Current state and future prospects of immunotherapy for glioma

Autores
Kamran, Neha; Alghamri, Mahmoud S.; Nunez, Felipe J.; Shah, Diana; Asad, Antonela Sofía; Candolfi, Marianela; Altshuler, David; Lowenstein, Pedro R.; Castro, Maria G.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is a large unmet need for effective therapeutic approaches for glioma, the most malignant brain tumor. Clinical and preclinical studies have enormously expanded our knowledge about the molecular aspects of this deadly disease and its interaction with the host immune system. In this review we highlight the wide array of immunotherapeutic interventions that are currently being tested in glioma patients. Given the molecular heterogeneity, tumor immunoediting and the profound immunosuppression that characterize glioma, it has become clear that combinatorial approaches targeting multiple pathways tailored to the genetic signature of the tumor will be required in order to achieve optimal therapeutic efficacy.
Fil: Kamran, Neha. University of Michigan; Estados Unidos
Fil: Alghamri, Mahmoud S.. University of Michigan; Estados Unidos
Fil: Nunez, Felipe J.. University of Michigan; Estados Unidos
Fil: Shah, Diana. University of Michigan; Estados Unidos
Fil: Asad, Antonela Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Altshuler, David. University of Michigan; Estados Unidos
Fil: Lowenstein, Pedro R.. University of Michigan; Estados Unidos
Fil: Castro, Maria G.. University of Michigan; Estados Unidos
Materia
CANCER VACCINES
CHECKPOINT BLOCKADE
GENE THERAPY
GLIOMA
IMMUNOTHERAPY
PASSIVE IMMUNOTHERAPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86972
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Current state and future prospects of immunotherapy for gliomaKamran, NehaAlghamri, Mahmoud S.Nunez, Felipe J.Shah, DianaAsad, Antonela SofíaCandolfi, MarianelaAltshuler, DavidLowenstein, Pedro R.Castro, Maria G.CANCER VACCINESCHECKPOINT BLOCKADEGENE THERAPYGLIOMAIMMUNOTHERAPYPASSIVE IMMUNOTHERAPYhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3There is a large unmet need for effective therapeutic approaches for glioma, the most malignant brain tumor. Clinical and preclinical studies have enormously expanded our knowledge about the molecular aspects of this deadly disease and its interaction with the host immune system. In this review we highlight the wide array of immunotherapeutic interventions that are currently being tested in glioma patients. Given the molecular heterogeneity, tumor immunoediting and the profound immunosuppression that characterize glioma, it has become clear that combinatorial approaches targeting multiple pathways tailored to the genetic signature of the tumor will be required in order to achieve optimal therapeutic efficacy.Fil: Kamran, Neha. University of Michigan; Estados UnidosFil: Alghamri, Mahmoud S.. University of Michigan; Estados UnidosFil: Nunez, Felipe J.. University of Michigan; Estados UnidosFil: Shah, Diana. University of Michigan; Estados UnidosFil: Asad, Antonela Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Altshuler, David. University of Michigan; Estados UnidosFil: Lowenstein, Pedro R.. University of Michigan; Estados UnidosFil: Castro, Maria G.. University of Michigan; Estados UnidosFuture Medicine2018-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86972Kamran, Neha; Alghamri, Mahmoud S.; Nunez, Felipe J.; Shah, Diana; Asad, Antonela Sofía; et al.; Current state and future prospects of immunotherapy for glioma; Future Medicine; Immunotherapy; 10; 4; 3-2018; 317-3391750-743XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/imt-2017-0122info:eu-repo/semantics/altIdentifier/doi/10.2217/imt-2017-0122info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:02:31Zoai:ri.conicet.gov.ar:11336/86972instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:02:31.865CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Current state and future prospects of immunotherapy for glioma
title Current state and future prospects of immunotherapy for glioma
spellingShingle Current state and future prospects of immunotherapy for glioma
Kamran, Neha
CANCER VACCINES
CHECKPOINT BLOCKADE
GENE THERAPY
GLIOMA
IMMUNOTHERAPY
PASSIVE IMMUNOTHERAPY
title_short Current state and future prospects of immunotherapy for glioma
title_full Current state and future prospects of immunotherapy for glioma
title_fullStr Current state and future prospects of immunotherapy for glioma
title_full_unstemmed Current state and future prospects of immunotherapy for glioma
title_sort Current state and future prospects of immunotherapy for glioma
dc.creator.none.fl_str_mv Kamran, Neha
Alghamri, Mahmoud S.
Nunez, Felipe J.
Shah, Diana
Asad, Antonela Sofía
Candolfi, Marianela
Altshuler, David
Lowenstein, Pedro R.
Castro, Maria G.
author Kamran, Neha
author_facet Kamran, Neha
Alghamri, Mahmoud S.
Nunez, Felipe J.
Shah, Diana
Asad, Antonela Sofía
Candolfi, Marianela
Altshuler, David
Lowenstein, Pedro R.
Castro, Maria G.
author_role author
author2 Alghamri, Mahmoud S.
Nunez, Felipe J.
Shah, Diana
Asad, Antonela Sofía
Candolfi, Marianela
Altshuler, David
Lowenstein, Pedro R.
Castro, Maria G.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CANCER VACCINES
CHECKPOINT BLOCKADE
GENE THERAPY
GLIOMA
IMMUNOTHERAPY
PASSIVE IMMUNOTHERAPY
topic CANCER VACCINES
CHECKPOINT BLOCKADE
GENE THERAPY
GLIOMA
IMMUNOTHERAPY
PASSIVE IMMUNOTHERAPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv There is a large unmet need for effective therapeutic approaches for glioma, the most malignant brain tumor. Clinical and preclinical studies have enormously expanded our knowledge about the molecular aspects of this deadly disease and its interaction with the host immune system. In this review we highlight the wide array of immunotherapeutic interventions that are currently being tested in glioma patients. Given the molecular heterogeneity, tumor immunoediting and the profound immunosuppression that characterize glioma, it has become clear that combinatorial approaches targeting multiple pathways tailored to the genetic signature of the tumor will be required in order to achieve optimal therapeutic efficacy.
Fil: Kamran, Neha. University of Michigan; Estados Unidos
Fil: Alghamri, Mahmoud S.. University of Michigan; Estados Unidos
Fil: Nunez, Felipe J.. University of Michigan; Estados Unidos
Fil: Shah, Diana. University of Michigan; Estados Unidos
Fil: Asad, Antonela Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Altshuler, David. University of Michigan; Estados Unidos
Fil: Lowenstein, Pedro R.. University of Michigan; Estados Unidos
Fil: Castro, Maria G.. University of Michigan; Estados Unidos
description There is a large unmet need for effective therapeutic approaches for glioma, the most malignant brain tumor. Clinical and preclinical studies have enormously expanded our knowledge about the molecular aspects of this deadly disease and its interaction with the host immune system. In this review we highlight the wide array of immunotherapeutic interventions that are currently being tested in glioma patients. Given the molecular heterogeneity, tumor immunoediting and the profound immunosuppression that characterize glioma, it has become clear that combinatorial approaches targeting multiple pathways tailored to the genetic signature of the tumor will be required in order to achieve optimal therapeutic efficacy.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86972
Kamran, Neha; Alghamri, Mahmoud S.; Nunez, Felipe J.; Shah, Diana; Asad, Antonela Sofía; et al.; Current state and future prospects of immunotherapy for glioma; Future Medicine; Immunotherapy; 10; 4; 3-2018; 317-339
1750-743X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86972
identifier_str_mv Kamran, Neha; Alghamri, Mahmoud S.; Nunez, Felipe J.; Shah, Diana; Asad, Antonela Sofía; et al.; Current state and future prospects of immunotherapy for glioma; Future Medicine; Immunotherapy; 10; 4; 3-2018; 317-339
1750-743X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/imt-2017-0122
info:eu-repo/semantics/altIdentifier/doi/10.2217/imt-2017-0122
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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