Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics

Autores
Hollmann, Axel; Martínez, Melina María Belén; Maturana, Patricia del Valle; Semorile, Liliana Carmen; Maffia, Paulo Cesar
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Antimicrobial peptides (AMPs) are promising novel antibiotics since they have shown antimicrobial activity against a wide range of bacterial species, including multiresistant bacteria; however, toxicity is the major barrier to convert antimicrobial peptides into active drugs. A profound and proper understanding of the complex interactions between these peptides and biological membranes using biophysical tools and model membranes seems to be a key factor in the race to develop a suitable antimicrobial peptide therapy for clinical use. In the search for such therapy, different combined approaches with conventional antibiotics have been evaluated in recent years and demonstrated to improve the therapeutic potential of AMPs. Some of these approaches have revealed promising additive or synergistic activity between AMPs and chemical antibiotics. This review will give an insight into the possibilities that physicochemical tools can give in the AMPs research and also address the state of the art on the current promising combined therapies between AMPs and conventional antibiotics, which appear to be a plausible future opportunity for AMPs treatment.
Fil: Hollmann, Axel. Universidad Nacional de Santiago del Estero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Martínez, Melina María Belén. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Maturana, Patricia del Valle. Universidad Nacional de Santiago del Estero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Semorile, Liliana Carmen. Universidad Nacional de Quilmes; Argentina
Fil: Maffia, Paulo Cesar. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ANTIMICROBIAL PEPTIDES
BIOPHYSICAL TOOLS
MODEL MEMBRANES
PEPTIDE-MEMBRANE INTERACTION
SYNERGISTIC EFFECT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/175936
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibioticsHollmann, AxelMartínez, Melina María BelénMaturana, Patricia del ValleSemorile, Liliana CarmenMaffia, Paulo CesarANTIMICROBIAL PEPTIDESBIOPHYSICAL TOOLSMODEL MEMBRANESPEPTIDE-MEMBRANE INTERACTIONSYNERGISTIC EFFECThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Antimicrobial peptides (AMPs) are promising novel antibiotics since they have shown antimicrobial activity against a wide range of bacterial species, including multiresistant bacteria; however, toxicity is the major barrier to convert antimicrobial peptides into active drugs. A profound and proper understanding of the complex interactions between these peptides and biological membranes using biophysical tools and model membranes seems to be a key factor in the race to develop a suitable antimicrobial peptide therapy for clinical use. In the search for such therapy, different combined approaches with conventional antibiotics have been evaluated in recent years and demonstrated to improve the therapeutic potential of AMPs. Some of these approaches have revealed promising additive or synergistic activity between AMPs and chemical antibiotics. This review will give an insight into the possibilities that physicochemical tools can give in the AMPs research and also address the state of the art on the current promising combined therapies between AMPs and conventional antibiotics, which appear to be a plausible future opportunity for AMPs treatment.Fil: Hollmann, Axel. Universidad Nacional de Santiago del Estero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Martínez, Melina María Belén. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Maturana, Patricia del Valle. Universidad Nacional de Santiago del Estero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Semorile, Liliana Carmen. Universidad Nacional de Quilmes; ArgentinaFil: Maffia, Paulo Cesar. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFrontiers Media2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/175936Hollmann, Axel; Martínez, Melina María Belén; Maturana, Patricia del Valle; Semorile, Liliana Carmen; Maffia, Paulo Cesar; Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics; Frontiers Media; Frontiers in Chemistry; 6; JUN; 6-2018; 1-132296-2646CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fchem.2018.00204/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fchem.2018.0020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:23:13Zoai:ri.conicet.gov.ar:11336/175936instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:23:13.517CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics
title Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics
spellingShingle Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics
Hollmann, Axel
ANTIMICROBIAL PEPTIDES
BIOPHYSICAL TOOLS
MODEL MEMBRANES
PEPTIDE-MEMBRANE INTERACTION
SYNERGISTIC EFFECT
title_short Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics
title_full Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics
title_fullStr Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics
title_full_unstemmed Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics
title_sort Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics
dc.creator.none.fl_str_mv Hollmann, Axel
Martínez, Melina María Belén
Maturana, Patricia del Valle
Semorile, Liliana Carmen
Maffia, Paulo Cesar
author Hollmann, Axel
author_facet Hollmann, Axel
Martínez, Melina María Belén
Maturana, Patricia del Valle
Semorile, Liliana Carmen
Maffia, Paulo Cesar
author_role author
author2 Martínez, Melina María Belén
Maturana, Patricia del Valle
Semorile, Liliana Carmen
Maffia, Paulo Cesar
author2_role author
author
author
author
dc.subject.none.fl_str_mv ANTIMICROBIAL PEPTIDES
BIOPHYSICAL TOOLS
MODEL MEMBRANES
PEPTIDE-MEMBRANE INTERACTION
SYNERGISTIC EFFECT
topic ANTIMICROBIAL PEPTIDES
BIOPHYSICAL TOOLS
MODEL MEMBRANES
PEPTIDE-MEMBRANE INTERACTION
SYNERGISTIC EFFECT
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Antimicrobial peptides (AMPs) are promising novel antibiotics since they have shown antimicrobial activity against a wide range of bacterial species, including multiresistant bacteria; however, toxicity is the major barrier to convert antimicrobial peptides into active drugs. A profound and proper understanding of the complex interactions between these peptides and biological membranes using biophysical tools and model membranes seems to be a key factor in the race to develop a suitable antimicrobial peptide therapy for clinical use. In the search for such therapy, different combined approaches with conventional antibiotics have been evaluated in recent years and demonstrated to improve the therapeutic potential of AMPs. Some of these approaches have revealed promising additive or synergistic activity between AMPs and chemical antibiotics. This review will give an insight into the possibilities that physicochemical tools can give in the AMPs research and also address the state of the art on the current promising combined therapies between AMPs and conventional antibiotics, which appear to be a plausible future opportunity for AMPs treatment.
Fil: Hollmann, Axel. Universidad Nacional de Santiago del Estero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Martínez, Melina María Belén. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Maturana, Patricia del Valle. Universidad Nacional de Santiago del Estero; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Semorile, Liliana Carmen. Universidad Nacional de Quilmes; Argentina
Fil: Maffia, Paulo Cesar. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Antimicrobial peptides (AMPs) are promising novel antibiotics since they have shown antimicrobial activity against a wide range of bacterial species, including multiresistant bacteria; however, toxicity is the major barrier to convert antimicrobial peptides into active drugs. A profound and proper understanding of the complex interactions between these peptides and biological membranes using biophysical tools and model membranes seems to be a key factor in the race to develop a suitable antimicrobial peptide therapy for clinical use. In the search for such therapy, different combined approaches with conventional antibiotics have been evaluated in recent years and demonstrated to improve the therapeutic potential of AMPs. Some of these approaches have revealed promising additive or synergistic activity between AMPs and chemical antibiotics. This review will give an insight into the possibilities that physicochemical tools can give in the AMPs research and also address the state of the art on the current promising combined therapies between AMPs and conventional antibiotics, which appear to be a plausible future opportunity for AMPs treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/175936
Hollmann, Axel; Martínez, Melina María Belén; Maturana, Patricia del Valle; Semorile, Liliana Carmen; Maffia, Paulo Cesar; Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics; Frontiers Media; Frontiers in Chemistry; 6; JUN; 6-2018; 1-13
2296-2646
CONICET Digital
CONICET
url http://hdl.handle.net/11336/175936
identifier_str_mv Hollmann, Axel; Martínez, Melina María Belén; Maturana, Patricia del Valle; Semorile, Liliana Carmen; Maffia, Paulo Cesar; Antimicrobial peptides: Interaction with model and biological membranes and synergism with chemical antibiotics; Frontiers Media; Frontiers in Chemistry; 6; JUN; 6-2018; 1-13
2296-2646
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fchem.2018.00204/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fchem.2018.0020
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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