Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction

Autores
Martins, Airton C.; Virgolini, Miriam Beatriz; Silva Ávila, Daiana; Scharf, Pablo; Li, Jung; Tinkov, Alexey A.; Skalny, Anatoly V.; Bowman, Aaron B.; Rocha, João B. T.; Aschner, Michael
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mitochondria play a crucial role in cellular respiration, ATP production, and the regulation of various cellular processes. Mitochondrial dysfunctions have been directly linked to pathophysiological conditions, making them a significant target of interest in toxicological research. In recent years, there has been a growing need to understand the intricate effects of xenobiotics on human health, necessitating the use of effective scientific research tools. Caenorhabditis elegans (C. elegans), a nonpathogenic nematode, has emerged as a powerful tool for investigating toxic mechanisms and mitochondrial dysfunction. With remarkable genetic homology to mammals, C. elegans has been used in studies to elucidate the impact of contaminants and drugs on mitochondrial function. This review focuses on the effects of several toxic metals and metalloids, drugs of abuse and pesticides on mitochondria, highlighting the utility of C. elegans as a model organism to investigate mitochondrial dysfunction induced by xenobiotics. Mitochondrial structure, function, and dynamics are discussed, emphasizing their essential role in cellular viability and the regulation of processes such as autophagy, apoptosis, and calcium homeostasis. Additionally, specific toxins and toxicants, such as arsenic, cadmium, and manganese are examined in the context of their impact on mitochondrial function and the utility of C. elegans in elucidating the underlying mechanisms. Furthermore, we demonstrate the utilization of C. elegans as an experimental model providing a promising platform for investigating the intricate relationships between xenobiotics and mitochondrial dysfunction. This knowledge could contribute to the development of strategies to mitigate the adverse effects of contaminants and drugs of abuse, ultimately enhancing our understanding of these complex processes and promoting human health.
Fil: Martins, Airton C.. Albert Einstein College of Medicine; Estados Unidos
Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Silva Ávila, Daiana. Universidade Federal do Pampa; Brasil
Fil: Scharf, Pablo. Universidade de Sao Paulo; Brasil
Fil: Li, Jung. Des Moines University; Estados Unidos
Fil: Tinkov, Alexey A.. Yaroslavl State University; Rusia
Fil: Skalny, Anatoly V.. Yaroslavl State University; Rusia
Fil: Bowman, Aaron B.. Purdue University; Estados Unidos
Fil: Rocha, João B. T.. Universidade Federal de Santa Maria; Brasil
Fil: Aschner, Michael. Albert Einstein College of Medicine; Estados Unidos
Materia
ARSENIC
C. ELEGANS
CADMIUM
ETHANOL
MANGANESE
MERCURY
MITOCHONDRIA
PESTICIDES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/229941
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/229941
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced DysfunctionMartins, Airton C.Virgolini, Miriam BeatrizSilva Ávila, DaianaScharf, PabloLi, JungTinkov, Alexey A.Skalny, Anatoly V.Bowman, Aaron B.Rocha, João B. T.Aschner, MichaelARSENICC. ELEGANSCADMIUMETHANOLMANGANESEMERCURYMITOCHONDRIAPESTICIDEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Mitochondria play a crucial role in cellular respiration, ATP production, and the regulation of various cellular processes. Mitochondrial dysfunctions have been directly linked to pathophysiological conditions, making them a significant target of interest in toxicological research. In recent years, there has been a growing need to understand the intricate effects of xenobiotics on human health, necessitating the use of effective scientific research tools. Caenorhabditis elegans (C. elegans), a nonpathogenic nematode, has emerged as a powerful tool for investigating toxic mechanisms and mitochondrial dysfunction. With remarkable genetic homology to mammals, C. elegans has been used in studies to elucidate the impact of contaminants and drugs on mitochondrial function. This review focuses on the effects of several toxic metals and metalloids, drugs of abuse and pesticides on mitochondria, highlighting the utility of C. elegans as a model organism to investigate mitochondrial dysfunction induced by xenobiotics. Mitochondrial structure, function, and dynamics are discussed, emphasizing their essential role in cellular viability and the regulation of processes such as autophagy, apoptosis, and calcium homeostasis. Additionally, specific toxins and toxicants, such as arsenic, cadmium, and manganese are examined in the context of their impact on mitochondrial function and the utility of C. elegans in elucidating the underlying mechanisms. Furthermore, we demonstrate the utilization of C. elegans as an experimental model providing a promising platform for investigating the intricate relationships between xenobiotics and mitochondrial dysfunction. This knowledge could contribute to the development of strategies to mitigate the adverse effects of contaminants and drugs of abuse, ultimately enhancing our understanding of these complex processes and promoting human health.Fil: Martins, Airton C.. Albert Einstein College of Medicine; Estados UnidosFil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Silva Ávila, Daiana. Universidade Federal do Pampa; BrasilFil: Scharf, Pablo. Universidade de Sao Paulo; BrasilFil: Li, Jung. Des Moines University; Estados UnidosFil: Tinkov, Alexey A.. Yaroslavl State University; RusiaFil: Skalny, Anatoly V.. Yaroslavl State University; RusiaFil: Bowman, Aaron B.. Purdue University; Estados UnidosFil: Rocha, João B. T.. Universidade Federal de Santa Maria; BrasilFil: Aschner, Michael. Albert Einstein College of Medicine; Estados UnidosMDPI2023-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/229941Martins, Airton C.; Virgolini, Miriam Beatriz; Silva Ávila, Daiana; Scharf, Pablo; Li, Jung; et al.; Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction; MDPI; Cells; 12; 17; 9-2023; 1-282073-4409CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/cells12172124info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:02Zoai:ri.conicet.gov.ar:11336/229941instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:03.233CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
title Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
spellingShingle Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
Martins, Airton C.
ARSENIC
C. ELEGANS
CADMIUM
ETHANOL
MANGANESE
MERCURY
MITOCHONDRIA
PESTICIDES
title_short Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
title_full Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
title_fullStr Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
title_full_unstemmed Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
title_sort Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
dc.creator.none.fl_str_mv Martins, Airton C.
Virgolini, Miriam Beatriz
Silva Ávila, Daiana
Scharf, Pablo
Li, Jung
Tinkov, Alexey A.
Skalny, Anatoly V.
Bowman, Aaron B.
Rocha, João B. T.
Aschner, Michael
author Martins, Airton C.
author_facet Martins, Airton C.
Virgolini, Miriam Beatriz
Silva Ávila, Daiana
Scharf, Pablo
Li, Jung
Tinkov, Alexey A.
Skalny, Anatoly V.
Bowman, Aaron B.
Rocha, João B. T.
Aschner, Michael
author_role author
author2 Virgolini, Miriam Beatriz
Silva Ávila, Daiana
Scharf, Pablo
Li, Jung
Tinkov, Alexey A.
Skalny, Anatoly V.
Bowman, Aaron B.
Rocha, João B. T.
Aschner, Michael
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ARSENIC
C. ELEGANS
CADMIUM
ETHANOL
MANGANESE
MERCURY
MITOCHONDRIA
PESTICIDES
topic ARSENIC
C. ELEGANS
CADMIUM
ETHANOL
MANGANESE
MERCURY
MITOCHONDRIA
PESTICIDES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mitochondria play a crucial role in cellular respiration, ATP production, and the regulation of various cellular processes. Mitochondrial dysfunctions have been directly linked to pathophysiological conditions, making them a significant target of interest in toxicological research. In recent years, there has been a growing need to understand the intricate effects of xenobiotics on human health, necessitating the use of effective scientific research tools. Caenorhabditis elegans (C. elegans), a nonpathogenic nematode, has emerged as a powerful tool for investigating toxic mechanisms and mitochondrial dysfunction. With remarkable genetic homology to mammals, C. elegans has been used in studies to elucidate the impact of contaminants and drugs on mitochondrial function. This review focuses on the effects of several toxic metals and metalloids, drugs of abuse and pesticides on mitochondria, highlighting the utility of C. elegans as a model organism to investigate mitochondrial dysfunction induced by xenobiotics. Mitochondrial structure, function, and dynamics are discussed, emphasizing their essential role in cellular viability and the regulation of processes such as autophagy, apoptosis, and calcium homeostasis. Additionally, specific toxins and toxicants, such as arsenic, cadmium, and manganese are examined in the context of their impact on mitochondrial function and the utility of C. elegans in elucidating the underlying mechanisms. Furthermore, we demonstrate the utilization of C. elegans as an experimental model providing a promising platform for investigating the intricate relationships between xenobiotics and mitochondrial dysfunction. This knowledge could contribute to the development of strategies to mitigate the adverse effects of contaminants and drugs of abuse, ultimately enhancing our understanding of these complex processes and promoting human health.
Fil: Martins, Airton C.. Albert Einstein College of Medicine; Estados Unidos
Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Silva Ávila, Daiana. Universidade Federal do Pampa; Brasil
Fil: Scharf, Pablo. Universidade de Sao Paulo; Brasil
Fil: Li, Jung. Des Moines University; Estados Unidos
Fil: Tinkov, Alexey A.. Yaroslavl State University; Rusia
Fil: Skalny, Anatoly V.. Yaroslavl State University; Rusia
Fil: Bowman, Aaron B.. Purdue University; Estados Unidos
Fil: Rocha, João B. T.. Universidade Federal de Santa Maria; Brasil
Fil: Aschner, Michael. Albert Einstein College of Medicine; Estados Unidos
description Mitochondria play a crucial role in cellular respiration, ATP production, and the regulation of various cellular processes. Mitochondrial dysfunctions have been directly linked to pathophysiological conditions, making them a significant target of interest in toxicological research. In recent years, there has been a growing need to understand the intricate effects of xenobiotics on human health, necessitating the use of effective scientific research tools. Caenorhabditis elegans (C. elegans), a nonpathogenic nematode, has emerged as a powerful tool for investigating toxic mechanisms and mitochondrial dysfunction. With remarkable genetic homology to mammals, C. elegans has been used in studies to elucidate the impact of contaminants and drugs on mitochondrial function. This review focuses on the effects of several toxic metals and metalloids, drugs of abuse and pesticides on mitochondria, highlighting the utility of C. elegans as a model organism to investigate mitochondrial dysfunction induced by xenobiotics. Mitochondrial structure, function, and dynamics are discussed, emphasizing their essential role in cellular viability and the regulation of processes such as autophagy, apoptosis, and calcium homeostasis. Additionally, specific toxins and toxicants, such as arsenic, cadmium, and manganese are examined in the context of their impact on mitochondrial function and the utility of C. elegans in elucidating the underlying mechanisms. Furthermore, we demonstrate the utilization of C. elegans as an experimental model providing a promising platform for investigating the intricate relationships between xenobiotics and mitochondrial dysfunction. This knowledge could contribute to the development of strategies to mitigate the adverse effects of contaminants and drugs of abuse, ultimately enhancing our understanding of these complex processes and promoting human health.
publishDate 2023
dc.date.none.fl_str_mv 2023-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/229941
Martins, Airton C.; Virgolini, Miriam Beatriz; Silva Ávila, Daiana; Scharf, Pablo; Li, Jung; et al.; Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction; MDPI; Cells; 12; 17; 9-2023; 1-28
2073-4409
CONICET Digital
CONICET
url http://hdl.handle.net/11336/229941
identifier_str_mv Martins, Airton C.; Virgolini, Miriam Beatriz; Silva Ávila, Daiana; Scharf, Pablo; Li, Jung; et al.; Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction; MDPI; Cells; 12; 17; 9-2023; 1-28
2073-4409
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/cells12172124
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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