CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA

Autores
González Buitrón, Martín; Romario Tunque Cahui, Ronaldo; García Ríos, Emilio; Hirsh, Layla; Fornasari, Maria Silvina; Parisi, Gustavo Daniel; Palopoli, Nicolás
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Conformational changes in RNA native ensembles are central to fulfill many of their biological roles. Systematic knowledge of the extent and possible modulators of this conformational diversity is desirable to better understand the relationship between RNA dynamics and function.We have developed CoDNaS-RNA as the first database of conformational diversity in RNA molecules. Known RNA structures are retrieved and clustered to identify alternative conformers of each molecule. Pairwise structural comparisons within each cluster allows to measure the variability of the molecule. Additional data on structural features, molecular interactions and functional annotations are provided. CoDNaS-RNA is implemented as a public resource that can be of much interest for computational and bench scientists alike.
Fil: González Buitrón, Martín. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romario Tunque Cahui, Ronaldo. Pontificia Universidad Católica de Perú; Perú
Fil: García Ríos, Emilio. Pontificia Universidad Católica de Perú; Perú
Fil: Hirsh, Layla. Pontificia Universidad Católica de Perú; Perú
Fil: Fornasari, Maria Silvina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palopoli, Nicolás. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
RNA
DATABASE
CONFORMATIONAL DIVERSITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/169952
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNAGonzález Buitrón, MartínRomario Tunque Cahui, RonaldoGarcía Ríos, EmilioHirsh, LaylaFornasari, Maria SilvinaParisi, Gustavo DanielPalopoli, NicolásRNADATABASECONFORMATIONAL DIVERSITYhttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Conformational changes in RNA native ensembles are central to fulfill many of their biological roles. Systematic knowledge of the extent and possible modulators of this conformational diversity is desirable to better understand the relationship between RNA dynamics and function.We have developed CoDNaS-RNA as the first database of conformational diversity in RNA molecules. Known RNA structures are retrieved and clustered to identify alternative conformers of each molecule. Pairwise structural comparisons within each cluster allows to measure the variability of the molecule. Additional data on structural features, molecular interactions and functional annotations are provided. CoDNaS-RNA is implemented as a public resource that can be of much interest for computational and bench scientists alike.Fil: González Buitrón, Martín. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Romario Tunque Cahui, Ronaldo. Pontificia Universidad Católica de Perú; PerúFil: García Ríos, Emilio. Pontificia Universidad Católica de Perú; PerúFil: Hirsh, Layla. Pontificia Universidad Católica de Perú; PerúFil: Fornasari, Maria Silvina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Palopoli, Nicolás. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaCold Spring Harbor Laboratory2020-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/169952González Buitrón, Martín; Romario Tunque Cahui, Ronaldo; García Ríos, Emilio; Hirsh, Layla ; Fornasari, Maria Silvina; et al.; CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA; Cold Spring Harbor Laboratory; bioRxiv; 10-2020; 1-50362-4331CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2020.10.30.362590v1.fullinfo:eu-repo/semantics/altIdentifier/doi/10.1101/2020.10.30.362590info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:58Zoai:ri.conicet.gov.ar:11336/169952instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:58.752CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA
title CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA
spellingShingle CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA
González Buitrón, Martín
RNA
DATABASE
CONFORMATIONAL DIVERSITY
title_short CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA
title_full CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA
title_fullStr CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA
title_full_unstemmed CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA
title_sort CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA
dc.creator.none.fl_str_mv González Buitrón, Martín
Romario Tunque Cahui, Ronaldo
García Ríos, Emilio
Hirsh, Layla
Fornasari, Maria Silvina
Parisi, Gustavo Daniel
Palopoli, Nicolás
author González Buitrón, Martín
author_facet González Buitrón, Martín
Romario Tunque Cahui, Ronaldo
García Ríos, Emilio
Hirsh, Layla
Fornasari, Maria Silvina
Parisi, Gustavo Daniel
Palopoli, Nicolás
author_role author
author2 Romario Tunque Cahui, Ronaldo
García Ríos, Emilio
Hirsh, Layla
Fornasari, Maria Silvina
Parisi, Gustavo Daniel
Palopoli, Nicolás
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv RNA
DATABASE
CONFORMATIONAL DIVERSITY
topic RNA
DATABASE
CONFORMATIONAL DIVERSITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Conformational changes in RNA native ensembles are central to fulfill many of their biological roles. Systematic knowledge of the extent and possible modulators of this conformational diversity is desirable to better understand the relationship between RNA dynamics and function.We have developed CoDNaS-RNA as the first database of conformational diversity in RNA molecules. Known RNA structures are retrieved and clustered to identify alternative conformers of each molecule. Pairwise structural comparisons within each cluster allows to measure the variability of the molecule. Additional data on structural features, molecular interactions and functional annotations are provided. CoDNaS-RNA is implemented as a public resource that can be of much interest for computational and bench scientists alike.
Fil: González Buitrón, Martín. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romario Tunque Cahui, Ronaldo. Pontificia Universidad Católica de Perú; Perú
Fil: García Ríos, Emilio. Pontificia Universidad Católica de Perú; Perú
Fil: Hirsh, Layla. Pontificia Universidad Católica de Perú; Perú
Fil: Fornasari, Maria Silvina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palopoli, Nicolás. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Conformational changes in RNA native ensembles are central to fulfill many of their biological roles. Systematic knowledge of the extent and possible modulators of this conformational diversity is desirable to better understand the relationship between RNA dynamics and function.We have developed CoDNaS-RNA as the first database of conformational diversity in RNA molecules. Known RNA structures are retrieved and clustered to identify alternative conformers of each molecule. Pairwise structural comparisons within each cluster allows to measure the variability of the molecule. Additional data on structural features, molecular interactions and functional annotations are provided. CoDNaS-RNA is implemented as a public resource that can be of much interest for computational and bench scientists alike.
publishDate 2020
dc.date.none.fl_str_mv 2020-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/169952
González Buitrón, Martín; Romario Tunque Cahui, Ronaldo; García Ríos, Emilio; Hirsh, Layla ; Fornasari, Maria Silvina; et al.; CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA; Cold Spring Harbor Laboratory; bioRxiv; 10-2020; 1-5
0362-4331
CONICET Digital
CONICET
url http://hdl.handle.net/11336/169952
identifier_str_mv González Buitrón, Martín; Romario Tunque Cahui, Ronaldo; García Ríos, Emilio; Hirsh, Layla ; Fornasari, Maria Silvina; et al.; CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA; Cold Spring Harbor Laboratory; bioRxiv; 10-2020; 1-5
0362-4331
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2020.10.30.362590v1.full
info:eu-repo/semantics/altIdentifier/doi/10.1101/2020.10.30.362590
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory
publisher.none.fl_str_mv Cold Spring Harbor Laboratory
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613162837475328
score 13.070432

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