Positive and neutral updating reconsolidate aversive episodic memories via different routes

Autores
Wang, Jingyi; Chen, Boxuan; Sha, Manqi; Gu, Yiran; Wu, Haitao; Forcato, Cecilia; Qin, Shaozheng
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aversive memories are long-lasting and prone to burden our emotional wellbeing and mental health. Yet, how to remedy the maladaptive effects of aversive memories remains elusive. Using memory reactivation and emotional updating manipulations, we investigated how positive and neutral emotion may update aversive memories for reconsolidation in humans. We found that positive updating after reactivation was equivalent to neutral updating in impairing true memories of a previous aversive event after a 12-hour wakeful delay, but induced more false memory. Moreover, additional 12-hour delay with overnight sleep did not further enlarge true memory differences, but attenuated the effect of reactivation and updating on false memory. Interestingly, the neutral rather than the positive updating reduced the emotional arousal of the aversive memory 24 h later. Our findings could serve as a reference for real-world therapeutic applications regarding how positive and neutral updating may reshape aversive memories, especially when taking wake- and sleep-filled reconsolidation into account.
Fil: Wang, Jingyi. Beijing Normal University; China
Fil: Chen, Boxuan. Beijing Normal University; China
Fil: Sha, Manqi. Beijing Normal University; China
Fil: Gu, Yiran. East China Normal University; China
Fil: Wu, Haitao. Beijing Institute of Basic Medical Sciences; China. Chinese Institute for Brain Research; China
Fil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires. Departamento de Investigación y Doctorado; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Qin, Shaozheng. Beijing Normal University; China. Chinese Institute for Brain Research; China
Materia
Episodic memory
Memory updating
Reconsolidation
False memory
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/164170
Acceder
id CONICETDig_1aa31db0d460d23653dc3805cafb3ac8
oai_identifier_str oai:ri.conicet.gov.ar:11336/164170
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Positive and neutral updating reconsolidate aversive episodic memories via different routesWang, JingyiChen, BoxuanSha, ManqiGu, YiranWu, HaitaoForcato, CeciliaQin, ShaozhengEpisodic memoryMemory updatingReconsolidationFalse memoryhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Aversive memories are long-lasting and prone to burden our emotional wellbeing and mental health. Yet, how to remedy the maladaptive effects of aversive memories remains elusive. Using memory reactivation and emotional updating manipulations, we investigated how positive and neutral emotion may update aversive memories for reconsolidation in humans. We found that positive updating after reactivation was equivalent to neutral updating in impairing true memories of a previous aversive event after a 12-hour wakeful delay, but induced more false memory. Moreover, additional 12-hour delay with overnight sleep did not further enlarge true memory differences, but attenuated the effect of reactivation and updating on false memory. Interestingly, the neutral rather than the positive updating reduced the emotional arousal of the aversive memory 24 h later. Our findings could serve as a reference for real-world therapeutic applications regarding how positive and neutral updating may reshape aversive memories, especially when taking wake- and sleep-filled reconsolidation into account.Fil: Wang, Jingyi. Beijing Normal University; ChinaFil: Chen, Boxuan. Beijing Normal University; ChinaFil: Sha, Manqi. Beijing Normal University; ChinaFil: Gu, Yiran. East China Normal University; ChinaFil: Wu, Haitao. Beijing Institute of Basic Medical Sciences; China. Chinese Institute for Brain Research; ChinaFil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires. Departamento de Investigación y Doctorado; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Qin, Shaozheng. Beijing Normal University; China. Chinese Institute for Brain Research; ChinaAcademic Press Inc Elsevier Science2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/164170Wang, Jingyi; Chen, Boxuan; Sha, Manqi; Gu, Yiran; Wu, Haitao; et al.; Positive and neutral updating reconsolidate aversive episodic memories via different routes; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 184; 107500; 1-2021; 1-412692-82052692-8205CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2021.01.04.424701v1info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1074742721001222info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2021.107500info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:07Zoai:ri.conicet.gov.ar:11336/164170instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:08.113CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Positive and neutral updating reconsolidate aversive episodic memories via different routes
title Positive and neutral updating reconsolidate aversive episodic memories via different routes
spellingShingle Positive and neutral updating reconsolidate aversive episodic memories via different routes
Wang, Jingyi
Episodic memory
Memory updating
Reconsolidation
False memory
title_short Positive and neutral updating reconsolidate aversive episodic memories via different routes
title_full Positive and neutral updating reconsolidate aversive episodic memories via different routes
title_fullStr Positive and neutral updating reconsolidate aversive episodic memories via different routes
title_full_unstemmed Positive and neutral updating reconsolidate aversive episodic memories via different routes
title_sort Positive and neutral updating reconsolidate aversive episodic memories via different routes
dc.creator.none.fl_str_mv Wang, Jingyi
Chen, Boxuan
Sha, Manqi
Gu, Yiran
Wu, Haitao
Forcato, Cecilia
Qin, Shaozheng
author Wang, Jingyi
author_facet Wang, Jingyi
Chen, Boxuan
Sha, Manqi
Gu, Yiran
Wu, Haitao
Forcato, Cecilia
Qin, Shaozheng
author_role author
author2 Chen, Boxuan
Sha, Manqi
Gu, Yiran
Wu, Haitao
Forcato, Cecilia
Qin, Shaozheng
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Episodic memory
Memory updating
Reconsolidation
False memory
topic Episodic memory
Memory updating
Reconsolidation
False memory
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Aversive memories are long-lasting and prone to burden our emotional wellbeing and mental health. Yet, how to remedy the maladaptive effects of aversive memories remains elusive. Using memory reactivation and emotional updating manipulations, we investigated how positive and neutral emotion may update aversive memories for reconsolidation in humans. We found that positive updating after reactivation was equivalent to neutral updating in impairing true memories of a previous aversive event after a 12-hour wakeful delay, but induced more false memory. Moreover, additional 12-hour delay with overnight sleep did not further enlarge true memory differences, but attenuated the effect of reactivation and updating on false memory. Interestingly, the neutral rather than the positive updating reduced the emotional arousal of the aversive memory 24 h later. Our findings could serve as a reference for real-world therapeutic applications regarding how positive and neutral updating may reshape aversive memories, especially when taking wake- and sleep-filled reconsolidation into account.
Fil: Wang, Jingyi. Beijing Normal University; China
Fil: Chen, Boxuan. Beijing Normal University; China
Fil: Sha, Manqi. Beijing Normal University; China
Fil: Gu, Yiran. East China Normal University; China
Fil: Wu, Haitao. Beijing Institute of Basic Medical Sciences; China. Chinese Institute for Brain Research; China
Fil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires. Departamento de Investigación y Doctorado; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Qin, Shaozheng. Beijing Normal University; China. Chinese Institute for Brain Research; China
description Aversive memories are long-lasting and prone to burden our emotional wellbeing and mental health. Yet, how to remedy the maladaptive effects of aversive memories remains elusive. Using memory reactivation and emotional updating manipulations, we investigated how positive and neutral emotion may update aversive memories for reconsolidation in humans. We found that positive updating after reactivation was equivalent to neutral updating in impairing true memories of a previous aversive event after a 12-hour wakeful delay, but induced more false memory. Moreover, additional 12-hour delay with overnight sleep did not further enlarge true memory differences, but attenuated the effect of reactivation and updating on false memory. Interestingly, the neutral rather than the positive updating reduced the emotional arousal of the aversive memory 24 h later. Our findings could serve as a reference for real-world therapeutic applications regarding how positive and neutral updating may reshape aversive memories, especially when taking wake- and sleep-filled reconsolidation into account.
publishDate 2021
dc.date.none.fl_str_mv 2021-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/164170
Wang, Jingyi; Chen, Boxuan; Sha, Manqi; Gu, Yiran; Wu, Haitao; et al.; Positive and neutral updating reconsolidate aversive episodic memories via different routes; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 184; 107500; 1-2021; 1-41
2692-8205
2692-8205
CONICET Digital
CONICET
url http://hdl.handle.net/11336/164170
identifier_str_mv Wang, Jingyi; Chen, Boxuan; Sha, Manqi; Gu, Yiran; Wu, Haitao; et al.; Positive and neutral updating reconsolidate aversive episodic memories via different routes; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 184; 107500; 1-2021; 1-41
2692-8205
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2021.01.04.424701v1
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1074742721001222
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2021.107500
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613091723051008
score 13.070432

Publicaciones similares