Rapid hippocampal plasticity supports motor sequence learning

Autores
Jacobacci, Florencia; Armony, Jorge L.; Yeffal, Abraham Ismael; Lerner, Gonzalo Martin; Amaro, Edson; Jovicich, Jorge; Doyone, Julien; Della Maggiore, Valeria Monica
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Recent evidence suggests that gains in performance observed while humans learn a novel motor sequence occur during the quiet rest periods interleaved with practice (micro-offline gains, MOGs). This phenomenon is reminiscent of memory replay observed in the hippocampus during spatial learning in rodents. Whether the hippocampus is also involved in the production of MOGs remains currently unknown. Using a multimodal approach in humans, here we show that activity in the hippocampus and the precuneus increases during the quiet rest periods and predicts the level of MOGs before asymptotic performance is achieved. These functional changes were followed by rapid alterations in brain microstructure in the order of minutes, suggesting that the same network that reactivates during the quiet periods of training undergoes structural plasticity. Our work points to the involvement of the hippocampal system in the reactivation of procedural memories.
Fil: Jacobacci, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Armony, Jorge L.. McGill University; Canadá
Fil: Yeffal, Abraham Ismael. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Lerner, Gonzalo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Amaro, Edson. Universidade de Sao Paulo; Brasil
Fil: Jovicich, Jorge. Universita degli Studi di Trento; Italia
Fil: Doyone, Julien. McGill University; Canadá
Fil: Della Maggiore, Valeria Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Materia
FUNCTIONAL MRI
HIPPOCAMPUS
MOTOR SEQUENCE LEARNING
REACTIVATION
STRUCTURAL PLASTICITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/267612
Acceder
id CONICETDig_076121909abd303c28a001c634ae47f4
oai_identifier_str oai:ri.conicet.gov.ar:11336/267612
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Rapid hippocampal plasticity supports motor sequence learningJacobacci, FlorenciaArmony, Jorge L.Yeffal, Abraham IsmaelLerner, Gonzalo MartinAmaro, EdsonJovicich, JorgeDoyone, JulienDella Maggiore, Valeria MonicaFUNCTIONAL MRIHIPPOCAMPUSMOTOR SEQUENCE LEARNINGREACTIVATIONSTRUCTURAL PLASTICITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Recent evidence suggests that gains in performance observed while humans learn a novel motor sequence occur during the quiet rest periods interleaved with practice (micro-offline gains, MOGs). This phenomenon is reminiscent of memory replay observed in the hippocampus during spatial learning in rodents. Whether the hippocampus is also involved in the production of MOGs remains currently unknown. Using a multimodal approach in humans, here we show that activity in the hippocampus and the precuneus increases during the quiet rest periods and predicts the level of MOGs before asymptotic performance is achieved. These functional changes were followed by rapid alterations in brain microstructure in the order of minutes, suggesting that the same network that reactivates during the quiet periods of training undergoes structural plasticity. Our work points to the involvement of the hippocampal system in the reactivation of procedural memories.Fil: Jacobacci, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Armony, Jorge L.. McGill University; CanadáFil: Yeffal, Abraham Ismael. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Lerner, Gonzalo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Amaro, Edson. Universidade de Sao Paulo; BrasilFil: Jovicich, Jorge. Universita degli Studi di Trento; ItaliaFil: Doyone, Julien. McGill University; CanadáFil: Della Maggiore, Valeria Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaNational Academy of Sciences2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267612Jacobacci, Florencia; Armony, Jorge L.; Yeffal, Abraham Ismael; Lerner, Gonzalo Martin; Amaro, Edson; et al.; Rapid hippocampal plasticity supports motor sequence learning; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 117; 38; 9-2020; 23898-239030027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2009576117info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:48:53Zoai:ri.conicet.gov.ar:11336/267612instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:48:53.361CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Rapid hippocampal plasticity supports motor sequence learning
title Rapid hippocampal plasticity supports motor sequence learning
spellingShingle Rapid hippocampal plasticity supports motor sequence learning
Jacobacci, Florencia
FUNCTIONAL MRI
HIPPOCAMPUS
MOTOR SEQUENCE LEARNING
REACTIVATION
STRUCTURAL PLASTICITY
title_short Rapid hippocampal plasticity supports motor sequence learning
title_full Rapid hippocampal plasticity supports motor sequence learning
title_fullStr Rapid hippocampal plasticity supports motor sequence learning
title_full_unstemmed Rapid hippocampal plasticity supports motor sequence learning
title_sort Rapid hippocampal plasticity supports motor sequence learning
dc.creator.none.fl_str_mv Jacobacci, Florencia
Armony, Jorge L.
Yeffal, Abraham Ismael
Lerner, Gonzalo Martin
Amaro, Edson
Jovicich, Jorge
Doyone, Julien
Della Maggiore, Valeria Monica
author Jacobacci, Florencia
author_facet Jacobacci, Florencia
Armony, Jorge L.
Yeffal, Abraham Ismael
Lerner, Gonzalo Martin
Amaro, Edson
Jovicich, Jorge
Doyone, Julien
Della Maggiore, Valeria Monica
author_role author
author2 Armony, Jorge L.
Yeffal, Abraham Ismael
Lerner, Gonzalo Martin
Amaro, Edson
Jovicich, Jorge
Doyone, Julien
Della Maggiore, Valeria Monica
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FUNCTIONAL MRI
HIPPOCAMPUS
MOTOR SEQUENCE LEARNING
REACTIVATION
STRUCTURAL PLASTICITY
topic FUNCTIONAL MRI
HIPPOCAMPUS
MOTOR SEQUENCE LEARNING
REACTIVATION
STRUCTURAL PLASTICITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Recent evidence suggests that gains in performance observed while humans learn a novel motor sequence occur during the quiet rest periods interleaved with practice (micro-offline gains, MOGs). This phenomenon is reminiscent of memory replay observed in the hippocampus during spatial learning in rodents. Whether the hippocampus is also involved in the production of MOGs remains currently unknown. Using a multimodal approach in humans, here we show that activity in the hippocampus and the precuneus increases during the quiet rest periods and predicts the level of MOGs before asymptotic performance is achieved. These functional changes were followed by rapid alterations in brain microstructure in the order of minutes, suggesting that the same network that reactivates during the quiet periods of training undergoes structural plasticity. Our work points to the involvement of the hippocampal system in the reactivation of procedural memories.
Fil: Jacobacci, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Armony, Jorge L.. McGill University; Canadá
Fil: Yeffal, Abraham Ismael. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Lerner, Gonzalo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Amaro, Edson. Universidade de Sao Paulo; Brasil
Fil: Jovicich, Jorge. Universita degli Studi di Trento; Italia
Fil: Doyone, Julien. McGill University; Canadá
Fil: Della Maggiore, Valeria Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
description Recent evidence suggests that gains in performance observed while humans learn a novel motor sequence occur during the quiet rest periods interleaved with practice (micro-offline gains, MOGs). This phenomenon is reminiscent of memory replay observed in the hippocampus during spatial learning in rodents. Whether the hippocampus is also involved in the production of MOGs remains currently unknown. Using a multimodal approach in humans, here we show that activity in the hippocampus and the precuneus increases during the quiet rest periods and predicts the level of MOGs before asymptotic performance is achieved. These functional changes were followed by rapid alterations in brain microstructure in the order of minutes, suggesting that the same network that reactivates during the quiet periods of training undergoes structural plasticity. Our work points to the involvement of the hippocampal system in the reactivation of procedural memories.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/267612
Jacobacci, Florencia; Armony, Jorge L.; Yeffal, Abraham Ismael; Lerner, Gonzalo Martin; Amaro, Edson; et al.; Rapid hippocampal plasticity supports motor sequence learning; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 117; 38; 9-2020; 23898-23903
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/267612
identifier_str_mv Jacobacci, Florencia; Armony, Jorge L.; Yeffal, Abraham Ismael; Lerner, Gonzalo Martin; Amaro, Edson; et al.; Rapid hippocampal plasticity supports motor sequence learning; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 117; 38; 9-2020; 23898-23903
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2009576117
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083010505474048
score 13.22299

Publicaciones similares