Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancrea...

Autores
Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; Justo, Iago; García Domingo, Maria I.; Ausania, Fabio; Muñoz Forner, Elena; Serrablo, Alejandro; Martin, Elena; Díez, Luis; Cepeda, Carmen; Marin, Luis; Alamo, Jose; Bernal, Carmen; Pereira, Sheila; Calero, Francisco; Tinoco, Jose; Paterna, Sandra; Cugat, Esteban; Fondevila, Constantino; Diego Alonso, Elisa; López Guerra, Diego; Gomez, Miguel; Denninghoff, Valeria Cecilia; Sabater, Luis
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma.
Fil: Padillo Ruiz, Javier. Universidad de Sevilla; España
Fil: Fresno Rodríguez, Cristóbal. Universidad Anahuac Mexico; México. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Suarez, Gonzalo. Universidad de Sevilla; España
Fil: Blanco, Gerardo. University of Extremadura; España
Fil: Muñoz Bellvis, Luis. Universidad de Salamanca; España
Fil: Justo, Iago. University Hospital October 12 in Madrid; España
Fil: García Domingo, Maria I.. Terrassa Mutual University Hospital; España
Fil: Ausania, Fabio. Universidad de Barcelona; España
Fil: Muñoz Forner, Elena. Universidad de Valencia; España
Fil: Serrablo, Alejandro. Miguel Servet University Hospital; España
Fil: Martin, Elena. Princess University Hospita; España
Fil: Díez, Luis. Clinical Hospital; España
Fil: Cepeda, Carmen. Universidad de Sevilla; España
Fil: Marin, Luis. Universidad de Sevilla; España
Fil: Alamo, Jose. Universidad de Sevilla; España
Fil: Bernal, Carmen. Universidad de Sevilla; España
Fil: Pereira, Sheila. Universidad de Sevilla; España
Fil: Calero, Francisco. Universidad de Sevilla; España
Fil: Tinoco, Jose. Universidad de Sevilla; España
Fil: Paterna, Sandra. Miguel Servet University Hospital; España
Fil: Cugat, Esteban. Terrassa Mutual University Hospital; España
Fil: Fondevila, Constantino. Universidad de Barcelona; España
Fil: Diego Alonso, Elisa. Universidad de Salamanca; España
Fil: López Guerra, Diego. University of Extremadura; España
Fil: Gomez, Miguel. Universidad de Sevilla; España
Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Sevilla; España
Fil: Sabater, Luis. Universidad de Valencia; España
Materia
CTC
pancreas
surgery
TNM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/263226

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trialPadillo Ruiz, JavierFresno Rodríguez, CristóbalSuarez, GonzaloBlanco, GerardoMuñoz Bellvis, LuisJusto, IagoGarcía Domingo, Maria I.Ausania, FabioMuñoz Forner, ElenaSerrablo, AlejandroMartin, ElenaDíez, LuisCepeda, CarmenMarin, LuisAlamo, JoseBernal, CarmenPereira, SheilaCalero, FranciscoTinoco, JosePaterna, SandraCugat, EstebanFondevila, ConstantinoDiego Alonso, ElisaLópez Guerra, DiegoGomez, MiguelDenninghoff, Valeria CeciliaSabater, LuisCTCpancreassurgeryTNMhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma.Fil: Padillo Ruiz, Javier. Universidad de Sevilla; EspañaFil: Fresno Rodríguez, Cristóbal. Universidad Anahuac Mexico; México. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Suarez, Gonzalo. Universidad de Sevilla; EspañaFil: Blanco, Gerardo. University of Extremadura; EspañaFil: Muñoz Bellvis, Luis. Universidad de Salamanca; EspañaFil: Justo, Iago. University Hospital October 12 in Madrid; EspañaFil: García Domingo, Maria I.. Terrassa Mutual University Hospital; EspañaFil: Ausania, Fabio. Universidad de Barcelona; EspañaFil: Muñoz Forner, Elena. Universidad de Valencia; EspañaFil: Serrablo, Alejandro. Miguel Servet University Hospital; EspañaFil: Martin, Elena. Princess University Hospita; EspañaFil: Díez, Luis. Clinical Hospital; EspañaFil: Cepeda, Carmen. Universidad de Sevilla; EspañaFil: Marin, Luis. Universidad de Sevilla; EspañaFil: Alamo, Jose. Universidad de Sevilla; EspañaFil: Bernal, Carmen. Universidad de Sevilla; EspañaFil: Pereira, Sheila. Universidad de Sevilla; EspañaFil: Calero, Francisco. Universidad de Sevilla; EspañaFil: Tinoco, Jose. Universidad de Sevilla; EspañaFil: Paterna, Sandra. Miguel Servet University Hospital; EspañaFil: Cugat, Esteban. Terrassa Mutual University Hospital; EspañaFil: Fondevila, Constantino. Universidad de Barcelona; EspañaFil: Diego Alonso, Elisa. Universidad de Salamanca; EspañaFil: López Guerra, Diego. University of Extremadura; EspañaFil: Gomez, Miguel. Universidad de Sevilla; EspañaFil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Sevilla; EspañaFil: Sabater, Luis. Universidad de Valencia; EspañaBJS Foundation Ltd2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/263226Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; et al.; Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial; BJS Foundation Ltd; BJS Open; 8; 6; 12-2024; 1-112474-9842CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/bjsopen/article/doi/10.1093/bjsopen/zrae123/7863330info:eu-repo/semantics/altIdentifier/doi/10.1093/bjsopen/zrae123info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:44Zoai:ri.conicet.gov.ar:11336/263226instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:44.711CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
title Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
spellingShingle Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
Padillo Ruiz, Javier
CTC
pancreas
surgery
TNM
title_short Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
title_full Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
title_fullStr Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
title_full_unstemmed Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
title_sort Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
dc.creator.none.fl_str_mv Padillo Ruiz, Javier
Fresno Rodríguez, Cristóbal
Suarez, Gonzalo
Blanco, Gerardo
Muñoz Bellvis, Luis
Justo, Iago
García Domingo, Maria I.
Ausania, Fabio
Muñoz Forner, Elena
Serrablo, Alejandro
Martin, Elena
Díez, Luis
Cepeda, Carmen
Marin, Luis
Alamo, Jose
Bernal, Carmen
Pereira, Sheila
Calero, Francisco
Tinoco, Jose
Paterna, Sandra
Cugat, Esteban
Fondevila, Constantino
Diego Alonso, Elisa
López Guerra, Diego
Gomez, Miguel
Denninghoff, Valeria Cecilia
Sabater, Luis
author Padillo Ruiz, Javier
author_facet Padillo Ruiz, Javier
Fresno Rodríguez, Cristóbal
Suarez, Gonzalo
Blanco, Gerardo
Muñoz Bellvis, Luis
Justo, Iago
García Domingo, Maria I.
Ausania, Fabio
Muñoz Forner, Elena
Serrablo, Alejandro
Martin, Elena
Díez, Luis
Cepeda, Carmen
Marin, Luis
Alamo, Jose
Bernal, Carmen
Pereira, Sheila
Calero, Francisco
Tinoco, Jose
Paterna, Sandra
Cugat, Esteban
Fondevila, Constantino
Diego Alonso, Elisa
López Guerra, Diego
Gomez, Miguel
Denninghoff, Valeria Cecilia
Sabater, Luis
author_role author
author2 Fresno Rodríguez, Cristóbal
Suarez, Gonzalo
Blanco, Gerardo
Muñoz Bellvis, Luis
Justo, Iago
García Domingo, Maria I.
Ausania, Fabio
Muñoz Forner, Elena
Serrablo, Alejandro
Martin, Elena
Díez, Luis
Cepeda, Carmen
Marin, Luis
Alamo, Jose
Bernal, Carmen
Pereira, Sheila
Calero, Francisco
Tinoco, Jose
Paterna, Sandra
Cugat, Esteban
Fondevila, Constantino
Diego Alonso, Elisa
López Guerra, Diego
Gomez, Miguel
Denninghoff, Valeria Cecilia
Sabater, Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CTC
pancreas
surgery
TNM
topic CTC
pancreas
surgery
TNM
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma.
Fil: Padillo Ruiz, Javier. Universidad de Sevilla; España
Fil: Fresno Rodríguez, Cristóbal. Universidad Anahuac Mexico; México. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Suarez, Gonzalo. Universidad de Sevilla; España
Fil: Blanco, Gerardo. University of Extremadura; España
Fil: Muñoz Bellvis, Luis. Universidad de Salamanca; España
Fil: Justo, Iago. University Hospital October 12 in Madrid; España
Fil: García Domingo, Maria I.. Terrassa Mutual University Hospital; España
Fil: Ausania, Fabio. Universidad de Barcelona; España
Fil: Muñoz Forner, Elena. Universidad de Valencia; España
Fil: Serrablo, Alejandro. Miguel Servet University Hospital; España
Fil: Martin, Elena. Princess University Hospita; España
Fil: Díez, Luis. Clinical Hospital; España
Fil: Cepeda, Carmen. Universidad de Sevilla; España
Fil: Marin, Luis. Universidad de Sevilla; España
Fil: Alamo, Jose. Universidad de Sevilla; España
Fil: Bernal, Carmen. Universidad de Sevilla; España
Fil: Pereira, Sheila. Universidad de Sevilla; España
Fil: Calero, Francisco. Universidad de Sevilla; España
Fil: Tinoco, Jose. Universidad de Sevilla; España
Fil: Paterna, Sandra. Miguel Servet University Hospital; España
Fil: Cugat, Esteban. Terrassa Mutual University Hospital; España
Fil: Fondevila, Constantino. Universidad de Barcelona; España
Fil: Diego Alonso, Elisa. Universidad de Salamanca; España
Fil: López Guerra, Diego. University of Extremadura; España
Fil: Gomez, Miguel. Universidad de Sevilla; España
Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Sevilla; España
Fil: Sabater, Luis. Universidad de Valencia; España
description Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma.
publishDate 2024
dc.date.none.fl_str_mv 2024-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/263226
Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; et al.; Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial; BJS Foundation Ltd; BJS Open; 8; 6; 12-2024; 1-11
2474-9842
CONICET Digital
CONICET
url http://hdl.handle.net/11336/263226
identifier_str_mv Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; et al.; Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial; BJS Foundation Ltd; BJS Open; 8; 6; 12-2024; 1-11
2474-9842
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/bjsopen/article/doi/10.1093/bjsopen/zrae123/7863330
info:eu-repo/semantics/altIdentifier/doi/10.1093/bjsopen/zrae123
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BJS Foundation Ltd
publisher.none.fl_str_mv BJS Foundation Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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