Age-related effects of restraint stress on ethanol intake

Autores
Wille-bille, Aranza; Ferreyra, Ana Ines; Sciangula, Martina; Pautassi, Ricardo Marcos
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Several work has suggested that adolescents may be significantly more sensitive to stress, and to ethanol-stress interactions, than adults. It is thus important to analyze stress-reactive drinking during adolescence and potential treatments to ameliorate it. Stress effects upon ethanol intake in animal rat models have been controversial, with studies indicating heightened, decreased or unaltered ethanol intake after stress. The present study analyzed the impact of chronic restraint stress (5 daily, 2h long, sessions) upon ethanol intake, assessed across two-weeks via intermittent, 18-h two bottle intake tests, in male and female adolescent and adult rats. We found greater ethanol intake and preference in stressed than in non-stressed female, but not in male, adolescent rats. This effect of stress was inhibited after blockade of kappa opioid receptors by norbinaltorphimine (10 mg/kg). Significant age-related differences were observed, with stressed-adult females drinking actually less than their same-age controls. In subsequent experiments we observed that adolescent stressed females exhibited signs of behavioral disinhibition when tested in a modified version of the concentric square field test. Altogether, these results confirm the hypothesis of greater adolescent reactivity to stress, which can result in increased liability for ethanol intake, particularly among females. Treatments that tackle the endogenous opioid system, in particular the kappa receptors, seem to hold promise as a therapeutic target to reduce this stress-mediated ethanol drinking.
Fil: Wille-bille, Aranza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Ferreyra, Ana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Sciangula, Martina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
Stress
Alcohol
Adolescents
Adults
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64200
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/64200
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Age-related effects of restraint stress on ethanol intakeWille-bille, AranzaFerreyra, Ana InesSciangula, MartinaPautassi, Ricardo MarcosStressAlcoholAdolescentsAdultshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Several work has suggested that adolescents may be significantly more sensitive to stress, and to ethanol-stress interactions, than adults. It is thus important to analyze stress-reactive drinking during adolescence and potential treatments to ameliorate it. Stress effects upon ethanol intake in animal rat models have been controversial, with studies indicating heightened, decreased or unaltered ethanol intake after stress. The present study analyzed the impact of chronic restraint stress (5 daily, 2h long, sessions) upon ethanol intake, assessed across two-weeks via intermittent, 18-h two bottle intake tests, in male and female adolescent and adult rats. We found greater ethanol intake and preference in stressed than in non-stressed female, but not in male, adolescent rats. This effect of stress was inhibited after blockade of kappa opioid receptors by norbinaltorphimine (10 mg/kg). Significant age-related differences were observed, with stressed-adult females drinking actually less than their same-age controls. In subsequent experiments we observed that adolescent stressed females exhibited signs of behavioral disinhibition when tested in a modified version of the concentric square field test. Altogether, these results confirm the hypothesis of greater adolescent reactivity to stress, which can result in increased liability for ethanol intake, particularly among females. Treatments that tackle the endogenous opioid system, in particular the kappa receptors, seem to hold promise as a therapeutic target to reduce this stress-mediated ethanol drinking.Fil: Wille-bille, Aranza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Ferreyra, Ana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Sciangula, Martina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaElsevier Science Inc2017-05-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64200Wille-bille, Aranza; Ferreyra, Ana Ines; Sciangula, Martina; Pautassi, Ricardo Marcos; Age-related effects of restraint stress on ethanol intake; Elsevier Science Inc; Alcohol; 60; 4-5-2017; 2290741-83291873-6823CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.alcohol.2017.02.293info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0741832917306328?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:55:01Zoai:ri.conicet.gov.ar:11336/64200instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:55:01.976CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Age-related effects of restraint stress on ethanol intake
title Age-related effects of restraint stress on ethanol intake
spellingShingle Age-related effects of restraint stress on ethanol intake
Wille-bille, Aranza
Stress
Alcohol
Adolescents
Adults
title_short Age-related effects of restraint stress on ethanol intake
title_full Age-related effects of restraint stress on ethanol intake
title_fullStr Age-related effects of restraint stress on ethanol intake
title_full_unstemmed Age-related effects of restraint stress on ethanol intake
title_sort Age-related effects of restraint stress on ethanol intake
dc.creator.none.fl_str_mv Wille-bille, Aranza
Ferreyra, Ana Ines
Sciangula, Martina
Pautassi, Ricardo Marcos
author Wille-bille, Aranza
author_facet Wille-bille, Aranza
Ferreyra, Ana Ines
Sciangula, Martina
Pautassi, Ricardo Marcos
author_role author
author2 Ferreyra, Ana Ines
Sciangula, Martina
Pautassi, Ricardo Marcos
author2_role author
author
author
dc.subject.none.fl_str_mv Stress
Alcohol
Adolescents
Adults
topic Stress
Alcohol
Adolescents
Adults
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Several work has suggested that adolescents may be significantly more sensitive to stress, and to ethanol-stress interactions, than adults. It is thus important to analyze stress-reactive drinking during adolescence and potential treatments to ameliorate it. Stress effects upon ethanol intake in animal rat models have been controversial, with studies indicating heightened, decreased or unaltered ethanol intake after stress. The present study analyzed the impact of chronic restraint stress (5 daily, 2h long, sessions) upon ethanol intake, assessed across two-weeks via intermittent, 18-h two bottle intake tests, in male and female adolescent and adult rats. We found greater ethanol intake and preference in stressed than in non-stressed female, but not in male, adolescent rats. This effect of stress was inhibited after blockade of kappa opioid receptors by norbinaltorphimine (10 mg/kg). Significant age-related differences were observed, with stressed-adult females drinking actually less than their same-age controls. In subsequent experiments we observed that adolescent stressed females exhibited signs of behavioral disinhibition when tested in a modified version of the concentric square field test. Altogether, these results confirm the hypothesis of greater adolescent reactivity to stress, which can result in increased liability for ethanol intake, particularly among females. Treatments that tackle the endogenous opioid system, in particular the kappa receptors, seem to hold promise as a therapeutic target to reduce this stress-mediated ethanol drinking.
Fil: Wille-bille, Aranza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Ferreyra, Ana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Sciangula, Martina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description Several work has suggested that adolescents may be significantly more sensitive to stress, and to ethanol-stress interactions, than adults. It is thus important to analyze stress-reactive drinking during adolescence and potential treatments to ameliorate it. Stress effects upon ethanol intake in animal rat models have been controversial, with studies indicating heightened, decreased or unaltered ethanol intake after stress. The present study analyzed the impact of chronic restraint stress (5 daily, 2h long, sessions) upon ethanol intake, assessed across two-weeks via intermittent, 18-h two bottle intake tests, in male and female adolescent and adult rats. We found greater ethanol intake and preference in stressed than in non-stressed female, but not in male, adolescent rats. This effect of stress was inhibited after blockade of kappa opioid receptors by norbinaltorphimine (10 mg/kg). Significant age-related differences were observed, with stressed-adult females drinking actually less than their same-age controls. In subsequent experiments we observed that adolescent stressed females exhibited signs of behavioral disinhibition when tested in a modified version of the concentric square field test. Altogether, these results confirm the hypothesis of greater adolescent reactivity to stress, which can result in increased liability for ethanol intake, particularly among females. Treatments that tackle the endogenous opioid system, in particular the kappa receptors, seem to hold promise as a therapeutic target to reduce this stress-mediated ethanol drinking.
publishDate 2017
dc.date.none.fl_str_mv 2017-05-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64200
Wille-bille, Aranza; Ferreyra, Ana Ines; Sciangula, Martina; Pautassi, Ricardo Marcos; Age-related effects of restraint stress on ethanol intake; Elsevier Science Inc; Alcohol; 60; 4-5-2017; 229
0741-8329
1873-6823
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64200
identifier_str_mv Wille-bille, Aranza; Ferreyra, Ana Ines; Sciangula, Martina; Pautassi, Ricardo Marcos; Age-related effects of restraint stress on ethanol intake; Elsevier Science Inc; Alcohol; 60; 4-5-2017; 229
0741-8329
1873-6823
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.alcohol.2017.02.293
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0741832917306328?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.121305

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