Capturing chaotic chromosomes: Pairing in action

Autores
Bertucci, Micka C.; Das, Arunika; Fitzgerald, Harriet C.; Goszczynski, Daniel Estanislao
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Accurate chromosome segregation is critical for the formation of haploid gametes, and therefore healthy offspring. Errors in segregation result in aneuploidy, which increases exponentially with maternal age (Hassold and Hunt, 2001). Maternally aged mouse oocytes were recently found to exhibit premature sister chromatid separation due to reduced levels of Securin, an essential regulator of sister chromatid cohesion (Nabti et al, 2017). This landmark finding was facilitated by using chromosome spreads that allow for the visualization of meiotic processes, such as recombination, synapsis, crossing over, and cohesion. This powerful technique is easy to perform and analyze, and allows for the identification of markers for different processes, including DNA damage and repair.
Fil: Bertucci, Micka C.. University of Chicago; Estados Unidos
Fil: Das, Arunika. University of Chicago; Estados Unidos
Fil: Fitzgerald, Harriet C.. University of Chicago; Estados Unidos
Fil: Goszczynski, Daniel Estanislao. University of Chicago; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Chromosomes
Meiosis
Age
Oocyte
Nivel de accesibilidad
acceso embargado
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48193
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/48193
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Capturing chaotic chromosomes: Pairing in actionBertucci, Micka C.Das, ArunikaFitzgerald, Harriet C.Goszczynski, Daniel EstanislaoChromosomesMeiosisAgeOocytehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Accurate chromosome segregation is critical for the formation of haploid gametes, and therefore healthy offspring. Errors in segregation result in aneuploidy, which increases exponentially with maternal age (Hassold and Hunt, 2001). Maternally aged mouse oocytes were recently found to exhibit premature sister chromatid separation due to reduced levels of Securin, an essential regulator of sister chromatid cohesion (Nabti et al, 2017). This landmark finding was facilitated by using chromosome spreads that allow for the visualization of meiotic processes, such as recombination, synapsis, crossing over, and cohesion. This powerful technique is easy to perform and analyze, and allows for the identification of markers for different processes, including DNA damage and repair.Fil: Bertucci, Micka C.. University of Chicago; Estados UnidosFil: Das, Arunika. University of Chicago; Estados UnidosFil: Fitzgerald, Harriet C.. University of Chicago; Estados UnidosFil: Goszczynski, Daniel Estanislao. University of Chicago; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley-liss, Div John Wiley & Sons Inc2018-03info:eu-repo/date/embargoEnd/2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48193Bertucci, Micka C.; Das, Arunika; Fitzgerald, Harriet C.; Goszczynski, Daniel Estanislao; Capturing chaotic chromosomes: Pairing in action; Wiley-liss, Div John Wiley & Sons Inc; Molecular Reproduction and Development; 85; 3; 3-2018; 173-1731040-452XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/mrd.22918info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mrd.22918info:eu-repo/semantics/embargoedAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:25:02Zoai:ri.conicet.gov.ar:11336/48193instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:25:03.053CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Capturing chaotic chromosomes: Pairing in action
title Capturing chaotic chromosomes: Pairing in action
spellingShingle Capturing chaotic chromosomes: Pairing in action
Bertucci, Micka C.
Chromosomes
Meiosis
Age
Oocyte
title_short Capturing chaotic chromosomes: Pairing in action
title_full Capturing chaotic chromosomes: Pairing in action
title_fullStr Capturing chaotic chromosomes: Pairing in action
title_full_unstemmed Capturing chaotic chromosomes: Pairing in action
title_sort Capturing chaotic chromosomes: Pairing in action
dc.creator.none.fl_str_mv Bertucci, Micka C.
Das, Arunika
Fitzgerald, Harriet C.
Goszczynski, Daniel Estanislao
author Bertucci, Micka C.
author_facet Bertucci, Micka C.
Das, Arunika
Fitzgerald, Harriet C.
Goszczynski, Daniel Estanislao
author_role author
author2 Das, Arunika
Fitzgerald, Harriet C.
Goszczynski, Daniel Estanislao
author2_role author
author
author
dc.subject.none.fl_str_mv Chromosomes
Meiosis
Age
Oocyte
topic Chromosomes
Meiosis
Age
Oocyte
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Accurate chromosome segregation is critical for the formation of haploid gametes, and therefore healthy offspring. Errors in segregation result in aneuploidy, which increases exponentially with maternal age (Hassold and Hunt, 2001). Maternally aged mouse oocytes were recently found to exhibit premature sister chromatid separation due to reduced levels of Securin, an essential regulator of sister chromatid cohesion (Nabti et al, 2017). This landmark finding was facilitated by using chromosome spreads that allow for the visualization of meiotic processes, such as recombination, synapsis, crossing over, and cohesion. This powerful technique is easy to perform and analyze, and allows for the identification of markers for different processes, including DNA damage and repair.
Fil: Bertucci, Micka C.. University of Chicago; Estados Unidos
Fil: Das, Arunika. University of Chicago; Estados Unidos
Fil: Fitzgerald, Harriet C.. University of Chicago; Estados Unidos
Fil: Goszczynski, Daniel Estanislao. University of Chicago; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Accurate chromosome segregation is critical for the formation of haploid gametes, and therefore healthy offspring. Errors in segregation result in aneuploidy, which increases exponentially with maternal age (Hassold and Hunt, 2001). Maternally aged mouse oocytes were recently found to exhibit premature sister chromatid separation due to reduced levels of Securin, an essential regulator of sister chromatid cohesion (Nabti et al, 2017). This landmark finding was facilitated by using chromosome spreads that allow for the visualization of meiotic processes, such as recombination, synapsis, crossing over, and cohesion. This powerful technique is easy to perform and analyze, and allows for the identification of markers for different processes, including DNA damage and repair.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
info:eu-repo/date/embargoEnd/2018-10-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48193
Bertucci, Micka C.; Das, Arunika; Fitzgerald, Harriet C.; Goszczynski, Daniel Estanislao; Capturing chaotic chromosomes: Pairing in action; Wiley-liss, Div John Wiley & Sons Inc; Molecular Reproduction and Development; 85; 3; 3-2018; 173-173
1040-452X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48193
identifier_str_mv Bertucci, Micka C.; Das, Arunika; Fitzgerald, Harriet C.; Goszczynski, Daniel Estanislao; Capturing chaotic chromosomes: Pairing in action; Wiley-liss, Div John Wiley & Sons Inc; Molecular Reproduction and Development; 85; 3; 3-2018; 173-173
1040-452X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/mrd.22918
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mrd.22918
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv embargoedAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981390397734912
score 12.48226

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