Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancrea...
- Autores
- Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; Justo, Iago; García Domingo, Maria I.; Ausania, Fabio; Muñoz Forner, Elena; Serrablo, Alejandro; Martin, Elena; Díez, Luis; Cepeda, Carmen; Marin, Luis; Alamo, Jose; Bernal, Carmen; Pereira, Sheila; Calero, Francisco; Tinoco, Jose; Paterna, Sandra; Cugat, Esteban; Fondevila, Constantino; Diego Alonso, Elisa; López Guerra, Diego; Gomez, Miguel; Denninghoff, Valeria Cecilia; Sabater, Luis
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma.
Fil: Padillo Ruiz, Javier. Universidad de Sevilla; España
Fil: Fresno Rodríguez, Cristóbal. Universidad Anahuac Mexico; México. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Suarez, Gonzalo. Universidad de Sevilla; España
Fil: Blanco, Gerardo. University of Extremadura; España
Fil: Muñoz Bellvis, Luis. Universidad de Salamanca; España
Fil: Justo, Iago. University Hospital October 12 in Madrid; España
Fil: García Domingo, Maria I.. Terrassa Mutual University Hospital; España
Fil: Ausania, Fabio. Universidad de Barcelona; España
Fil: Muñoz Forner, Elena. Universidad de Valencia; España
Fil: Serrablo, Alejandro. Miguel Servet University Hospital; España
Fil: Martin, Elena. Princess University Hospita; España
Fil: Díez, Luis. Clinical Hospital; España
Fil: Cepeda, Carmen. Universidad de Sevilla; España
Fil: Marin, Luis. Universidad de Sevilla; España
Fil: Alamo, Jose. Universidad de Sevilla; España
Fil: Bernal, Carmen. Universidad de Sevilla; España
Fil: Pereira, Sheila. Universidad de Sevilla; España
Fil: Calero, Francisco. Universidad de Sevilla; España
Fil: Tinoco, Jose. Universidad de Sevilla; España
Fil: Paterna, Sandra. Miguel Servet University Hospital; España
Fil: Cugat, Esteban. Terrassa Mutual University Hospital; España
Fil: Fondevila, Constantino. Universidad de Barcelona; España
Fil: Diego Alonso, Elisa. Universidad de Salamanca; España
Fil: López Guerra, Diego. University of Extremadura; España
Fil: Gomez, Miguel. Universidad de Sevilla; España
Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Sevilla; España
Fil: Sabater, Luis. Universidad de Valencia; España - Materia
-
CTC
pancreas
surgery
TNM - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/263226
Ver los metadatos del registro completo
id |
CONICETDig_10bb7687e3aa7488862957df02715b8b |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/263226 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trialPadillo Ruiz, JavierFresno Rodríguez, CristóbalSuarez, GonzaloBlanco, GerardoMuñoz Bellvis, LuisJusto, IagoGarcía Domingo, Maria I.Ausania, FabioMuñoz Forner, ElenaSerrablo, AlejandroMartin, ElenaDíez, LuisCepeda, CarmenMarin, LuisAlamo, JoseBernal, CarmenPereira, SheilaCalero, FranciscoTinoco, JosePaterna, SandraCugat, EstebanFondevila, ConstantinoDiego Alonso, ElisaLópez Guerra, DiegoGomez, MiguelDenninghoff, Valeria CeciliaSabater, LuisCTCpancreassurgeryTNMhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma.Fil: Padillo Ruiz, Javier. Universidad de Sevilla; EspañaFil: Fresno Rodríguez, Cristóbal. Universidad Anahuac Mexico; México. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Suarez, Gonzalo. Universidad de Sevilla; EspañaFil: Blanco, Gerardo. University of Extremadura; EspañaFil: Muñoz Bellvis, Luis. Universidad de Salamanca; EspañaFil: Justo, Iago. University Hospital October 12 in Madrid; EspañaFil: García Domingo, Maria I.. Terrassa Mutual University Hospital; EspañaFil: Ausania, Fabio. Universidad de Barcelona; EspañaFil: Muñoz Forner, Elena. Universidad de Valencia; EspañaFil: Serrablo, Alejandro. Miguel Servet University Hospital; EspañaFil: Martin, Elena. Princess University Hospita; EspañaFil: Díez, Luis. Clinical Hospital; EspañaFil: Cepeda, Carmen. Universidad de Sevilla; EspañaFil: Marin, Luis. Universidad de Sevilla; EspañaFil: Alamo, Jose. Universidad de Sevilla; EspañaFil: Bernal, Carmen. Universidad de Sevilla; EspañaFil: Pereira, Sheila. Universidad de Sevilla; EspañaFil: Calero, Francisco. Universidad de Sevilla; EspañaFil: Tinoco, Jose. Universidad de Sevilla; EspañaFil: Paterna, Sandra. Miguel Servet University Hospital; EspañaFil: Cugat, Esteban. Terrassa Mutual University Hospital; EspañaFil: Fondevila, Constantino. Universidad de Barcelona; EspañaFil: Diego Alonso, Elisa. Universidad de Salamanca; EspañaFil: López Guerra, Diego. University of Extremadura; EspañaFil: Gomez, Miguel. Universidad de Sevilla; EspañaFil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Sevilla; EspañaFil: Sabater, Luis. Universidad de Valencia; EspañaBJS Foundation Ltd2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/263226Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; et al.; Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial; BJS Foundation Ltd; BJS Open; 8; 6; 12-2024; 1-112474-9842CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/bjsopen/article/doi/10.1093/bjsopen/zrae123/7863330info:eu-repo/semantics/altIdentifier/doi/10.1093/bjsopen/zrae123info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:44Zoai:ri.conicet.gov.ar:11336/263226instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:44.711CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial |
title |
Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial |
spellingShingle |
Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial Padillo Ruiz, Javier CTC pancreas surgery TNM |
title_short |
Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial |
title_full |
Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial |
title_fullStr |
Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial |
title_full_unstemmed |
Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial |
title_sort |
Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial |
dc.creator.none.fl_str_mv |
Padillo Ruiz, Javier Fresno Rodríguez, Cristóbal Suarez, Gonzalo Blanco, Gerardo Muñoz Bellvis, Luis Justo, Iago García Domingo, Maria I. Ausania, Fabio Muñoz Forner, Elena Serrablo, Alejandro Martin, Elena Díez, Luis Cepeda, Carmen Marin, Luis Alamo, Jose Bernal, Carmen Pereira, Sheila Calero, Francisco Tinoco, Jose Paterna, Sandra Cugat, Esteban Fondevila, Constantino Diego Alonso, Elisa López Guerra, Diego Gomez, Miguel Denninghoff, Valeria Cecilia Sabater, Luis |
author |
Padillo Ruiz, Javier |
author_facet |
Padillo Ruiz, Javier Fresno Rodríguez, Cristóbal Suarez, Gonzalo Blanco, Gerardo Muñoz Bellvis, Luis Justo, Iago García Domingo, Maria I. Ausania, Fabio Muñoz Forner, Elena Serrablo, Alejandro Martin, Elena Díez, Luis Cepeda, Carmen Marin, Luis Alamo, Jose Bernal, Carmen Pereira, Sheila Calero, Francisco Tinoco, Jose Paterna, Sandra Cugat, Esteban Fondevila, Constantino Diego Alonso, Elisa López Guerra, Diego Gomez, Miguel Denninghoff, Valeria Cecilia Sabater, Luis |
author_role |
author |
author2 |
Fresno Rodríguez, Cristóbal Suarez, Gonzalo Blanco, Gerardo Muñoz Bellvis, Luis Justo, Iago García Domingo, Maria I. Ausania, Fabio Muñoz Forner, Elena Serrablo, Alejandro Martin, Elena Díez, Luis Cepeda, Carmen Marin, Luis Alamo, Jose Bernal, Carmen Pereira, Sheila Calero, Francisco Tinoco, Jose Paterna, Sandra Cugat, Esteban Fondevila, Constantino Diego Alonso, Elisa López Guerra, Diego Gomez, Miguel Denninghoff, Valeria Cecilia Sabater, Luis |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
CTC pancreas surgery TNM |
topic |
CTC pancreas surgery TNM |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma. Fil: Padillo Ruiz, Javier. Universidad de Sevilla; España Fil: Fresno Rodríguez, Cristóbal. Universidad Anahuac Mexico; México. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Suarez, Gonzalo. Universidad de Sevilla; España Fil: Blanco, Gerardo. University of Extremadura; España Fil: Muñoz Bellvis, Luis. Universidad de Salamanca; España Fil: Justo, Iago. University Hospital October 12 in Madrid; España Fil: García Domingo, Maria I.. Terrassa Mutual University Hospital; España Fil: Ausania, Fabio. Universidad de Barcelona; España Fil: Muñoz Forner, Elena. Universidad de Valencia; España Fil: Serrablo, Alejandro. Miguel Servet University Hospital; España Fil: Martin, Elena. Princess University Hospita; España Fil: Díez, Luis. Clinical Hospital; España Fil: Cepeda, Carmen. Universidad de Sevilla; España Fil: Marin, Luis. Universidad de Sevilla; España Fil: Alamo, Jose. Universidad de Sevilla; España Fil: Bernal, Carmen. Universidad de Sevilla; España Fil: Pereira, Sheila. Universidad de Sevilla; España Fil: Calero, Francisco. Universidad de Sevilla; España Fil: Tinoco, Jose. Universidad de Sevilla; España Fil: Paterna, Sandra. Miguel Servet University Hospital; España Fil: Cugat, Esteban. Terrassa Mutual University Hospital; España Fil: Fondevila, Constantino. Universidad de Barcelona; España Fil: Diego Alonso, Elisa. Universidad de Salamanca; España Fil: López Guerra, Diego. University of Extremadura; España Fil: Gomez, Miguel. Universidad de Sevilla; España Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Sevilla; España Fil: Sabater, Luis. Universidad de Valencia; España |
description |
Background: Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods: Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results: A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the notouch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion: Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/263226 Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; et al.; Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial; BJS Foundation Ltd; BJS Open; 8; 6; 12-2024; 1-11 2474-9842 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/263226 |
identifier_str_mv |
Padillo Ruiz, Javier; Fresno Rodríguez, Cristóbal; Suarez, Gonzalo; Blanco, Gerardo; Muñoz Bellvis, Luis; et al.; Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial; BJS Foundation Ltd; BJS Open; 8; 6; 12-2024; 1-11 2474-9842 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/bjsopen/article/doi/10.1093/bjsopen/zrae123/7863330 info:eu-repo/semantics/altIdentifier/doi/10.1093/bjsopen/zrae123 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
BJS Foundation Ltd |
publisher.none.fl_str_mv |
BJS Foundation Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613345694449664 |
score |
13.070432 |