Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis

Autores
De Jesus, Luís Cláudio Lima; Martins Drumond, Mariana; de Carvalho, André; Santos, Spencer S.; Martins, Flaviano S.; Ferreira, Ênio; Salgado Fernandes, Renata; Branco de Barros, André Luís; do Carmo, Fillipe Luis R; Perez, Pablo Fernando; Carvalho Azevedo, Vasco Ariston; Mancha Agresti, Pamela
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mucositis is a cytotoxic side effect caused by chemotherapy drugs, such as 5-Fluorouracil (5-FU), being a serious clinical issue. Lactobacillus spp. could be a helpful strategy to alleviate 5-FU chemotherapy-caused intestinal damage, due to their ability to contribute to intestinal homeostasis through improvement of microbiota balance and immunomodulation. In this work we evaluated the effect of Lactobacillus delbrueckii subsp. lactis CIDCA 133 fermented milk in 5-FU-induced experimental mucositis. Intestinal histology, permeability and biochemical parameters showed that animals administrated with 5-FU and treated with CIDCA 133 fermented milk presented reduced intestinal IgA secretion and lower permeability in the small bowel. We showed that this strain preserves villus/crypt ratio, reduces the loss of goblet cells and inflammatory infiltration in ileum sections of 5-FU-treated animals. In conclusion, CIDCA 133 is able to prevent the intestinal mucosa damage caused by 5-FU revealing to be a promising strategy for intestinal mucositis treatment.
Fil: De Jesus, Luís Cláudio Lima. Universidade Federal de Minas Gerais; Brasil
Fil: Martins Drumond, Mariana. Universidade Federal de Minas Gerais; Brasil
Fil: de Carvalho, André. Universidade Federal de Minas Gerais; Brasil
Fil: Santos, Spencer S.. Universidade Federal de Minas Gerais; Brasil
Fil: Martins, Flaviano S.. Universidade Federal de Minas Gerais; Brasil
Fil: Ferreira, Ênio. Universidade Federal de Minas Gerais; Brasil
Fil: Salgado Fernandes, Renata. Universidade Federal de Minas Gerais; Brasil
Fil: Branco de Barros, André Luís. Universidade Federal de Minas Gerais; Brasil
Fil: do Carmo, Fillipe Luis R. Universidade Federal de Minas Gerais; Brasil
Fil: Perez, Pablo Fernando. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina
Fil: Carvalho Azevedo, Vasco Ariston. Universidade Federal de Minas Gerais; Brasil
Fil: Mancha Agresti, Pamela. Universidade Federal de Minas Gerais; Brasil
Materia
PROBIOTICS
CANCER CHEMOTHERAPY
5-FLUOROURACIL
INTESTINAL MUCOSITIS
INFLAMMATION
PERMEABILITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/118625
Acceder
id CONICETDig_11b3196292d19d450f9d56028aa964c7
oai_identifier_str oai:ri.conicet.gov.ar:11336/118625
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositisDe Jesus, Luís Cláudio LimaMartins Drumond, Marianade Carvalho, AndréSantos, Spencer S.Martins, Flaviano S.Ferreira, ÊnioSalgado Fernandes, RenataBranco de Barros, André Luísdo Carmo, Fillipe Luis RPerez, Pablo FernandoCarvalho Azevedo, Vasco AristonMancha Agresti, PamelaPROBIOTICSCANCER CHEMOTHERAPY5-FLUOROURACILINTESTINAL MUCOSITISINFLAMMATIONPERMEABILITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Mucositis is a cytotoxic side effect caused by chemotherapy drugs, such as 5-Fluorouracil (5-FU), being a serious clinical issue. Lactobacillus spp. could be a helpful strategy to alleviate 5-FU chemotherapy-caused intestinal damage, due to their ability to contribute to intestinal homeostasis through improvement of microbiota balance and immunomodulation. In this work we evaluated the effect of Lactobacillus delbrueckii subsp. lactis CIDCA 133 fermented milk in 5-FU-induced experimental mucositis. Intestinal histology, permeability and biochemical parameters showed that animals administrated with 5-FU and treated with CIDCA 133 fermented milk presented reduced intestinal IgA secretion and lower permeability in the small bowel. We showed that this strain preserves villus/crypt ratio, reduces the loss of goblet cells and inflammatory infiltration in ileum sections of 5-FU-treated animals. In conclusion, CIDCA 133 is able to prevent the intestinal mucosa damage caused by 5-FU revealing to be a promising strategy for intestinal mucositis treatment.Fil: De Jesus, Luís Cláudio Lima. Universidade Federal de Minas Gerais; BrasilFil: Martins Drumond, Mariana. Universidade Federal de Minas Gerais; BrasilFil: de Carvalho, André. Universidade Federal de Minas Gerais; BrasilFil: Santos, Spencer S.. Universidade Federal de Minas Gerais; BrasilFil: Martins, Flaviano S.. Universidade Federal de Minas Gerais; BrasilFil: Ferreira, Ênio. Universidade Federal de Minas Gerais; BrasilFil: Salgado Fernandes, Renata. Universidade Federal de Minas Gerais; BrasilFil: Branco de Barros, André Luís. Universidade Federal de Minas Gerais; BrasilFil: do Carmo, Fillipe Luis R. Universidade Federal de Minas Gerais; BrasilFil: Perez, Pablo Fernando. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; ArgentinaFil: Carvalho Azevedo, Vasco Ariston. Universidade Federal de Minas Gerais; BrasilFil: Mancha Agresti, Pamela. Universidade Federal de Minas Gerais; BrasilElsevier2019-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/118625De Jesus, Luís Cláudio Lima; Martins Drumond, Mariana; de Carvalho, André; Santos, Spencer S.; Martins, Flaviano S.; et al.; Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis; Elsevier; Journal of Functional Foods; 53; 2-2019; 197-2071756-46462214-9414CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://tinyurl.com/y42kunohinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2018.12.027info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:24Zoai:ri.conicet.gov.ar:11336/118625instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:24.882CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis
title Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis
spellingShingle Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis
De Jesus, Luís Cláudio Lima
PROBIOTICS
CANCER CHEMOTHERAPY
5-FLUOROURACIL
INTESTINAL MUCOSITIS
INFLAMMATION
PERMEABILITY
title_short Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis
title_full Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis
title_fullStr Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis
title_full_unstemmed Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis
title_sort Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis
dc.creator.none.fl_str_mv De Jesus, Luís Cláudio Lima
Martins Drumond, Mariana
de Carvalho, André
Santos, Spencer S.
Martins, Flaviano S.
Ferreira, Ênio
Salgado Fernandes, Renata
Branco de Barros, André Luís
do Carmo, Fillipe Luis R
Perez, Pablo Fernando
Carvalho Azevedo, Vasco Ariston
Mancha Agresti, Pamela
author De Jesus, Luís Cláudio Lima
author_facet De Jesus, Luís Cláudio Lima
Martins Drumond, Mariana
de Carvalho, André
Santos, Spencer S.
Martins, Flaviano S.
Ferreira, Ênio
Salgado Fernandes, Renata
Branco de Barros, André Luís
do Carmo, Fillipe Luis R
Perez, Pablo Fernando
Carvalho Azevedo, Vasco Ariston
Mancha Agresti, Pamela
author_role author
author2 Martins Drumond, Mariana
de Carvalho, André
Santos, Spencer S.
Martins, Flaviano S.
Ferreira, Ênio
Salgado Fernandes, Renata
Branco de Barros, André Luís
do Carmo, Fillipe Luis R
Perez, Pablo Fernando
Carvalho Azevedo, Vasco Ariston
Mancha Agresti, Pamela
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PROBIOTICS
CANCER CHEMOTHERAPY
5-FLUOROURACIL
INTESTINAL MUCOSITIS
INFLAMMATION
PERMEABILITY
topic PROBIOTICS
CANCER CHEMOTHERAPY
5-FLUOROURACIL
INTESTINAL MUCOSITIS
INFLAMMATION
PERMEABILITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Mucositis is a cytotoxic side effect caused by chemotherapy drugs, such as 5-Fluorouracil (5-FU), being a serious clinical issue. Lactobacillus spp. could be a helpful strategy to alleviate 5-FU chemotherapy-caused intestinal damage, due to their ability to contribute to intestinal homeostasis through improvement of microbiota balance and immunomodulation. In this work we evaluated the effect of Lactobacillus delbrueckii subsp. lactis CIDCA 133 fermented milk in 5-FU-induced experimental mucositis. Intestinal histology, permeability and biochemical parameters showed that animals administrated with 5-FU and treated with CIDCA 133 fermented milk presented reduced intestinal IgA secretion and lower permeability in the small bowel. We showed that this strain preserves villus/crypt ratio, reduces the loss of goblet cells and inflammatory infiltration in ileum sections of 5-FU-treated animals. In conclusion, CIDCA 133 is able to prevent the intestinal mucosa damage caused by 5-FU revealing to be a promising strategy for intestinal mucositis treatment.
Fil: De Jesus, Luís Cláudio Lima. Universidade Federal de Minas Gerais; Brasil
Fil: Martins Drumond, Mariana. Universidade Federal de Minas Gerais; Brasil
Fil: de Carvalho, André. Universidade Federal de Minas Gerais; Brasil
Fil: Santos, Spencer S.. Universidade Federal de Minas Gerais; Brasil
Fil: Martins, Flaviano S.. Universidade Federal de Minas Gerais; Brasil
Fil: Ferreira, Ênio. Universidade Federal de Minas Gerais; Brasil
Fil: Salgado Fernandes, Renata. Universidade Federal de Minas Gerais; Brasil
Fil: Branco de Barros, André Luís. Universidade Federal de Minas Gerais; Brasil
Fil: do Carmo, Fillipe Luis R. Universidade Federal de Minas Gerais; Brasil
Fil: Perez, Pablo Fernando. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina
Fil: Carvalho Azevedo, Vasco Ariston. Universidade Federal de Minas Gerais; Brasil
Fil: Mancha Agresti, Pamela. Universidade Federal de Minas Gerais; Brasil
description Mucositis is a cytotoxic side effect caused by chemotherapy drugs, such as 5-Fluorouracil (5-FU), being a serious clinical issue. Lactobacillus spp. could be a helpful strategy to alleviate 5-FU chemotherapy-caused intestinal damage, due to their ability to contribute to intestinal homeostasis through improvement of microbiota balance and immunomodulation. In this work we evaluated the effect of Lactobacillus delbrueckii subsp. lactis CIDCA 133 fermented milk in 5-FU-induced experimental mucositis. Intestinal histology, permeability and biochemical parameters showed that animals administrated with 5-FU and treated with CIDCA 133 fermented milk presented reduced intestinal IgA secretion and lower permeability in the small bowel. We showed that this strain preserves villus/crypt ratio, reduces the loss of goblet cells and inflammatory infiltration in ileum sections of 5-FU-treated animals. In conclusion, CIDCA 133 is able to prevent the intestinal mucosa damage caused by 5-FU revealing to be a promising strategy for intestinal mucositis treatment.
publishDate 2019
dc.date.none.fl_str_mv 2019-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/118625
De Jesus, Luís Cláudio Lima; Martins Drumond, Mariana; de Carvalho, André; Santos, Spencer S.; Martins, Flaviano S.; et al.; Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis; Elsevier; Journal of Functional Foods; 53; 2-2019; 197-207
1756-4646
2214-9414
CONICET Digital
CONICET
url http://hdl.handle.net/11336/118625
identifier_str_mv De Jesus, Luís Cláudio Lima; Martins Drumond, Mariana; de Carvalho, André; Santos, Spencer S.; Martins, Flaviano S.; et al.; Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis; Elsevier; Journal of Functional Foods; 53; 2-2019; 197-207
1756-4646
2214-9414
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://tinyurl.com/y42kunoh
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2018.12.027
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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