The intervention of Nanotechnology against epithelial fungal diseases

Autores
Higa, Leticia Herminia; Schilrreff, Priscila; Perez, Ana Paula; Morilla, María José; Romero, Eder Lilia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fungal infections can attack epithelial tissues and, according to the immunological state of the patient, some of them invade deeper organs, becoming seriously life compromising. Besides, bloodstream and local infections associated with intravascular devices constitute a significant problem associated with increased mortality. Topical therapy is desirable since, in addition to targeting the site of infection, it reduces the risk of systemic side effects and increases patient compliance. In this review we describe the pros and cons of using nano-objects that being toxic in nature could be used to cover surfaces of medical devices, or can act as carriers for targeted delivery of antifungals to skin. Non-toxic nano-objects were also included because they improve the ocular delivery of antifungals, classically suffering from ineffective topical administration, difficult access for systemic medication or local invasive administration. The new preclinical developments of nanoparticulate agents against cutaneous and ocular mycosis are grouped in three main sections: (1) In vitro antifungal activity of metallic nanoparticles, (2) In vitro and in vivo antifungal activity of non metallic nanoparticles (3) Ocular delivery of non metallic nanoparticles.
Fil: Higa, Leticia Herminia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schilrreff, Priscila. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perez, Ana Paula. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Morilla, María José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romero, Eder Lilia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Nano-Objects
Metallic Nanoparticles
Ephitelia
Fungi
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/22944
Acceder
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spelling The intervention of Nanotechnology against epithelial fungal diseasesHiga, Leticia HerminiaSchilrreff, PriscilaPerez, Ana PaulaMorilla, María JoséRomero, Eder LiliaNano-ObjectsMetallic NanoparticlesEphiteliaFungihttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Fungal infections can attack epithelial tissues and, according to the immunological state of the patient, some of them invade deeper organs, becoming seriously life compromising. Besides, bloodstream and local infections associated with intravascular devices constitute a significant problem associated with increased mortality. Topical therapy is desirable since, in addition to targeting the site of infection, it reduces the risk of systemic side effects and increases patient compliance. In this review we describe the pros and cons of using nano-objects that being toxic in nature could be used to cover surfaces of medical devices, or can act as carriers for targeted delivery of antifungals to skin. Non-toxic nano-objects were also included because they improve the ocular delivery of antifungals, classically suffering from ineffective topical administration, difficult access for systemic medication or local invasive administration. The new preclinical developments of nanoparticulate agents against cutaneous and ocular mycosis are grouped in three main sections: (1) In vitro antifungal activity of metallic nanoparticles, (2) In vitro and in vivo antifungal activity of non metallic nanoparticles (3) Ocular delivery of non metallic nanoparticles.Fil: Higa, Leticia Herminia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schilrreff, Priscila. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perez, Ana Paula. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Morilla, María José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Romero, Eder Lilia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Scientific Publishers2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22944Higa, Leticia Herminia; Schilrreff, Priscila; Perez, Ana Paula; Morilla, María José; Romero, Eder Lilia; The intervention of Nanotechnology against epithelial fungal diseases; American Scientific Publishers; Journal of Biomaterials and Tissue Engineering; 3; 1; 2-2013; 70-882157-90832157-9091CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/contentone/asp/jbte/2013/00000003/00000001/art00006info:eu-repo/semantics/altIdentifier/doi/10.1166/jbt.2013.1065info:eu-repo/semantics/altIdentifier/url/http://www.aspbs.com/jbt/contents_jbt2013.htm#v3n1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:10:59Zoai:ri.conicet.gov.ar:11336/22944instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:00.15CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The intervention of Nanotechnology against epithelial fungal diseases
title The intervention of Nanotechnology against epithelial fungal diseases
spellingShingle The intervention of Nanotechnology against epithelial fungal diseases
Higa, Leticia Herminia
Nano-Objects
Metallic Nanoparticles
Ephitelia
Fungi
title_short The intervention of Nanotechnology against epithelial fungal diseases
title_full The intervention of Nanotechnology against epithelial fungal diseases
title_fullStr The intervention of Nanotechnology against epithelial fungal diseases
title_full_unstemmed The intervention of Nanotechnology against epithelial fungal diseases
title_sort The intervention of Nanotechnology against epithelial fungal diseases
dc.creator.none.fl_str_mv Higa, Leticia Herminia
Schilrreff, Priscila
Perez, Ana Paula
Morilla, María José
Romero, Eder Lilia
author Higa, Leticia Herminia
author_facet Higa, Leticia Herminia
Schilrreff, Priscila
Perez, Ana Paula
Morilla, María José
Romero, Eder Lilia
author_role author
author2 Schilrreff, Priscila
Perez, Ana Paula
Morilla, María José
Romero, Eder Lilia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Nano-Objects
Metallic Nanoparticles
Ephitelia
Fungi
topic Nano-Objects
Metallic Nanoparticles
Ephitelia
Fungi
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Fungal infections can attack epithelial tissues and, according to the immunological state of the patient, some of them invade deeper organs, becoming seriously life compromising. Besides, bloodstream and local infections associated with intravascular devices constitute a significant problem associated with increased mortality. Topical therapy is desirable since, in addition to targeting the site of infection, it reduces the risk of systemic side effects and increases patient compliance. In this review we describe the pros and cons of using nano-objects that being toxic in nature could be used to cover surfaces of medical devices, or can act as carriers for targeted delivery of antifungals to skin. Non-toxic nano-objects were also included because they improve the ocular delivery of antifungals, classically suffering from ineffective topical administration, difficult access for systemic medication or local invasive administration. The new preclinical developments of nanoparticulate agents against cutaneous and ocular mycosis are grouped in three main sections: (1) In vitro antifungal activity of metallic nanoparticles, (2) In vitro and in vivo antifungal activity of non metallic nanoparticles (3) Ocular delivery of non metallic nanoparticles.
Fil: Higa, Leticia Herminia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schilrreff, Priscila. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perez, Ana Paula. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Morilla, María José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romero, Eder Lilia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Fungal infections can attack epithelial tissues and, according to the immunological state of the patient, some of them invade deeper organs, becoming seriously life compromising. Besides, bloodstream and local infections associated with intravascular devices constitute a significant problem associated with increased mortality. Topical therapy is desirable since, in addition to targeting the site of infection, it reduces the risk of systemic side effects and increases patient compliance. In this review we describe the pros and cons of using nano-objects that being toxic in nature could be used to cover surfaces of medical devices, or can act as carriers for targeted delivery of antifungals to skin. Non-toxic nano-objects were also included because they improve the ocular delivery of antifungals, classically suffering from ineffective topical administration, difficult access for systemic medication or local invasive administration. The new preclinical developments of nanoparticulate agents against cutaneous and ocular mycosis are grouped in three main sections: (1) In vitro antifungal activity of metallic nanoparticles, (2) In vitro and in vivo antifungal activity of non metallic nanoparticles (3) Ocular delivery of non metallic nanoparticles.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22944
Higa, Leticia Herminia; Schilrreff, Priscila; Perez, Ana Paula; Morilla, María José; Romero, Eder Lilia; The intervention of Nanotechnology against epithelial fungal diseases; American Scientific Publishers; Journal of Biomaterials and Tissue Engineering; 3; 1; 2-2013; 70-88
2157-9083
2157-9091
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22944
identifier_str_mv Higa, Leticia Herminia; Schilrreff, Priscila; Perez, Ana Paula; Morilla, María José; Romero, Eder Lilia; The intervention of Nanotechnology against epithelial fungal diseases; American Scientific Publishers; Journal of Biomaterials and Tissue Engineering; 3; 1; 2-2013; 70-88
2157-9083
2157-9091
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/contentone/asp/jbte/2013/00000003/00000001/art00006
info:eu-repo/semantics/altIdentifier/doi/10.1166/jbt.2013.1065
info:eu-repo/semantics/altIdentifier/url/http://www.aspbs.com/jbt/contents_jbt2013.htm#v3n1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Scientific Publishers
publisher.none.fl_str_mv American Scientific Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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