Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome

Autores
Pierella Karlusich, Juan José; Ceccoli, Romina Denis; Graña, Martín; Romero, Héctor; Carrillo, Nestor Jose
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Oxidative stress and iron limitation represent the grim side of life in an oxygen-rich atmosphere. The versatile electron transfer shuttle ferredoxin,aniron-sulfurprotein,isparticularlysensitivetothesehardships,anditsdownregulationunderadverseconditionsseverely compromises survival of phototrophs. Replacement of ferredoxin by a stress-resistant isofunctional carrier, flavin-containing flavodoxin, is a widespread strategy employed by photosynthetic microorganisms to overcome environmental adversities. The flavodoxin gene was lostin the course ofplantevolution, but its reintroduction in transgenicplants confers increased tolerance to environmental stress and iron starvation, raising the question as to whya genetic asset with obvious adaptive value was not kept by natural selection. Phylogenetic analyses reveal that the evolutionary history of flavodoxin is intricate, with several horizontal gene transfer events between distant organisms, including Eukarya, Bacteria, and Archaea. The flavodoxin gene is unevenly distributed in most algal lineages, with flavodoxin-containing species being overrepresented in iron-limited regions and scarce or absent in iron-rich environments. Evaluation of cyanobacterial genomic and metagenomic data yielded essentially the same results, indicating that there was little selection pressure to retain flavodoxin in iron-rich coastal/freshwater phototrophs. Our results show a highly dynamic evolution pattern of flavodoxin tightly connected to the bioavailability of iron. Evidence presented here also indicates that the high concentration of iron in coastal and freshwater habitats may have facilitated the loss of flavodoxin in the freshwater ancestor of modern plants during the transition of photosynthetic organisms from the open oceans to the firm land.
Fil: Pierella Karlusich, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Ceccoli, Romina Denis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Graña, Martín. Instituto Pasteur de Montevideo; Uruguay
Fil: Romero, Héctor. Universidad de la Republica; Uruguay
Fil: Carrillo, Nestor Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Materia
Flavodoxin
Ferredoxin
Iron
Photosynthesis
Algae
Cyanobacteria
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13452
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/13452
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genomePierella Karlusich, Juan JoséCeccoli, Romina DenisGraña, MartínRomero, HéctorCarrillo, Nestor JoseFlavodoxinFerredoxinIronPhotosynthesisAlgaeCyanobacteriahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Oxidative stress and iron limitation represent the grim side of life in an oxygen-rich atmosphere. The versatile electron transfer shuttle ferredoxin,aniron-sulfurprotein,isparticularlysensitivetothesehardships,anditsdownregulationunderadverseconditionsseverely compromises survival of phototrophs. Replacement of ferredoxin by a stress-resistant isofunctional carrier, flavin-containing flavodoxin, is a widespread strategy employed by photosynthetic microorganisms to overcome environmental adversities. The flavodoxin gene was lostin the course ofplantevolution, but its reintroduction in transgenicplants confers increased tolerance to environmental stress and iron starvation, raising the question as to whya genetic asset with obvious adaptive value was not kept by natural selection. Phylogenetic analyses reveal that the evolutionary history of flavodoxin is intricate, with several horizontal gene transfer events between distant organisms, including Eukarya, Bacteria, and Archaea. The flavodoxin gene is unevenly distributed in most algal lineages, with flavodoxin-containing species being overrepresented in iron-limited regions and scarce or absent in iron-rich environments. Evaluation of cyanobacterial genomic and metagenomic data yielded essentially the same results, indicating that there was little selection pressure to retain flavodoxin in iron-rich coastal/freshwater phototrophs. Our results show a highly dynamic evolution pattern of flavodoxin tightly connected to the bioavailability of iron. Evidence presented here also indicates that the high concentration of iron in coastal and freshwater habitats may have facilitated the loss of flavodoxin in the freshwater ancestor of modern plants during the transition of photosynthetic organisms from the open oceans to the firm land.Fil: Pierella Karlusich, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Ceccoli, Romina Denis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Graña, Martín. Instituto Pasteur de Montevideo; UruguayFil: Romero, Héctor. Universidad de la Republica; UruguayFil: Carrillo, Nestor Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaOxford University Press2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13452Pierella Karlusich, Juan José; Ceccoli, Romina Denis; Graña, Martín; Romero, Héctor; Carrillo, Nestor Jose; Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome; Oxford University Press; Genome Biology and Evolution; 7; 3; 3-2015; 750–7671759-6653enginfo:eu-repo/semantics/altIdentifier/doi/10.1093/gbe/evv031info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/gbe/article-lookup/doi/10.1093/gbe/evv031info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:49Zoai:ri.conicet.gov.ar:11336/13452instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:49.734CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome
title Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome
spellingShingle Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome
Pierella Karlusich, Juan José
Flavodoxin
Ferredoxin
Iron
Photosynthesis
Algae
Cyanobacteria
title_short Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome
title_full Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome
title_fullStr Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome
title_full_unstemmed Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome
title_sort Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome
dc.creator.none.fl_str_mv Pierella Karlusich, Juan José
Ceccoli, Romina Denis
Graña, Martín
Romero, Héctor
Carrillo, Nestor Jose
author Pierella Karlusich, Juan José
author_facet Pierella Karlusich, Juan José
Ceccoli, Romina Denis
Graña, Martín
Romero, Héctor
Carrillo, Nestor Jose
author_role author
author2 Ceccoli, Romina Denis
Graña, Martín
Romero, Héctor
Carrillo, Nestor Jose
author2_role author
author
author
author
dc.subject.none.fl_str_mv Flavodoxin
Ferredoxin
Iron
Photosynthesis
Algae
Cyanobacteria
topic Flavodoxin
Ferredoxin
Iron
Photosynthesis
Algae
Cyanobacteria
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Oxidative stress and iron limitation represent the grim side of life in an oxygen-rich atmosphere. The versatile electron transfer shuttle ferredoxin,aniron-sulfurprotein,isparticularlysensitivetothesehardships,anditsdownregulationunderadverseconditionsseverely compromises survival of phototrophs. Replacement of ferredoxin by a stress-resistant isofunctional carrier, flavin-containing flavodoxin, is a widespread strategy employed by photosynthetic microorganisms to overcome environmental adversities. The flavodoxin gene was lostin the course ofplantevolution, but its reintroduction in transgenicplants confers increased tolerance to environmental stress and iron starvation, raising the question as to whya genetic asset with obvious adaptive value was not kept by natural selection. Phylogenetic analyses reveal that the evolutionary history of flavodoxin is intricate, with several horizontal gene transfer events between distant organisms, including Eukarya, Bacteria, and Archaea. The flavodoxin gene is unevenly distributed in most algal lineages, with flavodoxin-containing species being overrepresented in iron-limited regions and scarce or absent in iron-rich environments. Evaluation of cyanobacterial genomic and metagenomic data yielded essentially the same results, indicating that there was little selection pressure to retain flavodoxin in iron-rich coastal/freshwater phototrophs. Our results show a highly dynamic evolution pattern of flavodoxin tightly connected to the bioavailability of iron. Evidence presented here also indicates that the high concentration of iron in coastal and freshwater habitats may have facilitated the loss of flavodoxin in the freshwater ancestor of modern plants during the transition of photosynthetic organisms from the open oceans to the firm land.
Fil: Pierella Karlusich, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
Fil: Ceccoli, Romina Denis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Graña, Martín. Instituto Pasteur de Montevideo; Uruguay
Fil: Romero, Héctor. Universidad de la Republica; Uruguay
Fil: Carrillo, Nestor Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
description Oxidative stress and iron limitation represent the grim side of life in an oxygen-rich atmosphere. The versatile electron transfer shuttle ferredoxin,aniron-sulfurprotein,isparticularlysensitivetothesehardships,anditsdownregulationunderadverseconditionsseverely compromises survival of phototrophs. Replacement of ferredoxin by a stress-resistant isofunctional carrier, flavin-containing flavodoxin, is a widespread strategy employed by photosynthetic microorganisms to overcome environmental adversities. The flavodoxin gene was lostin the course ofplantevolution, but its reintroduction in transgenicplants confers increased tolerance to environmental stress and iron starvation, raising the question as to whya genetic asset with obvious adaptive value was not kept by natural selection. Phylogenetic analyses reveal that the evolutionary history of flavodoxin is intricate, with several horizontal gene transfer events between distant organisms, including Eukarya, Bacteria, and Archaea. The flavodoxin gene is unevenly distributed in most algal lineages, with flavodoxin-containing species being overrepresented in iron-limited regions and scarce or absent in iron-rich environments. Evaluation of cyanobacterial genomic and metagenomic data yielded essentially the same results, indicating that there was little selection pressure to retain flavodoxin in iron-rich coastal/freshwater phototrophs. Our results show a highly dynamic evolution pattern of flavodoxin tightly connected to the bioavailability of iron. Evidence presented here also indicates that the high concentration of iron in coastal and freshwater habitats may have facilitated the loss of flavodoxin in the freshwater ancestor of modern plants during the transition of photosynthetic organisms from the open oceans to the firm land.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13452
Pierella Karlusich, Juan José; Ceccoli, Romina Denis; Graña, Martín; Romero, Héctor; Carrillo, Nestor Jose; Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome; Oxford University Press; Genome Biology and Evolution; 7; 3; 3-2015; 750–767
1759-6653
url http://hdl.handle.net/11336/13452
identifier_str_mv Pierella Karlusich, Juan José; Ceccoli, Romina Denis; Graña, Martín; Romero, Héctor; Carrillo, Nestor Jose; Environmental selection pressures related to iron utilization are involved in the loss of the Flavodoxin Gene from the plant genome; Oxford University Press; Genome Biology and Evolution; 7; 3; 3-2015; 750–767
1759-6653
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/gbe/evv031
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/gbe/article-lookup/doi/10.1093/gbe/evv031
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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