The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing

Autores
Sexton, Jane E.; Desmonds, Terri; Quick, Kathryn; Taylor, Ruth; Abramowitz, Joel; Forge, Andy; Kros, Corné J.; Birnbaumer, Lutz; Wood, John N.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features of TRP channels include their high structural homology and their propensity to form heteromeric complexes which suggests potential functional redundancy. We previously showed that TRPC3 and TRPC6 double knockout animals have deficits in light touch and hearing whilst single knockouts were apparently normal. We have extended these studies to analyse deficits in global quadruple TRPC1, 3, 5 and 6 null mutant mice. We examined both touch and hearing in behavioural and electrophysiological assays, and provide evidence that the quadruple knockout mice have larger deficits than the TRPC3 TRPC6 double knockouts. Mechano-electrical transducer currents of cochlear outer hair cells were however normal. This suggests that TRPC1, TRPC3, TRPC5 and TRPC6 channels contribute to cutaneous and auditory mechanosensation in a combinatorial manner, but have no direct role in cochlear mechanotransduction.
Fil: Sexton, Jane E.. University College London; Reino Unido
Fil: Desmonds, Terri. University of Sussex; Reino Unido
Fil: Quick, Kathryn. University College London; Reino Unido
Fil: Taylor, Ruth. University College London; Reino Unido
Fil: Abramowitz, Joel. National Institute of Environmental Health Sciences; Estados Unidos
Fil: Forge, Andy. University College London; Reino Unido
Fil: Kros, Corné J.. University of Sussex; Reino Unido. University of Groningen; Países Bajos
Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. National Institute of Environmental Health Sciences; Estados Unidos
Fil: Wood, John N.. University College London; Reino Unido
Materia
Mechanosensation
Touch
Trp Channels
Dko
Double Knockout Mice
Quadko
Quadruple Knockout Mice
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/49344
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/49344
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearingSexton, Jane E.Desmonds, TerriQuick, KathrynTaylor, RuthAbramowitz, JoelForge, AndyKros, Corné J.Birnbaumer, LutzWood, John N.MechanosensationTouchTrp ChannelsDkoDouble Knockout MiceQuadkoQuadruple Knockout Micehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features of TRP channels include their high structural homology and their propensity to form heteromeric complexes which suggests potential functional redundancy. We previously showed that TRPC3 and TRPC6 double knockout animals have deficits in light touch and hearing whilst single knockouts were apparently normal. We have extended these studies to analyse deficits in global quadruple TRPC1, 3, 5 and 6 null mutant mice. We examined both touch and hearing in behavioural and electrophysiological assays, and provide evidence that the quadruple knockout mice have larger deficits than the TRPC3 TRPC6 double knockouts. Mechano-electrical transducer currents of cochlear outer hair cells were however normal. This suggests that TRPC1, TRPC3, TRPC5 and TRPC6 channels contribute to cutaneous and auditory mechanosensation in a combinatorial manner, but have no direct role in cochlear mechanotransduction.Fil: Sexton, Jane E.. University College London; Reino UnidoFil: Desmonds, Terri. University of Sussex; Reino UnidoFil: Quick, Kathryn. University College London; Reino UnidoFil: Taylor, Ruth. University College London; Reino UnidoFil: Abramowitz, Joel. National Institute of Environmental Health Sciences; Estados UnidosFil: Forge, Andy. University College London; Reino UnidoFil: Kros, Corné J.. University of Sussex; Reino Unido. University of Groningen; Países BajosFil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. National Institute of Environmental Health Sciences; Estados UnidosFil: Wood, John N.. University College London; Reino UnidoElsevier Ireland2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/49344Sexton, Jane E.; Desmonds, Terri; Quick, Kathryn; Taylor, Ruth; Abramowitz, Joel; et al.; The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing; Elsevier Ireland; Neuroscience Letters; 610; 1-2016; 36-420304-3940CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304394015302159info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neulet.2015.10.052info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683096/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:31:22Zoai:ri.conicet.gov.ar:11336/49344instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:31:22.832CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
title The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
spellingShingle The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
Sexton, Jane E.
Mechanosensation
Touch
Trp Channels
Dko
Double Knockout Mice
Quadko
Quadruple Knockout Mice
title_short The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
title_full The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
title_fullStr The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
title_full_unstemmed The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
title_sort The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
dc.creator.none.fl_str_mv Sexton, Jane E.
Desmonds, Terri
Quick, Kathryn
Taylor, Ruth
Abramowitz, Joel
Forge, Andy
Kros, Corné J.
Birnbaumer, Lutz
Wood, John N.
author Sexton, Jane E.
author_facet Sexton, Jane E.
Desmonds, Terri
Quick, Kathryn
Taylor, Ruth
Abramowitz, Joel
Forge, Andy
Kros, Corné J.
Birnbaumer, Lutz
Wood, John N.
author_role author
author2 Desmonds, Terri
Quick, Kathryn
Taylor, Ruth
Abramowitz, Joel
Forge, Andy
Kros, Corné J.
Birnbaumer, Lutz
Wood, John N.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mechanosensation
Touch
Trp Channels
Dko
Double Knockout Mice
Quadko
Quadruple Knockout Mice
topic Mechanosensation
Touch
Trp Channels
Dko
Double Knockout Mice
Quadko
Quadruple Knockout Mice
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features of TRP channels include their high structural homology and their propensity to form heteromeric complexes which suggests potential functional redundancy. We previously showed that TRPC3 and TRPC6 double knockout animals have deficits in light touch and hearing whilst single knockouts were apparently normal. We have extended these studies to analyse deficits in global quadruple TRPC1, 3, 5 and 6 null mutant mice. We examined both touch and hearing in behavioural and electrophysiological assays, and provide evidence that the quadruple knockout mice have larger deficits than the TRPC3 TRPC6 double knockouts. Mechano-electrical transducer currents of cochlear outer hair cells were however normal. This suggests that TRPC1, TRPC3, TRPC5 and TRPC6 channels contribute to cutaneous and auditory mechanosensation in a combinatorial manner, but have no direct role in cochlear mechanotransduction.
Fil: Sexton, Jane E.. University College London; Reino Unido
Fil: Desmonds, Terri. University of Sussex; Reino Unido
Fil: Quick, Kathryn. University College London; Reino Unido
Fil: Taylor, Ruth. University College London; Reino Unido
Fil: Abramowitz, Joel. National Institute of Environmental Health Sciences; Estados Unidos
Fil: Forge, Andy. University College London; Reino Unido
Fil: Kros, Corné J.. University of Sussex; Reino Unido. University of Groningen; Países Bajos
Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. National Institute of Environmental Health Sciences; Estados Unidos
Fil: Wood, John N.. University College London; Reino Unido
description Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features of TRP channels include their high structural homology and their propensity to form heteromeric complexes which suggests potential functional redundancy. We previously showed that TRPC3 and TRPC6 double knockout animals have deficits in light touch and hearing whilst single knockouts were apparently normal. We have extended these studies to analyse deficits in global quadruple TRPC1, 3, 5 and 6 null mutant mice. We examined both touch and hearing in behavioural and electrophysiological assays, and provide evidence that the quadruple knockout mice have larger deficits than the TRPC3 TRPC6 double knockouts. Mechano-electrical transducer currents of cochlear outer hair cells were however normal. This suggests that TRPC1, TRPC3, TRPC5 and TRPC6 channels contribute to cutaneous and auditory mechanosensation in a combinatorial manner, but have no direct role in cochlear mechanotransduction.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/49344
Sexton, Jane E.; Desmonds, Terri; Quick, Kathryn; Taylor, Ruth; Abramowitz, Joel; et al.; The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing; Elsevier Ireland; Neuroscience Letters; 610; 1-2016; 36-42
0304-3940
CONICET Digital
CONICET
url http://hdl.handle.net/11336/49344
identifier_str_mv Sexton, Jane E.; Desmonds, Terri; Quick, Kathryn; Taylor, Ruth; Abramowitz, Joel; et al.; The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing; Elsevier Ireland; Neuroscience Letters; 610; 1-2016; 36-42
0304-3940
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304394015302159
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neulet.2015.10.052
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683096/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082796868599808
score 13.22299

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