Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study

Autores
Lorenzo, Cristina; Zubiri, Cecilia; Zosi, Anabella; Miculan, Sandro; Neder, Daniela; Rocca, Ana; Sabban, Judith Cohen; Bigliardi, Roman; Biasoli, Maria Florencia; Manterola, Manuela; Savia, Maria de los Angeles; Perez, Luis Orlando; Hernández, Carlos Ruiz; Weinschelbaum, Renata; Fontenele Soares, Ana Cristina; Tahan, Soraia; Plante, Veronica; Boggio, Christian; Arcucci, Soledad; Monjaraz, Erick Toro; Mortarini, Maria Alejandra; Arrizabalo, Samantha; Saps, Miguel
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: To compare the features of multichannel intraluminal impedance and pH monitoring (MII-pH) tracings in children with cerebral palsy (CP) and children without CP.Methods: Multicenter, retrospective, analytical study. We examined tracings of children aged 1 to 15 years old, evaluated from May 2017 to January 2024. Population included two groups: Group 1 consisted of children with CP, while control group comprised children without CP who had extra-digestive symptoms suggestive of gastroesophageal reflux disease (GERD) but normal MII-pH results. Quantitative data were analyzed using analysis of variance and t tests. Qualitative data were analyzed using contingency tables and chi-square tests.Results: We studied 245 children. CP group included 110 children with a mean age of 5.71 years (standard deviation [SD] ± 4.24), while control group included 135 children with a mean age of 5.73 years (SD ± 3.39). The CP group had fewer reflux episodes (p = 0.0015), slower mean acid clearance time (p = 0.04), lower mean baseline impedance and mean nocturnal baseline impedance (p = 1.82e-07 and p = 7.50e-07).Conclusion: Children with CP have fewer reflux episodes and longer acid clearance times compared with children without CP.
Fil: Lorenzo, Cristina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Zubiri, Cecilia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Zosi, Anabella. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Miculan, Sandro. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Neder, Daniela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Rocca, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Sabban, Judith Cohen. Hospital Italiano; Argentina
Fil: Bigliardi, Roman. Hospital Nacional Profesor Alejandro Posadas.; Argentina
Fil: Biasoli, Maria Florencia. Gobierno de la Provincia de Buenos Aires. Hospital Zonal General de Agudos Doctor Ricardo Gutiérrez;
Fil: Manterola, Manuela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Savia, Maria de los Angeles. Hospital Horacio Cestino; Argentina
Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Hernández, Carlos Ruiz. Hospital Sant Joan de Deu Barcelona; España
Fil: Weinschelbaum, Renata. Hospital Sanatorio de Niños; Argentina
Fil: Fontenele Soares, Ana Cristina. Universidade Federal de Sao Paulo; Brasil
Fil: Tahan, Soraia. Universidade Federal de Sao Paulo; Brasil
Fil: Plante, Veronica. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano .; Argentina
Fil: Boggio, Christian. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano .; Argentina
Fil: Arcucci, Soledad. Hospital Italiano; Argentina
Fil: Monjaraz, Erick Toro. Instituto Nacional de Pediatría; México
Fil: Mortarini, Maria Alejandra. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Arrizabalo, Samantha. University of Miami; Estados Unidos
Fil: Saps, Miguel. University of Miami; Estados Unidos
Materia
Multichannel intraluminal impedance
ph
crebral palsy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280357
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/280357
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter studyLorenzo, CristinaZubiri, CeciliaZosi, AnabellaMiculan, SandroNeder, DanielaRocca, AnaSabban, Judith CohenBigliardi, RomanBiasoli, Maria FlorenciaManterola, ManuelaSavia, Maria de los AngelesPerez, Luis OrlandoHernández, Carlos RuizWeinschelbaum, RenataFontenele Soares, Ana CristinaTahan, SoraiaPlante, VeronicaBoggio, ChristianArcucci, SoledadMonjaraz, Erick ToroMortarini, Maria AlejandraArrizabalo, SamanthaSaps, MiguelMultichannel intraluminal impedancephcrebral palsyhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Objectives: To compare the features of multichannel intraluminal impedance and pH monitoring (MII-pH) tracings in children with cerebral palsy (CP) and children without CP.Methods: Multicenter, retrospective, analytical study. We examined tracings of children aged 1 to 15 years old, evaluated from May 2017 to January 2024. Population included two groups: Group 1 consisted of children with CP, while control group comprised children without CP who had extra-digestive symptoms suggestive of gastroesophageal reflux disease (GERD) but normal MII-pH results. Quantitative data were analyzed using analysis of variance and t tests. Qualitative data were analyzed using contingency tables and chi-square tests.Results: We studied 245 children. CP group included 110 children with a mean age of 5.71 years (standard deviation [SD] ± 4.24), while control group included 135 children with a mean age of 5.73 years (SD ± 3.39). The CP group had fewer reflux episodes (p = 0.0015), slower mean acid clearance time (p = 0.04), lower mean baseline impedance and mean nocturnal baseline impedance (p = 1.82e-07 and p = 7.50e-07).Conclusion: Children with CP have fewer reflux episodes and longer acid clearance times compared with children without CP.Fil: Lorenzo, Cristina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Zubiri, Cecilia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Zosi, Anabella. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Miculan, Sandro. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Neder, Daniela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Rocca, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Sabban, Judith Cohen. Hospital Italiano; ArgentinaFil: Bigliardi, Roman. Hospital Nacional Profesor Alejandro Posadas.; ArgentinaFil: Biasoli, Maria Florencia. Gobierno de la Provincia de Buenos Aires. Hospital Zonal General de Agudos Doctor Ricardo Gutiérrez;Fil: Manterola, Manuela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Savia, Maria de los Angeles. Hospital Horacio Cestino; ArgentinaFil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Hernández, Carlos Ruiz. Hospital Sant Joan de Deu Barcelona; EspañaFil: Weinschelbaum, Renata. Hospital Sanatorio de Niños; ArgentinaFil: Fontenele Soares, Ana Cristina. Universidade Federal de Sao Paulo; BrasilFil: Tahan, Soraia. Universidade Federal de Sao Paulo; BrasilFil: Plante, Veronica. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano .; ArgentinaFil: Boggio, Christian. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano .; ArgentinaFil: Arcucci, Soledad. Hospital Italiano; ArgentinaFil: Monjaraz, Erick Toro. Instituto Nacional de Pediatría; MéxicoFil: Mortarini, Maria Alejandra. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Arrizabalo, Samantha. University of Miami; Estados UnidosFil: Saps, Miguel. University of Miami; Estados UnidosWiley2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280357Lorenzo, Cristina; Zubiri, Cecilia; Zosi, Anabella; Miculan, Sandro; Neder, Daniela; et al.; Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study; Wiley; Journal Of Pediatric Gastroenterology And Nutrition; 81; 1; 5-2025; 125-1300277-2116CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/jpn3.70058info:eu-repo/semantics/altIdentifier/doi/10.1002/jpn3.70058info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:03:25Zoai:ri.conicet.gov.ar:11336/280357instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:03:25.532CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study
title Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study
spellingShingle Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study
Lorenzo, Cristina
Multichannel intraluminal impedance
ph
crebral palsy
title_short Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study
title_full Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study
title_fullStr Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study
title_full_unstemmed Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study
title_sort Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study
dc.creator.none.fl_str_mv Lorenzo, Cristina
Zubiri, Cecilia
Zosi, Anabella
Miculan, Sandro
Neder, Daniela
Rocca, Ana
Sabban, Judith Cohen
Bigliardi, Roman
Biasoli, Maria Florencia
Manterola, Manuela
Savia, Maria de los Angeles
Perez, Luis Orlando
Hernández, Carlos Ruiz
Weinschelbaum, Renata
Fontenele Soares, Ana Cristina
Tahan, Soraia
Plante, Veronica
Boggio, Christian
Arcucci, Soledad
Monjaraz, Erick Toro
Mortarini, Maria Alejandra
Arrizabalo, Samantha
Saps, Miguel
author Lorenzo, Cristina
author_facet Lorenzo, Cristina
Zubiri, Cecilia
Zosi, Anabella
Miculan, Sandro
Neder, Daniela
Rocca, Ana
Sabban, Judith Cohen
Bigliardi, Roman
Biasoli, Maria Florencia
Manterola, Manuela
Savia, Maria de los Angeles
Perez, Luis Orlando
Hernández, Carlos Ruiz
Weinschelbaum, Renata
Fontenele Soares, Ana Cristina
Tahan, Soraia
Plante, Veronica
Boggio, Christian
Arcucci, Soledad
Monjaraz, Erick Toro
Mortarini, Maria Alejandra
Arrizabalo, Samantha
Saps, Miguel
author_role author
author2 Zubiri, Cecilia
Zosi, Anabella
Miculan, Sandro
Neder, Daniela
Rocca, Ana
Sabban, Judith Cohen
Bigliardi, Roman
Biasoli, Maria Florencia
Manterola, Manuela
Savia, Maria de los Angeles
Perez, Luis Orlando
Hernández, Carlos Ruiz
Weinschelbaum, Renata
Fontenele Soares, Ana Cristina
Tahan, Soraia
Plante, Veronica
Boggio, Christian
Arcucci, Soledad
Monjaraz, Erick Toro
Mortarini, Maria Alejandra
Arrizabalo, Samantha
Saps, Miguel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Multichannel intraluminal impedance
ph
crebral palsy
topic Multichannel intraluminal impedance
ph
crebral palsy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: To compare the features of multichannel intraluminal impedance and pH monitoring (MII-pH) tracings in children with cerebral palsy (CP) and children without CP.Methods: Multicenter, retrospective, analytical study. We examined tracings of children aged 1 to 15 years old, evaluated from May 2017 to January 2024. Population included two groups: Group 1 consisted of children with CP, while control group comprised children without CP who had extra-digestive symptoms suggestive of gastroesophageal reflux disease (GERD) but normal MII-pH results. Quantitative data were analyzed using analysis of variance and t tests. Qualitative data were analyzed using contingency tables and chi-square tests.Results: We studied 245 children. CP group included 110 children with a mean age of 5.71 years (standard deviation [SD] ± 4.24), while control group included 135 children with a mean age of 5.73 years (SD ± 3.39). The CP group had fewer reflux episodes (p = 0.0015), slower mean acid clearance time (p = 0.04), lower mean baseline impedance and mean nocturnal baseline impedance (p = 1.82e-07 and p = 7.50e-07).Conclusion: Children with CP have fewer reflux episodes and longer acid clearance times compared with children without CP.
Fil: Lorenzo, Cristina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Zubiri, Cecilia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Zosi, Anabella. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Miculan, Sandro. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Neder, Daniela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Rocca, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Sabban, Judith Cohen. Hospital Italiano; Argentina
Fil: Bigliardi, Roman. Hospital Nacional Profesor Alejandro Posadas.; Argentina
Fil: Biasoli, Maria Florencia. Gobierno de la Provincia de Buenos Aires. Hospital Zonal General de Agudos Doctor Ricardo Gutiérrez;
Fil: Manterola, Manuela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Savia, Maria de los Angeles. Hospital Horacio Cestino; Argentina
Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Hernández, Carlos Ruiz. Hospital Sant Joan de Deu Barcelona; España
Fil: Weinschelbaum, Renata. Hospital Sanatorio de Niños; Argentina
Fil: Fontenele Soares, Ana Cristina. Universidade Federal de Sao Paulo; Brasil
Fil: Tahan, Soraia. Universidade Federal de Sao Paulo; Brasil
Fil: Plante, Veronica. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano .; Argentina
Fil: Boggio, Christian. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano .; Argentina
Fil: Arcucci, Soledad. Hospital Italiano; Argentina
Fil: Monjaraz, Erick Toro. Instituto Nacional de Pediatría; México
Fil: Mortarini, Maria Alejandra. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Arrizabalo, Samantha. University of Miami; Estados Unidos
Fil: Saps, Miguel. University of Miami; Estados Unidos
description Objectives: To compare the features of multichannel intraluminal impedance and pH monitoring (MII-pH) tracings in children with cerebral palsy (CP) and children without CP.Methods: Multicenter, retrospective, analytical study. We examined tracings of children aged 1 to 15 years old, evaluated from May 2017 to January 2024. Population included two groups: Group 1 consisted of children with CP, while control group comprised children without CP who had extra-digestive symptoms suggestive of gastroesophageal reflux disease (GERD) but normal MII-pH results. Quantitative data were analyzed using analysis of variance and t tests. Qualitative data were analyzed using contingency tables and chi-square tests.Results: We studied 245 children. CP group included 110 children with a mean age of 5.71 years (standard deviation [SD] ± 4.24), while control group included 135 children with a mean age of 5.73 years (SD ± 3.39). The CP group had fewer reflux episodes (p = 0.0015), slower mean acid clearance time (p = 0.04), lower mean baseline impedance and mean nocturnal baseline impedance (p = 1.82e-07 and p = 7.50e-07).Conclusion: Children with CP have fewer reflux episodes and longer acid clearance times compared with children without CP.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280357
Lorenzo, Cristina; Zubiri, Cecilia; Zosi, Anabella; Miculan, Sandro; Neder, Daniela; et al.; Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study; Wiley; Journal Of Pediatric Gastroenterology And Nutrition; 81; 1; 5-2025; 125-130
0277-2116
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280357
identifier_str_mv Lorenzo, Cristina; Zubiri, Cecilia; Zosi, Anabella; Miculan, Sandro; Neder, Daniela; et al.; Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study; Wiley; Journal Of Pediatric Gastroenterology And Nutrition; 81; 1; 5-2025; 125-130
0277-2116
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/jpn3.70058
info:eu-repo/semantics/altIdentifier/doi/10.1002/jpn3.70058
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176822

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