Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics

Autores
Riobo Del Galdo, Natalia A.; Lara Montero, Angela; Wertheimer Hermitte, Eva Victoria
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed by lung cancer. Given the importance of BC in public health, it is essential to identify biomarkers to predict prognosis, predetermine drug resistance and provide treatment guidelines that include personalized targeted therapies. The Hedgehog (Hh) signaling pathway plays an essential role in embryonic development, tissue regeneration, and stem cell renewal. Several lines of evidence endorse the important role of canonical and non-canonical Hh signaling in BC. In this comprehensive review we discuss the role of Hh signaling in breast development and homeostasis and its contribution to tumorigenesis and progression of different subtypes of BC. We also examine the efficacy of agents targeting different components of the Hh pathway both in preclinical models and in clinical trials. The contribution of the Hh pathway in BC tumorigenesis and progression, its prognostic role, and its value as a therapeutic target vary according to the molecular, clinical, and histopathological characteristics of the BC patients. The evidence presented here highlights the relevance of the Hh signaling in BC, and suggest that this pathway is key for BC progression and metastasis.
Fil: Riobo Del Galdo, Natalia A.. University Of Leeds.; Reino Unido
Fil: Lara Montero, Angela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Wertheimer Hermitte, Eva Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Materia
PATCHED-1
SMOOTHENED
TNBC
BREAST CANCER
CLINICAL TRIAL
GLIOMA-ASSOCIATED ONCOGENE
HEDGEHOG
SONIC
THERAPEUTICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120004
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and TherapeuticsRiobo Del Galdo, Natalia A.Lara Montero, AngelaWertheimer Hermitte, Eva VictoriaPATCHED-1SMOOTHENEDTNBCBREAST CANCERCLINICAL TRIALGLIOMA-ASSOCIATED ONCOGENEHEDGEHOGSONICTHERAPEUTICShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed by lung cancer. Given the importance of BC in public health, it is essential to identify biomarkers to predict prognosis, predetermine drug resistance and provide treatment guidelines that include personalized targeted therapies. The Hedgehog (Hh) signaling pathway plays an essential role in embryonic development, tissue regeneration, and stem cell renewal. Several lines of evidence endorse the important role of canonical and non-canonical Hh signaling in BC. In this comprehensive review we discuss the role of Hh signaling in breast development and homeostasis and its contribution to tumorigenesis and progression of different subtypes of BC. We also examine the efficacy of agents targeting different components of the Hh pathway both in preclinical models and in clinical trials. The contribution of the Hh pathway in BC tumorigenesis and progression, its prognostic role, and its value as a therapeutic target vary according to the molecular, clinical, and histopathological characteristics of the BC patients. The evidence presented here highlights the relevance of the Hh signaling in BC, and suggest that this pathway is key for BC progression and metastasis.Fil: Riobo Del Galdo, Natalia A.. University Of Leeds.; Reino UnidoFil: Lara Montero, Angela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Wertheimer Hermitte, Eva Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaMDPI2019-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120004Riobo Del Galdo, Natalia A.; Lara Montero, Angela; Wertheimer Hermitte, Eva Victoria; Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics; MDPI; Cells; 8; 4; 4-20192073-4409CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4409/8/4/375info:eu-repo/semantics/altIdentifier/doi/10.3390/cells8040375info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:45:31Zoai:ri.conicet.gov.ar:11336/120004instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:45:31.694CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
title Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
spellingShingle Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
Riobo Del Galdo, Natalia A.
PATCHED-1
SMOOTHENED
TNBC
BREAST CANCER
CLINICAL TRIAL
GLIOMA-ASSOCIATED ONCOGENE
HEDGEHOG
SONIC
THERAPEUTICS
title_short Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
title_full Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
title_fullStr Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
title_full_unstemmed Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
title_sort Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
dc.creator.none.fl_str_mv Riobo Del Galdo, Natalia A.
Lara Montero, Angela
Wertheimer Hermitte, Eva Victoria
author Riobo Del Galdo, Natalia A.
author_facet Riobo Del Galdo, Natalia A.
Lara Montero, Angela
Wertheimer Hermitte, Eva Victoria
author_role author
author2 Lara Montero, Angela
Wertheimer Hermitte, Eva Victoria
author2_role author
author
dc.subject.none.fl_str_mv PATCHED-1
SMOOTHENED
TNBC
BREAST CANCER
CLINICAL TRIAL
GLIOMA-ASSOCIATED ONCOGENE
HEDGEHOG
SONIC
THERAPEUTICS
topic PATCHED-1
SMOOTHENED
TNBC
BREAST CANCER
CLINICAL TRIAL
GLIOMA-ASSOCIATED ONCOGENE
HEDGEHOG
SONIC
THERAPEUTICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed by lung cancer. Given the importance of BC in public health, it is essential to identify biomarkers to predict prognosis, predetermine drug resistance and provide treatment guidelines that include personalized targeted therapies. The Hedgehog (Hh) signaling pathway plays an essential role in embryonic development, tissue regeneration, and stem cell renewal. Several lines of evidence endorse the important role of canonical and non-canonical Hh signaling in BC. In this comprehensive review we discuss the role of Hh signaling in breast development and homeostasis and its contribution to tumorigenesis and progression of different subtypes of BC. We also examine the efficacy of agents targeting different components of the Hh pathway both in preclinical models and in clinical trials. The contribution of the Hh pathway in BC tumorigenesis and progression, its prognostic role, and its value as a therapeutic target vary according to the molecular, clinical, and histopathological characteristics of the BC patients. The evidence presented here highlights the relevance of the Hh signaling in BC, and suggest that this pathway is key for BC progression and metastasis.
Fil: Riobo Del Galdo, Natalia A.. University Of Leeds.; Reino Unido
Fil: Lara Montero, Angela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Wertheimer Hermitte, Eva Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
description Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed by lung cancer. Given the importance of BC in public health, it is essential to identify biomarkers to predict prognosis, predetermine drug resistance and provide treatment guidelines that include personalized targeted therapies. The Hedgehog (Hh) signaling pathway plays an essential role in embryonic development, tissue regeneration, and stem cell renewal. Several lines of evidence endorse the important role of canonical and non-canonical Hh signaling in BC. In this comprehensive review we discuss the role of Hh signaling in breast development and homeostasis and its contribution to tumorigenesis and progression of different subtypes of BC. We also examine the efficacy of agents targeting different components of the Hh pathway both in preclinical models and in clinical trials. The contribution of the Hh pathway in BC tumorigenesis and progression, its prognostic role, and its value as a therapeutic target vary according to the molecular, clinical, and histopathological characteristics of the BC patients. The evidence presented here highlights the relevance of the Hh signaling in BC, and suggest that this pathway is key for BC progression and metastasis.
publishDate 2019
dc.date.none.fl_str_mv 2019-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120004
Riobo Del Galdo, Natalia A.; Lara Montero, Angela; Wertheimer Hermitte, Eva Victoria; Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics; MDPI; Cells; 8; 4; 4-2019
2073-4409
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120004
identifier_str_mv Riobo Del Galdo, Natalia A.; Lara Montero, Angela; Wertheimer Hermitte, Eva Victoria; Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics; MDPI; Cells; 8; 4; 4-2019
2073-4409
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4409/8/4/375
info:eu-repo/semantics/altIdentifier/doi/10.3390/cells8040375
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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