An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431

Autores
Li, Chunshun; Sarotti, Ariel Marcelo; Wu, Xiaohua; Yang, Baojun; Turkson, James; Chen, Yongfei; Liu, Qingsong; Cao, Shugeng
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian indigenous plant, Verbena sp. The structures of the new compounds were determined through the analysis of HRMS and NMR spectroscopic data. Compounds 1, 2, and 5 showed cytotoxic activities against TK-10 (human kidney adenocarcinoma cells), cisplatin sensitive A2780S (human ovarian carcinoma cells), and cisplatin resistant A2780CisR cell lines, with IC50 values between 6.7 to 29.2 µM.
Fil: Li, Chunshun. University of Hawaii; Estados Unidos
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Wu, Xiaohua. University of Hawaii; Estados Unidos
Fil: Yang, Baojun. University of Hawaii; Estados Unidos
Fil: Turkson, James. University of Hawaii; Estados Unidos
Fil: Chen, Yongfei. Chinese Academy of Sciences; República de China
Fil: Liu, Qingsong. Chinese Academy of Sciences; República de China
Fil: Cao, Shugeng. University of Hawaii; Estados Unidos
Materia
ENDOPHYTIC FUNGI
PEYRONELLAEA
BENZOQUINOLINE
ANTIPROLIFERATIVE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/108014
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/108014
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431Li, ChunshunSarotti, Ariel MarceloWu, XiaohuaYang, BaojunTurkson, JamesChen, YongfeiLiu, QingsongCao, ShugengENDOPHYTIC FUNGIPEYRONELLAEABENZOQUINOLINEANTIPROLIFERATIVEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian indigenous plant, Verbena sp. The structures of the new compounds were determined through the analysis of HRMS and NMR spectroscopic data. Compounds 1, 2, and 5 showed cytotoxic activities against TK-10 (human kidney adenocarcinoma cells), cisplatin sensitive A2780S (human ovarian carcinoma cells), and cisplatin resistant A2780CisR cell lines, with IC50 values between 6.7 to 29.2 µM.Fil: Li, Chunshun. University of Hawaii; Estados UnidosFil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Wu, Xiaohua. University of Hawaii; Estados UnidosFil: Yang, Baojun. University of Hawaii; Estados UnidosFil: Turkson, James. University of Hawaii; Estados UnidosFil: Chen, Yongfei. Chinese Academy of Sciences; República de ChinaFil: Liu, Qingsong. Chinese Academy of Sciences; República de ChinaFil: Cao, Shugeng. University of Hawaii; Estados UnidosMolecular Diversity Preservation International2019-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/108014Li, Chunshun; Sarotti, Ariel Marcelo; Wu, Xiaohua; Yang, Baojun; Turkson, James; et al.; An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431; Molecular Diversity Preservation International; Molecules; 24; 1; 1-2019; 1-111420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337129/info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules24010196info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/24/1/196info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:45:42Zoai:ri.conicet.gov.ar:11336/108014instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:45:43.252CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
title An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
spellingShingle An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
Li, Chunshun
ENDOPHYTIC FUNGI
PEYRONELLAEA
BENZOQUINOLINE
ANTIPROLIFERATIVE
title_short An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
title_full An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
title_fullStr An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
title_full_unstemmed An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
title_sort An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431
dc.creator.none.fl_str_mv Li, Chunshun
Sarotti, Ariel Marcelo
Wu, Xiaohua
Yang, Baojun
Turkson, James
Chen, Yongfei
Liu, Qingsong
Cao, Shugeng
author Li, Chunshun
author_facet Li, Chunshun
Sarotti, Ariel Marcelo
Wu, Xiaohua
Yang, Baojun
Turkson, James
Chen, Yongfei
Liu, Qingsong
Cao, Shugeng
author_role author
author2 Sarotti, Ariel Marcelo
Wu, Xiaohua
Yang, Baojun
Turkson, James
Chen, Yongfei
Liu, Qingsong
Cao, Shugeng
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ENDOPHYTIC FUNGI
PEYRONELLAEA
BENZOQUINOLINE
ANTIPROLIFERATIVE
topic ENDOPHYTIC FUNGI
PEYRONELLAEA
BENZOQUINOLINE
ANTIPROLIFERATIVE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian indigenous plant, Verbena sp. The structures of the new compounds were determined through the analysis of HRMS and NMR spectroscopic data. Compounds 1, 2, and 5 showed cytotoxic activities against TK-10 (human kidney adenocarcinoma cells), cisplatin sensitive A2780S (human ovarian carcinoma cells), and cisplatin resistant A2780CisR cell lines, with IC50 values between 6.7 to 29.2 µM.
Fil: Li, Chunshun. University of Hawaii; Estados Unidos
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Wu, Xiaohua. University of Hawaii; Estados Unidos
Fil: Yang, Baojun. University of Hawaii; Estados Unidos
Fil: Turkson, James. University of Hawaii; Estados Unidos
Fil: Chen, Yongfei. Chinese Academy of Sciences; República de China
Fil: Liu, Qingsong. Chinese Academy of Sciences; República de China
Fil: Cao, Shugeng. University of Hawaii; Estados Unidos
description A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian indigenous plant, Verbena sp. The structures of the new compounds were determined through the analysis of HRMS and NMR spectroscopic data. Compounds 1, 2, and 5 showed cytotoxic activities against TK-10 (human kidney adenocarcinoma cells), cisplatin sensitive A2780S (human ovarian carcinoma cells), and cisplatin resistant A2780CisR cell lines, with IC50 values between 6.7 to 29.2 µM.
publishDate 2019
dc.date.none.fl_str_mv 2019-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/108014
Li, Chunshun; Sarotti, Ariel Marcelo; Wu, Xiaohua; Yang, Baojun; Turkson, James; et al.; An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431; Molecular Diversity Preservation International; Molecules; 24; 1; 1-2019; 1-11
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/108014
identifier_str_mv Li, Chunshun; Sarotti, Ariel Marcelo; Wu, Xiaohua; Yang, Baojun; Turkson, James; et al.; An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431; Molecular Diversity Preservation International; Molecules; 24; 1; 1-2019; 1-11
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337129/
info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules24010196
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/24/1/196
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782155337760768
score 12.982451

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