Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells

Autores
Paez, Alejandra; Vazquez, Elba Susana; Gueron, Geraldine
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This paper refers to Paez et al.1 Prostate cancer (PCa) is the second leading cause of cancer death in men in the United States.2 Incidence increases with patient age and represents the most important risk factor. Localized PCa can be cured in most cases, but when the disease escapes the confines of the gland, the prospects for cure decrease drastically. Androgen ablation is the most effective way of halting PCa progression, but given sufficient time, growth of the cancer resumes in most cases and the disease becomes castration resistant (castration-resistant PCa (CRPC)).3 No therapy is curative for patients with CRPC, thus emerging a critical need to identify new therapy targets. Advanced PCa has been associated to the loss of cell adhesion molecules at adherens junctions.4 The delicate equilibrium between the cell pushing and pulling forces drive leading edge dynamics and cell migration. Interdigitating filopodia are vital for the proper alignment and establishment of the initial cell?cell adhesions, known as adhesion zippering, an event that contributes significantly to reduce the metastatic phenotype of tumor cells.
Fil: Paez, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Vazquez, Elba Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Gueron, Geraldine. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Materia
Cell Contacts
Heme oxygenase 1
prostate cancer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/56312
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/56312
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cellsPaez, AlejandraVazquez, Elba SusanaGueron, GeraldineCell ContactsHeme oxygenase 1prostate cancerhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This paper refers to Paez et al.1 Prostate cancer (PCa) is the second leading cause of cancer death in men in the United States.2 Incidence increases with patient age and represents the most important risk factor. Localized PCa can be cured in most cases, but when the disease escapes the confines of the gland, the prospects for cure decrease drastically. Androgen ablation is the most effective way of halting PCa progression, but given sufficient time, growth of the cancer resumes in most cases and the disease becomes castration resistant (castration-resistant PCa (CRPC)).3 No therapy is curative for patients with CRPC, thus emerging a critical need to identify new therapy targets. Advanced PCa has been associated to the loss of cell adhesion molecules at adherens junctions.4 The delicate equilibrium between the cell pushing and pulling forces drive leading edge dynamics and cell migration. Interdigitating filopodia are vital for the proper alignment and establishment of the initial cell?cell adhesions, known as adhesion zippering, an event that contributes significantly to reduce the metastatic phenotype of tumor cells.Fil: Paez, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Vazquez, Elba Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Gueron, Geraldine. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaNature Publishing Group-Springer2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/56312Paez, Alejandra; Vazquez, Elba Susana; Gueron, Geraldine; Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells; Nature Publishing Group-Springer; Cell Death Discovery; 3; 4-2017; 1-22058-7716CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/cddiscovery.2017.20info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/cddiscovery201720info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:22Zoai:ri.conicet.gov.ar:11336/56312instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:23.039CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells
title Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells
spellingShingle Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells
Paez, Alejandra
Cell Contacts
Heme oxygenase 1
prostate cancer
title_short Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells
title_full Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells
title_fullStr Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells
title_full_unstemmed Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells
title_sort Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells
dc.creator.none.fl_str_mv Paez, Alejandra
Vazquez, Elba Susana
Gueron, Geraldine
author Paez, Alejandra
author_facet Paez, Alejandra
Vazquez, Elba Susana
Gueron, Geraldine
author_role author
author2 Vazquez, Elba Susana
Gueron, Geraldine
author2_role author
author
dc.subject.none.fl_str_mv Cell Contacts
Heme oxygenase 1
prostate cancer
topic Cell Contacts
Heme oxygenase 1
prostate cancer
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This paper refers to Paez et al.1 Prostate cancer (PCa) is the second leading cause of cancer death in men in the United States.2 Incidence increases with patient age and represents the most important risk factor. Localized PCa can be cured in most cases, but when the disease escapes the confines of the gland, the prospects for cure decrease drastically. Androgen ablation is the most effective way of halting PCa progression, but given sufficient time, growth of the cancer resumes in most cases and the disease becomes castration resistant (castration-resistant PCa (CRPC)).3 No therapy is curative for patients with CRPC, thus emerging a critical need to identify new therapy targets. Advanced PCa has been associated to the loss of cell adhesion molecules at adherens junctions.4 The delicate equilibrium between the cell pushing and pulling forces drive leading edge dynamics and cell migration. Interdigitating filopodia are vital for the proper alignment and establishment of the initial cell?cell adhesions, known as adhesion zippering, an event that contributes significantly to reduce the metastatic phenotype of tumor cells.
Fil: Paez, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Vazquez, Elba Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Gueron, Geraldine. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
description This paper refers to Paez et al.1 Prostate cancer (PCa) is the second leading cause of cancer death in men in the United States.2 Incidence increases with patient age and represents the most important risk factor. Localized PCa can be cured in most cases, but when the disease escapes the confines of the gland, the prospects for cure decrease drastically. Androgen ablation is the most effective way of halting PCa progression, but given sufficient time, growth of the cancer resumes in most cases and the disease becomes castration resistant (castration-resistant PCa (CRPC)).3 No therapy is curative for patients with CRPC, thus emerging a critical need to identify new therapy targets. Advanced PCa has been associated to the loss of cell adhesion molecules at adherens junctions.4 The delicate equilibrium between the cell pushing and pulling forces drive leading edge dynamics and cell migration. Interdigitating filopodia are vital for the proper alignment and establishment of the initial cell?cell adhesions, known as adhesion zippering, an event that contributes significantly to reduce the metastatic phenotype of tumor cells.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/56312
Paez, Alejandra; Vazquez, Elba Susana; Gueron, Geraldine; Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells; Nature Publishing Group-Springer; Cell Death Discovery; 3; 4-2017; 1-2
2058-7716
CONICET Digital
CONICET
url http://hdl.handle.net/11336/56312
identifier_str_mv Paez, Alejandra; Vazquez, Elba Susana; Gueron, Geraldine; Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells; Nature Publishing Group-Springer; Cell Death Discovery; 3; 4-2017; 1-2
2058-7716
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/cddiscovery.2017.20
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/cddiscovery201720
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group-Springer
publisher.none.fl_str_mv Nature Publishing Group-Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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