Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1
- Autores
- Croci Russo, Diego Omar; Morande, Pablo Elías; Dergan Dylon, Leonardo Sebastian; Borge, Mercedes; Toscano, Marta Alicia; Stupirski, Juan Carlos; Bezares, R. F.; Avalos, J. S.; Narbaitz, M.; Gamberale, Romina; Rabinovich, Gabriel Adrián; Giordano, Mirta Nilda
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Accumulation of neoplastic cells in chronic lymphocytic leukemia (CLL) is conditioned by a variety of signals delivered by accompanying cells in lymphoid tissues. Here we examined the relevance of galectin-1 (Gal-1), a glycan-binding protein with immunoregulatory activity, within the CLL microenvironment. We found that monocytes in peripheral blood and stromal and myeloid cells in bone marrow biopsies are the main source of Gal1. Knocking down Gal1 in adherent nurse-like cells differentiated in vitro decreased the expression of activation markers (CD80, CD86, CD25) and mRNA levels of IL10 and CCL3 in CLL cells. The concentration of Gal1 in plasma was increased in CLL patients compared to healthy subjects. Likewise, we found a higher expression of Gal1 in bone marrow biopsies from patients with progressive disease. These results provide the first evidence of a role for Gal-1 in CLL cell differentiation and its expression in accompanying myeloid cells.
Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina
Fil: Dergan Dylon, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina
Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Stupirski, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Bezares, R. F.. Hospital General de Agudos "Dr T. Alvarez"; Argentina
Fil: Avalos, J. S.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Narbaitz, M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina
Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina - Materia
-
Galectin 1
Nurse-Like
Leukemia
B Cells - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/12438
Ver los metadatos del registro completo
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Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1Croci Russo, Diego OmarMorande, Pablo ElíasDergan Dylon, Leonardo SebastianBorge, MercedesToscano, Marta AliciaStupirski, Juan CarlosBezares, R. F.Avalos, J. S.Narbaitz, M.Gamberale, RominaRabinovich, Gabriel AdriánGiordano, Mirta NildaGalectin 1Nurse-LikeLeukemiaB Cellshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Accumulation of neoplastic cells in chronic lymphocytic leukemia (CLL) is conditioned by a variety of signals delivered by accompanying cells in lymphoid tissues. Here we examined the relevance of galectin-1 (Gal-1), a glycan-binding protein with immunoregulatory activity, within the CLL microenvironment. We found that monocytes in peripheral blood and stromal and myeloid cells in bone marrow biopsies are the main source of Gal1. Knocking down Gal1 in adherent nurse-like cells differentiated in vitro decreased the expression of activation markers (CD80, CD86, CD25) and mRNA levels of IL10 and CCL3 in CLL cells. The concentration of Gal1 in plasma was increased in CLL patients compared to healthy subjects. Likewise, we found a higher expression of Gal1 in bone marrow biopsies from patients with progressive disease. These results provide the first evidence of a role for Gal-1 in CLL cell differentiation and its expression in accompanying myeloid cells.Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; ArgentinaFil: Dergan Dylon, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; ArgentinaFil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Stupirski, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Bezares, R. F.. Hospital General de Agudos "Dr T. Alvarez"; ArgentinaFil: Avalos, J. S.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Narbaitz, M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; ArgentinaFil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; ArgentinaNature Publishing Group2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12438Croci Russo, Diego Omar; Morande, Pablo Elías; Dergan Dylon, Leonardo Sebastian; Borge, Mercedes; Toscano, Marta Alicia; et al.; Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1; Nature Publishing Group; Leukemia; 27; 6; 7-2012; 1413-14160887-6924enginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/leu/journal/v27/n6/full/leu2012315a.htmlinfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1038/leu.2012.315info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:07:47Zoai:ri.conicet.gov.ar:11336/12438instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:07:48.081CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1 |
| title |
Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1 |
| spellingShingle |
Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1 Croci Russo, Diego Omar Galectin 1 Nurse-Like Leukemia B Cells |
| title_short |
Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1 |
| title_full |
Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1 |
| title_fullStr |
Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1 |
| title_full_unstemmed |
Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1 |
| title_sort |
Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1 |
| dc.creator.none.fl_str_mv |
Croci Russo, Diego Omar Morande, Pablo Elías Dergan Dylon, Leonardo Sebastian Borge, Mercedes Toscano, Marta Alicia Stupirski, Juan Carlos Bezares, R. F. Avalos, J. S. Narbaitz, M. Gamberale, Romina Rabinovich, Gabriel Adrián Giordano, Mirta Nilda |
| author |
Croci Russo, Diego Omar |
| author_facet |
Croci Russo, Diego Omar Morande, Pablo Elías Dergan Dylon, Leonardo Sebastian Borge, Mercedes Toscano, Marta Alicia Stupirski, Juan Carlos Bezares, R. F. Avalos, J. S. Narbaitz, M. Gamberale, Romina Rabinovich, Gabriel Adrián Giordano, Mirta Nilda |
| author_role |
author |
| author2 |
Morande, Pablo Elías Dergan Dylon, Leonardo Sebastian Borge, Mercedes Toscano, Marta Alicia Stupirski, Juan Carlos Bezares, R. F. Avalos, J. S. Narbaitz, M. Gamberale, Romina Rabinovich, Gabriel Adrián Giordano, Mirta Nilda |
| author2_role |
author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Galectin 1 Nurse-Like Leukemia B Cells |
| topic |
Galectin 1 Nurse-Like Leukemia B Cells |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Accumulation of neoplastic cells in chronic lymphocytic leukemia (CLL) is conditioned by a variety of signals delivered by accompanying cells in lymphoid tissues. Here we examined the relevance of galectin-1 (Gal-1), a glycan-binding protein with immunoregulatory activity, within the CLL microenvironment. We found that monocytes in peripheral blood and stromal and myeloid cells in bone marrow biopsies are the main source of Gal1. Knocking down Gal1 in adherent nurse-like cells differentiated in vitro decreased the expression of activation markers (CD80, CD86, CD25) and mRNA levels of IL10 and CCL3 in CLL cells. The concentration of Gal1 in plasma was increased in CLL patients compared to healthy subjects. Likewise, we found a higher expression of Gal1 in bone marrow biopsies from patients with progressive disease. These results provide the first evidence of a role for Gal-1 in CLL cell differentiation and its expression in accompanying myeloid cells. Fil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina Fil: Dergan Dylon, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Stupirski, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Bezares, R. F.. Hospital General de Agudos "Dr T. Alvarez"; Argentina Fil: Avalos, J. S.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Narbaitz, M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental; Argentina |
| description |
Accumulation of neoplastic cells in chronic lymphocytic leukemia (CLL) is conditioned by a variety of signals delivered by accompanying cells in lymphoid tissues. Here we examined the relevance of galectin-1 (Gal-1), a glycan-binding protein with immunoregulatory activity, within the CLL microenvironment. We found that monocytes in peripheral blood and stromal and myeloid cells in bone marrow biopsies are the main source of Gal1. Knocking down Gal1 in adherent nurse-like cells differentiated in vitro decreased the expression of activation markers (CD80, CD86, CD25) and mRNA levels of IL10 and CCL3 in CLL cells. The concentration of Gal1 in plasma was increased in CLL patients compared to healthy subjects. Likewise, we found a higher expression of Gal1 in bone marrow biopsies from patients with progressive disease. These results provide the first evidence of a role for Gal-1 in CLL cell differentiation and its expression in accompanying myeloid cells. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-07 |
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publishedVersion |
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http://hdl.handle.net/11336/12438 Croci Russo, Diego Omar; Morande, Pablo Elías; Dergan Dylon, Leonardo Sebastian; Borge, Mercedes; Toscano, Marta Alicia; et al.; Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1; Nature Publishing Group; Leukemia; 27; 6; 7-2012; 1413-1416 0887-6924 |
| url |
http://hdl.handle.net/11336/12438 |
| identifier_str_mv |
Croci Russo, Diego Omar; Morande, Pablo Elías; Dergan Dylon, Leonardo Sebastian; Borge, Mercedes; Toscano, Marta Alicia; et al.; Nurse-like cells control the activity of chronic lymphocytic leukemia b cells via galectin-1; Nature Publishing Group; Leukemia; 27; 6; 7-2012; 1413-1416 0887-6924 |
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eng |
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eng |
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