Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children

Autores
De Palma, Giada; Nadal, Inmaculada; Medina, Marcela Susana; Donat, Ester; Ribes Koninckx, Carmen; Calabuig, Miguel; Sanz, Yolanda
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background. Coeliac disease is a chronic intestinal inflammatory disorder due to an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition of faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls. Results. IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. Bifidobacterium, Clostridium histolyticum, C. lituseburense and Faecalibacterium prausnitzii group proportions were less abundant (P < 0.050) in untreated CD patients than in healthy controls. Bacteroides-Prevotella group proportions were more abundant (P < 0.050) in untreated CD patients than in controls. Levels of IgA coating the Bacteroides-Prevotella group were significantly reduced (P < 0.050) in both CD patients in comparison with healthy controls. Conclusions. In CD patients, reduced IgA-coated bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.
Fil: De Palma, Giada. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
Fil: Nadal, Inmaculada. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
Fil: Medina, Marcela Susana. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Donat, Ester. Hospital Universitario La Fe de Valencia; España
Fil: Ribes Koninckx, Carmen. Hospital Universitario La Fe de Valencia; España
Fil: Calabuig, Miguel. Hospital General Universitario de Valencia; España
Fil: Sanz, Yolanda. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
Materia
CELIAC DISEASE
PROBIOTIC
IMMUNOGLOBULIN-COATED BACTERIA
BIFIDOBACTERIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/58811
Acceder
id CONICETDig_14c466cba4537606bab3fdde295014ca
oai_identifier_str oai:ri.conicet.gov.ar:11336/58811
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in childrenDe Palma, GiadaNadal, InmaculadaMedina, Marcela SusanaDonat, EsterRibes Koninckx, CarmenCalabuig, MiguelSanz, YolandaCELIAC DISEASEPROBIOTICIMMUNOGLOBULIN-COATED BACTERIABIFIDOBACTERIAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background. Coeliac disease is a chronic intestinal inflammatory disorder due to an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition of faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls. Results. IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. Bifidobacterium, Clostridium histolyticum, C. lituseburense and Faecalibacterium prausnitzii group proportions were less abundant (P < 0.050) in untreated CD patients than in healthy controls. Bacteroides-Prevotella group proportions were more abundant (P < 0.050) in untreated CD patients than in controls. Levels of IgA coating the Bacteroides-Prevotella group were significantly reduced (P < 0.050) in both CD patients in comparison with healthy controls. Conclusions. In CD patients, reduced IgA-coated bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.Fil: De Palma, Giada. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; EspañaFil: Nadal, Inmaculada. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; EspañaFil: Medina, Marcela Susana. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Donat, Ester. Hospital Universitario La Fe de Valencia; EspañaFil: Ribes Koninckx, Carmen. Hospital Universitario La Fe de Valencia; EspañaFil: Calabuig, Miguel. Hospital General Universitario de Valencia; EspañaFil: Sanz, Yolanda. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; EspañaBioMed Central2010-02-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/58811De Palma, Giada; Nadal, Inmaculada; Medina, Marcela Susana; Donat, Ester; Ribes Koninckx, Carmen; et al.; Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children; BioMed Central; BMC Microbiology; 10; 63; 24-2-2010; 1-71471-21801471-2180CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2180-10-63info:eu-repo/semantics/altIdentifier/url/https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-10-63info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:28:25Zoai:ri.conicet.gov.ar:11336/58811instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:28:25.55CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
title Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
spellingShingle Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
De Palma, Giada
CELIAC DISEASE
PROBIOTIC
IMMUNOGLOBULIN-COATED BACTERIA
BIFIDOBACTERIA
title_short Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
title_full Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
title_fullStr Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
title_full_unstemmed Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
title_sort Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children
dc.creator.none.fl_str_mv De Palma, Giada
Nadal, Inmaculada
Medina, Marcela Susana
Donat, Ester
Ribes Koninckx, Carmen
Calabuig, Miguel
Sanz, Yolanda
author De Palma, Giada
author_facet De Palma, Giada
Nadal, Inmaculada
Medina, Marcela Susana
Donat, Ester
Ribes Koninckx, Carmen
Calabuig, Miguel
Sanz, Yolanda
author_role author
author2 Nadal, Inmaculada
Medina, Marcela Susana
Donat, Ester
Ribes Koninckx, Carmen
Calabuig, Miguel
Sanz, Yolanda
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CELIAC DISEASE
PROBIOTIC
IMMUNOGLOBULIN-COATED BACTERIA
BIFIDOBACTERIA
topic CELIAC DISEASE
PROBIOTIC
IMMUNOGLOBULIN-COATED BACTERIA
BIFIDOBACTERIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background. Coeliac disease is a chronic intestinal inflammatory disorder due to an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition of faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls. Results. IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. Bifidobacterium, Clostridium histolyticum, C. lituseburense and Faecalibacterium prausnitzii group proportions were less abundant (P < 0.050) in untreated CD patients than in healthy controls. Bacteroides-Prevotella group proportions were more abundant (P < 0.050) in untreated CD patients than in controls. Levels of IgA coating the Bacteroides-Prevotella group were significantly reduced (P < 0.050) in both CD patients in comparison with healthy controls. Conclusions. In CD patients, reduced IgA-coated bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.
Fil: De Palma, Giada. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
Fil: Nadal, Inmaculada. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
Fil: Medina, Marcela Susana. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Donat, Ester. Hospital Universitario La Fe de Valencia; España
Fil: Ribes Koninckx, Carmen. Hospital Universitario La Fe de Valencia; España
Fil: Calabuig, Miguel. Hospital General Universitario de Valencia; España
Fil: Sanz, Yolanda. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España
description Background. Coeliac disease is a chronic intestinal inflammatory disorder due to an aberrant immune response to dietary gluten proteins in genetically predisposed individuals. Mucosal immune response through IgA secretion constitutes a first line of defence responsible for neutralizing noxious antigens and pathogens. The aim of this study was the characterization of the relationships between immunoglobulin-coated bacteria and bacterial composition of faeces of coeliac disease (CD) patients, untreated and treated with a gluten-free diet (GFD) and healthy controls. Results. IgA-coated faecal bacterial levels were significantly lower in both untreated and treated CD patients than in healthy controls. IgG and IgM-coated bacterial levels were also significantly lower in treated CD patients than in untreated CD patients and controls. Gram-positive to Gram-negative bacteria ratio was significantly reduced in both CD patients compared to controls. Bifidobacterium, Clostridium histolyticum, C. lituseburense and Faecalibacterium prausnitzii group proportions were less abundant (P < 0.050) in untreated CD patients than in healthy controls. Bacteroides-Prevotella group proportions were more abundant (P < 0.050) in untreated CD patients than in controls. Levels of IgA coating the Bacteroides-Prevotella group were significantly reduced (P < 0.050) in both CD patients in comparison with healthy controls. Conclusions. In CD patients, reduced IgA-coated bacteria is associated with intestinal dysbiosis, which altogether provide new insights into the possible relationships between the gut microbiota and the host defences in this disorder.
publishDate 2010
dc.date.none.fl_str_mv 2010-02-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/58811
De Palma, Giada; Nadal, Inmaculada; Medina, Marcela Susana; Donat, Ester; Ribes Koninckx, Carmen; et al.; Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children; BioMed Central; BMC Microbiology; 10; 63; 24-2-2010; 1-7
1471-2180
1471-2180
CONICET Digital
CONICET
url http://hdl.handle.net/11336/58811
identifier_str_mv De Palma, Giada; Nadal, Inmaculada; Medina, Marcela Susana; Donat, Ester; Ribes Koninckx, Carmen; et al.; Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children; BioMed Central; BMC Microbiology; 10; 63; 24-2-2010; 1-7
1471-2180
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2180-10-63
info:eu-repo/semantics/altIdentifier/url/https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-10-63
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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