Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences

Autores
Tomat, Analia Lorena; Salazar, Francisco Javier
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: A substantial body of epidemiological and experimental evidence suggests that a poor fetal and neonatal environment may "program" susceptibility in the offspring to later development of cardiovascular, renal and metabolic diseases. Materials and methods: This review focuses on current knowledge from the available literature regarding the mechanisms linking an adverse developmental environment with an increased risk for cardiovascular, renal and metabolic diseases in adult life. Moreover, this review highlights important sex-dependent differences in the adaptation to developmental insults. Results: Developmental programming of several diseases is secondary to changes in different mechanisms inducing important alterations in the normal development of several organs that lead to significant changes in birth weight. The different diseases occurring as a consequence of an adverse environment during development are secondary to morphological and functional cardiovascular and renal changes, to epigenetic changes and to an activation of several hormonal and regulatory systems, such as angiotensin II, sympathetic activity, nitric oxide, COX2-derived metabolites, oxidative stress and inflammation. The important sex-dependent differences in the developmental programming of diseases seem to be partly secondary to the effects of sex hormones. Recent studies have shown that the progression of these diseases is accelerated during aging in both sexes. Conclusions: The cardiovascular, renal and metabolic diseases during adult life that occur as a consequence of several insults during fetal and postnatal periods are secondary to multiple structural and functional changes. Future studies are needed in order to prevent the origin and reduce the incidence and consequences of developmental programmed diseases.
Fil: Tomat, Analia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina
Fil: Salazar, Francisco Javier. Universidad de Murcia; España
Materia
DEVELOPMENTAL PROGRAMMING
HYPERTENSION
RENAL DISEASES
RENIN-ANGIOTENSIN SYSTEM
SEX DIFFERENCES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84745
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/84745
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differencesTomat, Analia LorenaSalazar, Francisco JavierDEVELOPMENTAL PROGRAMMINGHYPERTENSIONRENAL DISEASESRENIN-ANGIOTENSIN SYSTEMSEX DIFFERENCEShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: A substantial body of epidemiological and experimental evidence suggests that a poor fetal and neonatal environment may "program" susceptibility in the offspring to later development of cardiovascular, renal and metabolic diseases. Materials and methods: This review focuses on current knowledge from the available literature regarding the mechanisms linking an adverse developmental environment with an increased risk for cardiovascular, renal and metabolic diseases in adult life. Moreover, this review highlights important sex-dependent differences in the adaptation to developmental insults. Results: Developmental programming of several diseases is secondary to changes in different mechanisms inducing important alterations in the normal development of several organs that lead to significant changes in birth weight. The different diseases occurring as a consequence of an adverse environment during development are secondary to morphological and functional cardiovascular and renal changes, to epigenetic changes and to an activation of several hormonal and regulatory systems, such as angiotensin II, sympathetic activity, nitric oxide, COX2-derived metabolites, oxidative stress and inflammation. The important sex-dependent differences in the developmental programming of diseases seem to be partly secondary to the effects of sex hormones. Recent studies have shown that the progression of these diseases is accelerated during aging in both sexes. Conclusions: The cardiovascular, renal and metabolic diseases during adult life that occur as a consequence of several insults during fetal and postnatal periods are secondary to multiple structural and functional changes. Future studies are needed in order to prevent the origin and reduce the incidence and consequences of developmental programmed diseases.Fil: Tomat, Analia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; ArgentinaFil: Salazar, Francisco Javier. Universidad de Murcia; EspañaDe Gruyter2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84745Tomat, Analia Lorena; Salazar, Francisco Javier; Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 18; 2; 5-2014; 63-771868-1891CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1515/hmbci-2013-0054info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/hmbci.2014.18.issue-2/hmbci-2013-0054/hmbci-2013-0054.xmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:42:54Zoai:ri.conicet.gov.ar:11336/84745instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:42:54.353CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences
title Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences
spellingShingle Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences
Tomat, Analia Lorena
DEVELOPMENTAL PROGRAMMING
HYPERTENSION
RENAL DISEASES
RENIN-ANGIOTENSIN SYSTEM
SEX DIFFERENCES
title_short Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences
title_full Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences
title_fullStr Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences
title_full_unstemmed Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences
title_sort Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences
dc.creator.none.fl_str_mv Tomat, Analia Lorena
Salazar, Francisco Javier
author Tomat, Analia Lorena
author_facet Tomat, Analia Lorena
Salazar, Francisco Javier
author_role author
author2 Salazar, Francisco Javier
author2_role author
dc.subject.none.fl_str_mv DEVELOPMENTAL PROGRAMMING
HYPERTENSION
RENAL DISEASES
RENIN-ANGIOTENSIN SYSTEM
SEX DIFFERENCES
topic DEVELOPMENTAL PROGRAMMING
HYPERTENSION
RENAL DISEASES
RENIN-ANGIOTENSIN SYSTEM
SEX DIFFERENCES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: A substantial body of epidemiological and experimental evidence suggests that a poor fetal and neonatal environment may "program" susceptibility in the offspring to later development of cardiovascular, renal and metabolic diseases. Materials and methods: This review focuses on current knowledge from the available literature regarding the mechanisms linking an adverse developmental environment with an increased risk for cardiovascular, renal and metabolic diseases in adult life. Moreover, this review highlights important sex-dependent differences in the adaptation to developmental insults. Results: Developmental programming of several diseases is secondary to changes in different mechanisms inducing important alterations in the normal development of several organs that lead to significant changes in birth weight. The different diseases occurring as a consequence of an adverse environment during development are secondary to morphological and functional cardiovascular and renal changes, to epigenetic changes and to an activation of several hormonal and regulatory systems, such as angiotensin II, sympathetic activity, nitric oxide, COX2-derived metabolites, oxidative stress and inflammation. The important sex-dependent differences in the developmental programming of diseases seem to be partly secondary to the effects of sex hormones. Recent studies have shown that the progression of these diseases is accelerated during aging in both sexes. Conclusions: The cardiovascular, renal and metabolic diseases during adult life that occur as a consequence of several insults during fetal and postnatal periods are secondary to multiple structural and functional changes. Future studies are needed in order to prevent the origin and reduce the incidence and consequences of developmental programmed diseases.
Fil: Tomat, Analia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina
Fil: Salazar, Francisco Javier. Universidad de Murcia; España
description Background: A substantial body of epidemiological and experimental evidence suggests that a poor fetal and neonatal environment may "program" susceptibility in the offspring to later development of cardiovascular, renal and metabolic diseases. Materials and methods: This review focuses on current knowledge from the available literature regarding the mechanisms linking an adverse developmental environment with an increased risk for cardiovascular, renal and metabolic diseases in adult life. Moreover, this review highlights important sex-dependent differences in the adaptation to developmental insults. Results: Developmental programming of several diseases is secondary to changes in different mechanisms inducing important alterations in the normal development of several organs that lead to significant changes in birth weight. The different diseases occurring as a consequence of an adverse environment during development are secondary to morphological and functional cardiovascular and renal changes, to epigenetic changes and to an activation of several hormonal and regulatory systems, such as angiotensin II, sympathetic activity, nitric oxide, COX2-derived metabolites, oxidative stress and inflammation. The important sex-dependent differences in the developmental programming of diseases seem to be partly secondary to the effects of sex hormones. Recent studies have shown that the progression of these diseases is accelerated during aging in both sexes. Conclusions: The cardiovascular, renal and metabolic diseases during adult life that occur as a consequence of several insults during fetal and postnatal periods are secondary to multiple structural and functional changes. Future studies are needed in order to prevent the origin and reduce the incidence and consequences of developmental programmed diseases.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84745
Tomat, Analia Lorena; Salazar, Francisco Javier; Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 18; 2; 5-2014; 63-77
1868-1891
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84745
identifier_str_mv Tomat, Analia Lorena; Salazar, Francisco Javier; Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 18; 2; 5-2014; 63-77
1868-1891
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1515/hmbci-2013-0054
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/hmbci.2014.18.issue-2/hmbci-2013-0054/hmbci-2013-0054.xml
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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