The temporal dynamics of enhancing a human declarative memory during reconsolidation

Autores
Coccoz, Veronica; Villalón Sandoval, Adolfo; Stehberg, Jimmy; Delorenzi, Alejandro
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
When a consolidated memory is reactivated, it can become labile and prone to enhancement or disruption, a process known as reconsolidation. The reconsolidation hypothesis has challenged the traditional view that memories after consolidation are fixed and unchangeable. Recent studies suggest that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new promise for the understanding of human memory persistence. Although reconsolidation studies typically use amnesic agents, it has also been shown that memory can be enhanced by pharmacological agents and real-life events during reconsolidation. Recently, we demonstrated that a mild stressor, cold pressor stress (CPS), can enhance human declarative memory during reconsolidation in a cued-recall test. Here we evaluate whether the recollection of 7- or 20-day-old long-term memories can be improved by exposure to two different neuromodulators: a mild stressor and glucose during reconsolidation. As expected, poor and very poor memory performance was found at the time of memory reactivation (days 6 and 20 after training). CPS during reconsolidation improved the long-term expression of a declarative memory 6 -but not 20-days after training. However, the administration of an oral source of glucose (juice), but not a diet juice, can enhance memory during reconsolidation even 20. days after training. Interestingly, when a recognition test was applied instead of a cued-recall test, memory performance was still robust at both 1 and 3. weeks after training. Here we show that the period in which this memory can be reactivated and become labile largely exceeds the period in which that memory is recalled, proving evidence that conscious access is not needed for reconsolidation. Present results are consistent with dissociation between the mechanisms mediating memory labilization and the mechanisms that underlie the behavioral expression of memory.
Fil: Coccoz, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Villalón Sandoval, Adolfo. Universidad Andrés Bello; Chile
Fil: Stehberg, Jimmy. Universidad Andrés Bello; Chile
Fil: Delorenzi, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Materia
FORGETTING
MEMORY ENHANCEMENT
MEMORY EXPRESSION
MEMORY MODULATION
PERSISTENCE
RECONSOLIDATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182462

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network_name_str CONICET Digital (CONICET)
spelling The temporal dynamics of enhancing a human declarative memory during reconsolidationCoccoz, VeronicaVillalón Sandoval, AdolfoStehberg, JimmyDelorenzi, AlejandroFORGETTINGMEMORY ENHANCEMENTMEMORY EXPRESSIONMEMORY MODULATIONPERSISTENCERECONSOLIDATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1When a consolidated memory is reactivated, it can become labile and prone to enhancement or disruption, a process known as reconsolidation. The reconsolidation hypothesis has challenged the traditional view that memories after consolidation are fixed and unchangeable. Recent studies suggest that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new promise for the understanding of human memory persistence. Although reconsolidation studies typically use amnesic agents, it has also been shown that memory can be enhanced by pharmacological agents and real-life events during reconsolidation. Recently, we demonstrated that a mild stressor, cold pressor stress (CPS), can enhance human declarative memory during reconsolidation in a cued-recall test. Here we evaluate whether the recollection of 7- or 20-day-old long-term memories can be improved by exposure to two different neuromodulators: a mild stressor and glucose during reconsolidation. As expected, poor and very poor memory performance was found at the time of memory reactivation (days 6 and 20 after training). CPS during reconsolidation improved the long-term expression of a declarative memory 6 -but not 20-days after training. However, the administration of an oral source of glucose (juice), but not a diet juice, can enhance memory during reconsolidation even 20. days after training. Interestingly, when a recognition test was applied instead of a cued-recall test, memory performance was still robust at both 1 and 3. weeks after training. Here we show that the period in which this memory can be reactivated and become labile largely exceeds the period in which that memory is recalled, proving evidence that conscious access is not needed for reconsolidation. Present results are consistent with dissociation between the mechanisms mediating memory labilization and the mechanisms that underlie the behavioral expression of memory.Fil: Coccoz, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Villalón Sandoval, Adolfo. Universidad Andrés Bello; ChileFil: Stehberg, Jimmy. Universidad Andrés Bello; ChileFil: Delorenzi, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaPergamon-Elsevier Science Ltd2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182462Coccoz, Veronica; Villalón Sandoval, Adolfo; Stehberg, Jimmy; Delorenzi, Alejandro; The temporal dynamics of enhancing a human declarative memory during reconsolidation; Pergamon-Elsevier Science Ltd; Neuroscience; 246; 8-2013; 397-4080306-4522CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0306452213003588info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2013.04.033info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:53:24Zoai:ri.conicet.gov.ar:11336/182462instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:53:25.299CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The temporal dynamics of enhancing a human declarative memory during reconsolidation
title The temporal dynamics of enhancing a human declarative memory during reconsolidation
spellingShingle The temporal dynamics of enhancing a human declarative memory during reconsolidation
Coccoz, Veronica
FORGETTING
MEMORY ENHANCEMENT
MEMORY EXPRESSION
MEMORY MODULATION
PERSISTENCE
RECONSOLIDATION
title_short The temporal dynamics of enhancing a human declarative memory during reconsolidation
title_full The temporal dynamics of enhancing a human declarative memory during reconsolidation
title_fullStr The temporal dynamics of enhancing a human declarative memory during reconsolidation
title_full_unstemmed The temporal dynamics of enhancing a human declarative memory during reconsolidation
title_sort The temporal dynamics of enhancing a human declarative memory during reconsolidation
dc.creator.none.fl_str_mv Coccoz, Veronica
Villalón Sandoval, Adolfo
Stehberg, Jimmy
Delorenzi, Alejandro
author Coccoz, Veronica
author_facet Coccoz, Veronica
Villalón Sandoval, Adolfo
Stehberg, Jimmy
Delorenzi, Alejandro
author_role author
author2 Villalón Sandoval, Adolfo
Stehberg, Jimmy
Delorenzi, Alejandro
author2_role author
author
author
dc.subject.none.fl_str_mv FORGETTING
MEMORY ENHANCEMENT
MEMORY EXPRESSION
MEMORY MODULATION
PERSISTENCE
RECONSOLIDATION
topic FORGETTING
MEMORY ENHANCEMENT
MEMORY EXPRESSION
MEMORY MODULATION
PERSISTENCE
RECONSOLIDATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv When a consolidated memory is reactivated, it can become labile and prone to enhancement or disruption, a process known as reconsolidation. The reconsolidation hypothesis has challenged the traditional view that memories after consolidation are fixed and unchangeable. Recent studies suggest that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new promise for the understanding of human memory persistence. Although reconsolidation studies typically use amnesic agents, it has also been shown that memory can be enhanced by pharmacological agents and real-life events during reconsolidation. Recently, we demonstrated that a mild stressor, cold pressor stress (CPS), can enhance human declarative memory during reconsolidation in a cued-recall test. Here we evaluate whether the recollection of 7- or 20-day-old long-term memories can be improved by exposure to two different neuromodulators: a mild stressor and glucose during reconsolidation. As expected, poor and very poor memory performance was found at the time of memory reactivation (days 6 and 20 after training). CPS during reconsolidation improved the long-term expression of a declarative memory 6 -but not 20-days after training. However, the administration of an oral source of glucose (juice), but not a diet juice, can enhance memory during reconsolidation even 20. days after training. Interestingly, when a recognition test was applied instead of a cued-recall test, memory performance was still robust at both 1 and 3. weeks after training. Here we show that the period in which this memory can be reactivated and become labile largely exceeds the period in which that memory is recalled, proving evidence that conscious access is not needed for reconsolidation. Present results are consistent with dissociation between the mechanisms mediating memory labilization and the mechanisms that underlie the behavioral expression of memory.
Fil: Coccoz, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Villalón Sandoval, Adolfo. Universidad Andrés Bello; Chile
Fil: Stehberg, Jimmy. Universidad Andrés Bello; Chile
Fil: Delorenzi, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
description When a consolidated memory is reactivated, it can become labile and prone to enhancement or disruption, a process known as reconsolidation. The reconsolidation hypothesis has challenged the traditional view that memories after consolidation are fixed and unchangeable. Recent studies suggest that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new promise for the understanding of human memory persistence. Although reconsolidation studies typically use amnesic agents, it has also been shown that memory can be enhanced by pharmacological agents and real-life events during reconsolidation. Recently, we demonstrated that a mild stressor, cold pressor stress (CPS), can enhance human declarative memory during reconsolidation in a cued-recall test. Here we evaluate whether the recollection of 7- or 20-day-old long-term memories can be improved by exposure to two different neuromodulators: a mild stressor and glucose during reconsolidation. As expected, poor and very poor memory performance was found at the time of memory reactivation (days 6 and 20 after training). CPS during reconsolidation improved the long-term expression of a declarative memory 6 -but not 20-days after training. However, the administration of an oral source of glucose (juice), but not a diet juice, can enhance memory during reconsolidation even 20. days after training. Interestingly, when a recognition test was applied instead of a cued-recall test, memory performance was still robust at both 1 and 3. weeks after training. Here we show that the period in which this memory can be reactivated and become labile largely exceeds the period in which that memory is recalled, proving evidence that conscious access is not needed for reconsolidation. Present results are consistent with dissociation between the mechanisms mediating memory labilization and the mechanisms that underlie the behavioral expression of memory.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182462
Coccoz, Veronica; Villalón Sandoval, Adolfo; Stehberg, Jimmy; Delorenzi, Alejandro; The temporal dynamics of enhancing a human declarative memory during reconsolidation; Pergamon-Elsevier Science Ltd; Neuroscience; 246; 8-2013; 397-408
0306-4522
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182462
identifier_str_mv Coccoz, Veronica; Villalón Sandoval, Adolfo; Stehberg, Jimmy; Delorenzi, Alejandro; The temporal dynamics of enhancing a human declarative memory during reconsolidation; Pergamon-Elsevier Science Ltd; Neuroscience; 246; 8-2013; 397-408
0306-4522
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0306452213003588
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2013.04.033
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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