Factoring the brain signatures of anesthesia concentration and level of arousal across individuals

Autores
Barttfeld, Pablo; Bekinschtein, Tristán Andrés; Salles, Alejo; Agú, Emanuel José; Adapa, Ram; Menon, David; Sigman, Mariano
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants? level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex.
Fil: Barttfeld, Pablo. Universidad Torcuato Di Tella; Argentina
Fil: Bekinschtein, Tristán Andrés. University of Cambridge; Reino Unido
Fil: Salles, Alejo. Universidad Torcuato Di Tella; Argentina
Fil: Agú, Emanuel José. University of Cambridge; Estados Unidos
Fil: Adapa, Ram. University of Cambridge; Estados Unidos
Fil: Menon, David. University of Cambridge; Estados Unidos
Fil: Sigman, Mariano. Universidad Torcuato Di Tella; Argentina
Materia
Functional Connectivity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47878
Acceder
id CONICETDig_0cd31b953a48fee335497aaa978d25bb
oai_identifier_str oai:ri.conicet.gov.ar:11336/47878
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Factoring the brain signatures of anesthesia concentration and level of arousal across individualsBarttfeld, PabloBekinschtein, Tristán AndrésSalles, AlejoAgú, Emanuel JoséAdapa, RamMenon, DavidSigman, MarianoFunctional ConnectivityCombining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants? level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex.Fil: Barttfeld, Pablo. Universidad Torcuato Di Tella; ArgentinaFil: Bekinschtein, Tristán Andrés. University of Cambridge; Reino UnidoFil: Salles, Alejo. Universidad Torcuato Di Tella; ArgentinaFil: Agú, Emanuel José. University of Cambridge; Estados UnidosFil: Adapa, Ram. University of Cambridge; Estados UnidosFil: Menon, David. University of Cambridge; Estados UnidosFil: Sigman, Mariano. Universidad Torcuato Di Tella; ArgentinaAcademic Press Inc Elsevier Science2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47878Barttfeld, Pablo; Bekinschtein, Tristán Andrés; Salles, Alejo; Agú, Emanuel José; Adapa, Ram; et al.; Factoring the brain signatures of anesthesia concentration and level of arousal across individuals; Academic Press Inc Elsevier Science; Neuroimage; 9; 12-2015; 1-71053-8119CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2213158215001515info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nicl.2015.08.013info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T11:38:08Zoai:ri.conicet.gov.ar:11336/47878instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 11:38:08.38CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
title Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
spellingShingle Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
Barttfeld, Pablo
Functional Connectivity
title_short Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
title_full Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
title_fullStr Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
title_full_unstemmed Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
title_sort Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
dc.creator.none.fl_str_mv Barttfeld, Pablo
Bekinschtein, Tristán Andrés
Salles, Alejo
Agú, Emanuel José
Adapa, Ram
Menon, David
Sigman, Mariano
author Barttfeld, Pablo
author_facet Barttfeld, Pablo
Bekinschtein, Tristán Andrés
Salles, Alejo
Agú, Emanuel José
Adapa, Ram
Menon, David
Sigman, Mariano
author_role author
author2 Bekinschtein, Tristán Andrés
Salles, Alejo
Agú, Emanuel José
Adapa, Ram
Menon, David
Sigman, Mariano
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Functional Connectivity
topic Functional Connectivity
dc.description.none.fl_txt_mv Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants? level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex.
Fil: Barttfeld, Pablo. Universidad Torcuato Di Tella; Argentina
Fil: Bekinschtein, Tristán Andrés. University of Cambridge; Reino Unido
Fil: Salles, Alejo. Universidad Torcuato Di Tella; Argentina
Fil: Agú, Emanuel José. University of Cambridge; Estados Unidos
Fil: Adapa, Ram. University of Cambridge; Estados Unidos
Fil: Menon, David. University of Cambridge; Estados Unidos
Fil: Sigman, Mariano. Universidad Torcuato Di Tella; Argentina
description Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants? level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47878
Barttfeld, Pablo; Bekinschtein, Tristán Andrés; Salles, Alejo; Agú, Emanuel José; Adapa, Ram; et al.; Factoring the brain signatures of anesthesia concentration and level of arousal across individuals; Academic Press Inc Elsevier Science; Neuroimage; 9; 12-2015; 1-7
1053-8119
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47878
identifier_str_mv Barttfeld, Pablo; Bekinschtein, Tristán Andrés; Salles, Alejo; Agú, Emanuel José; Adapa, Ram; et al.; Factoring the brain signatures of anesthesia concentration and level of arousal across individuals; Academic Press Inc Elsevier Science; Neuroimage; 9; 12-2015; 1-7
1053-8119
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2213158215001515
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nicl.2015.08.013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847426219537072128
score 13.10058

Publicaciones similares