ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis

Autores
Jurado, Javier Oscar; Pasquinelli, Virginia; Alvarez, Ivana Belén; Martínez, Gustavo Javier; Laufer, Natalia Lorna; Sued, Omar Gustavo; Cahn, Pedro; Musella, Rosa María; Abbate, Eduardo; Salomon, Horacio Eduardo; Quiroga, María Florencia
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Tuberculosis (TB) continues to be the most frequent cause of illness and death from an infectious agent globally, and its interaction with HIV is having devastating effects. To investigate how HIV alters the immune response to Mycobacterium tuberculosis (Mtb), we assessed basal and Mtb-induced proliferation, cytokine production, and expression of signalling lymphocytic activation molecule (SLAM), inducible costimulator (ICOS) and programmed death-1 (PD-1) on T lymphocytes from HIV-positive individuals coinfected with TB, HIV-positive subjects, TB patients and healthy donors (HD).Findings: HIV-TB patients showed increased ICOS, SLAM and PD-1 basal levels on T lymphocytes, whereas HIV-positive individuals displayed elevated levels of SLAM and PD-1, TB patients high levels of SLAM, and HD low levels of the three proteins. Mtb-stimulation enhanced ICOS expression in the four groups, but only TB and HD increased SLAM and PD-1 levels.Conclusions: These data show the immune deregulation that takes place during the immune response against TB in different study populations.
Fil: Jurado, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Alvarez, Ivana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Martínez, Gustavo Javier. University of Texas Health Science Center at Houston; Estados Unidos
Fil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Sued, Omar Gustavo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Cahn, Pedro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Musella, Rosa María. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "Raúl F. Vaccarezza".; Argentina
Fil: Abbate, Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "Raúl F. Vaccarezza".; Argentina
Fil: Salomon, Horacio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Materia
ICOS
SLAM
PD-1
HIV-TB COINFECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/269268
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/269268
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosisJurado, Javier OscarPasquinelli, VirginiaAlvarez, Ivana BelénMartínez, Gustavo JavierLaufer, Natalia LornaSued, Omar GustavoCahn, PedroMusella, Rosa MaríaAbbate, EduardoSalomon, Horacio EduardoQuiroga, María FlorenciaICOSSLAMPD-1HIV-TB COINFECTIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Tuberculosis (TB) continues to be the most frequent cause of illness and death from an infectious agent globally, and its interaction with HIV is having devastating effects. To investigate how HIV alters the immune response to Mycobacterium tuberculosis (Mtb), we assessed basal and Mtb-induced proliferation, cytokine production, and expression of signalling lymphocytic activation molecule (SLAM), inducible costimulator (ICOS) and programmed death-1 (PD-1) on T lymphocytes from HIV-positive individuals coinfected with TB, HIV-positive subjects, TB patients and healthy donors (HD).Findings: HIV-TB patients showed increased ICOS, SLAM and PD-1 basal levels on T lymphocytes, whereas HIV-positive individuals displayed elevated levels of SLAM and PD-1, TB patients high levels of SLAM, and HD low levels of the three proteins. Mtb-stimulation enhanced ICOS expression in the four groups, but only TB and HD increased SLAM and PD-1 levels.Conclusions: These data show the immune deregulation that takes place during the immune response against TB in different study populations.Fil: Jurado, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Alvarez, Ivana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Martínez, Gustavo Javier. University of Texas Health Science Center at Houston; Estados UnidosFil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Sued, Omar Gustavo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Cahn, Pedro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Musella, Rosa María. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "Raúl F. Vaccarezza".; ArgentinaFil: Abbate, Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "Raúl F. Vaccarezza".; ArgentinaFil: Salomon, Horacio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaWiley2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/269268Jurado, Javier Oscar; Pasquinelli, Virginia; Alvarez, Ivana Belén; Martínez, Gustavo Javier; Laufer, Natalia Lorna; et al.; ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis; Wiley; Journal of the International AIDS Society; 15; 2; 6-2012; 1-71758-2652CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.7448/IAS.15.2.17428info:eu-repo/semantics/altIdentifier/doi/10.7448/IAS.15.2.17428info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:21:24Zoai:ri.conicet.gov.ar:11336/269268instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:21:24.444CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis
title ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis
spellingShingle ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis
Jurado, Javier Oscar
ICOS
SLAM
PD-1
HIV-TB COINFECTION
title_short ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis
title_full ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis
title_fullStr ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis
title_full_unstemmed ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis
title_sort ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis
dc.creator.none.fl_str_mv Jurado, Javier Oscar
Pasquinelli, Virginia
Alvarez, Ivana Belén
Martínez, Gustavo Javier
Laufer, Natalia Lorna
Sued, Omar Gustavo
Cahn, Pedro
Musella, Rosa María
Abbate, Eduardo
Salomon, Horacio Eduardo
Quiroga, María Florencia
author Jurado, Javier Oscar
author_facet Jurado, Javier Oscar
Pasquinelli, Virginia
Alvarez, Ivana Belén
Martínez, Gustavo Javier
Laufer, Natalia Lorna
Sued, Omar Gustavo
Cahn, Pedro
Musella, Rosa María
Abbate, Eduardo
Salomon, Horacio Eduardo
Quiroga, María Florencia
author_role author
author2 Pasquinelli, Virginia
Alvarez, Ivana Belén
Martínez, Gustavo Javier
Laufer, Natalia Lorna
Sued, Omar Gustavo
Cahn, Pedro
Musella, Rosa María
Abbate, Eduardo
Salomon, Horacio Eduardo
Quiroga, María Florencia
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ICOS
SLAM
PD-1
HIV-TB COINFECTION
topic ICOS
SLAM
PD-1
HIV-TB COINFECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: Tuberculosis (TB) continues to be the most frequent cause of illness and death from an infectious agent globally, and its interaction with HIV is having devastating effects. To investigate how HIV alters the immune response to Mycobacterium tuberculosis (Mtb), we assessed basal and Mtb-induced proliferation, cytokine production, and expression of signalling lymphocytic activation molecule (SLAM), inducible costimulator (ICOS) and programmed death-1 (PD-1) on T lymphocytes from HIV-positive individuals coinfected with TB, HIV-positive subjects, TB patients and healthy donors (HD).Findings: HIV-TB patients showed increased ICOS, SLAM and PD-1 basal levels on T lymphocytes, whereas HIV-positive individuals displayed elevated levels of SLAM and PD-1, TB patients high levels of SLAM, and HD low levels of the three proteins. Mtb-stimulation enhanced ICOS expression in the four groups, but only TB and HD increased SLAM and PD-1 levels.Conclusions: These data show the immune deregulation that takes place during the immune response against TB in different study populations.
Fil: Jurado, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Alvarez, Ivana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Martínez, Gustavo Javier. University of Texas Health Science Center at Houston; Estados Unidos
Fil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Sued, Omar Gustavo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Cahn, Pedro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Musella, Rosa María. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "Raúl F. Vaccarezza".; Argentina
Fil: Abbate, Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "Raúl F. Vaccarezza".; Argentina
Fil: Salomon, Horacio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
description Background: Tuberculosis (TB) continues to be the most frequent cause of illness and death from an infectious agent globally, and its interaction with HIV is having devastating effects. To investigate how HIV alters the immune response to Mycobacterium tuberculosis (Mtb), we assessed basal and Mtb-induced proliferation, cytokine production, and expression of signalling lymphocytic activation molecule (SLAM), inducible costimulator (ICOS) and programmed death-1 (PD-1) on T lymphocytes from HIV-positive individuals coinfected with TB, HIV-positive subjects, TB patients and healthy donors (HD).Findings: HIV-TB patients showed increased ICOS, SLAM and PD-1 basal levels on T lymphocytes, whereas HIV-positive individuals displayed elevated levels of SLAM and PD-1, TB patients high levels of SLAM, and HD low levels of the three proteins. Mtb-stimulation enhanced ICOS expression in the four groups, but only TB and HD increased SLAM and PD-1 levels.Conclusions: These data show the immune deregulation that takes place during the immune response against TB in different study populations.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/269268
Jurado, Javier Oscar; Pasquinelli, Virginia; Alvarez, Ivana Belén; Martínez, Gustavo Javier; Laufer, Natalia Lorna; et al.; ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis; Wiley; Journal of the International AIDS Society; 15; 2; 6-2012; 1-7
1758-2652
CONICET Digital
CONICET
url http://hdl.handle.net/11336/269268
identifier_str_mv Jurado, Javier Oscar; Pasquinelli, Virginia; Alvarez, Ivana Belén; Martínez, Gustavo Javier; Laufer, Natalia Lorna; et al.; ICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis; Wiley; Journal of the International AIDS Society; 15; 2; 6-2012; 1-7
1758-2652
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.7448/IAS.15.2.17428
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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