A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice

Autores
de Carvalho Marchesin, Juliana; Sbaglia Celiberto, Larissa; Botinhon Orlando, Allan; Ivo de Medeiros, Alexandra; Pinto, Roseli Aparecida; Sampaio Zuanon, José Antônio; Spolidorio, Luis Carlos; dos Santos, Andrey; Taranto, Maria Pia; Umbelino Cavallini, Daniela Cardoso
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work investigates the effect of a soy-based probiotic drink (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) on the fecal microbiota composition, body weight and inflammatory parameters in diet-induced obese mice. The probiotic group had a lower body weight until 9th week of the study, reduced area and diameter of adipocytes, and showed a significant increase of IL-6 and IL-10 compared to the obesite non-treated group. The intake of a high-fat diet results in an increase of Lactobacillus spp. while the probiotic drink positively modulates the intestinal microbiota by maintaining the population of microorganisms belonging to the phylum Bacteroidetes and increases Bifidobacterium spp. Our study finds that the regular intake of this probiotic drink is able to reduce body weight gain and the size of adipocytes while modulating the fecal microbiota and the immune profile of animals, therefore acting in a beneficial manner in the control of obesity.
Fil: de Carvalho Marchesin, Juliana. Universidade Estadual de Campinas; Brasil
Fil: Sbaglia Celiberto, Larissa. Universidade Estadual de Campinas; Brasil
Fil: Botinhon Orlando, Allan. Universidade Estadual de Campinas; Brasil
Fil: Ivo de Medeiros, Alexandra. Universidade Estadual de Campinas; Brasil
Fil: Pinto, Roseli Aparecida. Universidade Estadual de Campinas; Brasil
Fil: Sampaio Zuanon, José Antônio. Universidade Estadual de Campinas; Brasil
Fil: Spolidorio, Luis Carlos. Universidade Estadual de Campinas; Brasil
Fil: dos Santos, Andrey. Universidade Estadual de Campinas; Brasil
Fil: Taranto, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Umbelino Cavallini, Daniela Cardoso. Universidade Estadual de Campinas; Brasil
Materia
Adipose Tissue
Cytokine
Fasting Blood Glucose
Intestinal Microbiota
Obesity
Probiotic
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/81435
Acceder
id CONICETDig_06b540b0fe4f499197375532f8d397a8
oai_identifier_str oai:ri.conicet.gov.ar:11336/81435
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese micede Carvalho Marchesin, JulianaSbaglia Celiberto, LarissaBotinhon Orlando, AllanIvo de Medeiros, AlexandraPinto, Roseli AparecidaSampaio Zuanon, José AntônioSpolidorio, Luis Carlosdos Santos, AndreyTaranto, Maria PiaUmbelino Cavallini, Daniela CardosoAdipose TissueCytokineFasting Blood GlucoseIntestinal MicrobiotaObesityProbiotichttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This work investigates the effect of a soy-based probiotic drink (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) on the fecal microbiota composition, body weight and inflammatory parameters in diet-induced obese mice. The probiotic group had a lower body weight until 9th week of the study, reduced area and diameter of adipocytes, and showed a significant increase of IL-6 and IL-10 compared to the obesite non-treated group. The intake of a high-fat diet results in an increase of Lactobacillus spp. while the probiotic drink positively modulates the intestinal microbiota by maintaining the population of microorganisms belonging to the phylum Bacteroidetes and increases Bifidobacterium spp. Our study finds that the regular intake of this probiotic drink is able to reduce body weight gain and the size of adipocytes while modulating the fecal microbiota and the immune profile of animals, therefore acting in a beneficial manner in the control of obesity.Fil: de Carvalho Marchesin, Juliana. Universidade Estadual de Campinas; BrasilFil: Sbaglia Celiberto, Larissa. Universidade Estadual de Campinas; BrasilFil: Botinhon Orlando, Allan. Universidade Estadual de Campinas; BrasilFil: Ivo de Medeiros, Alexandra. Universidade Estadual de Campinas; BrasilFil: Pinto, Roseli Aparecida. Universidade Estadual de Campinas; BrasilFil: Sampaio Zuanon, José Antônio. Universidade Estadual de Campinas; BrasilFil: Spolidorio, Luis Carlos. Universidade Estadual de Campinas; BrasilFil: dos Santos, Andrey. Universidade Estadual de Campinas; BrasilFil: Taranto, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Umbelino Cavallini, Daniela Cardoso. Universidade Estadual de Campinas; BrasilElsevier2018-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/81435de Carvalho Marchesin, Juliana; Sbaglia Celiberto, Larissa; Botinhon Orlando, Allan; Ivo de Medeiros, Alexandra; Pinto, Roseli Aparecida; et al.; A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice; Elsevier; Journal of Functional Foods; 48; 9; 9-2018; 302-3131756-4646CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2018.07.010info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1756464618303463?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:02Zoai:ri.conicet.gov.ar:11336/81435instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:02.554CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
title A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
spellingShingle A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
de Carvalho Marchesin, Juliana
Adipose Tissue
Cytokine
Fasting Blood Glucose
Intestinal Microbiota
Obesity
Probiotic
title_short A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
title_full A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
title_fullStr A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
title_full_unstemmed A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
title_sort A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
dc.creator.none.fl_str_mv de Carvalho Marchesin, Juliana
Sbaglia Celiberto, Larissa
Botinhon Orlando, Allan
Ivo de Medeiros, Alexandra
Pinto, Roseli Aparecida
Sampaio Zuanon, José Antônio
Spolidorio, Luis Carlos
dos Santos, Andrey
Taranto, Maria Pia
Umbelino Cavallini, Daniela Cardoso
author de Carvalho Marchesin, Juliana
author_facet de Carvalho Marchesin, Juliana
Sbaglia Celiberto, Larissa
Botinhon Orlando, Allan
Ivo de Medeiros, Alexandra
Pinto, Roseli Aparecida
Sampaio Zuanon, José Antônio
Spolidorio, Luis Carlos
dos Santos, Andrey
Taranto, Maria Pia
Umbelino Cavallini, Daniela Cardoso
author_role author
author2 Sbaglia Celiberto, Larissa
Botinhon Orlando, Allan
Ivo de Medeiros, Alexandra
Pinto, Roseli Aparecida
Sampaio Zuanon, José Antônio
Spolidorio, Luis Carlos
dos Santos, Andrey
Taranto, Maria Pia
Umbelino Cavallini, Daniela Cardoso
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Adipose Tissue
Cytokine
Fasting Blood Glucose
Intestinal Microbiota
Obesity
Probiotic
topic Adipose Tissue
Cytokine
Fasting Blood Glucose
Intestinal Microbiota
Obesity
Probiotic
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This work investigates the effect of a soy-based probiotic drink (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) on the fecal microbiota composition, body weight and inflammatory parameters in diet-induced obese mice. The probiotic group had a lower body weight until 9th week of the study, reduced area and diameter of adipocytes, and showed a significant increase of IL-6 and IL-10 compared to the obesite non-treated group. The intake of a high-fat diet results in an increase of Lactobacillus spp. while the probiotic drink positively modulates the intestinal microbiota by maintaining the population of microorganisms belonging to the phylum Bacteroidetes and increases Bifidobacterium spp. Our study finds that the regular intake of this probiotic drink is able to reduce body weight gain and the size of adipocytes while modulating the fecal microbiota and the immune profile of animals, therefore acting in a beneficial manner in the control of obesity.
Fil: de Carvalho Marchesin, Juliana. Universidade Estadual de Campinas; Brasil
Fil: Sbaglia Celiberto, Larissa. Universidade Estadual de Campinas; Brasil
Fil: Botinhon Orlando, Allan. Universidade Estadual de Campinas; Brasil
Fil: Ivo de Medeiros, Alexandra. Universidade Estadual de Campinas; Brasil
Fil: Pinto, Roseli Aparecida. Universidade Estadual de Campinas; Brasil
Fil: Sampaio Zuanon, José Antônio. Universidade Estadual de Campinas; Brasil
Fil: Spolidorio, Luis Carlos. Universidade Estadual de Campinas; Brasil
Fil: dos Santos, Andrey. Universidade Estadual de Campinas; Brasil
Fil: Taranto, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Umbelino Cavallini, Daniela Cardoso. Universidade Estadual de Campinas; Brasil
description This work investigates the effect of a soy-based probiotic drink (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) on the fecal microbiota composition, body weight and inflammatory parameters in diet-induced obese mice. The probiotic group had a lower body weight until 9th week of the study, reduced area and diameter of adipocytes, and showed a significant increase of IL-6 and IL-10 compared to the obesite non-treated group. The intake of a high-fat diet results in an increase of Lactobacillus spp. while the probiotic drink positively modulates the intestinal microbiota by maintaining the population of microorganisms belonging to the phylum Bacteroidetes and increases Bifidobacterium spp. Our study finds that the regular intake of this probiotic drink is able to reduce body weight gain and the size of adipocytes while modulating the fecal microbiota and the immune profile of animals, therefore acting in a beneficial manner in the control of obesity.
publishDate 2018
dc.date.none.fl_str_mv 2018-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/81435
de Carvalho Marchesin, Juliana; Sbaglia Celiberto, Larissa; Botinhon Orlando, Allan; Ivo de Medeiros, Alexandra; Pinto, Roseli Aparecida; et al.; A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice; Elsevier; Journal of Functional Foods; 48; 9; 9-2018; 302-313
1756-4646
CONICET Digital
CONICET
url http://hdl.handle.net/11336/81435
identifier_str_mv de Carvalho Marchesin, Juliana; Sbaglia Celiberto, Larissa; Botinhon Orlando, Allan; Ivo de Medeiros, Alexandra; Pinto, Roseli Aparecida; et al.; A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice; Elsevier; Journal of Functional Foods; 48; 9; 9-2018; 302-313
1756-4646
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2018.07.010
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1756464618303463?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269557239054336
score 13.13397

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