Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats

Autores
Lee, Boyeon; Pine, Michelle; Johnson, Larry; Besuhli, Valeria; Hiney, Jill K.; Les Dees, W.
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Manganese (Mn) is an important element for normal growth and reproduction. Because Mn accumulates in the hypothalamus and is capable of stimulating puberty-related hormones in female rats, we assessed whether this metal could cause similar effects in male rats. We have demonstrated that MnCl2, when administered acutely into the third ventricle of the brain, acts dose dependently to stimulate luteinizing hormone (LH) release. Furthermore, there was a dose dependent stimulation in the secretion of LH-releasing hormone (LHRH) from the medial basal hypothalamus in vitro, and administration of an LHRH receptor antagonist in vivo blocks Mn-induced LH release. To assess potential chronic effects of the metal, male pups were supplemented with 10 or 25 mg MnCl2 per kg by gastric gavage from day 15 until days 48 or 55, at which times developmental signs of spermatogenesis were assessed. Results demonstrate that while significant effects were not observed with the 10 mg/kg dose, the animals receiving the 25 mg/kg dose showed increased LH (p < 0.05), FSH (p < 0.01) and testosterone (p < 0.01) levels at 55 days of age. Furthermore, there was a concomitant increase in both daily sperm production (p < 0.05) and efficiency of spermatogenesis (p < 0.05), demonstrating a Mn-induced acceleration in spermatogenesis. Our results suggest Mn is a stimulator of prepubertal LHRH/LH secretion and may facilitate the normal onset of male puberty. These data also suggest that the metal may contribute to male precocious pubertal development should an individual be exposed to low but elevated levels of Mn too early in life.
Fil: Lee, Boyeon. Texas A&M University; Estados Unidos
Fil: Pine, Michelle. Texas A&M University; Estados Unidos
Fil: Johnson, Larry. Texas A&M University; Estados Unidos
Fil: Besuhli, Valeria. Texas A&M University; Estados Unidos
Fil: Hiney, Jill K.. Texas A&M University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Les Dees, W.. Texas A&M University; Estados Unidos
Materia
Puberty
Manganese
Luteinizing Hormone
Hypothalamus
Precocious Puberty
Spermatogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20198
Acceder
id CONICETDig_1a884c291bd3cff9318e54aff11002b2
oai_identifier_str oai:ri.conicet.gov.ar:11336/20198
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male ratsLee, BoyeonPine, MichelleJohnson, LarryBesuhli, ValeriaHiney, Jill K.Les Dees, W.PubertyManganeseLuteinizing HormoneHypothalamusPrecocious PubertySpermatogenesishttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Manganese (Mn) is an important element for normal growth and reproduction. Because Mn accumulates in the hypothalamus and is capable of stimulating puberty-related hormones in female rats, we assessed whether this metal could cause similar effects in male rats. We have demonstrated that MnCl2, when administered acutely into the third ventricle of the brain, acts dose dependently to stimulate luteinizing hormone (LH) release. Furthermore, there was a dose dependent stimulation in the secretion of LH-releasing hormone (LHRH) from the medial basal hypothalamus in vitro, and administration of an LHRH receptor antagonist in vivo blocks Mn-induced LH release. To assess potential chronic effects of the metal, male pups were supplemented with 10 or 25 mg MnCl2 per kg by gastric gavage from day 15 until days 48 or 55, at which times developmental signs of spermatogenesis were assessed. Results demonstrate that while significant effects were not observed with the 10 mg/kg dose, the animals receiving the 25 mg/kg dose showed increased LH (p < 0.05), FSH (p < 0.01) and testosterone (p < 0.01) levels at 55 days of age. Furthermore, there was a concomitant increase in both daily sperm production (p < 0.05) and efficiency of spermatogenesis (p < 0.05), demonstrating a Mn-induced acceleration in spermatogenesis. Our results suggest Mn is a stimulator of prepubertal LHRH/LH secretion and may facilitate the normal onset of male puberty. These data also suggest that the metal may contribute to male precocious pubertal development should an individual be exposed to low but elevated levels of Mn too early in life.Fil: Lee, Boyeon. Texas A&M University; Estados UnidosFil: Pine, Michelle. Texas A&M University; Estados UnidosFil: Johnson, Larry. Texas A&M University; Estados UnidosFil: Besuhli, Valeria. Texas A&M University; Estados UnidosFil: Hiney, Jill K.. Texas A&M University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Les Dees, W.. Texas A&M University; Estados UnidosElsevier Inc2006-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20198Lee, Boyeon; Pine, Michelle; Johnson, Larry; Besuhli, Valeria; Hiney, Jill K.; et al.; Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats; Elsevier Inc; Reproductive Toxicology; 22; 4; 11-2006; 580-5850890-6238CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0890623806000827info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reprotox.2006.03.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:42:17Zoai:ri.conicet.gov.ar:11336/20198instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:42:17.949CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats
title Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats
spellingShingle Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats
Lee, Boyeon
Puberty
Manganese
Luteinizing Hormone
Hypothalamus
Precocious Puberty
Spermatogenesis
title_short Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats
title_full Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats
title_fullStr Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats
title_full_unstemmed Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats
title_sort Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats
dc.creator.none.fl_str_mv Lee, Boyeon
Pine, Michelle
Johnson, Larry
Besuhli, Valeria
Hiney, Jill K.
Les Dees, W.
author Lee, Boyeon
author_facet Lee, Boyeon
Pine, Michelle
Johnson, Larry
Besuhli, Valeria
Hiney, Jill K.
Les Dees, W.
author_role author
author2 Pine, Michelle
Johnson, Larry
Besuhli, Valeria
Hiney, Jill K.
Les Dees, W.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Puberty
Manganese
Luteinizing Hormone
Hypothalamus
Precocious Puberty
Spermatogenesis
topic Puberty
Manganese
Luteinizing Hormone
Hypothalamus
Precocious Puberty
Spermatogenesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Manganese (Mn) is an important element for normal growth and reproduction. Because Mn accumulates in the hypothalamus and is capable of stimulating puberty-related hormones in female rats, we assessed whether this metal could cause similar effects in male rats. We have demonstrated that MnCl2, when administered acutely into the third ventricle of the brain, acts dose dependently to stimulate luteinizing hormone (LH) release. Furthermore, there was a dose dependent stimulation in the secretion of LH-releasing hormone (LHRH) from the medial basal hypothalamus in vitro, and administration of an LHRH receptor antagonist in vivo blocks Mn-induced LH release. To assess potential chronic effects of the metal, male pups were supplemented with 10 or 25 mg MnCl2 per kg by gastric gavage from day 15 until days 48 or 55, at which times developmental signs of spermatogenesis were assessed. Results demonstrate that while significant effects were not observed with the 10 mg/kg dose, the animals receiving the 25 mg/kg dose showed increased LH (p < 0.05), FSH (p < 0.01) and testosterone (p < 0.01) levels at 55 days of age. Furthermore, there was a concomitant increase in both daily sperm production (p < 0.05) and efficiency of spermatogenesis (p < 0.05), demonstrating a Mn-induced acceleration in spermatogenesis. Our results suggest Mn is a stimulator of prepubertal LHRH/LH secretion and may facilitate the normal onset of male puberty. These data also suggest that the metal may contribute to male precocious pubertal development should an individual be exposed to low but elevated levels of Mn too early in life.
Fil: Lee, Boyeon. Texas A&M University; Estados Unidos
Fil: Pine, Michelle. Texas A&M University; Estados Unidos
Fil: Johnson, Larry. Texas A&M University; Estados Unidos
Fil: Besuhli, Valeria. Texas A&M University; Estados Unidos
Fil: Hiney, Jill K.. Texas A&M University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Les Dees, W.. Texas A&M University; Estados Unidos
description Manganese (Mn) is an important element for normal growth and reproduction. Because Mn accumulates in the hypothalamus and is capable of stimulating puberty-related hormones in female rats, we assessed whether this metal could cause similar effects in male rats. We have demonstrated that MnCl2, when administered acutely into the third ventricle of the brain, acts dose dependently to stimulate luteinizing hormone (LH) release. Furthermore, there was a dose dependent stimulation in the secretion of LH-releasing hormone (LHRH) from the medial basal hypothalamus in vitro, and administration of an LHRH receptor antagonist in vivo blocks Mn-induced LH release. To assess potential chronic effects of the metal, male pups were supplemented with 10 or 25 mg MnCl2 per kg by gastric gavage from day 15 until days 48 or 55, at which times developmental signs of spermatogenesis were assessed. Results demonstrate that while significant effects were not observed with the 10 mg/kg dose, the animals receiving the 25 mg/kg dose showed increased LH (p < 0.05), FSH (p < 0.01) and testosterone (p < 0.01) levels at 55 days of age. Furthermore, there was a concomitant increase in both daily sperm production (p < 0.05) and efficiency of spermatogenesis (p < 0.05), demonstrating a Mn-induced acceleration in spermatogenesis. Our results suggest Mn is a stimulator of prepubertal LHRH/LH secretion and may facilitate the normal onset of male puberty. These data also suggest that the metal may contribute to male precocious pubertal development should an individual be exposed to low but elevated levels of Mn too early in life.
publishDate 2006
dc.date.none.fl_str_mv 2006-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20198
Lee, Boyeon; Pine, Michelle; Johnson, Larry; Besuhli, Valeria; Hiney, Jill K.; et al.; Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats; Elsevier Inc; Reproductive Toxicology; 22; 4; 11-2006; 580-585
0890-6238
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20198
identifier_str_mv Lee, Boyeon; Pine, Michelle; Johnson, Larry; Besuhli, Valeria; Hiney, Jill K.; et al.; Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats; Elsevier Inc; Reproductive Toxicology; 22; 4; 11-2006; 580-585
0890-6238
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0890623806000827
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reprotox.2006.03.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1843605890167472128
score 13.001348

Publicaciones similares