Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy

Autores
Preciado, María Victoria; Valva, Pamela; Escobar Gutierrez, Alejandro; Rahal, Paula; Ruiz Tovar, Karina; Yamasaki, Lilian; Vazquez Chacon, Carlos; Martinez Guarneros, Armando; Carpio Pedroza, Juan Carlos; Fonseca Coronado, Salvador; Cruz Rivera, Mayra
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hepatitis C virus (HCV) infection represents an important public health problem worldwide. Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors. Virus molecular evolution plays an important role in HCV transmission, disease progression and therapy outcome. The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures (e.g., host immune responses and antiviral therapy). HCV molecular evolution is shaped by different mechanisms including a high mutation rate, genetic bottlenecks, genetic drift, recombination, temporal variations and compartmentalization. These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner. Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV. As a result, superior sustained viral responses have been attained. The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer, more potent antivirals, bringing us one step closer to the interferon-free era.
Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Valva, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños ; Argentina
Fil: Escobar Gutierrez, Alejandro. Instituto de Diagnóstico y Referencia Epidemiológicos; México
Fil: Rahal, Paula. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Ruiz Tovar, Karina. Instituto de Diagnóstico y Referencia Epidemiológicos; México
Fil: Yamasaki, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Vazquez Chacon, Carlos. Instituto de Diagnóstico y Referencia Epidemiológicos; México
Fil: Martinez Guarneros, Armando. Instituto de Diagnóstico y Referencia Epidemiológicos; México
Fil: Carpio Pedroza, Juan Carlos. Instituto de Diagnóstico y Referencia Epidemiológicos; México
Fil: Fonseca Coronado, Salvador. Universidad Nacional Autónoma de México; México
Fil: Cruz Rivera, Mayra. Universidad Nacional Autónoma de México; México
Materia
Hepatitis C Virus
Direct-Acting Antiviral Agents
Disease Progression
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/37331
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/37331
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapyPreciado, María VictoriaValva, PamelaEscobar Gutierrez, AlejandroRahal, PaulaRuiz Tovar, KarinaYamasaki, LilianVazquez Chacon, CarlosMartinez Guarneros, ArmandoCarpio Pedroza, Juan CarlosFonseca Coronado, SalvadorCruz Rivera, MayraHepatitis C VirusDirect-Acting Antiviral AgentsDisease Progressionhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Hepatitis C virus (HCV) infection represents an important public health problem worldwide. Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors. Virus molecular evolution plays an important role in HCV transmission, disease progression and therapy outcome. The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures (e.g., host immune responses and antiviral therapy). HCV molecular evolution is shaped by different mechanisms including a high mutation rate, genetic bottlenecks, genetic drift, recombination, temporal variations and compartmentalization. These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner. Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV. As a result, superior sustained viral responses have been attained. The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer, more potent antivirals, bringing us one step closer to the interferon-free era.Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Valva, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños ; ArgentinaFil: Escobar Gutierrez, Alejandro. Instituto de Diagnóstico y Referencia Epidemiológicos; MéxicoFil: Rahal, Paula. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Ruiz Tovar, Karina. Instituto de Diagnóstico y Referencia Epidemiológicos; MéxicoFil: Yamasaki, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Vazquez Chacon, Carlos. Instituto de Diagnóstico y Referencia Epidemiológicos; MéxicoFil: Martinez Guarneros, Armando. Instituto de Diagnóstico y Referencia Epidemiológicos; MéxicoFil: Carpio Pedroza, Juan Carlos. Instituto de Diagnóstico y Referencia Epidemiológicos; MéxicoFil: Fonseca Coronado, Salvador. Universidad Nacional Autónoma de México; MéxicoFil: Cruz Rivera, Mayra. Universidad Nacional Autónoma de México; MéxicoBaishideng Publishing Group2014-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37331Preciado, María Victoria; Valva, Pamela; Escobar Gutierrez, Alejandro; Rahal, Paula; Ruiz Tovar, Karina; et al.; Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy; Baishideng Publishing Group; World Journal of Gastroenterology; 20; 43; 11-2014; 15992-160131007-93272219-2840CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v20.i43.15992info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v20/i43/15992.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:19Zoai:ri.conicet.gov.ar:11336/37331instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:20.121CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy
title Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy
spellingShingle Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy
Preciado, María Victoria
Hepatitis C Virus
Direct-Acting Antiviral Agents
Disease Progression
title_short Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy
title_full Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy
title_fullStr Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy
title_full_unstemmed Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy
title_sort Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy
dc.creator.none.fl_str_mv Preciado, María Victoria
Valva, Pamela
Escobar Gutierrez, Alejandro
Rahal, Paula
Ruiz Tovar, Karina
Yamasaki, Lilian
Vazquez Chacon, Carlos
Martinez Guarneros, Armando
Carpio Pedroza, Juan Carlos
Fonseca Coronado, Salvador
Cruz Rivera, Mayra
author Preciado, María Victoria
author_facet Preciado, María Victoria
Valva, Pamela
Escobar Gutierrez, Alejandro
Rahal, Paula
Ruiz Tovar, Karina
Yamasaki, Lilian
Vazquez Chacon, Carlos
Martinez Guarneros, Armando
Carpio Pedroza, Juan Carlos
Fonseca Coronado, Salvador
Cruz Rivera, Mayra
author_role author
author2 Valva, Pamela
Escobar Gutierrez, Alejandro
Rahal, Paula
Ruiz Tovar, Karina
Yamasaki, Lilian
Vazquez Chacon, Carlos
Martinez Guarneros, Armando
Carpio Pedroza, Juan Carlos
Fonseca Coronado, Salvador
Cruz Rivera, Mayra
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hepatitis C Virus
Direct-Acting Antiviral Agents
Disease Progression
topic Hepatitis C Virus
Direct-Acting Antiviral Agents
Disease Progression
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hepatitis C virus (HCV) infection represents an important public health problem worldwide. Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors. Virus molecular evolution plays an important role in HCV transmission, disease progression and therapy outcome. The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures (e.g., host immune responses and antiviral therapy). HCV molecular evolution is shaped by different mechanisms including a high mutation rate, genetic bottlenecks, genetic drift, recombination, temporal variations and compartmentalization. These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner. Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV. As a result, superior sustained viral responses have been attained. The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer, more potent antivirals, bringing us one step closer to the interferon-free era.
Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Valva, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños ; Argentina
Fil: Escobar Gutierrez, Alejandro. Instituto de Diagnóstico y Referencia Epidemiológicos; México
Fil: Rahal, Paula. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Ruiz Tovar, Karina. Instituto de Diagnóstico y Referencia Epidemiológicos; México
Fil: Yamasaki, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Vazquez Chacon, Carlos. Instituto de Diagnóstico y Referencia Epidemiológicos; México
Fil: Martinez Guarneros, Armando. Instituto de Diagnóstico y Referencia Epidemiológicos; México
Fil: Carpio Pedroza, Juan Carlos. Instituto de Diagnóstico y Referencia Epidemiológicos; México
Fil: Fonseca Coronado, Salvador. Universidad Nacional Autónoma de México; México
Fil: Cruz Rivera, Mayra. Universidad Nacional Autónoma de México; México
description Hepatitis C virus (HCV) infection represents an important public health problem worldwide. Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors. Virus molecular evolution plays an important role in HCV transmission, disease progression and therapy outcome. The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures (e.g., host immune responses and antiviral therapy). HCV molecular evolution is shaped by different mechanisms including a high mutation rate, genetic bottlenecks, genetic drift, recombination, temporal variations and compartmentalization. These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner. Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV. As a result, superior sustained viral responses have been attained. The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer, more potent antivirals, bringing us one step closer to the interferon-free era.
publishDate 2014
dc.date.none.fl_str_mv 2014-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/37331
Preciado, María Victoria; Valva, Pamela; Escobar Gutierrez, Alejandro; Rahal, Paula; Ruiz Tovar, Karina; et al.; Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy; Baishideng Publishing Group; World Journal of Gastroenterology; 20; 43; 11-2014; 15992-16013
1007-9327
2219-2840
CONICET Digital
CONICET
url http://hdl.handle.net/11336/37331
identifier_str_mv Preciado, María Victoria; Valva, Pamela; Escobar Gutierrez, Alejandro; Rahal, Paula; Ruiz Tovar, Karina; et al.; Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy; Baishideng Publishing Group; World Journal of Gastroenterology; 20; 43; 11-2014; 15992-16013
1007-9327
2219-2840
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v20.i43.15992
info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v20/i43/15992.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268967880622080
score 13.13397

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