Antiphospholipid antibodies impact the protein C (PC) pathway behavior

Autores
Gennari, Laura C.; Blanco, Alicia N.; Alberto, Maria Fabiana; Grosso, Silvia H.; Peirano, Andrea A.; Lazzari, María Ángela
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Antiphospholipid antibodies may interfere with the PC pathway, displaying a resistance to the activated PC (resistant phenotype). This effect was evaluated by the APCR and the ProCG systems in 36 lupus anticoagulant samples, yielding abnormal results in 47% of APCRoriginal, 17% of APCRmodified, and 22% of ProCG test. ProCG values correlated with APCRoriginal but not with APCRmodified. Most of lupus anticoagulants affecting the PC pathway showed abnormal APCRoriginal results but not abnormal ProCG values. The different behavior between both systems may be due to the heterogeneity of the antibodies or could be attributed to the fact that, in the ProCG, a PC activator is added, while the APCR employs already activated exogenous PC.
Fil: Gennari, Laura C.. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Blanco, Alicia N.. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Grosso, Silvia H.. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Peirano, Andrea A.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
Activated Protein C Resistance
Anticardiolipin Antibodies
Lupus Coagulation Inhibitor
Protein C
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55309
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Antiphospholipid antibodies impact the protein C (PC) pathway behaviorGennari, Laura C.Blanco, Alicia N.Alberto, Maria FabianaGrosso, Silvia H.Peirano, Andrea A.Lazzari, María ÁngelaActivated Protein C ResistanceAnticardiolipin AntibodiesLupus Coagulation InhibitorProtein CAntiphospholipid antibodies may interfere with the PC pathway, displaying a resistance to the activated PC (resistant phenotype). This effect was evaluated by the APCR and the ProCG systems in 36 lupus anticoagulant samples, yielding abnormal results in 47% of APCRoriginal, 17% of APCRmodified, and 22% of ProCG test. ProCG values correlated with APCRoriginal but not with APCRmodified. Most of lupus anticoagulants affecting the PC pathway showed abnormal APCRoriginal results but not abnormal ProCG values. The different behavior between both systems may be due to the heterogeneity of the antibodies or could be attributed to the fact that, in the ProCG, a PC activator is added, while the APCR employs already activated exogenous PC.Fil: Gennari, Laura C.. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; ArgentinaFil: Blanco, Alicia N.. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; ArgentinaFil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; ArgentinaFil: Grosso, Silvia H.. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; ArgentinaFil: Peirano, Andrea A.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaWiley-liss, Div John Wiley & Sons Inc2002-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55309Gennari, Laura C.; Blanco, Alicia N.; Alberto, Maria Fabiana; Grosso, Silvia H.; Peirano, Andrea A.; et al.; Antiphospholipid antibodies impact the protein C (PC) pathway behavior; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Hematology; 71; 2; 10-2002; 128-1300361-86091096-8652CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ajh.10180info:eu-repo/semantics/altIdentifier/doi/10.1002/ajh.10180info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:00:16Zoai:ri.conicet.gov.ar:11336/55309instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:00:17.086CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antiphospholipid antibodies impact the protein C (PC) pathway behavior
title Antiphospholipid antibodies impact the protein C (PC) pathway behavior
spellingShingle Antiphospholipid antibodies impact the protein C (PC) pathway behavior
Gennari, Laura C.
Activated Protein C Resistance
Anticardiolipin Antibodies
Lupus Coagulation Inhibitor
Protein C
title_short Antiphospholipid antibodies impact the protein C (PC) pathway behavior
title_full Antiphospholipid antibodies impact the protein C (PC) pathway behavior
title_fullStr Antiphospholipid antibodies impact the protein C (PC) pathway behavior
title_full_unstemmed Antiphospholipid antibodies impact the protein C (PC) pathway behavior
title_sort Antiphospholipid antibodies impact the protein C (PC) pathway behavior
dc.creator.none.fl_str_mv Gennari, Laura C.
Blanco, Alicia N.
Alberto, Maria Fabiana
Grosso, Silvia H.
Peirano, Andrea A.
Lazzari, María Ángela
author Gennari, Laura C.
author_facet Gennari, Laura C.
Blanco, Alicia N.
Alberto, Maria Fabiana
Grosso, Silvia H.
Peirano, Andrea A.
Lazzari, María Ángela
author_role author
author2 Blanco, Alicia N.
Alberto, Maria Fabiana
Grosso, Silvia H.
Peirano, Andrea A.
Lazzari, María Ángela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Activated Protein C Resistance
Anticardiolipin Antibodies
Lupus Coagulation Inhibitor
Protein C
topic Activated Protein C Resistance
Anticardiolipin Antibodies
Lupus Coagulation Inhibitor
Protein C
dc.description.none.fl_txt_mv Antiphospholipid antibodies may interfere with the PC pathway, displaying a resistance to the activated PC (resistant phenotype). This effect was evaluated by the APCR and the ProCG systems in 36 lupus anticoagulant samples, yielding abnormal results in 47% of APCRoriginal, 17% of APCRmodified, and 22% of ProCG test. ProCG values correlated with APCRoriginal but not with APCRmodified. Most of lupus anticoagulants affecting the PC pathway showed abnormal APCRoriginal results but not abnormal ProCG values. The different behavior between both systems may be due to the heterogeneity of the antibodies or could be attributed to the fact that, in the ProCG, a PC activator is added, while the APCR employs already activated exogenous PC.
Fil: Gennari, Laura C.. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Blanco, Alicia N.. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Grosso, Silvia H.. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina
Fil: Peirano, Andrea A.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description Antiphospholipid antibodies may interfere with the PC pathway, displaying a resistance to the activated PC (resistant phenotype). This effect was evaluated by the APCR and the ProCG systems in 36 lupus anticoagulant samples, yielding abnormal results in 47% of APCRoriginal, 17% of APCRmodified, and 22% of ProCG test. ProCG values correlated with APCRoriginal but not with APCRmodified. Most of lupus anticoagulants affecting the PC pathway showed abnormal APCRoriginal results but not abnormal ProCG values. The different behavior between both systems may be due to the heterogeneity of the antibodies or could be attributed to the fact that, in the ProCG, a PC activator is added, while the APCR employs already activated exogenous PC.
publishDate 2002
dc.date.none.fl_str_mv 2002-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55309
Gennari, Laura C.; Blanco, Alicia N.; Alberto, Maria Fabiana; Grosso, Silvia H.; Peirano, Andrea A.; et al.; Antiphospholipid antibodies impact the protein C (PC) pathway behavior; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Hematology; 71; 2; 10-2002; 128-130
0361-8609
1096-8652
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55309
identifier_str_mv Gennari, Laura C.; Blanco, Alicia N.; Alberto, Maria Fabiana; Grosso, Silvia H.; Peirano, Andrea A.; et al.; Antiphospholipid antibodies impact the protein C (PC) pathway behavior; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Hematology; 71; 2; 10-2002; 128-130
0361-8609
1096-8652
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ajh.10180
info:eu-repo/semantics/altIdentifier/doi/10.1002/ajh.10180
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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