Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains

Autores
Baez, Alejandra Lidia; Lo Presti, Maria Silvina; Fretes, Ricardo; Diaz, Cintia; Pons, Patricia; Bazán, Paola Carolina; Strauss, Mariana; Rivarola, Héctor Walter; Paglini Oliva, Patricia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chagasic cardiopathy has become one of the most frequent causes of heart failure and sudden death, as well as one of the most common causes of cardio-embolic stroke in Latin America. The myocyte response to oxidative stress involves the progression of cellular changes, primarily targeting the mitochondria and modifying therefore the energy supply. In this paper we analysed the effect of the infection of mice with 2 different strains of Trypanosoma cruzi (Tulahuen and SGO Z12) in the chronic indeterminate stage (75 days post-infection), upon the structure and function of cardiac mitochondria. The structural results showed that 83% of the mitochondria from the Tulahuen-infected mice presented an increase in their matrix and 91% of the mitochondria from the SGO Z12-infected group showed a reduction in their diameter (P< 0·05). When the Krebs cycle and mitochondrial respiratory chain functionality was analysed through the measurement of the citrate synthase and complexes I to IV activity, it showed that their activity was altered in all cases in a similar manner in both infected groups. In this paper we have demonstrated that the chronic indeterminate phase is not ‘silent’ and that cardiac mitochondria are clearly involved in the genesis and progression to the chronic chagasic cardiopathy when different factors alter the host-parasite equilibrium.
Fil: Baez, Alejandra Lidia. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Fil: Fretes, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Histología y Embriología; Argentina
Fil: Diaz, Cintia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Histología y Embriología; Argentina
Fil: Pons, Patricia. Universidad Nacional de Cordoba. Facultad de Medicina. Centro de Microscopia Electronica; Argentina
Fil: Bazán, Paola Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Fil: Rivarola, Héctor Walter. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Fil: Paglini Oliva, Patricia. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Materia
Chagas' Disease
Indeterminate Phase
Mitochondria
Trypanosoma Cruzi Strains
Respiratory Chain
Myocardiopathy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11516

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network_name_str CONICET Digital (CONICET)
spelling Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strainsBaez, Alejandra LidiaLo Presti, Maria SilvinaFretes, RicardoDiaz, CintiaPons, PatriciaBazán, Paola CarolinaStrauss, MarianaRivarola, Héctor WalterPaglini Oliva, PatriciaChagas' DiseaseIndeterminate PhaseMitochondriaTrypanosoma Cruzi StrainsRespiratory ChainMyocardiopathyhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Chagasic cardiopathy has become one of the most frequent causes of heart failure and sudden death, as well as one of the most common causes of cardio-embolic stroke in Latin America. The myocyte response to oxidative stress involves the progression of cellular changes, primarily targeting the mitochondria and modifying therefore the energy supply. In this paper we analysed the effect of the infection of mice with 2 different strains of Trypanosoma cruzi (Tulahuen and SGO Z12) in the chronic indeterminate stage (75 days post-infection), upon the structure and function of cardiac mitochondria. The structural results showed that 83% of the mitochondria from the Tulahuen-infected mice presented an increase in their matrix and 91% of the mitochondria from the SGO Z12-infected group showed a reduction in their diameter (P< 0·05). When the Krebs cycle and mitochondrial respiratory chain functionality was analysed through the measurement of the citrate synthase and complexes I to IV activity, it showed that their activity was altered in all cases in a similar manner in both infected groups. In this paper we have demonstrated that the chronic indeterminate phase is not ‘silent’ and that cardiac mitochondria are clearly involved in the genesis and progression to the chronic chagasic cardiopathy when different factors alter the host-parasite equilibrium.Fil: Baez, Alejandra Lidia. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; ArgentinaFil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; ArgentinaFil: Fretes, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Histología y Embriología; ArgentinaFil: Diaz, Cintia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Histología y Embriología; ArgentinaFil: Pons, Patricia. Universidad Nacional de Cordoba. Facultad de Medicina. Centro de Microscopia Electronica; ArgentinaFil: Bazán, Paola Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; ArgentinaFil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; ArgentinaFil: Rivarola, Héctor Walter. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; ArgentinaFil: Paglini Oliva, Patricia. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; ArgentinaCambridge University Press2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11516Baez, Alejandra Lidia; Lo Presti, Maria Silvina; Fretes, Ricardo; Diaz, Cintia; Pons, Patricia; et al.; Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains; Cambridge University Press; Parasitology; 140; 3; 3-2013; 414-4210031-18201469-8161enginfo:eu-repo/semantics/altIdentifier/doi/10.1017/S0031182012001771info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/parasitology/article/chronic-indeterminate-phase-of-chagas-disease-mitochondrial-involvement-in-infection-with-two-strains/88FEE43DF8FF31E24614BE5C7E450719info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:56Zoai:ri.conicet.gov.ar:11336/11516instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:56.862CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains
title Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains
spellingShingle Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains
Baez, Alejandra Lidia
Chagas' Disease
Indeterminate Phase
Mitochondria
Trypanosoma Cruzi Strains
Respiratory Chain
Myocardiopathy
title_short Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains
title_full Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains
title_fullStr Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains
title_full_unstemmed Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains
title_sort Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains
dc.creator.none.fl_str_mv Baez, Alejandra Lidia
Lo Presti, Maria Silvina
Fretes, Ricardo
Diaz, Cintia
Pons, Patricia
Bazán, Paola Carolina
Strauss, Mariana
Rivarola, Héctor Walter
Paglini Oliva, Patricia
author Baez, Alejandra Lidia
author_facet Baez, Alejandra Lidia
Lo Presti, Maria Silvina
Fretes, Ricardo
Diaz, Cintia
Pons, Patricia
Bazán, Paola Carolina
Strauss, Mariana
Rivarola, Héctor Walter
Paglini Oliva, Patricia
author_role author
author2 Lo Presti, Maria Silvina
Fretes, Ricardo
Diaz, Cintia
Pons, Patricia
Bazán, Paola Carolina
Strauss, Mariana
Rivarola, Héctor Walter
Paglini Oliva, Patricia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chagas' Disease
Indeterminate Phase
Mitochondria
Trypanosoma Cruzi Strains
Respiratory Chain
Myocardiopathy
topic Chagas' Disease
Indeterminate Phase
Mitochondria
Trypanosoma Cruzi Strains
Respiratory Chain
Myocardiopathy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chagasic cardiopathy has become one of the most frequent causes of heart failure and sudden death, as well as one of the most common causes of cardio-embolic stroke in Latin America. The myocyte response to oxidative stress involves the progression of cellular changes, primarily targeting the mitochondria and modifying therefore the energy supply. In this paper we analysed the effect of the infection of mice with 2 different strains of Trypanosoma cruzi (Tulahuen and SGO Z12) in the chronic indeterminate stage (75 days post-infection), upon the structure and function of cardiac mitochondria. The structural results showed that 83% of the mitochondria from the Tulahuen-infected mice presented an increase in their matrix and 91% of the mitochondria from the SGO Z12-infected group showed a reduction in their diameter (P< 0·05). When the Krebs cycle and mitochondrial respiratory chain functionality was analysed through the measurement of the citrate synthase and complexes I to IV activity, it showed that their activity was altered in all cases in a similar manner in both infected groups. In this paper we have demonstrated that the chronic indeterminate phase is not ‘silent’ and that cardiac mitochondria are clearly involved in the genesis and progression to the chronic chagasic cardiopathy when different factors alter the host-parasite equilibrium.
Fil: Baez, Alejandra Lidia. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Fil: Fretes, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Histología y Embriología; Argentina
Fil: Diaz, Cintia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Histología y Embriología; Argentina
Fil: Pons, Patricia. Universidad Nacional de Cordoba. Facultad de Medicina. Centro de Microscopia Electronica; Argentina
Fil: Bazán, Paola Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Fil: Rivarola, Héctor Walter. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
Fil: Paglini Oliva, Patricia. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina
description Chagasic cardiopathy has become one of the most frequent causes of heart failure and sudden death, as well as one of the most common causes of cardio-embolic stroke in Latin America. The myocyte response to oxidative stress involves the progression of cellular changes, primarily targeting the mitochondria and modifying therefore the energy supply. In this paper we analysed the effect of the infection of mice with 2 different strains of Trypanosoma cruzi (Tulahuen and SGO Z12) in the chronic indeterminate stage (75 days post-infection), upon the structure and function of cardiac mitochondria. The structural results showed that 83% of the mitochondria from the Tulahuen-infected mice presented an increase in their matrix and 91% of the mitochondria from the SGO Z12-infected group showed a reduction in their diameter (P< 0·05). When the Krebs cycle and mitochondrial respiratory chain functionality was analysed through the measurement of the citrate synthase and complexes I to IV activity, it showed that their activity was altered in all cases in a similar manner in both infected groups. In this paper we have demonstrated that the chronic indeterminate phase is not ‘silent’ and that cardiac mitochondria are clearly involved in the genesis and progression to the chronic chagasic cardiopathy when different factors alter the host-parasite equilibrium.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11516
Baez, Alejandra Lidia; Lo Presti, Maria Silvina; Fretes, Ricardo; Diaz, Cintia; Pons, Patricia; et al.; Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains; Cambridge University Press; Parasitology; 140; 3; 3-2013; 414-421
0031-1820
1469-8161
url http://hdl.handle.net/11336/11516
identifier_str_mv Baez, Alejandra Lidia; Lo Presti, Maria Silvina; Fretes, Ricardo; Diaz, Cintia; Pons, Patricia; et al.; Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains; Cambridge University Press; Parasitology; 140; 3; 3-2013; 414-421
0031-1820
1469-8161
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1017/S0031182012001771
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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