1067-1927
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38122
identifier_str_mv Mohn, Claudia Ester; Steimetz, Tammy; Surkin, Pablo Nicolas; Fernández Solari, José Javier; Elverdín, Juan Carlos; et al.; Effects of saliva on early post-tooth extraction tissue repair in rats; Wiley Blackwell Publishing, Inc; Wound Repair And Regeneration : Official Publication Of The Wound Healing Society [and The European Tissue Repair Society.; 23; 2; 3-2015; 241-250
1067-1927
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/wrr.12271
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/wrr.12271/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1849873443149840384
score 13.011256

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