Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancrea...

Autores: Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; Justo, Iago; García Domingo, Maria I.; Ausania, Fabio; Muñoz Forner, Elena; Serrablo, Alejandro; Martin, Elena; Díez, Luis; Cepeda, Carmen; Marin, Luis; Alamo, Jose; Bernal, Carmen; Pereira, Sheila; Calero, Francisco; Tinoco, Jose; Paterna, Sandra; Cugat, Esteban; Fondevila, Constantino; Diego Alonso, Elisa; López Guerra, Diego; Gomez, Miguel; Denninghoff, Valeria Cecilia; Sabater, Luis
Año de publicación: 2024
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma.
Fil: Padillo Ruiz, Javier. Universidad de Sevilla; España
Fil: Fresno Rodríguez, Cristóbal. Universidad Anahuac Mexico; México. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Suarez, Gonzalo. Universidad de Sevilla; España
Fil: Blanco, Gerardo. University of Extremadura; España
Fil: Muñoz Bellvis, Luis. Universidad de Salamanca; España
Fil: Justo, Iago. University Hospital October 12 in Madrid; España
Fil: García Domingo, Maria I.. Terrassa Mutual University Hospital; España
Fil: Ausania, Fabio. Universidad de Barcelona; España
Fil: Muñoz Forner, Elena. Universidad de Valencia; España
Fil: Serrablo, Alejandro. Miguel Servet University Hospital; España
Fil: Martin, Elena. Princess University Hospita; España
Fil: Díez, Luis. Clinical Hospital; España
Fil: Cepeda, Carmen. Universidad de Sevilla; España
Fil: Marin, Luis. Universidad de Sevilla; España
Fil: Alamo, Jose. Universidad de Sevilla; España
Fil: Bernal, Carmen. Universidad de Sevilla; España
Fil: Pereira, Sheila. Universidad de Sevilla; España
Fil: Calero, Francisco. Universidad de Sevilla; España
Fil: Tinoco, Jose. Universidad de Sevilla; España
Fil: Paterna, Sandra. Miguel Servet University Hospital; España
Fil: Cugat, Esteban. Terrassa Mutual University Hospital; España
Fil: Fondevila, Constantino. Universidad de Barcelona; España
Fil: Diego Alonso, Elisa. Universidad de Salamanca; España
Fil: López Guerra, Diego. University of Extremadura; España
Fil: Gomez, Miguel. Universidad de Sevilla; España
Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Sevilla; España
Fil: Sabater, Luis. Universidad de Valencia; España
Materia: CTC
pancreas
surgery
TNM
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/263226

Acceder

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oai_identifier_str	oai:ri.conicet.gov.ar:11336/263226
network_acronym_str	CONICETDig
repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trialPadillo Ruiz, JavierFresno Rodríguez, CristóbalSuarez, GonzaloBlanco, GerardoMuñoz Bellvis, LuisJusto, IagoGarcía Domingo, Maria I.Ausania, FabioMuñoz Forner, ElenaSerrablo, AlejandroMartin, ElenaDíez, LuisCepeda, CarmenMarin, LuisAlamo, JoseBernal, CarmenPereira, SheilaCalero, FranciscoTinoco, JosePaterna, SandraCugat, EstebanFondevila, ConstantinoDiego Alonso, ElisaLópez Guerra, DiegoGomez, MiguelDenninghoff, Valeria CeciliaSabater, LuisCTCpancreassurgeryTNMhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma.Fil: Padillo Ruiz, Javier. Universidad de Sevilla; EspañaFil: Fresno Rodríguez, Cristóbal. Universidad Anahuac Mexico; México. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Suarez, Gonzalo. Universidad de Sevilla; EspañaFil: Blanco, Gerardo. University of Extremadura; EspañaFil: Muñoz Bellvis, Luis. Universidad de Salamanca; EspañaFil: Justo, Iago. University Hospital October 12 in Madrid; EspañaFil: García Domingo, Maria I.. Terrassa Mutual University Hospital; EspañaFil: Ausania, Fabio. Universidad de Barcelona; EspañaFil: Muñoz Forner, Elena. Universidad de Valencia; EspañaFil: Serrablo, Alejandro. Miguel Servet University Hospital; EspañaFil: Martin, Elena. Princess University Hospita; EspañaFil: Díez, Luis. Clinical Hospital; EspañaFil: Cepeda, Carmen. Universidad de Sevilla; EspañaFil: Marin, Luis. Universidad de Sevilla; EspañaFil: Alamo, Jose. Universidad de Sevilla; EspañaFil: Bernal, Carmen. Universidad de Sevilla; EspañaFil: Pereira, Sheila. Universidad de Sevilla; EspañaFil: Calero, Francisco. Universidad de Sevilla; EspañaFil: Tinoco, Jose. Universidad de Sevilla; EspañaFil: Paterna, Sandra. Miguel Servet University Hospital; EspañaFil: Cugat, Esteban. Terrassa Mutual University Hospital; EspañaFil: Fondevila, Constantino. Universidad de Barcelona; EspañaFil: Diego Alonso, Elisa. Universidad de Salamanca; EspañaFil: López Guerra, Diego. University of Extremadura; EspañaFil: Gomez, Miguel. Universidad de Sevilla; EspañaFil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Sevilla; EspañaFil: Sabater, Luis. Universidad de Valencia; EspañaBJS Foundation Ltd2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/263226Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; et al.; Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial; BJS Foundation Ltd; BJS Open; 8; 6; 12-2024; 1-112474-9842CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/bjsopen/article/doi/10.1093/bjsopen/zrae123/7863330info:eu-repo/semantics/altIdentifier/doi/10.1093/bjsopen/zrae123info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:35:48Zoai:ri.conicet.gov.ar:11336/263226instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:35:49.166CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
title	Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
spellingShingle	Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial Padillo Ruiz, Javier CTC pancreas surgery TNM
title_short	Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
title_full	Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
title_fullStr	Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
title_full_unstemmed	Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
title_sort	Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
dc.creator.none.fl_str_mv	Padillo Ruiz, Javier Fresno Rodríguez, Cristóbal Suarez, Gonzalo Blanco, Gerardo Muñoz Bellvis, Luis Justo, Iago García Domingo, Maria I. Ausania, Fabio Muñoz Forner, Elena Serrablo, Alejandro Martin, Elena Díez, Luis Cepeda, Carmen Marin, Luis Alamo, Jose Bernal, Carmen Pereira, Sheila Calero, Francisco Tinoco, Jose Paterna, Sandra Cugat, Esteban Fondevila, Constantino Diego Alonso, Elisa López Guerra, Diego Gomez, Miguel Denninghoff, Valeria Cecilia Sabater, Luis
author	Padillo Ruiz, Javier
author_facet	Padillo Ruiz, Javier Fresno Rodríguez, Cristóbal Suarez, Gonzalo Blanco, Gerardo Muñoz Bellvis, Luis Justo, Iago García Domingo, Maria I. Ausania, Fabio Muñoz Forner, Elena Serrablo, Alejandro Martin, Elena Díez, Luis Cepeda, Carmen Marin, Luis Alamo, Jose Bernal, Carmen Pereira, Sheila Calero, Francisco Tinoco, Jose Paterna, Sandra Cugat, Esteban Fondevila, Constantino Diego Alonso, Elisa López Guerra, Diego Gomez, Miguel Denninghoff, Valeria Cecilia Sabater, Luis
author_role	author
author2	Fresno Rodríguez, Cristóbal Suarez, Gonzalo Blanco, Gerardo Muñoz Bellvis, Luis Justo, Iago García Domingo, Maria I. Ausania, Fabio Muñoz Forner, Elena Serrablo, Alejandro Martin, Elena Díez, Luis Cepeda, Carmen Marin, Luis Alamo, Jose Bernal, Carmen Pereira, Sheila Calero, Francisco Tinoco, Jose Paterna, Sandra Cugat, Esteban Fondevila, Constantino Diego Alonso, Elisa López Guerra, Diego Gomez, Miguel Denninghoff, Valeria Cecilia Sabater, Luis
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	CTC pancreas surgery TNM
topic	CTC pancreas surgery TNM
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma. Fil: Padillo Ruiz, Javier. Universidad de Sevilla; España Fil: Fresno Rodríguez, Cristóbal. Universidad Anahuac Mexico; México. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Suarez, Gonzalo. Universidad de Sevilla; España Fil: Blanco, Gerardo. University of Extremadura; España Fil: Muñoz Bellvis, Luis. Universidad de Salamanca; España Fil: Justo, Iago. University Hospital October 12 in Madrid; España Fil: García Domingo, Maria I.. Terrassa Mutual University Hospital; España Fil: Ausania, Fabio. Universidad de Barcelona; España Fil: Muñoz Forner, Elena. Universidad de Valencia; España Fil: Serrablo, Alejandro. Miguel Servet University Hospital; España Fil: Martin, Elena. Princess University Hospita; España Fil: Díez, Luis. Clinical Hospital; España Fil: Cepeda, Carmen. Universidad de Sevilla; España Fil: Marin, Luis. Universidad de Sevilla; España Fil: Alamo, Jose. Universidad de Sevilla; España Fil: Bernal, Carmen. Universidad de Sevilla; España Fil: Pereira, Sheila. Universidad de Sevilla; España Fil: Calero, Francisco. Universidad de Sevilla; España Fil: Tinoco, Jose. Universidad de Sevilla; España Fil: Paterna, Sandra. Miguel Servet University Hospital; España Fil: Cugat, Esteban. Terrassa Mutual University Hospital; España Fil: Fondevila, Constantino. Universidad de Barcelona; España Fil: Diego Alonso, Elisa. Universidad de Salamanca; España Fil: López Guerra, Diego. University of Extremadura; España Fil: Gomez, Miguel. Universidad de Sevilla; España Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Sevilla; España Fil: Sabater, Luis. Universidad de Valencia; España
description	Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma.
publishDate	2024
dc.date.none.fl_str_mv	2024-12
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/263226 Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; et al.; Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial; BJS Foundation Ltd; BJS Open; 8; 6; 12-2024; 1-11 2474-9842 CONICET Digital CONICET
url	http://hdl.handle.net/11336/263226
identifier_str_mv	Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; et al.; Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial; BJS Foundation Ltd; BJS Open; 8; 6; 12-2024; 1-11 2474-9842 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/bjsopen/article/doi/10.1093/bjsopen/zrae123/7863330 info:eu-repo/semantics/altIdentifier/doi/10.1093/bjsopen/zrae123
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	BJS Foundation Ltd
publisher.none.fl_str_mv	BJS Foundation Ltd
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score	13.22299

Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancrea...

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