Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications

Autores
Palomo, Addys González; Santana, Rancés Blanco; Pérez, Xiomara Escobar; Santana, Damián Blanco; Gabri, Mariano Rolando; Monzon, Kalet León; Pérez, Adriana Carr
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Interaction between epidermal growth factor receptor (EGFR) signaling with GM3 ganglioside expression has been previously described. However, little is known about EGFR and NeuGcGM3 co-expression in cancer patients and their therapeutic implications. In this paper, we evaluate the co-expression of EGFR and NeuGcGM3 ganglioside in tumors from 92 patients and in two spontaneous lung metastasis models of mice (Lewis lung carcinoma (3LL-D122) in C57BL/6 and mammary carcinoma (4T1) in BALB/c). As results, co-expression of EGFR and NeuGcGM3 ganglioside was frequently observed in 63 of 92 patients (68 %), independently of histological subtype. Moreover, EGFR is co-expressed with NeuGcGM3 ganglioside in the metastasis of 3LL-D122 and 4T1 murine models. Such dual expression appears to be therapeutically relevant, since combined therapy with mAbs against these two molecules synergistically increase the survival of mice treated. Overall, our results suggest that NeuGcGM3 and EGFR may coordinately contribute to the tumor cell biology and that therapeutic combinations against these two targets might be a valid strategy to explore.
Fil: Palomo, Addys González. Centro de Inmunología Molecular; Cuba
Fil: Santana, Rancés Blanco. Centro de Inmunología Molecular; Cuba
Fil: Pérez, Xiomara Escobar. Instituto Nacional de Oncología y Radiobiología; Cuba
Fil: Santana, Damián Blanco. Instituto Nacional de Oncología y Radiobiología; Cuba
Fil: Gabri, Mariano Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Monzon, Kalet León. Centro de Inmunología Molecular; Cuba
Fil: Pérez, Adriana Carr. Centro de Inmunología Molecular; Cuba
Materia
Co-expression
Combination therapy
EGFR
NeuGcGM3
Pulmonary metastasis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/90950
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implicationsPalomo, Addys GonzálezSantana, Rancés BlancoPérez, Xiomara EscobarSantana, Damián BlancoGabri, Mariano RolandoMonzon, Kalet LeónPérez, Adriana CarrCo-expressionCombination therapyEGFRNeuGcGM3Pulmonary metastasishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Interaction between epidermal growth factor receptor (EGFR) signaling with GM3 ganglioside expression has been previously described. However, little is known about EGFR and NeuGcGM3 co-expression in cancer patients and their therapeutic implications. In this paper, we evaluate the co-expression of EGFR and NeuGcGM3 ganglioside in tumors from 92 patients and in two spontaneous lung metastasis models of mice (Lewis lung carcinoma (3LL-D122) in C57BL/6 and mammary carcinoma (4T1) in BALB/c). As results, co-expression of EGFR and NeuGcGM3 ganglioside was frequently observed in 63 of 92 patients (68 %), independently of histological subtype. Moreover, EGFR is co-expressed with NeuGcGM3 ganglioside in the metastasis of 3LL-D122 and 4T1 murine models. Such dual expression appears to be therapeutically relevant, since combined therapy with mAbs against these two molecules synergistically increase the survival of mice treated. Overall, our results suggest that NeuGcGM3 and EGFR may coordinately contribute to the tumor cell biology and that therapeutic combinations against these two targets might be a valid strategy to explore.Fil: Palomo, Addys González. Centro de Inmunología Molecular; CubaFil: Santana, Rancés Blanco. Centro de Inmunología Molecular; CubaFil: Pérez, Xiomara Escobar. Instituto Nacional de Oncología y Radiobiología; CubaFil: Santana, Damián Blanco. Instituto Nacional de Oncología y Radiobiología; CubaFil: Gabri, Mariano Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; ArgentinaFil: Monzon, Kalet León. Centro de Inmunología Molecular; CubaFil: Pérez, Adriana Carr. Centro de Inmunología Molecular; CubaSpringer2016-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/90950Palomo, Addys González; Santana, Rancés Blanco; Pérez, Xiomara Escobar; Santana, Damián Blanco; Gabri, Mariano Rolando; et al.; Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications; Springer; Clinical & Experimental Metastasis; 33; 7; 10-2016; 717-7250262-0898CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10585-016-9811-0info:eu-repo/semantics/altIdentifier/doi/10.1007/s10585-016-9811-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:54Zoai:ri.conicet.gov.ar:11336/90950instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:54.541CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications
title Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications
spellingShingle Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications
Palomo, Addys González
Co-expression
Combination therapy
EGFR
NeuGcGM3
Pulmonary metastasis
title_short Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications
title_full Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications
title_fullStr Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications
title_full_unstemmed Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications
title_sort Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications
dc.creator.none.fl_str_mv Palomo, Addys González
Santana, Rancés Blanco
Pérez, Xiomara Escobar
Santana, Damián Blanco
Gabri, Mariano Rolando
Monzon, Kalet León
Pérez, Adriana Carr
author Palomo, Addys González
author_facet Palomo, Addys González
Santana, Rancés Blanco
Pérez, Xiomara Escobar
Santana, Damián Blanco
Gabri, Mariano Rolando
Monzon, Kalet León
Pérez, Adriana Carr
author_role author
author2 Santana, Rancés Blanco
Pérez, Xiomara Escobar
Santana, Damián Blanco
Gabri, Mariano Rolando
Monzon, Kalet León
Pérez, Adriana Carr
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Co-expression
Combination therapy
EGFR
NeuGcGM3
Pulmonary metastasis
topic Co-expression
Combination therapy
EGFR
NeuGcGM3
Pulmonary metastasis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Interaction between epidermal growth factor receptor (EGFR) signaling with GM3 ganglioside expression has been previously described. However, little is known about EGFR and NeuGcGM3 co-expression in cancer patients and their therapeutic implications. In this paper, we evaluate the co-expression of EGFR and NeuGcGM3 ganglioside in tumors from 92 patients and in two spontaneous lung metastasis models of mice (Lewis lung carcinoma (3LL-D122) in C57BL/6 and mammary carcinoma (4T1) in BALB/c). As results, co-expression of EGFR and NeuGcGM3 ganglioside was frequently observed in 63 of 92 patients (68 %), independently of histological subtype. Moreover, EGFR is co-expressed with NeuGcGM3 ganglioside in the metastasis of 3LL-D122 and 4T1 murine models. Such dual expression appears to be therapeutically relevant, since combined therapy with mAbs against these two molecules synergistically increase the survival of mice treated. Overall, our results suggest that NeuGcGM3 and EGFR may coordinately contribute to the tumor cell biology and that therapeutic combinations against these two targets might be a valid strategy to explore.
Fil: Palomo, Addys González. Centro de Inmunología Molecular; Cuba
Fil: Santana, Rancés Blanco. Centro de Inmunología Molecular; Cuba
Fil: Pérez, Xiomara Escobar. Instituto Nacional de Oncología y Radiobiología; Cuba
Fil: Santana, Damián Blanco. Instituto Nacional de Oncología y Radiobiología; Cuba
Fil: Gabri, Mariano Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Monzon, Kalet León. Centro de Inmunología Molecular; Cuba
Fil: Pérez, Adriana Carr. Centro de Inmunología Molecular; Cuba
description Interaction between epidermal growth factor receptor (EGFR) signaling with GM3 ganglioside expression has been previously described. However, little is known about EGFR and NeuGcGM3 co-expression in cancer patients and their therapeutic implications. In this paper, we evaluate the co-expression of EGFR and NeuGcGM3 ganglioside in tumors from 92 patients and in two spontaneous lung metastasis models of mice (Lewis lung carcinoma (3LL-D122) in C57BL/6 and mammary carcinoma (4T1) in BALB/c). As results, co-expression of EGFR and NeuGcGM3 ganglioside was frequently observed in 63 of 92 patients (68 %), independently of histological subtype. Moreover, EGFR is co-expressed with NeuGcGM3 ganglioside in the metastasis of 3LL-D122 and 4T1 murine models. Such dual expression appears to be therapeutically relevant, since combined therapy with mAbs against these two molecules synergistically increase the survival of mice treated. Overall, our results suggest that NeuGcGM3 and EGFR may coordinately contribute to the tumor cell biology and that therapeutic combinations against these two targets might be a valid strategy to explore.
publishDate 2016
dc.date.none.fl_str_mv 2016-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/90950
Palomo, Addys González; Santana, Rancés Blanco; Pérez, Xiomara Escobar; Santana, Damián Blanco; Gabri, Mariano Rolando; et al.; Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications; Springer; Clinical & Experimental Metastasis; 33; 7; 10-2016; 717-725
0262-0898
CONICET Digital
CONICET
url http://hdl.handle.net/11336/90950
identifier_str_mv Palomo, Addys González; Santana, Rancés Blanco; Pérez, Xiomara Escobar; Santana, Damián Blanco; Gabri, Mariano Rolando; et al.; Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications; Springer; Clinical & Experimental Metastasis; 33; 7; 10-2016; 717-725
0262-0898
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10585-016-9811-0
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10585-016-9811-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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