Isl1 is required for multiple aspects of motor neuron development

Autores
Liang, Xingqun; Song, Mi Ryoung; Xu, ZengGuang; Lanuza, Guillermo Marcos; Liu, Yali; Zhuang, Tao; Chen, Yihan; Pfaff, Samuel L; Evans, Sylvia M; Sun, Yunfu
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons.
Fil: Liang, Xingqun. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China. University Of California At San Diego; Estados Unidos
Fil: Song, Mi Ryoung. School of Life Sciences Gwangju Institute of Science and Technology. Bioimaging Research Center and Cell Dynamics Research Center; Corea del Sur
Fil: Xu, ZengGuang. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Liu, Yali. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
Fil: Zhuang, Tao. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
Fil: Chen, Yihan. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
Fil: Pfaff, Samuel L. The Salk Institute. Gene Expression Laboratory; Estados Unidos
Fil: Evans, Sylvia M. Institute of Science and Technology; Corea del Sur. University Of California At San Diego; Estados Unidos
Fil: Sun, Yunfu. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China. University Of California At San Diego; Estados Unidos
Materia
Motoneuron
Development
Spinal Cord
Specification
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12808
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/12808
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Isl1 is required for multiple aspects of motor neuron developmentLiang, XingqunSong, Mi RyoungXu, ZengGuangLanuza, Guillermo MarcosLiu, YaliZhuang, TaoChen, YihanPfaff, Samuel LEvans, Sylvia MSun, YunfuMotoneuronDevelopmentSpinal CordSpecificationhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons.Fil: Liang, Xingqun. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China. University Of California At San Diego; Estados UnidosFil: Song, Mi Ryoung. School of Life Sciences Gwangju Institute of Science and Technology. Bioimaging Research Center and Cell Dynamics Research Center; Corea del SurFil: Xu, ZengGuang. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; ChinaFil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; ArgentinaFil: Liu, Yali. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; ChinaFil: Zhuang, Tao. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; ChinaFil: Chen, Yihan. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; ChinaFil: Pfaff, Samuel L. The Salk Institute. Gene Expression Laboratory; Estados UnidosFil: Evans, Sylvia M. Institute of Science and Technology; Corea del Sur. University Of California At San Diego; Estados UnidosFil: Sun, Yunfu. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China. University Of California At San Diego; Estados UnidosElsevier2011-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12808Liang, Xingqun; Song, Mi Ryoung; Xu, ZengGuang; Lanuza, Guillermo Marcos; Liu, Yali; et al.; Isl1 is required for multiple aspects of motor neuron development; Elsevier; Molecular And Cellular Neurosciences.; 47; 3; 5-2011; 215-2221044-7431enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1044743111000923info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mcn.2011.04.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:42Zoai:ri.conicet.gov.ar:11336/12808instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:42.546CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Isl1 is required for multiple aspects of motor neuron development
title Isl1 is required for multiple aspects of motor neuron development
spellingShingle Isl1 is required for multiple aspects of motor neuron development
Liang, Xingqun
Motoneuron
Development
Spinal Cord
Specification
title_short Isl1 is required for multiple aspects of motor neuron development
title_full Isl1 is required for multiple aspects of motor neuron development
title_fullStr Isl1 is required for multiple aspects of motor neuron development
title_full_unstemmed Isl1 is required for multiple aspects of motor neuron development
title_sort Isl1 is required for multiple aspects of motor neuron development
dc.creator.none.fl_str_mv Liang, Xingqun
Song, Mi Ryoung
Xu, ZengGuang
Lanuza, Guillermo Marcos
Liu, Yali
Zhuang, Tao
Chen, Yihan
Pfaff, Samuel L
Evans, Sylvia M
Sun, Yunfu
author Liang, Xingqun
author_facet Liang, Xingqun
Song, Mi Ryoung
Xu, ZengGuang
Lanuza, Guillermo Marcos
Liu, Yali
Zhuang, Tao
Chen, Yihan
Pfaff, Samuel L
Evans, Sylvia M
Sun, Yunfu
author_role author
author2 Song, Mi Ryoung
Xu, ZengGuang
Lanuza, Guillermo Marcos
Liu, Yali
Zhuang, Tao
Chen, Yihan
Pfaff, Samuel L
Evans, Sylvia M
Sun, Yunfu
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Motoneuron
Development
Spinal Cord
Specification
topic Motoneuron
Development
Spinal Cord
Specification
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons.
Fil: Liang, Xingqun. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China. University Of California At San Diego; Estados Unidos
Fil: Song, Mi Ryoung. School of Life Sciences Gwangju Institute of Science and Technology. Bioimaging Research Center and Cell Dynamics Research Center; Corea del Sur
Fil: Xu, ZengGuang. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Liu, Yali. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
Fil: Zhuang, Tao. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
Fil: Chen, Yihan. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China
Fil: Pfaff, Samuel L. The Salk Institute. Gene Expression Laboratory; Estados Unidos
Fil: Evans, Sylvia M. Institute of Science and Technology; Corea del Sur. University Of California At San Diego; Estados Unidos
Fil: Sun, Yunfu. Tongji University. School of Medicine. Key Laboratory of Arrhythmia; China. University Of California At San Diego; Estados Unidos
description The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons.
publishDate 2011
dc.date.none.fl_str_mv 2011-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12808
Liang, Xingqun; Song, Mi Ryoung; Xu, ZengGuang; Lanuza, Guillermo Marcos; Liu, Yali; et al.; Isl1 is required for multiple aspects of motor neuron development; Elsevier; Molecular And Cellular Neurosciences.; 47; 3; 5-2011; 215-222
1044-7431
url http://hdl.handle.net/11336/12808
identifier_str_mv Liang, Xingqun; Song, Mi Ryoung; Xu, ZengGuang; Lanuza, Guillermo Marcos; Liu, Yali; et al.; Isl1 is required for multiple aspects of motor neuron development; Elsevier; Molecular And Cellular Neurosciences.; 47; 3; 5-2011; 215-222
1044-7431
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1044743111000923
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mcn.2011.04.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270055601012736
score 13.13397

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