Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients

Autores
Vuilleumier, Pascal Henri; Arguissain, Federico Gabriel; Biurrun Manresa, José Alberto; Neziri, Alban Ymer; Nirkko, Arto Christian; Andersen, Ole Kæseler; Arendt-Nielsen, Lars; Curatolo, Michele
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this case-control study was to examine differences in neural correlates of pain facilitatory and inhibitory mechanisms between acute low back pain (LBP) patients and healthy individuals. Pressure pain tolerance, electrical pain detection thresholds, pain ratings to repetitive suprathreshold electrical stimulation (SES) and conditioned pain modulation (CPM) were assessed in 18 patients with acute LBP and 18 healthy control participants. Furthermore, event-related potentials (ERPs) in response to repetitive SES were obtained from high-density electroencephalography. Results showed that the LBP group presented lower pressure pain tolerance and higher pain ratings to SES compared with the control group. Both groups displayed effective CPM, with no differences in CPM magnitude between groups. Both groups presented similar reductions in ERP amplitudes during CPM, but ERP responses to repetitive SES were significantly larger in the LBP group. In conclusion, acute LBP patients presented enhanced pain facilitatory mechanisms, whereas no significant changes in pain inhibitory mechanisms were observed. These results provide new insight into the central mechanisms underlying acute LBP. Perspective: This article present evidence that acute LBP patients show enhanced pain facilitation and unaltered pain inhibition compared with pain-free volunteers. These results provide new insight into the central mechanisms underlying acute LBP.
Fil: Vuilleumier, Pascal Henri. University of Bern; Suiza
Fil: Arguissain, Federico Gabriel. Aalborg University; Dinamarca
Fil: Biurrun Manresa, José Alberto. Aalborg University; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Entre Rios. Universidad Nacional de Entre Rios. Centro de Investigaciones y Transferencia de Entre Rios; Argentina
Fil: Neziri, Alban Ymer. University of Bern; Suiza. Regional Hospital of Langenthal; Suiza
Fil: Nirkko, Arto Christian. University of Bern; Suiza
Fil: Andersen, Ole Kæseler. Aalborg University; Dinamarca
Fil: Arendt-Nielsen, Lars. Aalborg University; Dinamarca
Fil: Curatolo, Michele. Aalborg University; Dinamarca. University of Washington; Estados Unidos
Materia
Acute Low Back Pain
Conditioned Pain Modulation
Endogenous Inhibition
Event-Related Potentials
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40998
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/40998
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain PatientsVuilleumier, Pascal HenriArguissain, Federico GabrielBiurrun Manresa, José AlbertoNeziri, Alban YmerNirkko, Arto ChristianAndersen, Ole KæselerArendt-Nielsen, LarsCuratolo, MicheleAcute Low Back PainConditioned Pain ModulationEndogenous InhibitionEvent-Related Potentialshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of this case-control study was to examine differences in neural correlates of pain facilitatory and inhibitory mechanisms between acute low back pain (LBP) patients and healthy individuals. Pressure pain tolerance, electrical pain detection thresholds, pain ratings to repetitive suprathreshold electrical stimulation (SES) and conditioned pain modulation (CPM) were assessed in 18 patients with acute LBP and 18 healthy control participants. Furthermore, event-related potentials (ERPs) in response to repetitive SES were obtained from high-density electroencephalography. Results showed that the LBP group presented lower pressure pain tolerance and higher pain ratings to SES compared with the control group. Both groups displayed effective CPM, with no differences in CPM magnitude between groups. Both groups presented similar reductions in ERP amplitudes during CPM, but ERP responses to repetitive SES were significantly larger in the LBP group. In conclusion, acute LBP patients presented enhanced pain facilitatory mechanisms, whereas no significant changes in pain inhibitory mechanisms were observed. These results provide new insight into the central mechanisms underlying acute LBP. Perspective: This article present evidence that acute LBP patients show enhanced pain facilitation and unaltered pain inhibition compared with pain-free volunteers. These results provide new insight into the central mechanisms underlying acute LBP.Fil: Vuilleumier, Pascal Henri. University of Bern; SuizaFil: Arguissain, Federico Gabriel. Aalborg University; DinamarcaFil: Biurrun Manresa, José Alberto. Aalborg University; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Entre Rios. Universidad Nacional de Entre Rios. Centro de Investigaciones y Transferencia de Entre Rios; ArgentinaFil: Neziri, Alban Ymer. University of Bern; Suiza. Regional Hospital of Langenthal; SuizaFil: Nirkko, Arto Christian. University of Bern; SuizaFil: Andersen, Ole Kæseler. Aalborg University; DinamarcaFil: Arendt-Nielsen, Lars. Aalborg University; DinamarcaFil: Curatolo, Michele. Aalborg University; Dinamarca. University of Washington; Estados UnidosChurchill Livingstone2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40998Vuilleumier, Pascal Henri; Arguissain, Federico Gabriel; Biurrun Manresa, José Alberto; Neziri, Alban Ymer; Nirkko, Arto Christian; et al.; Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients; Churchill Livingstone; Journal Of Pain; 18; 11; 5-2017; 1313-13231526-5900CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpain.2017.05.008info:eu-repo/semantics/altIdentifier/url/http://www.jpain.org/article/S1526-5900(17)30617-X/fulltextinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:44Zoai:ri.conicet.gov.ar:11336/40998instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:44.557CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients
title Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients
spellingShingle Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients
Vuilleumier, Pascal Henri
Acute Low Back Pain
Conditioned Pain Modulation
Endogenous Inhibition
Event-Related Potentials
title_short Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients
title_full Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients
title_fullStr Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients
title_full_unstemmed Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients
title_sort Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients
dc.creator.none.fl_str_mv Vuilleumier, Pascal Henri
Arguissain, Federico Gabriel
Biurrun Manresa, José Alberto
Neziri, Alban Ymer
Nirkko, Arto Christian
Andersen, Ole Kæseler
Arendt-Nielsen, Lars
Curatolo, Michele
author Vuilleumier, Pascal Henri
author_facet Vuilleumier, Pascal Henri
Arguissain, Federico Gabriel
Biurrun Manresa, José Alberto
Neziri, Alban Ymer
Nirkko, Arto Christian
Andersen, Ole Kæseler
Arendt-Nielsen, Lars
Curatolo, Michele
author_role author
author2 Arguissain, Federico Gabriel
Biurrun Manresa, José Alberto
Neziri, Alban Ymer
Nirkko, Arto Christian
Andersen, Ole Kæseler
Arendt-Nielsen, Lars
Curatolo, Michele
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Acute Low Back Pain
Conditioned Pain Modulation
Endogenous Inhibition
Event-Related Potentials
topic Acute Low Back Pain
Conditioned Pain Modulation
Endogenous Inhibition
Event-Related Potentials
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this case-control study was to examine differences in neural correlates of pain facilitatory and inhibitory mechanisms between acute low back pain (LBP) patients and healthy individuals. Pressure pain tolerance, electrical pain detection thresholds, pain ratings to repetitive suprathreshold electrical stimulation (SES) and conditioned pain modulation (CPM) were assessed in 18 patients with acute LBP and 18 healthy control participants. Furthermore, event-related potentials (ERPs) in response to repetitive SES were obtained from high-density electroencephalography. Results showed that the LBP group presented lower pressure pain tolerance and higher pain ratings to SES compared with the control group. Both groups displayed effective CPM, with no differences in CPM magnitude between groups. Both groups presented similar reductions in ERP amplitudes during CPM, but ERP responses to repetitive SES were significantly larger in the LBP group. In conclusion, acute LBP patients presented enhanced pain facilitatory mechanisms, whereas no significant changes in pain inhibitory mechanisms were observed. These results provide new insight into the central mechanisms underlying acute LBP. Perspective: This article present evidence that acute LBP patients show enhanced pain facilitation and unaltered pain inhibition compared with pain-free volunteers. These results provide new insight into the central mechanisms underlying acute LBP.
Fil: Vuilleumier, Pascal Henri. University of Bern; Suiza
Fil: Arguissain, Federico Gabriel. Aalborg University; Dinamarca
Fil: Biurrun Manresa, José Alberto. Aalborg University; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Entre Rios. Universidad Nacional de Entre Rios. Centro de Investigaciones y Transferencia de Entre Rios; Argentina
Fil: Neziri, Alban Ymer. University of Bern; Suiza. Regional Hospital of Langenthal; Suiza
Fil: Nirkko, Arto Christian. University of Bern; Suiza
Fil: Andersen, Ole Kæseler. Aalborg University; Dinamarca
Fil: Arendt-Nielsen, Lars. Aalborg University; Dinamarca
Fil: Curatolo, Michele. Aalborg University; Dinamarca. University of Washington; Estados Unidos
description The aim of this case-control study was to examine differences in neural correlates of pain facilitatory and inhibitory mechanisms between acute low back pain (LBP) patients and healthy individuals. Pressure pain tolerance, electrical pain detection thresholds, pain ratings to repetitive suprathreshold electrical stimulation (SES) and conditioned pain modulation (CPM) were assessed in 18 patients with acute LBP and 18 healthy control participants. Furthermore, event-related potentials (ERPs) in response to repetitive SES were obtained from high-density electroencephalography. Results showed that the LBP group presented lower pressure pain tolerance and higher pain ratings to SES compared with the control group. Both groups displayed effective CPM, with no differences in CPM magnitude between groups. Both groups presented similar reductions in ERP amplitudes during CPM, but ERP responses to repetitive SES were significantly larger in the LBP group. In conclusion, acute LBP patients presented enhanced pain facilitatory mechanisms, whereas no significant changes in pain inhibitory mechanisms were observed. These results provide new insight into the central mechanisms underlying acute LBP. Perspective: This article present evidence that acute LBP patients show enhanced pain facilitation and unaltered pain inhibition compared with pain-free volunteers. These results provide new insight into the central mechanisms underlying acute LBP.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40998
Vuilleumier, Pascal Henri; Arguissain, Federico Gabriel; Biurrun Manresa, José Alberto; Neziri, Alban Ymer; Nirkko, Arto Christian; et al.; Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients; Churchill Livingstone; Journal Of Pain; 18; 11; 5-2017; 1313-1323
1526-5900
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40998
identifier_str_mv Vuilleumier, Pascal Henri; Arguissain, Federico Gabriel; Biurrun Manresa, José Alberto; Neziri, Alban Ymer; Nirkko, Arto Christian; et al.; Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients; Churchill Livingstone; Journal Of Pain; 18; 11; 5-2017; 1313-1323
1526-5900
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpain.2017.05.008
info:eu-repo/semantics/altIdentifier/url/http://www.jpain.org/article/S1526-5900(17)30617-X/fulltext
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Churchill Livingstone
publisher.none.fl_str_mv Churchill Livingstone
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613486228799488
score 13.070432

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