Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects

Autores
Rind, F. Claire; Wernitznig, Stefan; Pölt, Peter; Zankel, Armin; Gütl, Daniel; Sztarker, Julieta; Leitinger, Gerd
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In locusts, two lobula giant movement detector neurons (LGMDs) act as looming object detectors. Their reproducible responses to looming and their ethological significance makes them models for single neuron computation. But there is no comprehensive picture of the neurons that connect directly to each LGMD. We used high-through-put serial block-face scanning-electron-microscopy to reconstruct the network of input-synapses onto the LGMDs over spatial scales ranging from single synapses and small circuits, up to dendritic branches and total excitatory input. Reconstructions reveal that many trans-medullary-afferents (TmAs) connect the eye with each LGMD, one TmA per facet per LGMD. But when a TmA synapses with an LGMD it also connects laterally with another TmA. These inter-TmA synapses are always reciprocal. Total excitatory input to the LGMD 1 and 2 comes from 131,000 and 186,000 synapses reaching densities of 3.1 and 2.6 synapses per μm 2 respectively. We explored the computational consequences of reciprocal synapses between each TmA and 6 others from neighbouring columns. Since any lateral interactions between LGMD inputs have always been inhibitory we may assume these reciprocal lateral connections are most likely inhibitory. Such reciprocal inhibitory synapses increased the LGMD's selectivity for looming over passing objects, particularly at the beginning of object approach.
Fil: Rind, F. Claire. University of Newcastle; Reino Unido. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; Austria
Fil: Wernitznig, Stefan. University of Newcastle; Reino Unido. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; Austria
Fil: Pölt, Peter. Graz University of Technology; Austria. Graz Centre for Electron Microscopy; Austria
Fil: Zankel, Armin. Graz University of Technology; Austria. Graz Centre for Electron Microscopy; Austria
Fil: Gütl, Daniel. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; Austria
Fil: Sztarker, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Leitinger, Gerd. University of Newcastle; Reino Unido. BioTechMed Graz; Austria
Materia
COLISION AVOIDANCE
LOCUST
LGMD
ELECTRON MICROSCOPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/61432
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/61432
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objectsRind, F. ClaireWernitznig, StefanPölt, PeterZankel, ArminGütl, DanielSztarker, JulietaLeitinger, GerdCOLISION AVOIDANCELOCUSTLGMDELECTRON MICROSCOPYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In locusts, two lobula giant movement detector neurons (LGMDs) act as looming object detectors. Their reproducible responses to looming and their ethological significance makes them models for single neuron computation. But there is no comprehensive picture of the neurons that connect directly to each LGMD. We used high-through-put serial block-face scanning-electron-microscopy to reconstruct the network of input-synapses onto the LGMDs over spatial scales ranging from single synapses and small circuits, up to dendritic branches and total excitatory input. Reconstructions reveal that many trans-medullary-afferents (TmAs) connect the eye with each LGMD, one TmA per facet per LGMD. But when a TmA synapses with an LGMD it also connects laterally with another TmA. These inter-TmA synapses are always reciprocal. Total excitatory input to the LGMD 1 and 2 comes from 131,000 and 186,000 synapses reaching densities of 3.1 and 2.6 synapses per μm 2 respectively. We explored the computational consequences of reciprocal synapses between each TmA and 6 others from neighbouring columns. Since any lateral interactions between LGMD inputs have always been inhibitory we may assume these reciprocal lateral connections are most likely inhibitory. Such reciprocal inhibitory synapses increased the LGMD's selectivity for looming over passing objects, particularly at the beginning of object approach.Fil: Rind, F. Claire. University of Newcastle; Reino Unido. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; AustriaFil: Wernitznig, Stefan. University of Newcastle; Reino Unido. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; AustriaFil: Pölt, Peter. Graz University of Technology; Austria. Graz Centre for Electron Microscopy; AustriaFil: Zankel, Armin. Graz University of Technology; Austria. Graz Centre for Electron Microscopy; AustriaFil: Gütl, Daniel. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; AustriaFil: Sztarker, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Leitinger, Gerd. University of Newcastle; Reino Unido. BioTechMed Graz; AustriaNature Publishing Group2016-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/61432Rind, F. Claire; Wernitznig, Stefan; Pölt, Peter; Zankel, Armin; Gütl, Daniel; et al.; Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects; Nature Publishing Group; Scientific Reports; 6; 10-2016; 1-162045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/srep35525info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep35525info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:10:12Zoai:ri.conicet.gov.ar:11336/61432instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:10:12.699CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects
title Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects
spellingShingle Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects
Rind, F. Claire
COLISION AVOIDANCE
LOCUST
LGMD
ELECTRON MICROSCOPY
title_short Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects
title_full Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects
title_fullStr Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects
title_full_unstemmed Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects
title_sort Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects
dc.creator.none.fl_str_mv Rind, F. Claire
Wernitznig, Stefan
Pölt, Peter
Zankel, Armin
Gütl, Daniel
Sztarker, Julieta
Leitinger, Gerd
author Rind, F. Claire
author_facet Rind, F. Claire
Wernitznig, Stefan
Pölt, Peter
Zankel, Armin
Gütl, Daniel
Sztarker, Julieta
Leitinger, Gerd
author_role author
author2 Wernitznig, Stefan
Pölt, Peter
Zankel, Armin
Gütl, Daniel
Sztarker, Julieta
Leitinger, Gerd
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv COLISION AVOIDANCE
LOCUST
LGMD
ELECTRON MICROSCOPY
topic COLISION AVOIDANCE
LOCUST
LGMD
ELECTRON MICROSCOPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In locusts, two lobula giant movement detector neurons (LGMDs) act as looming object detectors. Their reproducible responses to looming and their ethological significance makes them models for single neuron computation. But there is no comprehensive picture of the neurons that connect directly to each LGMD. We used high-through-put serial block-face scanning-electron-microscopy to reconstruct the network of input-synapses onto the LGMDs over spatial scales ranging from single synapses and small circuits, up to dendritic branches and total excitatory input. Reconstructions reveal that many trans-medullary-afferents (TmAs) connect the eye with each LGMD, one TmA per facet per LGMD. But when a TmA synapses with an LGMD it also connects laterally with another TmA. These inter-TmA synapses are always reciprocal. Total excitatory input to the LGMD 1 and 2 comes from 131,000 and 186,000 synapses reaching densities of 3.1 and 2.6 synapses per μm 2 respectively. We explored the computational consequences of reciprocal synapses between each TmA and 6 others from neighbouring columns. Since any lateral interactions between LGMD inputs have always been inhibitory we may assume these reciprocal lateral connections are most likely inhibitory. Such reciprocal inhibitory synapses increased the LGMD's selectivity for looming over passing objects, particularly at the beginning of object approach.
Fil: Rind, F. Claire. University of Newcastle; Reino Unido. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; Austria
Fil: Wernitznig, Stefan. University of Newcastle; Reino Unido. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; Austria
Fil: Pölt, Peter. Graz University of Technology; Austria. Graz Centre for Electron Microscopy; Austria
Fil: Zankel, Armin. Graz University of Technology; Austria. Graz Centre for Electron Microscopy; Austria
Fil: Gütl, Daniel. Medical University of Graz. Institute of Cell Biology, Histology and Embryology; Austria
Fil: Sztarker, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Leitinger, Gerd. University of Newcastle; Reino Unido. BioTechMed Graz; Austria
description In locusts, two lobula giant movement detector neurons (LGMDs) act as looming object detectors. Their reproducible responses to looming and their ethological significance makes them models for single neuron computation. But there is no comprehensive picture of the neurons that connect directly to each LGMD. We used high-through-put serial block-face scanning-electron-microscopy to reconstruct the network of input-synapses onto the LGMDs over spatial scales ranging from single synapses and small circuits, up to dendritic branches and total excitatory input. Reconstructions reveal that many trans-medullary-afferents (TmAs) connect the eye with each LGMD, one TmA per facet per LGMD. But when a TmA synapses with an LGMD it also connects laterally with another TmA. These inter-TmA synapses are always reciprocal. Total excitatory input to the LGMD 1 and 2 comes from 131,000 and 186,000 synapses reaching densities of 3.1 and 2.6 synapses per μm 2 respectively. We explored the computational consequences of reciprocal synapses between each TmA and 6 others from neighbouring columns. Since any lateral interactions between LGMD inputs have always been inhibitory we may assume these reciprocal lateral connections are most likely inhibitory. Such reciprocal inhibitory synapses increased the LGMD's selectivity for looming over passing objects, particularly at the beginning of object approach.
publishDate 2016
dc.date.none.fl_str_mv 2016-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/61432
Rind, F. Claire; Wernitznig, Stefan; Pölt, Peter; Zankel, Armin; Gütl, Daniel; et al.; Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects; Nature Publishing Group; Scientific Reports; 6; 10-2016; 1-16
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/61432
identifier_str_mv Rind, F. Claire; Wernitznig, Stefan; Pölt, Peter; Zankel, Armin; Gütl, Daniel; et al.; Two identified looming detectors in the locust: Ubiquitous lateral connections among their inputs contribute to selective responses to looming objects; Nature Publishing Group; Scientific Reports; 6; 10-2016; 1-16
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/srep35525
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep35525
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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