Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release
- Autores
- Marengo, Robinson Cristian; Mengatto, Luciano Nicolas; Olivares, María Laura; Berli, Claudio Luis Alberto
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The prevalence of tuberculosis continuously grows and there is an imperious need to improve the therapeutic efficacy of approved drugs for clinical use. Here we report the encapsulation of isoniazid (INH) in egg white/ - carrageenan microparticles, which are intended for drug vehiculation through the gastrointestinal tract and con- trolled release in the ileum. Spherical and highly monodisperse microparticles (255 mm average diameter) were obtained by droplet-based microfluidics and subsequent microwave irradiation. The entire amount of INH added to the particles was encapsulated. Infrared spectra revealed the formation of esters, hydrogen bonding, and Mail- lard reaction in the biopolymer matrix. In vitro release experiments were carried out in media that systematically emulate the stomach and intestinal tract conditions: 37 °C, NaCl 0.05 mol/L, pH 1.6, for the first 2 h, and Tris?HCl 0.1 mol/L, pH 7, for the next 24 h. A small fraction of the loaded INH was released in the first medium and most of the drug was progressively delivered in the second medium. The release profiles of microparticles were analyzed by using classical kinetic models, which enabled to hypothesize the release mechanism of INH from the biopolymer matrix. This knowledge, together with the ability to control the governing parameters of microfluidic elaboration, opens further possibilities for designing optimal prototypes for sustained release.
Fil: Marengo, Robinson Cristian. Universidad Nacional del Litoral; Argentina
Fil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Olivares, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Berli, Claudio Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina - Materia
-
ISONIAZID
ENCAPSULATION
MICROFLUIDICS
DRUG RELEASE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/150280
Ver los metadatos del registro completo
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Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained releaseMarengo, Robinson CristianMengatto, Luciano NicolasOlivares, María LauraBerli, Claudio Luis AlbertoISONIAZIDENCAPSULATIONMICROFLUIDICSDRUG RELEASEhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The prevalence of tuberculosis continuously grows and there is an imperious need to improve the therapeutic efficacy of approved drugs for clinical use. Here we report the encapsulation of isoniazid (INH) in egg white/ - carrageenan microparticles, which are intended for drug vehiculation through the gastrointestinal tract and con- trolled release in the ileum. Spherical and highly monodisperse microparticles (255 mm average diameter) were obtained by droplet-based microfluidics and subsequent microwave irradiation. The entire amount of INH added to the particles was encapsulated. Infrared spectra revealed the formation of esters, hydrogen bonding, and Mail- lard reaction in the biopolymer matrix. In vitro release experiments were carried out in media that systematically emulate the stomach and intestinal tract conditions: 37 °C, NaCl 0.05 mol/L, pH 1.6, for the first 2 h, and Tris?HCl 0.1 mol/L, pH 7, for the next 24 h. A small fraction of the loaded INH was released in the first medium and most of the drug was progressively delivered in the second medium. The release profiles of microparticles were analyzed by using classical kinetic models, which enabled to hypothesize the release mechanism of INH from the biopolymer matrix. This knowledge, together with the ability to control the governing parameters of microfluidic elaboration, opens further possibilities for designing optimal prototypes for sustained release.Fil: Marengo, Robinson Cristian. Universidad Nacional del Litoral; ArgentinaFil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Olivares, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Berli, Claudio Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaElsevier2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/150280Marengo, Robinson Cristian; Mengatto, Luciano Nicolas; Olivares, María Laura; Berli, Claudio Luis Alberto; Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release; Elsevier; Food Hydrocolloids; 1; 11-2021; 1-82667-0259CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2667025921000339info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fhfh.2021.100041info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:40Zoai:ri.conicet.gov.ar:11336/150280instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:40.42CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release |
title |
Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release |
spellingShingle |
Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release Marengo, Robinson Cristian ISONIAZID ENCAPSULATION MICROFLUIDICS DRUG RELEASE |
title_short |
Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release |
title_full |
Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release |
title_fullStr |
Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release |
title_full_unstemmed |
Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release |
title_sort |
Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release |
dc.creator.none.fl_str_mv |
Marengo, Robinson Cristian Mengatto, Luciano Nicolas Olivares, María Laura Berli, Claudio Luis Alberto |
author |
Marengo, Robinson Cristian |
author_facet |
Marengo, Robinson Cristian Mengatto, Luciano Nicolas Olivares, María Laura Berli, Claudio Luis Alberto |
author_role |
author |
author2 |
Mengatto, Luciano Nicolas Olivares, María Laura Berli, Claudio Luis Alberto |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
ISONIAZID ENCAPSULATION MICROFLUIDICS DRUG RELEASE |
topic |
ISONIAZID ENCAPSULATION MICROFLUIDICS DRUG RELEASE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.5 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
The prevalence of tuberculosis continuously grows and there is an imperious need to improve the therapeutic efficacy of approved drugs for clinical use. Here we report the encapsulation of isoniazid (INH) in egg white/ - carrageenan microparticles, which are intended for drug vehiculation through the gastrointestinal tract and con- trolled release in the ileum. Spherical and highly monodisperse microparticles (255 mm average diameter) were obtained by droplet-based microfluidics and subsequent microwave irradiation. The entire amount of INH added to the particles was encapsulated. Infrared spectra revealed the formation of esters, hydrogen bonding, and Mail- lard reaction in the biopolymer matrix. In vitro release experiments were carried out in media that systematically emulate the stomach and intestinal tract conditions: 37 °C, NaCl 0.05 mol/L, pH 1.6, for the first 2 h, and Tris?HCl 0.1 mol/L, pH 7, for the next 24 h. A small fraction of the loaded INH was released in the first medium and most of the drug was progressively delivered in the second medium. The release profiles of microparticles were analyzed by using classical kinetic models, which enabled to hypothesize the release mechanism of INH from the biopolymer matrix. This knowledge, together with the ability to control the governing parameters of microfluidic elaboration, opens further possibilities for designing optimal prototypes for sustained release. Fil: Marengo, Robinson Cristian. Universidad Nacional del Litoral; Argentina Fil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Olivares, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Berli, Claudio Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina |
description |
The prevalence of tuberculosis continuously grows and there is an imperious need to improve the therapeutic efficacy of approved drugs for clinical use. Here we report the encapsulation of isoniazid (INH) in egg white/ - carrageenan microparticles, which are intended for drug vehiculation through the gastrointestinal tract and con- trolled release in the ileum. Spherical and highly monodisperse microparticles (255 mm average diameter) were obtained by droplet-based microfluidics and subsequent microwave irradiation. The entire amount of INH added to the particles was encapsulated. Infrared spectra revealed the formation of esters, hydrogen bonding, and Mail- lard reaction in the biopolymer matrix. In vitro release experiments were carried out in media that systematically emulate the stomach and intestinal tract conditions: 37 °C, NaCl 0.05 mol/L, pH 1.6, for the first 2 h, and Tris?HCl 0.1 mol/L, pH 7, for the next 24 h. A small fraction of the loaded INH was released in the first medium and most of the drug was progressively delivered in the second medium. The release profiles of microparticles were analyzed by using classical kinetic models, which enabled to hypothesize the release mechanism of INH from the biopolymer matrix. This knowledge, together with the ability to control the governing parameters of microfluidic elaboration, opens further possibilities for designing optimal prototypes for sustained release. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/150280 Marengo, Robinson Cristian; Mengatto, Luciano Nicolas; Olivares, María Laura; Berli, Claudio Luis Alberto; Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release; Elsevier; Food Hydrocolloids; 1; 11-2021; 1-8 2667-0259 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/150280 |
identifier_str_mv |
Marengo, Robinson Cristian; Mengatto, Luciano Nicolas; Olivares, María Laura; Berli, Claudio Luis Alberto; Microfluidics-based encapsulation of isoniazid in egg white/carrageenan microparticles for sustained release; Elsevier; Food Hydrocolloids; 1; 11-2021; 1-8 2667-0259 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2667025921000339 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fhfh.2021.100041 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614255874146304 |
score |
13.070432 |