Breast cancer analysis by confocal energy dispersive micro-XRD

Autores
Escudero, Rodrigo Oscar; Cabral, María C.; Valladares, Mariana; Franco, María A.; Perez, Roberto Daniel
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work, the confocal energy dispersive micro-XRD technique has been employed to efficiently study differences between normal and malignant carcinomas in breast tissues. This technique has been implemented with low angular divergence glass monocapillaries in the excitation and detection channels. The microdiffractometer operates with a scattering angle of (20.3 ± 0.9)° that defines a cross section for analysis (0.178 mm × 0.175 mm), with a depth resolution of 1.18 mm. The obtained momentum transfer resolution between 3.9 and 10.9% was found to be highly useful to identify the scattering profiles of adipose tissues without any data processing. Differentiation between tissues with similar scattering profiles, such as fibroglandular and neoplastic tissues, has been achieved by processing the spectra within the framework of diffraction theory for scattering intensity. The obtained results allowed the development of a deterministic diagnostic model based on the evaluation of the depth profiles by confocal micro-XRD. In this model, the modulation of the scattering profiles caused by X-ray attenuation was analyzed to differentiate neoplastic tissues. The spatial resolution of the technique was the key aspect of the process, helping to detect variations in X-ray attenuation and to select uniform volume of analysis without superimposed scattering profiles.
Fil: Escudero, Rodrigo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Cabral, María C.. Hospital Provincial Maternal Dr. Felipe Lucini; Argentina
Fil: Valladares, Mariana. Hospital Provincial Maternal Dr. Felipe Lucini; Argentina
Fil: Franco, María A.. Hospital Provincial Maternal Dr. Felipe Lucini; Argentina
Fil: Perez, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Materia
Micro-XRD
Confocal
Breast cancer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/137094
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Breast cancer analysis by confocal energy dispersive micro-XRDEscudero, Rodrigo OscarCabral, María C.Valladares, MarianaFranco, María A.Perez, Roberto DanielMicro-XRDConfocalBreast cancerhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1In this work, the confocal energy dispersive micro-XRD technique has been employed to efficiently study differences between normal and malignant carcinomas in breast tissues. This technique has been implemented with low angular divergence glass monocapillaries in the excitation and detection channels. The microdiffractometer operates with a scattering angle of (20.3 ± 0.9)° that defines a cross section for analysis (0.178 mm × 0.175 mm), with a depth resolution of 1.18 mm. The obtained momentum transfer resolution between 3.9 and 10.9% was found to be highly useful to identify the scattering profiles of adipose tissues without any data processing. Differentiation between tissues with similar scattering profiles, such as fibroglandular and neoplastic tissues, has been achieved by processing the spectra within the framework of diffraction theory for scattering intensity. The obtained results allowed the development of a deterministic diagnostic model based on the evaluation of the depth profiles by confocal micro-XRD. In this model, the modulation of the scattering profiles caused by X-ray attenuation was analyzed to differentiate neoplastic tissues. The spatial resolution of the technique was the key aspect of the process, helping to detect variations in X-ray attenuation and to select uniform volume of analysis without superimposed scattering profiles.Fil: Escudero, Rodrigo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Cabral, María C.. Hospital Provincial Maternal Dr. Felipe Lucini; ArgentinaFil: Valladares, Mariana. Hospital Provincial Maternal Dr. Felipe Lucini; ArgentinaFil: Franco, María A.. Hospital Provincial Maternal Dr. Felipe Lucini; ArgentinaFil: Perez, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaRoyal Society of Chemistry2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/137094Escudero, Rodrigo Oscar; Cabral, María C.; Valladares, Mariana; Franco, María A.; Perez, Roberto Daniel; Breast cancer analysis by confocal energy dispersive micro-XRD; Royal Society of Chemistry; Analytical Methods; 12; 9; 3-2020; 1250-12561759-96601759-9679CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=C9AY02183Cinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C9AY02183Cinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:35:39Zoai:ri.conicet.gov.ar:11336/137094instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:35:39.472CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Breast cancer analysis by confocal energy dispersive micro-XRD
title Breast cancer analysis by confocal energy dispersive micro-XRD
spellingShingle Breast cancer analysis by confocal energy dispersive micro-XRD
Escudero, Rodrigo Oscar
Micro-XRD
Confocal
Breast cancer
title_short Breast cancer analysis by confocal energy dispersive micro-XRD
title_full Breast cancer analysis by confocal energy dispersive micro-XRD
title_fullStr Breast cancer analysis by confocal energy dispersive micro-XRD
title_full_unstemmed Breast cancer analysis by confocal energy dispersive micro-XRD
title_sort Breast cancer analysis by confocal energy dispersive micro-XRD
dc.creator.none.fl_str_mv Escudero, Rodrigo Oscar
Cabral, María C.
Valladares, Mariana
Franco, María A.
Perez, Roberto Daniel
author Escudero, Rodrigo Oscar
author_facet Escudero, Rodrigo Oscar
Cabral, María C.
Valladares, Mariana
Franco, María A.
Perez, Roberto Daniel
author_role author
author2 Cabral, María C.
Valladares, Mariana
Franco, María A.
Perez, Roberto Daniel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Micro-XRD
Confocal
Breast cancer
topic Micro-XRD
Confocal
Breast cancer
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this work, the confocal energy dispersive micro-XRD technique has been employed to efficiently study differences between normal and malignant carcinomas in breast tissues. This technique has been implemented with low angular divergence glass monocapillaries in the excitation and detection channels. The microdiffractometer operates with a scattering angle of (20.3 ± 0.9)° that defines a cross section for analysis (0.178 mm × 0.175 mm), with a depth resolution of 1.18 mm. The obtained momentum transfer resolution between 3.9 and 10.9% was found to be highly useful to identify the scattering profiles of adipose tissues without any data processing. Differentiation between tissues with similar scattering profiles, such as fibroglandular and neoplastic tissues, has been achieved by processing the spectra within the framework of diffraction theory for scattering intensity. The obtained results allowed the development of a deterministic diagnostic model based on the evaluation of the depth profiles by confocal micro-XRD. In this model, the modulation of the scattering profiles caused by X-ray attenuation was analyzed to differentiate neoplastic tissues. The spatial resolution of the technique was the key aspect of the process, helping to detect variations in X-ray attenuation and to select uniform volume of analysis without superimposed scattering profiles.
Fil: Escudero, Rodrigo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Cabral, María C.. Hospital Provincial Maternal Dr. Felipe Lucini; Argentina
Fil: Valladares, Mariana. Hospital Provincial Maternal Dr. Felipe Lucini; Argentina
Fil: Franco, María A.. Hospital Provincial Maternal Dr. Felipe Lucini; Argentina
Fil: Perez, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
description In this work, the confocal energy dispersive micro-XRD technique has been employed to efficiently study differences between normal and malignant carcinomas in breast tissues. This technique has been implemented with low angular divergence glass monocapillaries in the excitation and detection channels. The microdiffractometer operates with a scattering angle of (20.3 ± 0.9)° that defines a cross section for analysis (0.178 mm × 0.175 mm), with a depth resolution of 1.18 mm. The obtained momentum transfer resolution between 3.9 and 10.9% was found to be highly useful to identify the scattering profiles of adipose tissues without any data processing. Differentiation between tissues with similar scattering profiles, such as fibroglandular and neoplastic tissues, has been achieved by processing the spectra within the framework of diffraction theory for scattering intensity. The obtained results allowed the development of a deterministic diagnostic model based on the evaluation of the depth profiles by confocal micro-XRD. In this model, the modulation of the scattering profiles caused by X-ray attenuation was analyzed to differentiate neoplastic tissues. The spatial resolution of the technique was the key aspect of the process, helping to detect variations in X-ray attenuation and to select uniform volume of analysis without superimposed scattering profiles.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/137094
Escudero, Rodrigo Oscar; Cabral, María C.; Valladares, Mariana; Franco, María A.; Perez, Roberto Daniel; Breast cancer analysis by confocal energy dispersive micro-XRD; Royal Society of Chemistry; Analytical Methods; 12; 9; 3-2020; 1250-1256
1759-9660
1759-9679
CONICET Digital
CONICET
url http://hdl.handle.net/11336/137094
identifier_str_mv Escudero, Rodrigo Oscar; Cabral, María C.; Valladares, Mariana; Franco, María A.; Perez, Roberto Daniel; Breast cancer analysis by confocal energy dispersive micro-XRD; Royal Society of Chemistry; Analytical Methods; 12; 9; 3-2020; 1250-1256
1759-9660
1759-9679
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=C9AY02183C
info:eu-repo/semantics/altIdentifier/doi/10.1039/C9AY02183C
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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