Evaluation of Halogenated Coumarins for Antimosquito Properties

Autores
Narayanaswamy, Venugopala K.; Gleiser, Raquel M.; Kasumbwe, Kabange; Aldhubiab, Bandar E.; Attimarad, Mahesh V.; Odhav, Bharti
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes. Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis, a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. Five compounds exerted 100% larval mortality within 24 h of exposure. All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. Repellent properties could not be evidenced. Five compounds were considered potential larvicidal agents for further research and development, while adulticidal activity was considered only mild to moderate.
Fil: Narayanaswamy, Venugopala K.. King Faisal University; Arabia Saudita. Durban University of Technology; Sudáfrica
Fil: Gleiser, Raquel M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinar de Biología Vegetal (p). Grupo Vinculado Centro de Relevamiento y Evaluacion de Recursos Agricolas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Kasumbwe, Kabange. Durban University of Technology; Sudáfrica
Fil: Aldhubiab, Bandar E.. King Faisal University; Arabia Saudita
Fil: Attimarad, Mahesh V.. King Faisal University; Arabia Saudita
Fil: Odhav, Bharti. Durban University of Technology; Sudáfrica
Materia
Insecticide
Repellent
Mosquito
Coumarin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/34422
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of Halogenated Coumarins for Antimosquito PropertiesNarayanaswamy, Venugopala K.Gleiser, Raquel M.Kasumbwe, KabangeAldhubiab, Bandar E.Attimarad, Mahesh V.Odhav, BhartiInsecticideRepellentMosquitoCoumarinhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Mosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes. Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis, a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. Five compounds exerted 100% larval mortality within 24 h of exposure. All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. Repellent properties could not be evidenced. Five compounds were considered potential larvicidal agents for further research and development, while adulticidal activity was considered only mild to moderate.Fil: Narayanaswamy, Venugopala K.. King Faisal University; Arabia Saudita. Durban University of Technology; SudáfricaFil: Gleiser, Raquel M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinar de Biología Vegetal (p). Grupo Vinculado Centro de Relevamiento y Evaluacion de Recursos Agricolas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Kasumbwe, Kabange. Durban University of Technology; SudáfricaFil: Aldhubiab, Bandar E.. King Faisal University; Arabia SauditaFil: Attimarad, Mahesh V.. King Faisal University; Arabia SauditaFil: Odhav, Bharti. Durban University of Technology; SudáfricaHindawi Publishing Corporation2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/34422Narayanaswamy, Venugopala K. ; Gleiser, Raquel M.; Kasumbwe, Kabange; Aldhubiab, Bandar E. ; Attimarad, Mahesh V.; et al.; Evaluation of Halogenated Coumarins for Antimosquito Properties; Hindawi Publishing Corporation; The Scientific World Journal; 2014; 12-2014; 1-6; 1898242356-61401537-744XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1155/2014/189824info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/tswj/2014/189824/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T11:45:02Zoai:ri.conicet.gov.ar:11336/34422instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 11:45:02.983CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of Halogenated Coumarins for Antimosquito Properties
title Evaluation of Halogenated Coumarins for Antimosquito Properties
spellingShingle Evaluation of Halogenated Coumarins for Antimosquito Properties
Narayanaswamy, Venugopala K.
Insecticide
Repellent
Mosquito
Coumarin
title_short Evaluation of Halogenated Coumarins for Antimosquito Properties
title_full Evaluation of Halogenated Coumarins for Antimosquito Properties
title_fullStr Evaluation of Halogenated Coumarins for Antimosquito Properties
title_full_unstemmed Evaluation of Halogenated Coumarins for Antimosquito Properties
title_sort Evaluation of Halogenated Coumarins for Antimosquito Properties
dc.creator.none.fl_str_mv Narayanaswamy, Venugopala K.
Gleiser, Raquel M.
Kasumbwe, Kabange
Aldhubiab, Bandar E.
Attimarad, Mahesh V.
Odhav, Bharti
author Narayanaswamy, Venugopala K.
author_facet Narayanaswamy, Venugopala K.
Gleiser, Raquel M.
Kasumbwe, Kabange
Aldhubiab, Bandar E.
Attimarad, Mahesh V.
Odhav, Bharti
author_role author
author2 Gleiser, Raquel M.
Kasumbwe, Kabange
Aldhubiab, Bandar E.
Attimarad, Mahesh V.
Odhav, Bharti
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Insecticide
Repellent
Mosquito
Coumarin
topic Insecticide
Repellent
Mosquito
Coumarin
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Mosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes. Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis, a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. Five compounds exerted 100% larval mortality within 24 h of exposure. All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. Repellent properties could not be evidenced. Five compounds were considered potential larvicidal agents for further research and development, while adulticidal activity was considered only mild to moderate.
Fil: Narayanaswamy, Venugopala K.. King Faisal University; Arabia Saudita. Durban University of Technology; Sudáfrica
Fil: Gleiser, Raquel M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinar de Biología Vegetal (p). Grupo Vinculado Centro de Relevamiento y Evaluacion de Recursos Agricolas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Kasumbwe, Kabange. Durban University of Technology; Sudáfrica
Fil: Aldhubiab, Bandar E.. King Faisal University; Arabia Saudita
Fil: Attimarad, Mahesh V.. King Faisal University; Arabia Saudita
Fil: Odhav, Bharti. Durban University of Technology; Sudáfrica
description Mosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes. Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis, a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. Five compounds exerted 100% larval mortality within 24 h of exposure. All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. Repellent properties could not be evidenced. Five compounds were considered potential larvicidal agents for further research and development, while adulticidal activity was considered only mild to moderate.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/34422
Narayanaswamy, Venugopala K. ; Gleiser, Raquel M.; Kasumbwe, Kabange; Aldhubiab, Bandar E. ; Attimarad, Mahesh V.; et al.; Evaluation of Halogenated Coumarins for Antimosquito Properties; Hindawi Publishing Corporation; The Scientific World Journal; 2014; 12-2014; 1-6; 189824
2356-6140
1537-744X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/34422
identifier_str_mv Narayanaswamy, Venugopala K. ; Gleiser, Raquel M.; Kasumbwe, Kabange; Aldhubiab, Bandar E. ; Attimarad, Mahesh V.; et al.; Evaluation of Halogenated Coumarins for Antimosquito Properties; Hindawi Publishing Corporation; The Scientific World Journal; 2014; 12-2014; 1-6; 189824
2356-6140
1537-744X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/189824
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/tswj/2014/189824/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.10058

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