Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations

Autores
Genaro, Ana Maria; Klecha, Alicia Juana; Frick, Luciana Romina; Barreiro Arcos, María Laura; Cremaschi, Graciela Alicia
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The interaction between the immune and the neuroendocrine systems involves, in a bidirectional circuit, shared cellular receptors and their coupled signaling pathways. Disruptions of this circuit lead to pathological situations. Between the endocrine factors, thyroid hormones show to play a role in immunomodulation, maintaining immune system homeostasis in response to stress-mediated immunosuppression. Several experimental evidences showed that hypothyroidism leads to a depression of humoral and cell-mediated immune responses, effects that were reversed by restoration of the euthyroid state. By other hand, chronic stressful situations impair T-cell mediated immunity, affecting the intracellular signals involved in lymphocyte activation. Consequently, a reduction in both T-cell dependent antibody production and lymphocyte function were also described. Besides, a decrease in thyroid hormone serum levels was observed in these conditions. These stress-induced endocrine-immune alterations impact in tumor development, as an enhancement of tumor growth was described in animal models of chronic stress. Interestingly, hormone replacement treatment of chronic stressed animals, which restored the euthyroid status, reversed the observed reduction of T-cell responses improving the outcome of tumor bearing animals. These evidences strengthen the important role that thyroid hormones play in immunomodulation, with a special emphasis in their participation as neuroendocrine regulators of stress-mediated immune deficit.
Fil: Genaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Klecha, Alicia Juana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Frick, Luciana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Barreiro Arcos, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Cremaschi, Graciela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Materia
IMMUNE SYSTEM
NEUROENDOCRINE SYSTEM
STRESS
THYROID HORMONES
TUMOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117854
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterationsGenaro, Ana MariaKlecha, Alicia JuanaFrick, Luciana RominaBarreiro Arcos, María LauraCremaschi, Graciela AliciaIMMUNE SYSTEMNEUROENDOCRINE SYSTEMSTRESSTHYROID HORMONESTUMORhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The interaction between the immune and the neuroendocrine systems involves, in a bidirectional circuit, shared cellular receptors and their coupled signaling pathways. Disruptions of this circuit lead to pathological situations. Between the endocrine factors, thyroid hormones show to play a role in immunomodulation, maintaining immune system homeostasis in response to stress-mediated immunosuppression. Several experimental evidences showed that hypothyroidism leads to a depression of humoral and cell-mediated immune responses, effects that were reversed by restoration of the euthyroid state. By other hand, chronic stressful situations impair T-cell mediated immunity, affecting the intracellular signals involved in lymphocyte activation. Consequently, a reduction in both T-cell dependent antibody production and lymphocyte function were also described. Besides, a decrease in thyroid hormone serum levels was observed in these conditions. These stress-induced endocrine-immune alterations impact in tumor development, as an enhancement of tumor growth was described in animal models of chronic stress. Interestingly, hormone replacement treatment of chronic stressed animals, which restored the euthyroid status, reversed the observed reduction of T-cell responses improving the outcome of tumor bearing animals. These evidences strengthen the important role that thyroid hormones play in immunomodulation, with a special emphasis in their participation as neuroendocrine regulators of stress-mediated immune deficit.Fil: Genaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Klecha, Alicia Juana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Frick, Luciana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Barreiro Arcos, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Cremaschi, Graciela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaBentham Science Publishers2009-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117854Genaro, Ana Maria; Klecha, Alicia Juana; Frick, Luciana Romina; Barreiro Arcos, María Laura; Cremaschi, Graciela Alicia; Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations; Bentham Science Publishers; Current Immunology Reviews; 6; 4; 10-2009; 339-3471573-3955CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/86958/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/1573395511006040339info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:07:04Zoai:ri.conicet.gov.ar:11336/117854instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:07:04.87CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations
title Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations
spellingShingle Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations
Genaro, Ana Maria
IMMUNE SYSTEM
NEUROENDOCRINE SYSTEM
STRESS
THYROID HORMONES
TUMOR
title_short Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations
title_full Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations
title_fullStr Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations
title_full_unstemmed Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations
title_sort Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations
dc.creator.none.fl_str_mv Genaro, Ana Maria
Klecha, Alicia Juana
Frick, Luciana Romina
Barreiro Arcos, María Laura
Cremaschi, Graciela Alicia
author Genaro, Ana Maria
author_facet Genaro, Ana Maria
Klecha, Alicia Juana
Frick, Luciana Romina
Barreiro Arcos, María Laura
Cremaschi, Graciela Alicia
author_role author
author2 Klecha, Alicia Juana
Frick, Luciana Romina
Barreiro Arcos, María Laura
Cremaschi, Graciela Alicia
author2_role author
author
author
author
dc.subject.none.fl_str_mv IMMUNE SYSTEM
NEUROENDOCRINE SYSTEM
STRESS
THYROID HORMONES
TUMOR
topic IMMUNE SYSTEM
NEUROENDOCRINE SYSTEM
STRESS
THYROID HORMONES
TUMOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The interaction between the immune and the neuroendocrine systems involves, in a bidirectional circuit, shared cellular receptors and their coupled signaling pathways. Disruptions of this circuit lead to pathological situations. Between the endocrine factors, thyroid hormones show to play a role in immunomodulation, maintaining immune system homeostasis in response to stress-mediated immunosuppression. Several experimental evidences showed that hypothyroidism leads to a depression of humoral and cell-mediated immune responses, effects that were reversed by restoration of the euthyroid state. By other hand, chronic stressful situations impair T-cell mediated immunity, affecting the intracellular signals involved in lymphocyte activation. Consequently, a reduction in both T-cell dependent antibody production and lymphocyte function were also described. Besides, a decrease in thyroid hormone serum levels was observed in these conditions. These stress-induced endocrine-immune alterations impact in tumor development, as an enhancement of tumor growth was described in animal models of chronic stress. Interestingly, hormone replacement treatment of chronic stressed animals, which restored the euthyroid status, reversed the observed reduction of T-cell responses improving the outcome of tumor bearing animals. These evidences strengthen the important role that thyroid hormones play in immunomodulation, with a special emphasis in their participation as neuroendocrine regulators of stress-mediated immune deficit.
Fil: Genaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Klecha, Alicia Juana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Frick, Luciana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Barreiro Arcos, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Cremaschi, Graciela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
description The interaction between the immune and the neuroendocrine systems involves, in a bidirectional circuit, shared cellular receptors and their coupled signaling pathways. Disruptions of this circuit lead to pathological situations. Between the endocrine factors, thyroid hormones show to play a role in immunomodulation, maintaining immune system homeostasis in response to stress-mediated immunosuppression. Several experimental evidences showed that hypothyroidism leads to a depression of humoral and cell-mediated immune responses, effects that were reversed by restoration of the euthyroid state. By other hand, chronic stressful situations impair T-cell mediated immunity, affecting the intracellular signals involved in lymphocyte activation. Consequently, a reduction in both T-cell dependent antibody production and lymphocyte function were also described. Besides, a decrease in thyroid hormone serum levels was observed in these conditions. These stress-induced endocrine-immune alterations impact in tumor development, as an enhancement of tumor growth was described in animal models of chronic stress. Interestingly, hormone replacement treatment of chronic stressed animals, which restored the euthyroid status, reversed the observed reduction of T-cell responses improving the outcome of tumor bearing animals. These evidences strengthen the important role that thyroid hormones play in immunomodulation, with a special emphasis in their participation as neuroendocrine regulators of stress-mediated immune deficit.
publishDate 2009
dc.date.none.fl_str_mv 2009-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117854
Genaro, Ana Maria; Klecha, Alicia Juana; Frick, Luciana Romina; Barreiro Arcos, María Laura; Cremaschi, Graciela Alicia; Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations; Bentham Science Publishers; Current Immunology Reviews; 6; 4; 10-2009; 339-347
1573-3955
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117854
identifier_str_mv Genaro, Ana Maria; Klecha, Alicia Juana; Frick, Luciana Romina; Barreiro Arcos, María Laura; Cremaschi, Graciela Alicia; Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations; Bentham Science Publishers; Current Immunology Reviews; 6; 4; 10-2009; 339-347
1573-3955
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/86958/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/1573395511006040339
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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