Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties

Autores
da Costa, Valeria; Mariño, Karina Valeria; Rodríguez Zraquia, Santiago A.; Festari, María Florencia; Lores, Pablo; Costa, Monique; Landeira, Mercedes; Rabinovich, Gabriel Adrián; Vliet, Sandra J. van; Freire, Teresa
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the O-glycosylation pathways that influenced the interaction with mouse MGL2 and the immunomodulatory properties of DCs. Thus, the identification of the biological programs triggered by Tn+ cancer cells might contribute to an improved understanding of the molecular mechanisms elicited by MGL-dependent immune regulatory circuits.
Fil: da Costa, Valeria. Universidad de la República; Uruguay
Fil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rodríguez Zraquia, Santiago A.. Universidad de la República; Uruguay
Fil: Festari, María Florencia. Universidad de la República; Uruguay
Fil: Lores, Pablo. Universidad de la República; Uruguay
Fil: Costa, Monique. Universidad de la República; Uruguay
Fil: Landeira, Mercedes. Universidad de la República; Uruguay
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Vliet, Sandra J. van. Vrije Universiteit Amsterdam; Países Bajos
Fil: Freire, Teresa. Universidad de la República; Uruguay
Materia
LUNG CANCER
MACROPHAGES
TN ANTIGEN
GLYCOSYLATION
DENDRITIC CELLS
TN ANTIGEN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/210110
Acceder
id CONICETDig_0826a06af3a0db651b1766bcda5a6e8a
oai_identifier_str oai:ri.conicet.gov.ar:11336/210110
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory propertiesda Costa, ValeriaMariño, Karina ValeriaRodríguez Zraquia, Santiago A.Festari, María FlorenciaLores, PabloCosta, MoniqueLandeira, MercedesRabinovich, Gabriel AdriánVliet, Sandra J. vanFreire, TeresaLUNG CANCERMACROPHAGESTN ANTIGENGLYCOSYLATIONDENDRITIC CELLSTN ANTIGENhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the O-glycosylation pathways that influenced the interaction with mouse MGL2 and the immunomodulatory properties of DCs. Thus, the identification of the biological programs triggered by Tn+ cancer cells might contribute to an improved understanding of the molecular mechanisms elicited by MGL-dependent immune regulatory circuits.Fil: da Costa, Valeria. Universidad de la República; UruguayFil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rodríguez Zraquia, Santiago A.. Universidad de la República; UruguayFil: Festari, María Florencia. Universidad de la República; UruguayFil: Lores, Pablo. Universidad de la República; UruguayFil: Costa, Monique. Universidad de la República; UruguayFil: Landeira, Mercedes. Universidad de la República; UruguayFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Vliet, Sandra J. van. Vrije Universiteit Amsterdam; Países BajosFil: Freire, Teresa. Universidad de la República; UruguayMolecular Diversity Preservation International2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/210110da Costa, Valeria; Mariño, Karina Valeria; Rodríguez Zraquia, Santiago A.; Festari, María Florencia; Lores, Pablo; et al.; Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 23; 19; 10-2022; 1-141422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/ijms231912047info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:35Zoai:ri.conicet.gov.ar:11336/210110instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:35.937CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties
title Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties
spellingShingle Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties
da Costa, Valeria
LUNG CANCER
MACROPHAGES
TN ANTIGEN
GLYCOSYLATION
DENDRITIC CELLS
TN ANTIGEN
title_short Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties
title_full Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties
title_fullStr Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties
title_full_unstemmed Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties
title_sort Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties
dc.creator.none.fl_str_mv da Costa, Valeria
Mariño, Karina Valeria
Rodríguez Zraquia, Santiago A.
Festari, María Florencia
Lores, Pablo
Costa, Monique
Landeira, Mercedes
Rabinovich, Gabriel Adrián
Vliet, Sandra J. van
Freire, Teresa
author da Costa, Valeria
author_facet da Costa, Valeria
Mariño, Karina Valeria
Rodríguez Zraquia, Santiago A.
Festari, María Florencia
Lores, Pablo
Costa, Monique
Landeira, Mercedes
Rabinovich, Gabriel Adrián
Vliet, Sandra J. van
Freire, Teresa
author_role author
author2 Mariño, Karina Valeria
Rodríguez Zraquia, Santiago A.
Festari, María Florencia
Lores, Pablo
Costa, Monique
Landeira, Mercedes
Rabinovich, Gabriel Adrián
Vliet, Sandra J. van
Freire, Teresa
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv LUNG CANCER
MACROPHAGES
TN ANTIGEN
GLYCOSYLATION
DENDRITIC CELLS
TN ANTIGEN
topic LUNG CANCER
MACROPHAGES
TN ANTIGEN
GLYCOSYLATION
DENDRITIC CELLS
TN ANTIGEN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the O-glycosylation pathways that influenced the interaction with mouse MGL2 and the immunomodulatory properties of DCs. Thus, the identification of the biological programs triggered by Tn+ cancer cells might contribute to an improved understanding of the molecular mechanisms elicited by MGL-dependent immune regulatory circuits.
Fil: da Costa, Valeria. Universidad de la República; Uruguay
Fil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rodríguez Zraquia, Santiago A.. Universidad de la República; Uruguay
Fil: Festari, María Florencia. Universidad de la República; Uruguay
Fil: Lores, Pablo. Universidad de la República; Uruguay
Fil: Costa, Monique. Universidad de la República; Uruguay
Fil: Landeira, Mercedes. Universidad de la República; Uruguay
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Vliet, Sandra J. van. Vrije Universiteit Amsterdam; Países Bajos
Fil: Freire, Teresa. Universidad de la República; Uruguay
description Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the O-glycosylation pathways that influenced the interaction with mouse MGL2 and the immunomodulatory properties of DCs. Thus, the identification of the biological programs triggered by Tn+ cancer cells might contribute to an improved understanding of the molecular mechanisms elicited by MGL-dependent immune regulatory circuits.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/210110
da Costa, Valeria; Mariño, Karina Valeria; Rodríguez Zraquia, Santiago A.; Festari, María Florencia; Lores, Pablo; et al.; Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 23; 19; 10-2022; 1-14
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/210110
identifier_str_mv da Costa, Valeria; Mariño, Karina Valeria; Rodríguez Zraquia, Santiago A.; Festari, María Florencia; Lores, Pablo; et al.; Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 23; 19; 10-2022; 1-14
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms231912047
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269104802627584
score 13.13397

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