Timely Questions Emerging in Chronobiology: The Circadian Clock Keeps on Ticking

• Autores: Chawla, Sangeeta; O'Neill, John; Knight, Marina I.; He, Yuqing; Wang, Lei; Maronde, Erik; Gil Rodríguez, Sergio; van Ooijen, Gerben; Garbarino Pico, Eduardo; Wolf, Eva; Dkhissi Benyahya, Ouria; Nikhat, Anjoom; Chakrabarti, Shaon; Youngstedt, Shawn D.; Zi Ching Mak, Natalie; Provencio, Ignacio; Oster, Henrik; Goel, Namni; Caba, Mario; Oosthuizen, Maria; Duffield, Giles E.; Chabot, Christopher; Davis, Seth J.
• Año de publicación: 2024
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Circadian rhythms; Biocondensates; Chronomedicine; Chronotherapy
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Chronobiology investigations have revealed much about cellular and physiological clockworks but we are far from having a complete mechanistic understanding of the physiological and ecological implications. Here we present some unresolved questions in circadian biology research as posed by the editorial staff and guest contributors to the Journal of Circadian Rhythms. This collection of ideas is not meant to be comprehensive but does reveal the breadth of our observations on emerging trends in chronobiology and circadian biology. It is amazing what could be achieved with various expected innovations in technologies, techniques, and mathematical tools that are being developed. We fully expect strengthening mechanistic work will be linked to health care and environmental understandings of circadian function. Now that most clock genes are known, linking these to physiological, metabolic, and developmental traits requires investigations from the single molecule to the terrestrial ecological scales. Real answers are expected for these questions over the next decade. Where are the circadian clocks at a cellular level? How are clocks coupled cellularly to generate organism level outcomes? How do communities of circadian organisms rhythmically interact with each other? In what way does the natural genetic variation in populations sculpt community behaviors? How will methods development for circadian research be used in disparate academic and commercial endeavors? These and other questions make it a very exciting time to be working as a chronobiologist.
Fil: Chawla, Sangeeta. University of York; Reino Unido
Fil: O'Neill, John. MRC Laboratory of Molecular Biology; Reino Unido
Fil: Knight, Marina I.. University of York; Reino Unido
Fil: He, Yuqing. China National Botanical Garden; China
Fil: Wang, Lei. China National Botanical Garden; China
Fil: Maronde, Erik. Goethe Universitat Frankfurt; Alemania
Fil: Gil Rodríguez, Sergio. University of Edinburgh; Reino Unido
Fil: van Ooijen, Gerben. University of Edinburgh; Reino Unido
Fil: Garbarino Pico, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Wolf, Eva. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Dkhissi Benyahya, Ouria. Inserm; Francia
Fil: Nikhat, Anjoom. Simons Centre for the Study of Living Machines; India
Fil: Chakrabarti, Shaon. Simons Centre for the Study of Living Machines; India
Fil: Youngstedt, Shawn D.. Arizona State University; Estados Unidos
Fil: Zi Ching Mak, Natalie. University of Arizona; Estados Unidos
Fil: Provencio, Ignacio. University of Virginia; Estados Unidos
Fil: Oster, Henrik. University of Luebeck; Alemania
Fil: Goel, Namni. Rush University Medical Center;
Fil: Caba, Mario. Universidad Veracruzana; México
Fil: Oosthuizen, Maria. University of Pretoria; Sudáfrica
Fil: Duffield, Giles E.. University of Notre Dame; Estados Unidos
Fil: Chabot, Christopher. Plymouth State University; Estados Unidos
Fil: Davis, Seth J.. University of York; Reino Unido