Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review

Autores
Sandoval, María Macarena; Bardach, Ariel Esteban; Rojas Roque, Carlos; Alconada, Tomás; Gomez, Jorge A.; Pinto, Thatiana; Palermo, Carolina; Ciapponi, Agustín
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Detailed information is needed on the dynamic pattern of antimicrobial resistance (AMR) in Neisseria gonorrhoeae in Latin America and the Caribbean (LAC). Objectives: To conduct a systematic review of AMR in N. gonorrhoeae in LAC. Methods: Electronic searches without language restrictions were conducted in PubMed, Embase, Cochrane Library, EconLIT, Cumulative Index of Nursing and Allied Health Literature, Centre for Reviews and Dissemination, and Latin American and Caribbean Literature in Health Sciences. Studies were eligible if published between 1 January 2011 and 13 February 2021, conducted in any LAC country (regardless of age, sex and population) and measured frequency and/or patterns of AMR to any antimicrobial in N. gonorrhoeae. The WHO Global Gonococcal Antimicrobial Surveillance Programme (WHO-GASP) for LAC countries and Latin American AMR Surveillance Network databases were searched. AMR study quality was evaluated according to WHO recommendations. Results: AMR data for 38, 417 isolates collected in 1990–2018 were included from 31 publications, reporting data from Argentina, Brazil, Colombia, Peru, Uruguay, Venezuela and WHO-GASP. Resistance to extended-spectrum cephalosporins was infrequent (0.09%–8.5%). Resistance to azithromycin was up to 32% in the published studies and up to 61% in WHO-GASP. Resistance to penicillin, tetracycline and ciprofloxacin was high (17.6%–98%, 20.7%–90% and 5.9%–89%, respectively). Resistance to gentamicin was not reported, and resistance to spectinomycin was reported in one study. Conclusions: This review provides data on resistance to azithromycin, potentially important given its use as first-line empirical treatment, and indicates the need for improved surveillance of gonococcal AMR in LAC.
Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Rojas Roque, Carlos. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Gomez, Jorge A.. Gsk; Argentina
Fil: Pinto, Thatiana. Glaxosmithkline Pharmaceuticals Sa/nv; Bélgica
Fil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Materia
Neisseria gonorrhoeae
Antimicrobial resistance
Latin America
Systematic review
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/228780
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/228780
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic reviewSandoval, María MacarenaBardach, Ariel EstebanRojas Roque, CarlosAlconada, TomásGomez, Jorge A.Pinto, ThatianaPalermo, CarolinaCiapponi, AgustínNeisseria gonorrhoeaeAntimicrobial resistanceLatin AmericaSystematic reviewhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Detailed information is needed on the dynamic pattern of antimicrobial resistance (AMR) in Neisseria gonorrhoeae in Latin America and the Caribbean (LAC). Objectives: To conduct a systematic review of AMR in N. gonorrhoeae in LAC. Methods: Electronic searches without language restrictions were conducted in PubMed, Embase, Cochrane Library, EconLIT, Cumulative Index of Nursing and Allied Health Literature, Centre for Reviews and Dissemination, and Latin American and Caribbean Literature in Health Sciences. Studies were eligible if published between 1 January 2011 and 13 February 2021, conducted in any LAC country (regardless of age, sex and population) and measured frequency and/or patterns of AMR to any antimicrobial in N. gonorrhoeae. The WHO Global Gonococcal Antimicrobial Surveillance Programme (WHO-GASP) for LAC countries and Latin American AMR Surveillance Network databases were searched. AMR study quality was evaluated according to WHO recommendations. Results: AMR data for 38, 417 isolates collected in 1990–2018 were included from 31 publications, reporting data from Argentina, Brazil, Colombia, Peru, Uruguay, Venezuela and WHO-GASP. Resistance to extended-spectrum cephalosporins was infrequent (0.09%–8.5%). Resistance to azithromycin was up to 32% in the published studies and up to 61% in WHO-GASP. Resistance to penicillin, tetracycline and ciprofloxacin was high (17.6%–98%, 20.7%–90% and 5.9%–89%, respectively). Resistance to gentamicin was not reported, and resistance to spectinomycin was reported in one study. Conclusions: This review provides data on resistance to azithromycin, potentially important given its use as first-line empirical treatment, and indicates the need for improved surveillance of gonococcal AMR in LAC.Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Rojas Roque, Carlos. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Gomez, Jorge A.. Gsk; ArgentinaFil: Pinto, Thatiana. Glaxosmithkline Pharmaceuticals Sa/nv; BélgicaFil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaOxford University Press2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/228780Sandoval, María Macarena; Bardach, Ariel Esteban; Rojas Roque, Carlos; Alconada, Tomás; Gomez, Jorge A.; et al.; Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review; Oxford University Press; Journal of Antimicrobial Chemotherapy; 78; 6; 6-2023; 1322-13360305-7453CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dkad071info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jac/article/78/6/1322/7165460info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:49Zoai:ri.conicet.gov.ar:11336/228780instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:49.669CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review
title Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review
spellingShingle Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review
Sandoval, María Macarena
Neisseria gonorrhoeae
Antimicrobial resistance
Latin America
Systematic review
title_short Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review
title_full Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review
title_fullStr Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review
title_full_unstemmed Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review
title_sort Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review
dc.creator.none.fl_str_mv Sandoval, María Macarena
Bardach, Ariel Esteban
Rojas Roque, Carlos
Alconada, Tomás
Gomez, Jorge A.
Pinto, Thatiana
Palermo, Carolina
Ciapponi, Agustín
author Sandoval, María Macarena
author_facet Sandoval, María Macarena
Bardach, Ariel Esteban
Rojas Roque, Carlos
Alconada, Tomás
Gomez, Jorge A.
Pinto, Thatiana
Palermo, Carolina
Ciapponi, Agustín
author_role author
author2 Bardach, Ariel Esteban
Rojas Roque, Carlos
Alconada, Tomás
Gomez, Jorge A.
Pinto, Thatiana
Palermo, Carolina
Ciapponi, Agustín
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neisseria gonorrhoeae
Antimicrobial resistance
Latin America
Systematic review
topic Neisseria gonorrhoeae
Antimicrobial resistance
Latin America
Systematic review
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Detailed information is needed on the dynamic pattern of antimicrobial resistance (AMR) in Neisseria gonorrhoeae in Latin America and the Caribbean (LAC). Objectives: To conduct a systematic review of AMR in N. gonorrhoeae in LAC. Methods: Electronic searches without language restrictions were conducted in PubMed, Embase, Cochrane Library, EconLIT, Cumulative Index of Nursing and Allied Health Literature, Centre for Reviews and Dissemination, and Latin American and Caribbean Literature in Health Sciences. Studies were eligible if published between 1 January 2011 and 13 February 2021, conducted in any LAC country (regardless of age, sex and population) and measured frequency and/or patterns of AMR to any antimicrobial in N. gonorrhoeae. The WHO Global Gonococcal Antimicrobial Surveillance Programme (WHO-GASP) for LAC countries and Latin American AMR Surveillance Network databases were searched. AMR study quality was evaluated according to WHO recommendations. Results: AMR data for 38, 417 isolates collected in 1990–2018 were included from 31 publications, reporting data from Argentina, Brazil, Colombia, Peru, Uruguay, Venezuela and WHO-GASP. Resistance to extended-spectrum cephalosporins was infrequent (0.09%–8.5%). Resistance to azithromycin was up to 32% in the published studies and up to 61% in WHO-GASP. Resistance to penicillin, tetracycline and ciprofloxacin was high (17.6%–98%, 20.7%–90% and 5.9%–89%, respectively). Resistance to gentamicin was not reported, and resistance to spectinomycin was reported in one study. Conclusions: This review provides data on resistance to azithromycin, potentially important given its use as first-line empirical treatment, and indicates the need for improved surveillance of gonococcal AMR in LAC.
Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Rojas Roque, Carlos. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Gomez, Jorge A.. Gsk; Argentina
Fil: Pinto, Thatiana. Glaxosmithkline Pharmaceuticals Sa/nv; Bélgica
Fil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
description Background: Detailed information is needed on the dynamic pattern of antimicrobial resistance (AMR) in Neisseria gonorrhoeae in Latin America and the Caribbean (LAC). Objectives: To conduct a systematic review of AMR in N. gonorrhoeae in LAC. Methods: Electronic searches without language restrictions were conducted in PubMed, Embase, Cochrane Library, EconLIT, Cumulative Index of Nursing and Allied Health Literature, Centre for Reviews and Dissemination, and Latin American and Caribbean Literature in Health Sciences. Studies were eligible if published between 1 January 2011 and 13 February 2021, conducted in any LAC country (regardless of age, sex and population) and measured frequency and/or patterns of AMR to any antimicrobial in N. gonorrhoeae. The WHO Global Gonococcal Antimicrobial Surveillance Programme (WHO-GASP) for LAC countries and Latin American AMR Surveillance Network databases were searched. AMR study quality was evaluated according to WHO recommendations. Results: AMR data for 38, 417 isolates collected in 1990–2018 were included from 31 publications, reporting data from Argentina, Brazil, Colombia, Peru, Uruguay, Venezuela and WHO-GASP. Resistance to extended-spectrum cephalosporins was infrequent (0.09%–8.5%). Resistance to azithromycin was up to 32% in the published studies and up to 61% in WHO-GASP. Resistance to penicillin, tetracycline and ciprofloxacin was high (17.6%–98%, 20.7%–90% and 5.9%–89%, respectively). Resistance to gentamicin was not reported, and resistance to spectinomycin was reported in one study. Conclusions: This review provides data on resistance to azithromycin, potentially important given its use as first-line empirical treatment, and indicates the need for improved surveillance of gonococcal AMR in LAC.
publishDate 2023
dc.date.none.fl_str_mv 2023-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/228780
Sandoval, María Macarena; Bardach, Ariel Esteban; Rojas Roque, Carlos; Alconada, Tomás; Gomez, Jorge A.; et al.; Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review; Oxford University Press; Journal of Antimicrobial Chemotherapy; 78; 6; 6-2023; 1322-1336
0305-7453
CONICET Digital
CONICET
url http://hdl.handle.net/11336/228780
identifier_str_mv Sandoval, María Macarena; Bardach, Ariel Esteban; Rojas Roque, Carlos; Alconada, Tomás; Gomez, Jorge A.; et al.; Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: A systematic review; Oxford University Press; Journal of Antimicrobial Chemotherapy; 78; 6; 6-2023; 1322-1336
0305-7453
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dkad071
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jac/article/78/6/1322/7165460
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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