A critical period for experience-dependent remodeling of adult-born neuron connectivity

Autores
Bergami, Mateo; Masserdotti, Giacomo; Temprana, Silvio Gabriel; Motori, Elisa; Eriksson, Therese M.; Gobel, Jana; Yang, Sung Min; Conzelmann, Karl Kklaus; Schinder, Alejandro Fabian; Gotz, Magdalena; Berninger, Bunedikt
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes in their innervation following environmental enrichment (EE). We found that EE exposure between 2-6 weeks following neuron birth, rather than merely increasing the number of new neurons, profoundly affected their pattern of monosynaptic inputs. Both local innervation by interneurons and to even greater degree long-distance innervation by cortical neurons were markedly enhanced. Furthermore, following EE, new neurons received inputs from CA3 and CA1 inhibitory neurons that were rarely observed under control conditions. While EE-induced changes in inhibitory innervation were largely transient, cortical innervation remained increased after returning animals to control conditions. Our findings demonstrate an unprecedented experience-dependent reorganization of connections impinging onto adult-born neurons, which is likely to have important impact on their contribution to hippocampal information processing.
Fil: Bergami, Mateo. University Hospital of Cologne; Alemania. Ludwig Maximilians Universitat; Alemania
Fil: Masserdotti, Giacomo. Ludwig Maximilians Universitat; Alemania. Helmholtz Zentrum Munchen; Alemania
Fil: Temprana, Silvio Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Motori, Elisa. Max Planck Institute for Biology of Ageing; Alemania
Fil: Eriksson, Therese M.. University Hospital of Cologne; Alemania
Fil: Gobel, Jana. University Hospital of Cologne; Alemania
Fil: Yang, Sung Min. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Conzelmann, Karl Kklaus. Ludwig Maximilians Universitat; Alemania
Fil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Gotz, Magdalena. Ludwig Maximilians Universitat; Alemania. Helmholtz Zentrum Munchen; Alemania
Fil: Berninger, Bunedikt. Ludwig Maximilians Universitat; Alemania. University Medical Center of the Johannes Gutenberg University; Alemania
Materia
Adult Neurogenesis
Enriched Environment
Synaptogenesis
Critical Period
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15287
Acceder
id CONICETDig_0c2850555ada49d581d8b3f4e70fcf89
oai_identifier_str oai:ri.conicet.gov.ar:11336/15287
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A critical period for experience-dependent remodeling of adult-born neuron connectivityBergami, MateoMasserdotti, GiacomoTemprana, Silvio GabrielMotori, ElisaEriksson, Therese M.Gobel, JanaYang, Sung MinConzelmann, Karl KklausSchinder, Alejandro FabianGotz, MagdalenaBerninger, BunediktAdult NeurogenesisEnriched EnvironmentSynaptogenesisCritical Periodhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes in their innervation following environmental enrichment (EE). We found that EE exposure between 2-6 weeks following neuron birth, rather than merely increasing the number of new neurons, profoundly affected their pattern of monosynaptic inputs. Both local innervation by interneurons and to even greater degree long-distance innervation by cortical neurons were markedly enhanced. Furthermore, following EE, new neurons received inputs from CA3 and CA1 inhibitory neurons that were rarely observed under control conditions. While EE-induced changes in inhibitory innervation were largely transient, cortical innervation remained increased after returning animals to control conditions. Our findings demonstrate an unprecedented experience-dependent reorganization of connections impinging onto adult-born neurons, which is likely to have important impact on their contribution to hippocampal information processing.Fil: Bergami, Mateo. University Hospital of Cologne; Alemania. Ludwig Maximilians Universitat; AlemaniaFil: Masserdotti, Giacomo. Ludwig Maximilians Universitat; Alemania. Helmholtz Zentrum Munchen; AlemaniaFil: Temprana, Silvio Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; ArgentinaFil: Motori, Elisa. Max Planck Institute for Biology of Ageing; AlemaniaFil: Eriksson, Therese M.. University Hospital of Cologne; AlemaniaFil: Gobel, Jana. University Hospital of Cologne; AlemaniaFil: Yang, Sung Min. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; ArgentinaFil: Conzelmann, Karl Kklaus. Ludwig Maximilians Universitat; AlemaniaFil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; ArgentinaFil: Gotz, Magdalena. Ludwig Maximilians Universitat; Alemania. Helmholtz Zentrum Munchen; AlemaniaFil: Berninger, Bunedikt. Ludwig Maximilians Universitat; Alemania. University Medical Center of the Johannes Gutenberg University; AlemaniaCell Press2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15287Bergami, Mateo; Masserdotti, Giacomo; Temprana, Silvio Gabriel; Motori, Elisa; Eriksson, Therese M.; et al.; A critical period for experience-dependent remodeling of adult-born neuron connectivity; Cell Press; Neuron; 85; 4; 2-2015; 710-7171097-4199enginfo:eu-repo/semantics/altIdentifier/url/http://www.cell.com/neuron/fulltext/S0896-6273(15)00002-1info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2015.01.001info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896627315000021info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:37:54Zoai:ri.conicet.gov.ar:11336/15287instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:37:55.214CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A critical period for experience-dependent remodeling of adult-born neuron connectivity
title A critical period for experience-dependent remodeling of adult-born neuron connectivity
spellingShingle A critical period for experience-dependent remodeling of adult-born neuron connectivity
Bergami, Mateo
Adult Neurogenesis
Enriched Environment
Synaptogenesis
Critical Period
title_short A critical period for experience-dependent remodeling of adult-born neuron connectivity
title_full A critical period for experience-dependent remodeling of adult-born neuron connectivity
title_fullStr A critical period for experience-dependent remodeling of adult-born neuron connectivity
title_full_unstemmed A critical period for experience-dependent remodeling of adult-born neuron connectivity
title_sort A critical period for experience-dependent remodeling of adult-born neuron connectivity
dc.creator.none.fl_str_mv Bergami, Mateo
Masserdotti, Giacomo
Temprana, Silvio Gabriel
Motori, Elisa
Eriksson, Therese M.
Gobel, Jana
Yang, Sung Min
Conzelmann, Karl Kklaus
Schinder, Alejandro Fabian
Gotz, Magdalena
Berninger, Bunedikt
author Bergami, Mateo
author_facet Bergami, Mateo
Masserdotti, Giacomo
Temprana, Silvio Gabriel
Motori, Elisa
Eriksson, Therese M.
Gobel, Jana
Yang, Sung Min
Conzelmann, Karl Kklaus
Schinder, Alejandro Fabian
Gotz, Magdalena
Berninger, Bunedikt
author_role author
author2 Masserdotti, Giacomo
Temprana, Silvio Gabriel
Motori, Elisa
Eriksson, Therese M.
Gobel, Jana
Yang, Sung Min
Conzelmann, Karl Kklaus
Schinder, Alejandro Fabian
Gotz, Magdalena
Berninger, Bunedikt
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Adult Neurogenesis
Enriched Environment
Synaptogenesis
Critical Period
topic Adult Neurogenesis
Enriched Environment
Synaptogenesis
Critical Period
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes in their innervation following environmental enrichment (EE). We found that EE exposure between 2-6 weeks following neuron birth, rather than merely increasing the number of new neurons, profoundly affected their pattern of monosynaptic inputs. Both local innervation by interneurons and to even greater degree long-distance innervation by cortical neurons were markedly enhanced. Furthermore, following EE, new neurons received inputs from CA3 and CA1 inhibitory neurons that were rarely observed under control conditions. While EE-induced changes in inhibitory innervation were largely transient, cortical innervation remained increased after returning animals to control conditions. Our findings demonstrate an unprecedented experience-dependent reorganization of connections impinging onto adult-born neurons, which is likely to have important impact on their contribution to hippocampal information processing.
Fil: Bergami, Mateo. University Hospital of Cologne; Alemania. Ludwig Maximilians Universitat; Alemania
Fil: Masserdotti, Giacomo. Ludwig Maximilians Universitat; Alemania. Helmholtz Zentrum Munchen; Alemania
Fil: Temprana, Silvio Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Motori, Elisa. Max Planck Institute for Biology of Ageing; Alemania
Fil: Eriksson, Therese M.. University Hospital of Cologne; Alemania
Fil: Gobel, Jana. University Hospital of Cologne; Alemania
Fil: Yang, Sung Min. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Conzelmann, Karl Kklaus. Ludwig Maximilians Universitat; Alemania
Fil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Gotz, Magdalena. Ludwig Maximilians Universitat; Alemania. Helmholtz Zentrum Munchen; Alemania
Fil: Berninger, Bunedikt. Ludwig Maximilians Universitat; Alemania. University Medical Center of the Johannes Gutenberg University; Alemania
description Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes in their innervation following environmental enrichment (EE). We found that EE exposure between 2-6 weeks following neuron birth, rather than merely increasing the number of new neurons, profoundly affected their pattern of monosynaptic inputs. Both local innervation by interneurons and to even greater degree long-distance innervation by cortical neurons were markedly enhanced. Furthermore, following EE, new neurons received inputs from CA3 and CA1 inhibitory neurons that were rarely observed under control conditions. While EE-induced changes in inhibitory innervation were largely transient, cortical innervation remained increased after returning animals to control conditions. Our findings demonstrate an unprecedented experience-dependent reorganization of connections impinging onto adult-born neurons, which is likely to have important impact on their contribution to hippocampal information processing.
publishDate 2015
dc.date.none.fl_str_mv 2015-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15287
Bergami, Mateo; Masserdotti, Giacomo; Temprana, Silvio Gabriel; Motori, Elisa; Eriksson, Therese M.; et al.; A critical period for experience-dependent remodeling of adult-born neuron connectivity; Cell Press; Neuron; 85; 4; 2-2015; 710-717
1097-4199
url http://hdl.handle.net/11336/15287
identifier_str_mv Bergami, Mateo; Masserdotti, Giacomo; Temprana, Silvio Gabriel; Motori, Elisa; Eriksson, Therese M.; et al.; A critical period for experience-dependent remodeling of adult-born neuron connectivity; Cell Press; Neuron; 85; 4; 2-2015; 710-717
1097-4199
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.cell.com/neuron/fulltext/S0896-6273(15)00002-1
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2015.01.001
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896627315000021
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083498982506496
score 13.22299

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