Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death

Autores
Hoffiz, Yarely C.; Castillo Ruiz, Alexandra; Hall, Megan A. L.; Hite, Taylor A.; Gray, Jennifer M.; Cisternas, Carla Daniela; Cortes, Laura R.; Jacobs, Andrew J.; Forger, Nancy G.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Long-standing clinical findings report a dramatic surge of vasopressin in umbilical cord blood of the human neonate, but the neural underpinnings and function(s) of this phenomenon remain obscure. We studied neural activation in perinatal mice and rats, and found that birth triggers activation of the suprachiasmatic, supraoptic, and paraventricular nuclei of the hypothalamus. This was seen whether mice were born vaginally or via Cesarean section (C-section), and when birth timing was experimentally manipulated. Neuronal phenotyping showed that the activated neurons were predominantly vasopressinergic, and vasopressin mRNA increased fivefold in the hypothalamus during the 2–3 days before birth. Copeptin, a surrogate marker of vasopressin, was elevated 30-to 50-fold in plasma of perinatal mice, with higher levels after a vaginal than a C-section birth. We also found an acute decrease in plasma osmolality after a vaginal, but not C-section birth, suggesting that the difference in vasopressin release between birth modes is functionally meaningful. When vasopressin was administered centrally to newborns, we found an ~ 50% reduction in neuronal cell death in specific brain areas. Collectively, our results identify a conserved neuroendocrine response to birth that is sensitive to birth mode, and influences peripheral physiology and neurodevelopment.
Fil: Hoffiz, Yarely C.. Georgia State University; Estados Unidos
Fil: Castillo Ruiz, Alexandra. Georgia State University; Estados Unidos
Fil: Hall, Megan A. L.. Georgia State University; Estados Unidos
Fil: Hite, Taylor A.. Georgia State University; Estados Unidos
Fil: Gray, Jennifer M.. Georgia State University; Estados Unidos
Fil: Cisternas, Carla Daniela. Georgia State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Cortes, Laura R.. Georgia State University; Estados Unidos
Fil: Jacobs, Andrew J.. Georgia State University; Estados Unidos
Fil: Forger, Nancy G.. Georgia State University; Estados Unidos
Materia
VASOPRESSIN
VAGINAL BIRTH
CESAREAN SECTION
NEURAL ACTIVATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/168729
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell deathHoffiz, Yarely C.Castillo Ruiz, AlexandraHall, Megan A. L.Hite, Taylor A.Gray, Jennifer M.Cisternas, Carla DanielaCortes, Laura R.Jacobs, Andrew J.Forger, Nancy G.VASOPRESSINVAGINAL BIRTHCESAREAN SECTIONNEURAL ACTIVATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Long-standing clinical findings report a dramatic surge of vasopressin in umbilical cord blood of the human neonate, but the neural underpinnings and function(s) of this phenomenon remain obscure. We studied neural activation in perinatal mice and rats, and found that birth triggers activation of the suprachiasmatic, supraoptic, and paraventricular nuclei of the hypothalamus. This was seen whether mice were born vaginally or via Cesarean section (C-section), and when birth timing was experimentally manipulated. Neuronal phenotyping showed that the activated neurons were predominantly vasopressinergic, and vasopressin mRNA increased fivefold in the hypothalamus during the 2–3 days before birth. Copeptin, a surrogate marker of vasopressin, was elevated 30-to 50-fold in plasma of perinatal mice, with higher levels after a vaginal than a C-section birth. We also found an acute decrease in plasma osmolality after a vaginal, but not C-section birth, suggesting that the difference in vasopressin release between birth modes is functionally meaningful. When vasopressin was administered centrally to newborns, we found an ~ 50% reduction in neuronal cell death in specific brain areas. Collectively, our results identify a conserved neuroendocrine response to birth that is sensitive to birth mode, and influences peripheral physiology and neurodevelopment.Fil: Hoffiz, Yarely C.. Georgia State University; Estados UnidosFil: Castillo Ruiz, Alexandra. Georgia State University; Estados UnidosFil: Hall, Megan A. L.. Georgia State University; Estados UnidosFil: Hite, Taylor A.. Georgia State University; Estados UnidosFil: Gray, Jennifer M.. Georgia State University; Estados UnidosFil: Cisternas, Carla Daniela. Georgia State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Cortes, Laura R.. Georgia State University; Estados UnidosFil: Jacobs, Andrew J.. Georgia State University; Estados UnidosFil: Forger, Nancy G.. Georgia State University; Estados UnidosNature Publishing Group2021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/168729Hoffiz, Yarely C.; Castillo Ruiz, Alexandra; Hall, Megan A. L.; Hite, Taylor A.; Gray, Jennifer M.; et al.; Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death; Nature Publishing Group; Scientific Reports; 11; 1; 12-2021; 1-142045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-021-81511-1info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-021-81511-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:13:38Zoai:ri.conicet.gov.ar:11336/168729instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:13:38.921CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
spellingShingle Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
Hoffiz, Yarely C.
VASOPRESSIN
VAGINAL BIRTH
CESAREAN SECTION
NEURAL ACTIVATION
title_short Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_full Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_fullStr Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_full_unstemmed Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_sort Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
dc.creator.none.fl_str_mv Hoffiz, Yarely C.
Castillo Ruiz, Alexandra
Hall, Megan A. L.
Hite, Taylor A.
Gray, Jennifer M.
Cisternas, Carla Daniela
Cortes, Laura R.
Jacobs, Andrew J.
Forger, Nancy G.
author Hoffiz, Yarely C.
author_facet Hoffiz, Yarely C.
Castillo Ruiz, Alexandra
Hall, Megan A. L.
Hite, Taylor A.
Gray, Jennifer M.
Cisternas, Carla Daniela
Cortes, Laura R.
Jacobs, Andrew J.
Forger, Nancy G.
author_role author
author2 Castillo Ruiz, Alexandra
Hall, Megan A. L.
Hite, Taylor A.
Gray, Jennifer M.
Cisternas, Carla Daniela
Cortes, Laura R.
Jacobs, Andrew J.
Forger, Nancy G.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv VASOPRESSIN
VAGINAL BIRTH
CESAREAN SECTION
NEURAL ACTIVATION
topic VASOPRESSIN
VAGINAL BIRTH
CESAREAN SECTION
NEURAL ACTIVATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Long-standing clinical findings report a dramatic surge of vasopressin in umbilical cord blood of the human neonate, but the neural underpinnings and function(s) of this phenomenon remain obscure. We studied neural activation in perinatal mice and rats, and found that birth triggers activation of the suprachiasmatic, supraoptic, and paraventricular nuclei of the hypothalamus. This was seen whether mice were born vaginally or via Cesarean section (C-section), and when birth timing was experimentally manipulated. Neuronal phenotyping showed that the activated neurons were predominantly vasopressinergic, and vasopressin mRNA increased fivefold in the hypothalamus during the 2–3 days before birth. Copeptin, a surrogate marker of vasopressin, was elevated 30-to 50-fold in plasma of perinatal mice, with higher levels after a vaginal than a C-section birth. We also found an acute decrease in plasma osmolality after a vaginal, but not C-section birth, suggesting that the difference in vasopressin release between birth modes is functionally meaningful. When vasopressin was administered centrally to newborns, we found an ~ 50% reduction in neuronal cell death in specific brain areas. Collectively, our results identify a conserved neuroendocrine response to birth that is sensitive to birth mode, and influences peripheral physiology and neurodevelopment.
Fil: Hoffiz, Yarely C.. Georgia State University; Estados Unidos
Fil: Castillo Ruiz, Alexandra. Georgia State University; Estados Unidos
Fil: Hall, Megan A. L.. Georgia State University; Estados Unidos
Fil: Hite, Taylor A.. Georgia State University; Estados Unidos
Fil: Gray, Jennifer M.. Georgia State University; Estados Unidos
Fil: Cisternas, Carla Daniela. Georgia State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Cortes, Laura R.. Georgia State University; Estados Unidos
Fil: Jacobs, Andrew J.. Georgia State University; Estados Unidos
Fil: Forger, Nancy G.. Georgia State University; Estados Unidos
description Long-standing clinical findings report a dramatic surge of vasopressin in umbilical cord blood of the human neonate, but the neural underpinnings and function(s) of this phenomenon remain obscure. We studied neural activation in perinatal mice and rats, and found that birth triggers activation of the suprachiasmatic, supraoptic, and paraventricular nuclei of the hypothalamus. This was seen whether mice were born vaginally or via Cesarean section (C-section), and when birth timing was experimentally manipulated. Neuronal phenotyping showed that the activated neurons were predominantly vasopressinergic, and vasopressin mRNA increased fivefold in the hypothalamus during the 2–3 days before birth. Copeptin, a surrogate marker of vasopressin, was elevated 30-to 50-fold in plasma of perinatal mice, with higher levels after a vaginal than a C-section birth. We also found an acute decrease in plasma osmolality after a vaginal, but not C-section birth, suggesting that the difference in vasopressin release between birth modes is functionally meaningful. When vasopressin was administered centrally to newborns, we found an ~ 50% reduction in neuronal cell death in specific brain areas. Collectively, our results identify a conserved neuroendocrine response to birth that is sensitive to birth mode, and influences peripheral physiology and neurodevelopment.
publishDate 2021
dc.date.none.fl_str_mv 2021-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/168729
Hoffiz, Yarely C.; Castillo Ruiz, Alexandra; Hall, Megan A. L.; Hite, Taylor A.; Gray, Jennifer M.; et al.; Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death; Nature Publishing Group; Scientific Reports; 11; 1; 12-2021; 1-14
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/168729
identifier_str_mv Hoffiz, Yarely C.; Castillo Ruiz, Alexandra; Hall, Megan A. L.; Hite, Taylor A.; Gray, Jennifer M.; et al.; Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death; Nature Publishing Group; Scientific Reports; 11; 1; 12-2021; 1-14
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-021-81511-1
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-021-81511-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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